Hypoxia Inducible Factor Activates the Transforming Growth Factor-α/Epidermal Growth Factor Receptor Growth Stimulatory Pathway in VHL-/- Renal Cell Carcinoma Cells

Journal of Biological Chemistry

Volumn 278, Issue 45, 2003, Pages 44966-44974

  Gunaratnam, Lakshman ^a   Morley, Melissa ^a   Franovic, Aleksandra ^a   De Paulsen, Natalie ^a   Mekhail, Karim ^a   Parolin, Doris A E ^b   Nakamura, Eijiro ^c   Lorimer, Ian A J ^b   Lee, Stephen ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b OTTAWA REGIONAL CANCER CENTRE   (Canada)

^c HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYMES; MUTAGENESIS; TUMORS;

CANCER CELLS;

BIOCHEMISTRY;

4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; 6,7 DIMETHOXY 2 PHENYLQUINOXALINE; EPIDERMAL GROWTH FACTOR RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1; LIGAND; MITOGENIC AGENT; PROTEIN INHIBITOR; TRANILAST; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; CANCER GROWTH; CARCINOGENESIS; CARCINOMA CELL; CELL PROLIFERATION; CLEAR CELL CARCINOMA; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GROWTH STIMULATION; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; REGULATORY MECHANISM; SERUM; TUMOR SUPPRESSOR GENE; UPREGULATION; VON HIPPEL LINDAU DISEASE;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOOD; CARCINOMA, RENAL CELL; CELL DIVISION; CULTURE MEDIA; GENE EXPRESSION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY NEOPLASMS; MUTATION; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 0242581718     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M305502200     Document Type: Article

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