메뉴 건너뛰기




Volumn 110, Issue 3, 2008, Pages 465-475

Hypoxia-inducible factor 1α is closely linked to an aggressive phenotype in breast cancer

Author keywords

Hypoxia inducible factor 1 breast cancer; Immunohistochemistry; Prognostic factor; Vascular endothelial growth factor

Indexed keywords

ANTHRACYCLINE; ANTINEOPLASTIC AGENT; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; KI 67 ANTIGEN; PROGESTERONE RECEPTOR; PROTEIN P53; VASCULOTROPIN;

EID: 46949094778     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10549-007-9742-1     Document Type: Article
Times cited : (134)

References (46)
  • 1
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • 23
    • Vaupel P, Kallinowski F, Okunieff P (1989) Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49(23):6449-6465
    • (1989) Cancer Res , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 2
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • 12
    • Semenza GL, Wang GL (1992) A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12(12):5447-5454
    • (1992) Mol Cell Biol , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 3
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • 4
    • Hockel M, Vaupel P (2001) Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 93(4):266-276
    • (2001) J Natl Cancer Inst , vol.93 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 4
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • 12
    • Wang GL et al (1995) Hypoxia-inducible factor 1 is a basic-helix-loop- helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92(12): 5510-5514
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1
  • 5
    • 0029753008 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
    • 50
    • Huang LE et al (1996) Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 271(50):32253-32259
    • (1996) J Biol Chem , vol.271 , pp. 32253-32259
    • Huang, L.E.1
  • 6
    • 0037064010 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    • 41
    • Fukuda R et al (2002) Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 277(41):38205-38211
    • (2002) J Biol Chem , vol.277 , pp. 38205-38211
    • Fukuda, R.1
  • 7
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • 6
    • Zhong H et al (2000) Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60(6):1541-1545
    • (2000) Cancer Res , vol.60 , pp. 1541-1545
    • Zhong, H.1
  • 8
    • 0034682783 scopus 로고    scopus 로고
    • Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
    • 33
    • Cockman ME et al (2000) Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J Biol Chem 275(33):25733-25741
    • (2000) J Biol Chem , vol.275 , pp. 25733-25741
    • Cockman, M.E.1
  • 9
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • 6733
    • Maxwell PH et al (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399(6733):271-275
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1
  • 10
    • 0033776536 scopus 로고    scopus 로고
    • Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
    • 7
    • Ohh M et al (2000) Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol 2(7):423-427
    • (2000) Nat Cell Biol , vol.2 , pp. 423-427
    • Ohh, M.1
  • 11
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
    • 2
    • Talks KL et al (2000) The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 157(2):411-421
    • (2000) Am J Pathol , vol.157 , pp. 411-421
    • Talks, K.L.1
  • 12
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
    • 22
    • Zhong H et al (1999) Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59(22):5830-5835
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zhong, H.1
  • 13
    • 0035300410 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1alpha: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
    • 7
    • Aebersold DM et al (2001) Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 61(7):2911-2916
    • (2001) Cancer Res , vol.61 , pp. 2911-2916
    • Aebersold, D.M.1
  • 14
    • 0037500967 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer
    • 6
    • Bachtiary B et al (2003) Overexpression of hypoxia-inducible factor 1alpha indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer. Clin Cancer Res 9(6):2234-2240
    • (2003) Clin Cancer Res , vol.9 , pp. 2234-2240
    • Bachtiary, B.1
  • 15
    • 0038282482 scopus 로고    scopus 로고
    • The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy
    • 21
    • Unruh A et al (2003) The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy. Oncogene 22(21):3213-3220
    • (2003) Oncogene , vol.22 , pp. 3213-3220
    • Unruh, A.1
  • 16
    • 0037443587 scopus 로고    scopus 로고
    • Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma
    • 6
    • Bos R et al (2003) Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 97(6):1573-1581
    • (2003) Cancer , vol.97 , pp. 1573-1581
    • Bos, R.1
  • 17
    • 0026072872 scopus 로고
    • Pathological prognostic factors in breast cancer. I. the value of histological grade in breast cancer: Experience from a large study with long-term follow-up
    • 5
    • Elston CW, Ellis IO (1991) Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19(5):403-410
    • (1991) Histopathology , vol.19 , pp. 403-410
    • Elston, C.W.1    Ellis, I.O.2
  • 18
    • 0035925072 scopus 로고    scopus 로고
    • Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis
    • 4
    • Bos R et al (2001) Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. J Natl Cancer Inst 93(4):309-314
    • (2001) J Natl Cancer Inst , vol.93 , pp. 309-314
    • Bos, R.1
  • 19
    • 0036789574 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
    • 20
    • Hudson CC et al (2002) Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol 22(20):7004-7014
    • (2002) Mol Cell Biol , vol.22 , pp. 7004-7014
    • Hudson, C.C.1
  • 20
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • 10
    • Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3(10):721-732
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 21
    • 19944434232 scopus 로고    scopus 로고
    • Differential prognostic impact of hypoxia induced and diffuse HIF-1alpha expression in invasive breast cancer
    • 2
    • Vleugel MM et al (2005) Differential prognostic impact of hypoxia induced and diffuse HIF-1alpha expression in invasive breast cancer. J Clin Pathol 58(2):172-177
    • (2005) J Clin Pathol , vol.58 , pp. 172-177
    • Vleugel, M.M.1
  • 22
    • 9744250235 scopus 로고    scopus 로고
    • C-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent
    • 23
    • Giatromanolaki A et al (2004) c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent. Clin Cancer Res 10(23):7972-7977
    • (2004) Clin Cancer Res , vol.10 , pp. 7972-7977
    • Giatromanolaki, A.1
  • 23
    • 3142724677 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 alpha in high-risk breast cancer: An independent prognostic parameter?
    • 3
    • Gruber G et al (2004) Hypoxia-inducible factor 1 alpha in high-risk breast cancer: an independent prognostic parameter? Breast Cancer Res 6(3):R191-198
    • (2004) Breast Cancer Res , vol.6 , pp. 191-198
    • Gruber, G.1
  • 24
    • 0035676830 scopus 로고    scopus 로고
    • A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts
    • 12
    • Kurebayashi J et al (2001) A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts. Jpn J Cancer Res 92(12):1342-1351
    • (2001) Jpn J Cancer Res , vol.92 , pp. 1342-1351
    • Kurebayashi, J.1
  • 25
    • 0031684721 scopus 로고    scopus 로고
    • The HER-2/neu oncogene in breast cancer: Prognostic factor, predictive factor, and target for therapy
    • 4
    • Ross JS, Fletcher JA (1998) The HER-2/neu oncogene in breast cancer: prognostic factor, predictive factor, and target for therapy. Oncologist 3(4):237-252
    • (1998) Oncologist , vol.3 , pp. 237-252
    • Ross, J.S.1    Fletcher, J.A.2
  • 26
    • 0029985805 scopus 로고    scopus 로고
    • Quantitative analysis of vascular endothelial growth factor in primary breast cancer
    • 6
    • Toi M et al (1996) Quantitative analysis of vascular endothelial growth factor in primary breast cancer. Cancer 77(6):1101-1106
    • (1996) Cancer , vol.77 , pp. 1101-1106
    • Toi, M.1
  • 27
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • 6
    • Ferrara N, Gerber HP, LeCouter J (2003) The biology of VEGF and its receptors. Nat Med 9(6):669-676
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 28
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • 9
    • Forsythe JA et al (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16(9):4604-4613
    • (1996) Mol Cell Biol , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1
  • 29
    • 0029039195 scopus 로고
    • Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
    • 22
    • Levy AP et al (1995) Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem 270(22):13333-13340
    • (1995) J Biol Chem , vol.270 , pp. 13333-13340
    • Levy, A.P.1
  • 30
    • 0036468899 scopus 로고    scopus 로고
    • Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer
    • 3
    • Ristimaki A et al (2002) Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. Cancer Res 62(3):632-635
    • (2002) Cancer Res , vol.62 , pp. 632-635
    • Ristimaki, A.1
  • 31
    • 7044227910 scopus 로고    scopus 로고
    • NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 activity: Multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms
    • 4
    • Zhong H, Willard M, Simons J (2004) NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms. Int J Cancer 112(4):585-595
    • (2004) Int J Cancer , vol.112 , pp. 585-595
    • Zhong, H.1    Willard, M.2    Simons, J.3
  • 32
    • 0032192140 scopus 로고    scopus 로고
    • The complexity of p53 modulation: Emerging patterns from divergent signals
    • 19
    • Giaccia AJ, Kastan MB (1998) The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev 12(19):2973-2983
    • (1998) Genes Dev , vol.12 , pp. 2973-2983
    • Giaccia, A.J.1    Kastan, M.B.2
  • 33
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • 3
    • Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88(3):323-331
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 34
    • 7044271020 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1alpha and cell cycle proteins in invasive breast cancer are estrogen receptor related
    • 4
    • Bos R et al (2004) Expression of hypoxia-inducible factor-1alpha and cell cycle proteins in invasive breast cancer are estrogen receptor related. Breast Cancer Res 6(4):R450-459
    • (2004) Breast Cancer Res , vol.6 , pp. 450-459
    • Bos, R.1
  • 35
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    • 6692
    • Carmeliet P et al (1998) Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394(6692):485-490
    • (1998) Nature , vol.394 , pp. 485-490
    • Carmeliet, P.1
  • 36
    • 0032568150 scopus 로고    scopus 로고
    • Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
    • 6674
    • An WG et al (1998) Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature 392(6674):405-408
    • (1998) Nature , vol.392 , pp. 405-408
    • An, W.G.1
  • 37
    • 0033954247 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
    • 1
    • Ravi R et al (2000) Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev 14(1):34-44
    • (2000) Genes Dev , vol.14 , pp. 34-44
    • Ravi, R.1
  • 38
    • 0028875410 scopus 로고
    • Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy
    • 10
    • Bergh J et al (1995) Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy. Nat Med 1(10):1029-1034
    • (1995) Nat Med , vol.1 , pp. 1029-1034
    • Bergh, J.1
  • 39
    • 0030058617 scopus 로고    scopus 로고
    • The p53 gene in breast cancer: Prognostic value of complementary DNA sequencing versus immunohistochemistry
    • 3-4
    • Sjogren S et al (1996) The p53 gene in breast cancer: prognostic value of complementary DNA sequencing versus immunohistochemistry. J Natl Cancer Inst 88(3-4):173-182
    • (1996) J Natl Cancer Inst , vol.88 , pp. 173-182
    • Sjogren, S.1
  • 40
    • 3142534607 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer
    • 2
    • Theodoropoulos VE et al (2004) Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer. Eur Urol 46(2):200-208
    • (2004) Eur Urol , vol.46 , pp. 200-208
    • Theodoropoulos, V.E.1
  • 41
    • 3042816190 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 alpha in non small cell lung cancer: Relation to growth factor, protease and apoptosis pathways
    • 1
    • Swinson DE et al (2004) Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways. Int J Cancer 111(1):43-50
    • (2004) Int J Cancer , vol.111 , pp. 43-50
    • Swinson, D.E.1
  • 42
    • 0038725471 scopus 로고    scopus 로고
    • CD105 is important for angiogenesis: Evidence and potential applications
    • 9
    • Duff SE et al (2003) CD105 is important for angiogenesis: evidence and potential applications. Faseb J 17(9):984-992
    • (2003) Faseb J , vol.17 , pp. 984-992
    • Duff, S.E.1
  • 43
    • 0036278899 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer
    • 6
    • Schindl M et al (2002) Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer. Clin Cancer Res 8(6):1831-1837
    • (2002) Clin Cancer Res , vol.8 , pp. 1831-1837
    • Schindl, M.1
  • 44
    • 23244463512 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor HIF-1alpha predicts early relapse in breast cancer: Retrospective study in a series of 745 patients
    • 5
    • Dales JP et al (2005) Overexpression of hypoxia-inducible factor HIF-1alpha predicts early relapse in breast cancer: retrospective study in a series of 745 patients. Int J Cancer 116(5):734-739
    • (2005) Int J Cancer , vol.116 , pp. 734-739
    • Dales, J.P.1
  • 45
    • 0035395098 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: Its impact on prognosis and on neoangiogenesis
    • 1
    • Birner P et al (2001) Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis. Cancer 92(1):165-171
    • (2001) Cancer , vol.92 , pp. 165-171
    • Birner, P.1
  • 46
    • 0034282518 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
    • 17
    • Birner P et al (2000) Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res 60(17):4693-4696
    • (2000) Cancer Res , vol.60 , pp. 4693-4696
    • Birner, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.