Hypoxia-inducible factor α subunit stabilization by NEDD8 conjugation is reactive oxygen species-dependent

Journal of Biological Chemistry

Volumn 286, Issue 9, 2011, Pages 6963-6970

  Ryu, Ji Hye ^a   Li, Shan Hua ^a,b   Park, Hyoung Sook ^a   Park, Jong Wan ^a   Lee, ByungLan ^a   Chun, Yang Sook ^a  

^a Seoul National University College of Medicine   (South Korea)

^b XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER THERAPY; CELL LINES; CELLULAR ADAPTATION; CONJUGATION PROCESS; HYPOXIA-INDUCIBLE FACTORS; MITOCHONDRIAL RESPIRATORY CHAIN; OXYGEN-SENSING; PROLYL HYDROXYLASE; REACTIVE OXYGEN SPECIES; STABILIZING EFFECTS; SUBSTRATE PROTEINS; UBIQUITIN-LIKE;

CELL CULTURE; DISEASES; GENES; MITOCHONDRIA; OXYGEN; SENSORS;

PROTEINS;

ANTIOXIDANT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; NEDD8 PROTEIN; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; VON HIPPEL LINDAU PROTEIN;

ARTICLE; CELL LINE; CONJUGATION; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; HYPOXIA; MITOCHONDRION; NUCLEOTIDE SEQUENCE; OXYGEN SENSING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

ANOXIA; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; HEK293 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NEOPLASMS; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEIN BINDING; PROTEIN STABILITY; PROTEIN SUBUNITS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINS; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 79953170581     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.188706     Document Type: Article

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