Small-Molecule Inhibitors of HIF-2a Translation Link Its 5′UTR Iron-Responsive Element to Oxygen Sensing

Molecular Cell

Volumn 32, Issue 6, 2008, Pages 838-848

  Zimmer, Michael ^a   Ebert, Benjamin L ^b   Neil, Christopher ^a   Brenner, Keith ^a   Papaioannou, Ioannis ^a   Melas, Antonia ^a   Tolliday, Nicola ^c   Lamb, Justin ^b   Pantopoulos, Kostas ^d   Golub, Todd ^b   Iliopoulos, Othon ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

CHEMBIO; RNA; SIGNALING

Indexed keywords

CD71 ANTIGEN; HYPOXIA INDUCIBLE FACTOR 2ALPHA; IRON REGULATORY PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; SHORT HAIRPIN RNA;

5' UNTRANSLATED REGION; ARTICLE; CELL HYPOXIA; CONTROLLED STUDY; GENE DISRUPTION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; IRON CHELATION; IRON RESPONSIVE ELEMENT; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; OXYGEN SENSING; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RNA TRANSLATION; UPREGULATION;

5' UNTRANSLATED REGIONS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL HYPOXIA; CELL PROLIFERATION; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; IRON; IRON CHELATING AGENTS; IRON-REGULATORY PROTEINS; OXYGEN; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PROTEIN KINASES; PROTEIN STABILITY; RECEPTORS, TRANSFERRIN; RESPONSE ELEMENTS; RNA STABILITY; RNA, MESSENGER; SMALL MOLECULE LIBRARIES;

EID: 57849147670     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2008.12.004     Document Type: Article

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