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Volumn 13, Issue 6, 2006, Pages 941-950

The complexity of p53 stabilization and activation

Author keywords

Cell cycle control; Cellular stress; Other factors; p53; Post translational modifications

Indexed keywords

DNA; DOUBLE STRANDED DNA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NUCLEOLIN; PROTEASOME; PROTEIN MDM2; PROTEIN MDMX; PROTEIN P53; RIBOSOME PROTEIN; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN PROTEIN LIGASE;

EID: 33646757232     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401925     Document Type: Review
Times cited : (572)

References (101)
  • 1
    • 25844475838 scopus 로고    scopus 로고
    • On the road to cancer: Aneuploidy and the mitotic checkpoint
    • Kops GJ, Weaver BA and Clevand DW (2005) On the road to cancer: aneuploidy and the mitotic checkpoint. Nat. Rev. Cancer 10: 773-785.
    • (2005) Nat. Rev. Cancer , vol.10 , pp. 773-785
    • Kops, G.J.1    Weaver, B.A.2    Clevand, D.W.3
  • 2
    • 0642375477 scopus 로고    scopus 로고
    • The p53 saga: The good, the bad, and the dead
    • Oren M (2001-2002) The p53 saga: The good, the bad, and the dead. Harvey Lect. 97: 57-82.
    • (2001) Harvey Lect. , vol.97 , pp. 57-82
    • Oren, M.1
  • 3
    • 32544444419 scopus 로고    scopus 로고
    • The p53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: Influence of tumor site, type of mutation, and adjuvant treatment
    • and TP53-CRC Collaborative Study Group
    • Russo A, Bazan V, Iacopetta B, Kerr D, Soussi T, Gebbia N and TP53-CRC Collaborative Study Group (2005) The p53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: Influence of tumor site, type of mutation, and adjuvant treatment. J. Clin. Oncol. 30: 7518-7528.
    • (2005) J. Clin. Oncol. , vol.30 , pp. 7518-7528
    • Russo, A.1    Bazan, V.2    Iacopetta, B.3    Kerr, D.4    Soussi, T.5    Gebbia, N.6
  • 4
    • 21644455492 scopus 로고    scopus 로고
    • p53 in cancer a paradigm for modern management of cancer
    • Steele RJ and Lane DP (2005) p53 in cancer. a paradigm for modern management of cancer. Surgeon 3: 197-205.
    • (2005) Surgeon , vol.3 , pp. 197-205
    • Steele, R.J.1    Lane, D.P.2
  • 7
    • 0033153336 scopus 로고    scopus 로고
    • p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in γ-irradiated mouse fibroblasts
    • Tang W, Willers H and Powell SN (1999) p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in γ-irradiated mouse fibroblasts. Cancer Res. 59: 2562-2565.
    • (1999) Cancer Res. , vol.59 , pp. 2562-2565
    • Tang, W.1    Willers, H.2    Powell, S.N.3
  • 8
    • 4344577088 scopus 로고    scopus 로고
    • Role of p53 in sensing oxidative DNA damage in response to reactive oxygen species - Generating agents
    • Achanta G and Huang P (2004) Role of p53 in sensing oxidative DNA damage in response to reactive oxygen species - generating agents. Cancer Res. 64: 6233-6239.
    • (2004) Cancer Res. , vol.64 , pp. 6233-6239
    • Achanta, G.1    Huang, P.2
  • 9
    • 31144448796 scopus 로고    scopus 로고
    • Cooperation between BRCA1 and p53 in repair of cyclobutane pyrimidine dimers
    • Navaraj A, Mori T and El- Diery WS (2005) Cooperation between BRCA1 and p53 in repair of cyclobutane pyrimidine dimers. Cancer Biol. Ther. 12: 1409-1414.
    • (2005) Cancer Biol. Ther. , vol.12 , pp. 1409-1414
    • Navaraj, A.1    Mori, T.2    El- Diery, W.S.3
  • 10
    • 0033552595 scopus 로고    scopus 로고
    • Regulation of p53 in response to DNA damage
    • Lakin ND and Jackson SP (1999) Regulation of p53 in response to DNA damage. Oncogene 18: 7644-7655.
    • (1999) Oncogene , vol.18 , pp. 7644-7655
    • Lakin, N.D.1    Jackson, S.P.2
  • 11
    • 18344377030 scopus 로고    scopus 로고
    • The p53 pathway: Positive and negative feedback loops
    • Harris SL and Levine AJ (2005) The p53 pathway: Positive and negative feedback loops. Oncogene 24: 2899-2908.
    • (2005) Oncogene , vol.24 , pp. 2899-2908
    • Harris, S.L.1    Levine, A.J.2
  • 12
    • 0021616838 scopus 로고
    • UV irradiation stimulates level of p53 cellular tumor antigen in nontransformed mouse cells
    • Maltzman W and Czyzyk L (1984) UV irradiation stimulates level of p53 cellular tumor antigen in nontransformed mouse cells. Mol. Cell. Biol. 4: 1689-1694.
    • (1984) Mol. Cell. Biol. , vol.4 , pp. 1689-1694
    • Maltzman, W.1    Czyzyk, L.2
  • 15
    • 0037373853 scopus 로고    scopus 로고
    • Delayed reactivation of p53 in the progeny of cells surviving ionizing radiation
    • Suzuki K, Yokoyama S, Waseda S, Kodama S and Watanabe M (2003) Delayed reactivation of p53 in the progeny of cells surviving ionizing radiation. Cancer Res. 63: 936-941.
    • (2003) Cancer Res. , vol.63 , pp. 936-941
    • Suzuki, K.1    Yokoyama, S.2    Waseda, S.3    Kodama, S.4    Watanabe, M.5
  • 17
    • 0037363075 scopus 로고    scopus 로고
    • Does the ribosome translate cancer?
    • Ruggero D and Pandolfi PP (2003) Does the ribosome translate cancer? Nat. Rev. Cancer 3: 179-192.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 179-192
    • Ruggero, D.1    Pandolfi, P.P.2
  • 20
    • 0029964158 scopus 로고    scopus 로고
    • A reversible p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
    • Linke SP, Clarkin KC, Di Leonardo A, Tsou A and Wahl GM (1996) A reversible p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev. 10: 934-947.
    • (1996) Genes Dev. , vol.10 , pp. 934-947
    • Linke, S.P.1    Clarkin, K.C.2    Di Leonardo, A.3    Tsou, A.4    Wahl, G.M.5
  • 28
    • 0031840253 scopus 로고    scopus 로고
    • ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
    • Waterman MJ, Stavridi ES, Waterman JL and Halazonetis TD (1998) ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins. Nat. Genet. 19: 175-178.
    • (1998) Nat. Genet. , vol.19 , pp. 175-178
    • Waterman, M.J.1    Stavridi, E.S.2    Waterman, J.L.3    Halazonetis, T.D.4
  • 31
    • 0030797585 scopus 로고    scopus 로고
    • Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
    • Gu W and Roeder RG (1997) Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90: 595-606.
    • (1997) Cell , vol.90 , pp. 595-606
    • Gu, W.1    Roeder, R.G.2
  • 34
    • 0035341813 scopus 로고    scopus 로고
    • p53 and PML: New partners in tumor suppression
    • Gottifredi V and Prives C (2001) p53 and PML: New partners in tumor suppression. Trends Cell Biol. 11: 184-187.
    • (2001) Trends Cell Biol. , vol.11 , pp. 184-187
    • Gottifredi, V.1    Prives, C.2
  • 35
    • 0033080726 scopus 로고    scopus 로고
    • Effects of hexamethylene bisacetamide on p53 protein expression of MeC-1 cell line and cell differentiation
    • Liu B, Situ Z, Wu J and Chen J (1999) Effects of hexamethylene bisacetamide on p53 protein expression of MeC-1 cell line and cell differentiation. Hua. Xi. Kou. Qiang. Yi. Xue. Za. Zhi. 17: 17-19.
    • (1999) Hua. Xi. Kou. Qiang. Yi. Xue. Za. Zhi. , vol.17 , pp. 17-19
    • Liu, B.1    Situ, Z.2    Wu, J.3    Chen, J.4
  • 36
    • 0034881964 scopus 로고    scopus 로고
    • Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment
    • Espinosa JM and Emerson BM (2001) Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Mol. Cell 8: 57-69.
    • (2001) Mol. Cell , vol.8 , pp. 57-69
    • Espinosa, J.M.1    Emerson, B.M.2
  • 37
  • 38
    • 0035966316 scopus 로고    scopus 로고
    • Why is p53 acetylated?
    • Prives C and Manley JL (2001) Why is p53 acetylated? Cell 107: 815-818.
    • (2001) Cell , vol.107 , pp. 815-818
    • Prives, C.1    Manley, J.L.2
  • 39
    • 10644225068 scopus 로고    scopus 로고
    • Identification and characterization of the IKKalpha promoter: Positive and negative regulation by ETS-1 and p53, respectively
    • Gu L, Zhu N, Findley HW, Woods WG and Zhou M (2004) Identification and characterization of the IKKalpha promoter: Positive and negative regulation by ETS-1 and p53, respectively. J. Biol. Chem. 279: 52141-52149.
    • (2004) J. Biol. Chem. , vol.279 , pp. 52141-52149
    • Gu, L.1    Zhu, N.2    Findley, H.W.3    Woods, W.G.4    Zhou, M.5
  • 40
    • 22544484456 scopus 로고    scopus 로고
    • The C-terminal lysines fine-tune p53 stress responses in a mouse model but are not required for stability control or transactivation
    • Krummel KA, Lee CJ, Toledo F and Wahl GM (2005) The C-terminal lysines fine-tune p53 stress responses in a mouse model but are not required for stability control or transactivation. Proc. Natl. Acad. Sci. USA 102: 10188-10193.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 10188-10193
    • Krummel, K.A.1    Lee, C.J.2    Toledo, F.3    Wahl, G.M.4
  • 41
    • 0037184969 scopus 로고    scopus 로고
    • Acetylation of p53 inhibits its ubiguition by Mdm2
    • Li M, Luo J, Brooks CL and Gu W (2002) Acetylation of p53 inhibits its ubiguition by Mdm2. J. Biol. Chem. 52: 50607-50611.
    • (2002) J. Biol. Chem. , vol.52 , pp. 50607-50611
    • Li, M.1    Luo, J.2    Brooks, C.L.3    Gu, W.4
  • 42
    • 0034818446 scopus 로고    scopus 로고
    • Post-translational modifications and activation of p53 by genotoxic stresses
    • Apella E and Anderson CW (2001) Post-translational modifications and activation of p53 by genotoxic stresses. Eur. J. Biochem. 268: 2764-2772.
    • (2001) Eur. J. Biochem. , vol.268 , pp. 2764-2772
    • Apella, E.1    Anderson, C.W.2
  • 45
    • 0037167835 scopus 로고    scopus 로고
    • Cancer. Pinning a change on p53
    • Ryan KM and Vousden KH (2002) Cancer. pinning a change on p53. Nature 419: 795-797.
    • (2002) Nature , vol.419 , pp. 795-797
    • Ryan, K.M.1    Vousden, K.H.2
  • 47
    • 0033522143 scopus 로고    scopus 로고
    • DNA damage induced p53 stabilization: No indication for an involvement of p53 phosphorylation
    • Blattner C, Tobiasch E, Litfen M, Rahmsdorf HJ and Herrlich P (1999) DNA damage induced p53 stabilization: No indication for an involvement of p53 phosphorylation. Oncogene 18: 1723-1732.
    • (1999) Oncogene , vol.18 , pp. 1723-1732
    • Blattner, C.1    Tobiasch, E.2    Litfen, M.3    Rahmsdorf, H.J.4    Herrlich, P.5
  • 51
  • 53
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
    • Jones SN, Roe AE, Donehower LA and Bradley A (1995) Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378: 206-208.
    • (1995) Nature , vol.378 , pp. 206-208
    • Jones, S.N.1    Roe, A.E.2    Donehower, L.A.3    Bradley, A.4
  • 54
    • 0034708458 scopus 로고    scopus 로고
    • Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
    • Fang S, Jensen JP, Ludwig RL, Vousden KH and Weissman AM (2000) Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J. Biol. Chem. 275: 8945-8951.
    • (2000) J. Biol. Chem. , vol.275 , pp. 8945-8951
    • Fang, S.1    Jensen, J.P.2    Ludwig, R.L.3    Vousden, K.H.4    Weissman, A.M.5
  • 55
    • 0036247821 scopus 로고    scopus 로고
    • p53-Mdm2 - The affair that never ends
    • Alarcon-Vargas D and Ronai Z (2002) p53-Mdm2 - the affair that never ends. Carcinogenesis 23: 541-547.
    • (2002) Carcinogenesis , vol.23 , pp. 541-547
    • Alarcon-Vargas, D.1    Ronai, Z.2
  • 56
    • 0033592868 scopus 로고    scopus 로고
    • Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
    • Khosravi R, Maya R, Gottlieb T, Oren M, Shiloh Y and Shkedy D (1999) Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc. Natl. Acad. Sci. USA. 96: 14973-14977.
    • (1999) Proc. Natl. Acad. Sci. USA. , vol.96 , pp. 14973-14977
    • Khosravi, R.1    Maya, R.2    Gottlieb, T.3    Oren, M.4    Shiloh, Y.5    Shkedy, D.6
  • 61
    • 0033963335 scopus 로고    scopus 로고
    • MdmX protects p53 from Mdm2-mediated degradation
    • Jackson MW and Berberich SJ (2000) MdmX protects p53 from Mdm2-mediated degradation. Mol. Cell. Biol. 20: 1001-1007.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1001-1007
    • Jackson, M.W.1    Berberich, S.J.2
  • 65
    • 27144444111 scopus 로고    scopus 로고
    • ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
    • Chen L, Gilkes DM, Pan Y, Lane WS and Chen J (2005) ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J. 24: 3411-3422.
    • (2005) EMBO J. , vol.24 , pp. 3411-3422
    • Chen, L.1    Gilkes, D.M.2    Pan, Y.3    Lane, W.S.4    Chen, J.5
  • 67
    • 25444478027 scopus 로고    scopus 로고
    • ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favour of p53 activation
    • Meulmeester E, Pereg Y, Shiloh Y and Jochemsen AG (2005) ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favour of p53 activation. Cell Cycle 4: 1166-1170.
    • (2005) Cell Cycle , vol.4 , pp. 1166-1170
    • Meulmeester, E.1    Pereg, Y.2    Shiloh, Y.3    Jochemsen, A.G.4
  • 68
    • 0141993691 scopus 로고    scopus 로고
    • Cell cycle control, DNA damage checkpoints and cancer
    • Laiho M and Latonen L (2003) Cell cycle control, DNA damage checkpoints and cancer. Ann. Med. 6: 391-397.
    • (2003) Ann. Med. , vol.6 , pp. 391-397
    • Laiho, M.1    Latonen, L.2
  • 69
  • 70
    • 0030218023 scopus 로고    scopus 로고
    • Ataxia-telangiectasia: A multifaceted genetic disorder associated with defective signal transduction
    • Lavin MF and Shiloh Y (1997) Ataxia-telangiectasia: A multifaceted genetic disorder associated with defective signal transduction. Curr. Opin. Immunol. 8: 459-464.
    • (1997) Curr. Opin. Immunol. , vol.8 , pp. 459-464
    • Lavin, M.F.1    Shiloh, Y.2
  • 71
    • 28444433678 scopus 로고    scopus 로고
    • The two edges of the ATM sword: Co-operation between repair and checkpoint functions
    • Lobrich M and Jeggo PA (2005) The two edges of the ATM sword: co-operation between repair and checkpoint functions. Radiother. Oncol. 76: 112-118.
    • (2005) Radiother. Oncol. , vol.76 , pp. 112-118
    • Lobrich, M.1    Jeggo, P.A.2
  • 73
    • 0034987331 scopus 로고    scopus 로고
    • Prognostic value of p53 mutations in patients with locally advanced esophageal carcinoma treated with definitive chemoradiotherapy
    • Ito T, Kaneko K, Makino R, Ito H, Konishi K, Kurahashi T, Kitahara T and Mitamura K (2001) Prognostic value of p53 mutations in patients with locally advanced esophageal carcinoma treated with definitive chemoradiotherapy. J. Gastroenterol. 36: 303-311.
    • (2001) J. Gastroenterol. , vol.36 , pp. 303-311
    • Ito, T.1    Kaneko, K.2    Makino, R.3    Ito, H.4    Konishi, K.5    Kurahashi, T.6    Kitahara, T.7    Mitamura, K.8
  • 74
    • 0027486024 scopus 로고
    • Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells
    • Khanna KK and Lavin MF (1993) Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells. Oncogene 8: 307-312.
    • (1993) Oncogene , vol.8 , pp. 307-312
    • Khanna, K.K.1    Lavin, M.F.2
  • 76
    • 0034649511 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 at serine 20 correlates with p21 and Mdm-2 induction in vivo
    • Jabbur JR, Huang P and Zhang W (2001) DNA damage-induced phosphorylation of p53 at serine 20 correlates with p21 and Mdm-2 induction in vivo. Oncogene 19: 6203-6208.
    • (2001) Oncogene , vol.19 , pp. 6203-6208
    • Jabbur, J.R.1    Huang, P.2    Zhang, W.3
  • 77
    • 4544368682 scopus 로고    scopus 로고
    • Stabilization of alanine substituted p53 protein at Ser15, Thr18, and Ser20 in response to ionizing radiation
    • Yamauchi M, Suzuki K, Kodama S and Watanabe M (2004) Stabilization of alanine substituted p53 protein at Ser15, Thr18, and Ser20 in response to ionizing radiation. Biochem. Biophys. Res. Commun. 323: 906-911.
    • (2004) Biochem. Biophys. Res. Commun. , vol.323 , pp. 906-911
    • Yamauchi, M.1    Suzuki, K.2    Kodama, S.3    Watanabe, M.4
  • 79
    • 0037162506 scopus 로고    scopus 로고
    • Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response
    • Jack MT, Woo RA, Hirao A, Cheung A, Mak TW and Lee PW (2002) Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response. Proc. Natl. Acad. Sci. USA. 99: 9825-9829.
    • (2002) Proc. Natl. Acad. Sci. USA. , vol.99 , pp. 9825-9829
    • Jack, M.T.1    Woo, R.A.2    Hirao, A.3    Cheung, A.4    Mak, T.W.5    Lee, P.W.6
  • 81
    • 1842421376 scopus 로고    scopus 로고
    • A dynamic role of HAUSP in the p53-Mdm2 pathway
    • Li M, Brooks CL, Kon N and Gu W (2004) A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol. Cell 13: 879-886.
    • (2004) Mol. Cell , vol.13 , pp. 879-886
    • Li, M.1    Brooks, C.L.2    Kon, N.3    Gu, W.4
  • 82
    • 3242774545 scopus 로고    scopus 로고
    • HAUSP is required for p53 destabilization
    • Cummins JM and Vogelstein B (2004) HAUSP is required for p53 destabilization. Cell Cycle 3: 689-692.
    • (2004) Cell Cycle , vol.3 , pp. 689-692
    • Cummins, J.M.1    Vogelstein, B.2
  • 83
    • 0036791010 scopus 로고    scopus 로고
    • Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQ01
    • Asher G, Lotem J, Sachs L, Kahana C and Shaul Y (2002) Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQ01. Proc. Natl. Acad. Sci. USA. 99: 13125-13130.
    • (2002) Proc. Natl. Acad. Sci. USA. , vol.99 , pp. 13125-13130
    • Asher, G.1    Lotem, J.2    Sachs, L.3    Kahana, C.4    Shaul, Y.5
  • 84
    • 25444445785 scopus 로고    scopus 로고
    • p53 proteasomal degradation: Poly-ubiquitination is not the whole story
    • Asher G and Shaul Y (2005) p53 proteasomal degradation: poly-ubiquitination is not the whole story. Cell Cycle 4: 1015-1018.
    • (2005) Cell Cycle , vol.4 , pp. 1015-1018
    • Asher, G.1    Shaul, Y.2
  • 90
    • 0344011603 scopus 로고    scopus 로고
    • Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses
    • Rubbi CP and Milner J (2003) Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses. EMBO J. 22: 6068-6077.
    • (2003) EMBO J. , vol.22 , pp. 6068-6077
    • Rubbi, C.P.1    Milner, J.2
  • 91
  • 92
    • 2342491487 scopus 로고    scopus 로고
    • Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation
    • Kurki S, Peltonen K, Latonen L, Kiviharju TM, Ojala PM, Meek D and Laiho M (2004) Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation. Cancer Cell 5: 465-475.
    • (2004) Cancer Cell , vol.5 , pp. 465-475
    • Kurki, S.1    Peltonen, K.2    Latonen, L.3    Kiviharju, T.M.4    Ojala, P.M.5    Meek, D.6    Laiho, M.7
  • 93
    • 0035890610 scopus 로고    scopus 로고
    • Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator
    • Wang Y, Li J, Boder RN, Kraker A, Lawrence T, Leopold WA and Sun Y (2001) Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator. Cancer Res. 61: 8211-8217.
    • (2001) Cancer Res. , vol.61 , pp. 8211-8217
    • Wang, Y.1    Li, J.2    Boder, R.N.3    Kraker, A.4    Lawrence, T.5    Leopold, W.A.6    Sun, Y.7
  • 94
    • 3142682521 scopus 로고    scopus 로고
    • HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function
    • Di Stefano V, Blandino G, Sacchi A, Soddu S and D'Orazi G (2004) HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function. Oncogene 23: 5185-5192.
    • (2004) Oncogene , vol.23 , pp. 5185-5192
    • Di Stefano, V.1    Blandino, G.2    Sacchi, A.3    Soddu, S.4    D'Orazi, G.5
  • 96
    • 2542509324 scopus 로고    scopus 로고
    • Cleavage of poly(ADP-ribose) transferase during p53-independent apoptosis in rat liver after treatment with N-nitrosomorpholine and cyproterone acetate
    • Wesierska-Gadek J, Bugajska-Schretter A, Low-Baselli A and Grasl-Kraupp B (1999) Cleavage of poly(ADP-ribose) transferase during p53-independent apoptosis in rat liver after treatment with N-nitrosomorpholine and cyproterone acetate. Mol. Carcinog. 24: 263-275.
    • (1999) Mol. Carcinog. , vol.24 , pp. 263-275
    • Wesierska-Gadek, J.1    Bugajska-Schretter, A.2    Low-Baselli, A.3    Grasl-Kraupp, B.4
  • 97
    • 0034961678 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase-1 regulates the stability of the wild-type p53 protein
    • Wesierska-Gadek J and Schmid G (2001) Poly (ADP-ribose) polymerase-1 regulates the stability of the wild-type p53 protein. Cell. Mol. Biol. Lett. 6: 117-140.
    • (2001) Cell. Mol. Biol. Lett. , vol.6 , pp. 117-140
    • Wesierska-Gadek, J.1    Schmid, G.2
  • 98
    • 0033759112 scopus 로고    scopus 로고
    • Overexpressed poly (ADP-ribose) polymerase delays the release of rat cells from p53-mediated G(1) checkpoint
    • Wesierska-Gadek J and Schmid G (2000) Overexpressed poly (ADP-ribose) polymerase delays the release of rat cells from p53-mediated G(1) checkpoint. J. Cell. Biochem. 80: 85-103.
    • (2000) J. Cell. Biochem. , vol.80 , pp. 85-103
    • Wesierska-Gadek, J.1    Schmid, G.2
  • 99
    • 0037805627 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation
    • Wieler S, Gagne JP, Vaziri H, Poirier GG and Benchimol S (2003) Poly (ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation. J. Biol. Chem. 278: 18914-18921.
    • (2003) J. Biol. Chem. , vol.278 , pp. 18914-18921
    • Wieler, S.1    Gagne, J.P.2    Vaziri, H.3    Poirier, G.G.4    Benchimol, S.5
  • 100
    • 28944446040 scopus 로고    scopus 로고
    • hnRNPK: An HDM2 target and transcriptional coactivator of p53 in response to DNA damage
    • Moumen A, Masterson P, O'Connor MJ and Jackson SP (2005) hnRNPK: An HDM2 target and transcriptional coactivator of p53 in response to DNA damage. Cell 123: 1065-1078.
    • (2005) Cell , vol.123 , pp. 1065-1078
    • Moumen, A.1    Masterson, P.2    O'Connor, M.J.3    Jackson, S.P.4
  • 101
    • 26244459242 scopus 로고    scopus 로고
    • Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin
    • Takagi M, Absalon MJ, McLure KG and Kastan MB (2005) Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 123: 49-63.
    • (2005) Cell , vol.123 , pp. 49-63
    • Takagi, M.1    Absalon, M.J.2    McLure, K.G.3    Kastan, M.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.