-
1
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;3:721-32.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
2
-
-
4644239258
-
Genetic basis of cancer of the kidney: Disease-specific approaches to therapy
-
Linehan WM, Vasselli J, Srinivasan R, et al. Genetic basis of cancer of the kidney: disease-specific approaches to therapy. Clin Cancer Res 2004;10:6282-9S.
-
(2004)
Clin Cancer Res
, vol.10
-
-
Linehan, W.M.1
Vasselli, J.2
Srinivasan, R.3
-
3
-
-
0034676331
-
Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
-
Krieg M, Haas R, Brauch H, Acker T, Flamme I, Plate KH. Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene 2000;19:5435-43.
-
(2000)
Oncogene
, vol.19
, pp. 5435-5443
-
-
Krieg, M.1
Haas, R.2
Brauch, H.3
Acker, T.4
Flamme, I.5
Plate, K.H.6
-
5
-
-
18744375998
-
Regulation and destabilization of HIF-1α by ARD1-mediated acetylation
-
Jeong JW, Bae MK, Ahn MY, et al. Regulation and destabilization of HIF-1α by ARD1-mediated acetylation. Cell 2002;111:709-20.
-
(2002)
Cell
, vol.111
, pp. 709-720
-
-
Jeong, J.W.1
Bae, M.K.2
Ahn, M.Y.3
-
6
-
-
0036211013
-
Histone acetylation: A switch between repressive and permissive chromatin. Second in review series on chromatin dynamics
-
Eberharter A, Becker PB. Histone acetylation: a switch between repressive and permissive chromatin. Second in review series on chromatin dynamics. EMBO Rep 2002;3:224-9.
-
(2002)
EMBO Rep
, vol.3
, pp. 224-229
-
-
Eberharter, A.1
Becker, P.B.2
-
7
-
-
13844252820
-
Regulation of histone deacetylase activities
-
Sengupta N, Seto E. Regulation of histone deacetylase activities. J Cell Biochem 2004;93:57-67.
-
(2004)
J Cell Biochem
, vol.93
, pp. 57-67
-
-
Sengupta, N.1
Seto, E.2
-
8
-
-
0036008097
-
Deacetylase enzymes: Biological functions and the use of small-molecule inhibitors
-
Grozinger CM, Schreiber SL. Deacetylase enzymes: biological functions and the use of small-molecule inhibitors. Chem Biol 2002;9:3-16.
-
(2002)
Chem Biol
, vol.9
, pp. 3-16
-
-
Grozinger, C.M.1
Schreiber, S.L.2
-
9
-
-
16244366803
-
Class II histone deacetylases: From sequence to function, regulation, and clinical implication
-
Yang XJ, Gregoire S. Class II histone deacetylases: from sequence to function, regulation, and clinical implication. Mol Cell Biol 2005;25:2873-84.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 2873-2884
-
-
Yang, X.J.1
Gregoire, S.2
-
10
-
-
0036527775
-
Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer
-
Johnstone RW. Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat Rev Drug Discov 2002;1:287-99.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 287-299
-
-
Johnstone, R.W.1
-
11
-
-
8544225755
-
Differential protein acetylation induced by novel histone deacetylase inhibitors
-
Glaser KB, Li J, Pease LJ, et al. Differential protein acetylation induced by novel histone deacetylase inhibitors. Biochem Biophys Res Commun 2004;325:683-90.
-
(2004)
Biochem Biophys Res Commun
, vol.325
, pp. 683-690
-
-
Glaser, K.B.1
Li, J.2
Pease, L.J.3
-
12
-
-
0035793107
-
Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin
-
Furumai R, Komatsu Y, Nishino N, Khochbin S, Yoshida M, Horinouchi S. Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. Proc Natl Acad Sci U S A 2001;98:87-92.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 87-92
-
-
Furumai, R.1
Komatsu, Y.2
Nishino, N.3
Khochbin, S.4
Yoshida, M.5
Horinouchi, S.6
-
13
-
-
18244383806
-
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
-
Gottlicher M, Minucci S, Zhu P, et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 2001;20:6969-78.
-
(2001)
EMBO J
, vol.20
, pp. 6969-6978
-
-
Gottlicher, M.1
Minucci, S.2
Zhu, P.3
-
14
-
-
0842325787
-
Histone deacetylase is a target of valproic acid-mediated cellular differentiation
-
Gurvich N, Tsygankova OM, Meinkoth JL, Klein PS. Histone deacetylase is a target of valproic acid-mediated cellular differentiation. Cancer Res 2004;64:1079-86.
-
(2004)
Cancer Res
, vol.64
, pp. 1079-1086
-
-
Gurvich, N.1
Tsygankova, O.M.2
Meinkoth, J.L.3
Klein, P.S.4
-
15
-
-
4644364508
-
The histone deacetylase inhibitor NVP-LAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584
-
Qian DZ, Wang X, Kachhap SK, et al. The histone deacetylase inhibitor NVP-LAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584. Cancer Res 2004;64:6626-34.
-
(2004)
Cancer Res
, vol.64
, pp. 6626-6634
-
-
Qian, D.Z.1
Wang, X.2
Kachhap, S.K.3
-
16
-
-
0037225763
-
Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1α activity
-
Mie Lee Y, Kim SH, Kim HS, et al. Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1α activity. Biochem Biophys Res Commun 2003;300:241-6.
-
(2003)
Biochem Biophys Res Commun
, vol.300
, pp. 241-246
-
-
Mie Lee, Y.1
Kim, S.H.2
Kim, H.S.3
-
17
-
-
27744450043
-
Interaction between HIF-1α (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1α
-
Arnesen T, Kong X, Evjenth R, et al. Interaction between HIF-1α (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1α. FEBS Lett 2005;579:6428-32.
-
(2005)
FEBS Lett
, vol.579
, pp. 6428-6432
-
-
Arnesen, T.1
Kong, X.2
Evjenth, R.3
-
18
-
-
0037119415
-
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway
-
Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway. J Biol Chem 2002;277:29936-44.
-
(2002)
J Biol Chem
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mimnaugh, E.G.3
Martinez, A.4
Cuttitta, F.5
Neckers, L.M.6
-
19
-
-
0030460724
-
Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase a gene promoters contain essential binding sites for hypoxia-inducible factor 1
-
Semenza GL, Jiang BH, Leung SW, et al. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 1996;271:32529-37.
-
(1996)
J Biol Chem
, vol.271
, pp. 32529-32537
-
-
Semenza, G.L.1
Jiang, B.H.2
Leung, S.W.3
-
20
-
-
0035012605
-
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
-
Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 2001;21:3995-4004.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3995-4004
-
-
Laughner, E.1
Taghavi, P.2
Chiles, K.3
Mahon, P.C.4
Semenza, G.L.5
-
21
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon PC, Hirota K, Semenza GL. FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 2001;15:2675-86.
-
(2001)
Genes Dev
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
22
-
-
25444465116
-
Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1α accumulation and activity by disrupting microtubule function
-
Escuin D, Kline ER, Giannakakou P. Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1α accumulation and activity by disrupting microtubule function. Cancer Res 2005;65:9021-8.
-
(2005)
Cancer Res
, vol.65
, pp. 9021-9028
-
-
Escuin, D.1
Kline, E.R.2
Giannakakou, P.3
-
23
-
-
0037448671
-
Cell biology: Tubulin acetylation and cell motility
-
Palazzo A, Ackerman B, Gundersen GG. Cell biology: tubulin acetylation and cell motility. Nature 2003;421:230.
-
(2003)
Nature
, vol.421
, pp. 230
-
-
Palazzo, A.1
Ackerman, B.2
Gundersen, G.G.3
-
24
-
-
12244295468
-
In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation
-
Matsuyama A, Shimazu T, Sumida Y, et al. In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J 2002;21:6820-31.
-
(2002)
EMBO J
, vol.21
, pp. 6820-6831
-
-
Matsuyama, A.1
Shimazu, T.2
Sumida, Y.3
-
25
-
-
0037161744
-
HDAC6 is a microtubule-associated deacetylase
-
Hubbert C, Guardiola A, Shao R, et al. HDAC6 is a microtubule-associated deacetylase. Nature 2002;417:455-8.
-
(2002)
Nature
, vol.417
, pp. 455-458
-
-
Hubbert, C.1
Guardiola, A.2
Shao, R.3
-
26
-
-
0036682284
-
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway
-
Rapisarda A, Uranchimeg B, Scudiero DA, et al. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res 2002;62:4316-24.
-
(2002)
Cancer Res
, vol.62
, pp. 4316-4324
-
-
Rapisarda, A.1
Uranchimeg, B.2
Scudiero, D.A.3
-
27
-
-
0037413948
-
Is HIF-1α a valid therapeutic target?
-
Pili R, Donehower RC. Is HIF-1α a valid therapeutic target? J Natl Cancer Inst 2003;95:498-9.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 498-499
-
-
Pili, R.1
Donehower, R.C.2
-
28
-
-
4744368147
-
Histone deacetylase 7 associates with hypoxia-inducible factor 1α and increases transcriptional activity
-
Kato H, Tamamizu-Kato S, Shibasaki F. Histone deacetylase 7 associates with hypoxia-inducible factor 1α and increases transcriptional activity. J Biol Chem 2004;279:41966-74.
-
(2004)
J Biol Chem
, vol.279
, pp. 41966-41974
-
-
Kato, H.1
Tamamizu-Kato, S.2
Shibasaki, F.3
-
29
-
-
22844432021
-
Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: A novel basis for antileukemia activity of histone deacetylase inhibitors
-
Bali P, Pranpat M, Bradner J, et al. Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. J Biol Chem 2005;280:26729-34.
-
(2005)
J Biol Chem
, vol.280
, pp. 26729-26734
-
-
Bali, P.1
Pranpat, M.2
Bradner, J.3
-
30
-
-
21144444486
-
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
-
Kovacs JJ, Murphy PJ, Gaillard S, et al. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol Cell 2005;18:601-7.
-
(2005)
Mol Cell
, vol.18
, pp. 601-607
-
-
Kovacs, J.J.1
Murphy, P.J.2
Gaillard, S.3
-
31
-
-
14844344773
-
Association with class IIa histone deacetylases up-regulates the sumoylation of MEF2 transcription factors
-
Gregoire S, Yang XJ. Association with class IIa histone deacetylases up-regulates the sumoylation of MEF2 transcription factors. Mol Cell Biol 2005;25:2273-87.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 2273-2287
-
-
Gregoire, S.1
Yang, X.J.2
-
32
-
-
2342661143
-
Intratumoral hypoxia, radiation resistance, and HIF-1
-
Semenza GL. Intratumoral hypoxia, radiation resistance, and HIF-1. Cancer Cell 2004;5:405-6.
-
(2004)
Cancer Cell
, vol.5
, pp. 405-406
-
-
Semenza, G.L.1
-
33
-
-
31144458716
-
How avastin potentiates chemotherapeutic drugs: Action and reaction in antiangiogenic therapy
-
Blagosklonny MV. How avastin potentiates chemotherapeutic drugs: action and reaction in antiangiogenic therapy. Cancer Biol Ther 2005;4:1307-10.
-
(2005)
Cancer Biol Ther
, vol.4
, pp. 1307-1310
-
-
Blagosklonny, M.V.1
|