Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

Nature Medicine

Volumn 8, Issue 7, 2002, Pages 702-710

  Compernolle, Veerle ^a   Brusselmans, Koen ^a   Acker, Till ^b   Hoet, Peter ^c   Tjwa, Marc ^a   Beck, Heike ^b   Plaisance, Stéphane ^a   Dor, Yuval ^d   Keshet, Eli ^d   Lupu, Florea ^e   Nemery, Benoit ^c   Dewerchin, Mieke ^a   Van Veldhoven, Paul ^c   Plate, Karl ^b   Moons, Lieve ^a   Collen, Désiré ^a   Carmeliet, Peter ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b GOETHE UNIVERSITY   (Germany)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^e OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL CELL GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 2, ALPHA SUBUNIT; HYPOXIA-INDUCIBLE FACTOR 2, ALPHA SUBUNIT; LYMPHOKINE; TRANSACTIVATOR PROTEIN; VASCULOTROPIN; VASCULOTROPIN A; GLYCOGEN; HYPOXIA INDUCIBLE FACTOR 2ALPHA; ISOPROTEIN; LUNG SURFACTANT; MONOCLONAL ANTIBODY; PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR;

ADULT RESPIRATORY DISTRESS SYNDROME; AGING; ANIMAL; ARTICLE; DISEASE MODEL; DRUG EFFECT; GENETICS; GROWTH, DEVELOPMENT AND AGING; LUNG; LUNG ALVEOLUS; LUNG DISEASE; MOUSE; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA; TRANSGENIC MOUSE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BINDING SITE; BIOTRANSFORMATION; CELL CULTURE; CELL LEVEL; CONTROLLED STUDY; FEMALE; FETUS LUNG MATURATION; INHIBITION KINETICS; LUNG ALVEOLUS CELL TYPE 2; NEWBORN; NONHUMAN; PERINATAL PERIOD; PREMATURITY; PRIORITY JOURNAL; PROTECTION; REGULATORY MECHANISM; RESPIRATORY DISTRESS SYNDROME; STIMULATION;

AGING; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; DISEASE MODELS, ANIMAL; ENDOTHELIAL GROWTH FACTORS; LUNG; LUNG DISEASES; LYMPHOKINES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PULMONARY ALVEOLI; RESPIRATORY DISTRESS SYNDROME, ADULT; RESPIRATORY MUCOSA; TRANS-ACTIVATORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0035983324     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm721     Document Type: Article

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