Prognostic significance of co-overexpression of the EGFR/IGFBP-2/HIF-2A genes in astrocytomas

Journal of Neuro-Oncology

Volumn 83, Issue 3, 2007, Pages 233-239

  Scrideli, Carlos A ^a   Carlotti Jr , Carlos G ^a   Mata, Juliana F ^a   Neder, Luciano ^a   Machado, Helio R ^a   Oba Sinjo, Sueli M ^a   Rosemberg, Sergio ^a   Marie, Suely K N ^a   Tone, Luiz G ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Astrocytoma; CNS tumor; EGFR; Glioblastoma; HIF 2A; IGFBP 2

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; HYPOXIA INDUCIBLE FACTOR 2ALPHA;

ARTICLE; ASTROCYTOMA; BRAIN TISSUE; CLINICAL FEATURE; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE INTERACTION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC CORRELATION; GLIOMA; HUMAN; HUMAN TISSUE; KRUSKAL WALLIS TEST; MAJOR CLINICAL STUDY; MICRODISSECTION; MULTIVARIATE ANALYSIS; PATHOPHYSIOLOGY; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; SURVIVAL RATE; UNIVARIATE ANALYSIS; WHITE MATTER;

ADULT; ASTROCYTOMA; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BRAIN NEOPLASMS; CHILD; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; MALE; MICRODISSECTION; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM;

EID: 34250781164     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-007-9328-0     Document Type: Article

References (26)

1. Khatua S, Peterson KM, Brown KM et al (2003) Overexpression of the EGFR/ FKBP12/HIF-2alpha pathway identified in childhood astrocytomas by angiogenesis gene profiling. Cancer Res 63:1865-1870
2. Wang H, Wang H, Shen W et al (2003) Insulin-like growth factor binding protein 2 enhances glioblastoma invasion by activating invasion-enhancing genes. Cancer Res 63:4315-4321
3. Kheihues P, Cavanee WK (eds) (2000) World Heath Organization classification of tumours. Pathology and genetics of tumours of the nervous system. IARC Press, Lyon, France
4. Behin A, Hoang-Xuan K, Carpentier AF, Delattre JY (2003). Primary brain tumours in adults. Lancet 361:323-331
5. Ichimura K, Ohgaki H, Kleihues P, Collins VP (2004) Molecular pathogenesis of astrocytic tumours. J Neurooncol 70:137-160
6. Mischel PS, Cloughesy TF, Nelson SF (2004) DNA-microarray analysis of brain cancer: Molecular classification for therapy. Nat Rev Neurosci 5:782-792
7. Huang H, Colella S, Kurrer M, Yonekawa Y, Kleihues P, Ohgaki H (2000) Gene expression profiling of low-grade diffuse astrocytomas by cDNA arrays. Cancer Res 60:6868-6874
8. Godard S, Getz G, Delorenzi M et al (2003) Classification of human astrocytic gliomas on the basis of gene expression: A correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes. Cancer Res 63:6613-6625
9. Freije WA, Castro-Vargas FE, Fang Z et al (2004) Gene expression profiling of gliomas strongly predicts survival. Cancer Res 64:6503-6510
10. Scrideli CA, Cazzaniga G, Fazio G et al (2003) Gene expression profile unravels significant differences between childhood and adult Ph+ acute lymphoblastic leukemia. Leukemia 17:2234-2237
11. Arjona D, Bello MJ, Alonso ME et al (2005) Molecular analysis of the EGFR gene in astrocytic gliomas: MRNA expression, quantitative-PCR analysis of non-homogeneous gene amplification and DNA sequence alterations. Neuropathol Appl Neurobiol 31:384-394
12. Varela M, Ranunculo SM, Monrad A et al (2004) EGF-R and PDGF-R, but not bcl-2, overexpression predict overall survival in patients with low-grade astrocytomas. J Surg Oncol 86:34-40
13. Fuller GN, Rhee CH, Hess KR et al (1999) Reactivation of insulin-like growth factor binding protein 2 expression in glioblastoma multiforme: A revelation by parallel gene expression profiling. Cancer Res 59:4228-4232
14. Elmlinger MW, Deininger MH, Schuett BS et al (2001) In vivo expression of insulin-like growth factor-binding protein-2 in human gliomas increases with the tumor grade. Endocrinology 142:1652-1658
15. Pugh CW, Ratcliffe PJ (2003) Regulation of angiogenesis by hypoxia: Role of the HIF system. Nat Med 9:677-684
16. Boddy JL, Fox SB, Han C et al (2005) The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer. Clin Cancer Res 11:7658-7663
17. Raval RR, Lau KM, Tran MG et al (2005) Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol 25:5675-5686
18. Koukourakis MI, Giatromanolaki A, Sivridis E et al (2002) Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer. Int J Radiat Oncol Biol Phys 53:1192-1202
19. Acker T, Diez-Juan A, Aragones J et al (2005) Genetic evidence for a tumor suppressor role of HIF-2alpha. Cancer Cell 8:131-141
20. Giatromanolaki A, Sivridis E, Fiska A, Koukourakis MI (2006) Hypoxia-inducible factor-2 alpha (HIF-2 alpha) induces angiogenesis in breast carcinomas. Appl Immunohistochem Mol Morphol 14:78-82
21. Busund LT, Richardsen E, Busund R et al (2002) Significant expression of IGFBP2 in breast cancer compared with benign lesions. J Clin Pathol 58:361-366
22. Reardon DA, Rich JN, Friedman HS, Bigner DD (2006). Recent advances in the treatment of malignant astrocytoma. J Clin Oncol 24:1253-1265
23. Reardon DA, Quinn JA, Vredenburgh JJ et al (2006) Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma. Clin Cancer Res 12:860-868
24. Carroll VA, Ashcroft M (2006) Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: Implications for targeting the HIF pathway. Cancer Res 66:6264-6270
25. Gleave M, Miyake H, Chi K (2005) Beyond simple castration: Targeting the molecular basis of treatment resistance in advanced prostate cancer. Cancer Chemother Pharmacol 56(Suppl 1):47-57
26. Bozec A, Fischel JL, Milano G (2006) Epidermal growth factor receptor/ angiogenesis dual targeting: Preclinical experience. Curr Opin Oncol 18:330-334