-
1
-
-
0024408986
-
Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
-
23
-
Vaupel P, Kallinowski F, Okunieff P (1989) Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49(23):6449-6465
-
(1989)
Cancer Res
, vol.49
, pp. 6449-6465
-
-
Vaupel, P.1
Kallinowski, F.2
Okunieff, P.3
-
2
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
12
-
Semenza GL, Wang GL (1992) A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 12(12):5447-5454
-
(1992)
Mol Cell Biol
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
3
-
-
0035925098
-
Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
-
4
-
Hockel M, Vaupel P (2001) Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 93(4):266-276
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 266-276
-
-
Hockel, M.1
Vaupel, P.2
-
4
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
12
-
Wang GL et al (1995) Hypoxia-inducible factor 1 is a basic-helix-loop- helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92(12): 5510-5514
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
-
5
-
-
0029753008
-
Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
-
50
-
Huang LE et al (1996) Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 271(50):32253-32259
-
(1996)
J Biol Chem
, vol.271
, pp. 32253-32259
-
-
Huang, L.E.1
-
6
-
-
0037064010
-
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
-
41
-
Fukuda R et al (2002) Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 277(41):38205-38211
-
(2002)
J Biol Chem
, vol.277
, pp. 38205-38211
-
-
Fukuda, R.1
-
7
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
6
-
Zhong H et al (2000) Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 60(6):1541-1545
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
-
8
-
-
0034682783
-
Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
-
33
-
Cockman ME et al (2000) Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J Biol Chem 275(33):25733-25741
-
(2000)
J Biol Chem
, vol.275
, pp. 25733-25741
-
-
Cockman, M.E.1
-
9
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
6733
-
Maxwell PH et al (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399(6733):271-275
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
-
10
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
-
7
-
Ohh M et al (2000) Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol 2(7):423-427
-
(2000)
Nat Cell Biol
, vol.2
, pp. 423-427
-
-
Ohh, M.1
-
11
-
-
0033870281
-
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
-
2
-
Talks KL et al (2000) The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 157(2):411-421
-
(2000)
Am J Pathol
, vol.157
, pp. 411-421
-
-
Talks, K.L.1
-
12
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
22
-
Zhong H et al (1999) Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59(22):5830-5835
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
-
13
-
-
0035300410
-
Expression of hypoxia-inducible factor-1alpha: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
-
7
-
Aebersold DM et al (2001) Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 61(7):2911-2916
-
(2001)
Cancer Res
, vol.61
, pp. 2911-2916
-
-
Aebersold, D.M.1
-
14
-
-
0037500967
-
Overexpression of hypoxia-inducible factor 1alpha indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer
-
6
-
Bachtiary B et al (2003) Overexpression of hypoxia-inducible factor 1alpha indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer. Clin Cancer Res 9(6):2234-2240
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2234-2240
-
-
Bachtiary, B.1
-
15
-
-
0038282482
-
The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy
-
21
-
Unruh A et al (2003) The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy. Oncogene 22(21):3213-3220
-
(2003)
Oncogene
, vol.22
, pp. 3213-3220
-
-
Unruh, A.1
-
16
-
-
0037443587
-
Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma
-
6
-
Bos R et al (2003) Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 97(6):1573-1581
-
(2003)
Cancer
, vol.97
, pp. 1573-1581
-
-
Bos, R.1
-
17
-
-
0026072872
-
Pathological prognostic factors in breast cancer. I. the value of histological grade in breast cancer: Experience from a large study with long-term follow-up
-
5
-
Elston CW, Ellis IO (1991) Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19(5):403-410
-
(1991)
Histopathology
, vol.19
, pp. 403-410
-
-
Elston, C.W.1
Ellis, I.O.2
-
18
-
-
0035925072
-
Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis
-
4
-
Bos R et al (2001) Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. J Natl Cancer Inst 93(4):309-314
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 309-314
-
-
Bos, R.1
-
19
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
-
20
-
Hudson CC et al (2002) Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol 22(20):7004-7014
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
-
20
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
10
-
Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3(10):721-732
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
21
-
-
19944434232
-
Differential prognostic impact of hypoxia induced and diffuse HIF-1alpha expression in invasive breast cancer
-
2
-
Vleugel MM et al (2005) Differential prognostic impact of hypoxia induced and diffuse HIF-1alpha expression in invasive breast cancer. J Clin Pathol 58(2):172-177
-
(2005)
J Clin Pathol
, vol.58
, pp. 172-177
-
-
Vleugel, M.M.1
-
22
-
-
9744250235
-
C-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent
-
23
-
Giatromanolaki A et al (2004) c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent. Clin Cancer Res 10(23):7972-7977
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7972-7977
-
-
Giatromanolaki, A.1
-
23
-
-
3142724677
-
Hypoxia-inducible factor 1 alpha in high-risk breast cancer: An independent prognostic parameter?
-
3
-
Gruber G et al (2004) Hypoxia-inducible factor 1 alpha in high-risk breast cancer: an independent prognostic parameter? Breast Cancer Res 6(3):R191-198
-
(2004)
Breast Cancer Res
, vol.6
, pp. 191-198
-
-
Gruber, G.1
-
24
-
-
0035676830
-
A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts
-
12
-
Kurebayashi J et al (2001) A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts. Jpn J Cancer Res 92(12):1342-1351
-
(2001)
Jpn J Cancer Res
, vol.92
, pp. 1342-1351
-
-
Kurebayashi, J.1
-
25
-
-
0031684721
-
The HER-2/neu oncogene in breast cancer: Prognostic factor, predictive factor, and target for therapy
-
4
-
Ross JS, Fletcher JA (1998) The HER-2/neu oncogene in breast cancer: prognostic factor, predictive factor, and target for therapy. Oncologist 3(4):237-252
-
(1998)
Oncologist
, vol.3
, pp. 237-252
-
-
Ross, J.S.1
Fletcher, J.A.2
-
26
-
-
0029985805
-
Quantitative analysis of vascular endothelial growth factor in primary breast cancer
-
6
-
Toi M et al (1996) Quantitative analysis of vascular endothelial growth factor in primary breast cancer. Cancer 77(6):1101-1106
-
(1996)
Cancer
, vol.77
, pp. 1101-1106
-
-
Toi, M.1
-
27
-
-
0037699954
-
The biology of VEGF and its receptors
-
6
-
Ferrara N, Gerber HP, LeCouter J (2003) The biology of VEGF and its receptors. Nat Med 9(6):669-676
-
(2003)
Nat Med
, vol.9
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.P.2
Lecouter, J.3
-
28
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
9
-
Forsythe JA et al (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16(9):4604-4613
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
-
29
-
-
0029039195
-
Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
-
22
-
Levy AP et al (1995) Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem 270(22):13333-13340
-
(1995)
J Biol Chem
, vol.270
, pp. 13333-13340
-
-
Levy, A.P.1
-
30
-
-
0036468899
-
Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer
-
3
-
Ristimaki A et al (2002) Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. Cancer Res 62(3):632-635
-
(2002)
Cancer Res
, vol.62
, pp. 632-635
-
-
Ristimaki, A.1
-
31
-
-
7044227910
-
NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 activity: Multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms
-
4
-
Zhong H, Willard M, Simons J (2004) NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms. Int J Cancer 112(4):585-595
-
(2004)
Int J Cancer
, vol.112
, pp. 585-595
-
-
Zhong, H.1
Willard, M.2
Simons, J.3
-
32
-
-
0032192140
-
The complexity of p53 modulation: Emerging patterns from divergent signals
-
19
-
Giaccia AJ, Kastan MB (1998) The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev 12(19):2973-2983
-
(1998)
Genes Dev
, vol.12
, pp. 2973-2983
-
-
Giaccia, A.J.1
Kastan, M.B.2
-
33
-
-
0030941458
-
P53, the cellular gatekeeper for growth and division
-
3
-
Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88(3):323-331
-
(1997)
Cell
, vol.88
, pp. 323-331
-
-
Levine, A.J.1
-
34
-
-
7044271020
-
Expression of hypoxia-inducible factor-1alpha and cell cycle proteins in invasive breast cancer are estrogen receptor related
-
4
-
Bos R et al (2004) Expression of hypoxia-inducible factor-1alpha and cell cycle proteins in invasive breast cancer are estrogen receptor related. Breast Cancer Res 6(4):R450-459
-
(2004)
Breast Cancer Res
, vol.6
, pp. 450-459
-
-
Bos, R.1
-
35
-
-
0032581277
-
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
6692
-
Carmeliet P et al (1998) Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394(6692):485-490
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
-
36
-
-
0032568150
-
Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
-
6674
-
An WG et al (1998) Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature 392(6674):405-408
-
(1998)
Nature
, vol.392
, pp. 405-408
-
-
An, W.G.1
-
37
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
-
1
-
Ravi R et al (2000) Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev 14(1):34-44
-
(2000)
Genes Dev
, vol.14
, pp. 34-44
-
-
Ravi, R.1
-
38
-
-
0028875410
-
Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy
-
10
-
Bergh J et al (1995) Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy. Nat Med 1(10):1029-1034
-
(1995)
Nat Med
, vol.1
, pp. 1029-1034
-
-
Bergh, J.1
-
39
-
-
0030058617
-
The p53 gene in breast cancer: Prognostic value of complementary DNA sequencing versus immunohistochemistry
-
3-4
-
Sjogren S et al (1996) The p53 gene in breast cancer: prognostic value of complementary DNA sequencing versus immunohistochemistry. J Natl Cancer Inst 88(3-4):173-182
-
(1996)
J Natl Cancer Inst
, vol.88
, pp. 173-182
-
-
Sjogren, S.1
-
40
-
-
3142534607
-
Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer
-
2
-
Theodoropoulos VE et al (2004) Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer. Eur Urol 46(2):200-208
-
(2004)
Eur Urol
, vol.46
, pp. 200-208
-
-
Theodoropoulos, V.E.1
-
41
-
-
3042816190
-
Hypoxia-inducible factor-1 alpha in non small cell lung cancer: Relation to growth factor, protease and apoptosis pathways
-
1
-
Swinson DE et al (2004) Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways. Int J Cancer 111(1):43-50
-
(2004)
Int J Cancer
, vol.111
, pp. 43-50
-
-
Swinson, D.E.1
-
42
-
-
0038725471
-
CD105 is important for angiogenesis: Evidence and potential applications
-
9
-
Duff SE et al (2003) CD105 is important for angiogenesis: evidence and potential applications. Faseb J 17(9):984-992
-
(2003)
Faseb J
, vol.17
, pp. 984-992
-
-
Duff, S.E.1
-
43
-
-
0036278899
-
Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer
-
6
-
Schindl M et al (2002) Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer. Clin Cancer Res 8(6):1831-1837
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1831-1837
-
-
Schindl, M.1
-
44
-
-
23244463512
-
Overexpression of hypoxia-inducible factor HIF-1alpha predicts early relapse in breast cancer: Retrospective study in a series of 745 patients
-
5
-
Dales JP et al (2005) Overexpression of hypoxia-inducible factor HIF-1alpha predicts early relapse in breast cancer: retrospective study in a series of 745 patients. Int J Cancer 116(5):734-739
-
(2005)
Int J Cancer
, vol.116
, pp. 734-739
-
-
Dales, J.P.1
-
45
-
-
0035395098
-
Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: Its impact on prognosis and on neoangiogenesis
-
1
-
Birner P et al (2001) Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis. Cancer 92(1):165-171
-
(2001)
Cancer
, vol.92
, pp. 165-171
-
-
Birner, P.1
-
46
-
-
0034282518
-
Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
-
17
-
Birner P et al (2000) Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res 60(17):4693-4696
-
(2000)
Cancer Res
, vol.60
, pp. 4693-4696
-
-
Birner, P.1
|