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Volumn 203, Issue , 2011, Pages 1-33

Targeting type 2 diabetes

Author keywords

DPP 4; Insulin resistance; Metformin; Pioglitazone; Type 2 diabetes

Indexed keywords

BROMOCRIPTINE; CD36 ANTIGEN; EXENDIN 4; FATTY ACID BINDING PROTEIN; FATTY ACID TRANSPORTER; GLIBENCLAMIDE; GLUCOKINASE; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; I KAPPA B KINASE; INITIATION FACTOR 2ALPHA; INSULIN; INSULIN DERIVATIVE; INTERLEUKIN 6; LIPID; LIRAGLUTIDE; METFORMIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; PLACEBO; POTASSIUM CHANNEL; RIMONABANT; ROSIGLITAZONE; ROTIGOTINE; SAXAGLIPTIN; SITAGLIPTIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR PDX 1; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; VILDAGLIPTIN; ANTIDIABETIC AGENT; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; THIAZOLIDINE DERIVATIVE;

EID: 79955605399     PISSN: 01712004     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-17214-4_1     Document Type: Review
Times cited : (4)

References (248)
  • 1
    • 77952503211 scopus 로고    scopus 로고
    • Pathogenesis of insulin resistance in skeletal muscle
    • Abdul-Ghani MA, DeFronzo RA (2010) Pathogenesis of insulin resistance in skeletal muscle. J Biomed Biotechnol 2010:476279
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 476279
    • Abdul-Ghani, M.A.1    DeFronzo, R.A.2
  • 2
  • 4
    • 14644415476 scopus 로고    scopus 로고
    • Metabolic dysregulation with atypical antipsychotics occurs in the absence of underlying disease: A placebo-controlled study of olanzapine and risperidone in dogs
    • DOI 10.2337/diabetes.54.3.862
    • Ader M, Kim SP, Catalano KJ, Ionut V, Hucking K, Richey JM, Kabir M, Bergman RN (2005) Metabolic dysregulation with atypical antipsychotics occurs in the absence of underlying disease: a placebo-controlled study of olanzapine and risperidone in dogs. Diabetes 54: 862-871 (Pubitemid 40322092)
    • (2005) Diabetes , vol.54 , Issue.3 , pp. 862-871
    • Ader, M.1    Kim, S.P.2    Catalano, K.J.3    Ionut, V.4    Hucking, K.5    Richey, J.M.6    Kabir, M.7    Bergman, R.N.8
  • 5
    • 0037059330 scopus 로고    scopus 로고
    • 307in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
    • DOI 10.1074/jbc.M101521200
    • Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF (2002) Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 277:1531-1537 (Pubitemid 34968910)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.2 , pp. 1531-1537
    • Aguirre, V.1    Werner, E.D.2    Giraud, J.3    Lee, Y.H.4    Shoelson, S.E.5    White, M.F.6
  • 6
    • 33847022735 scopus 로고    scopus 로고
    • Role of hypothalamic adenosine 50-monophosphate- activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia
    • Alquier T, Kawashima J, Tsuji Y, Kahn BB (2007) Role of hypothalamic adenosine 50-monophosphate- activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia. Endocrinology 148:1367-1375
    • (2007) Endocrinology , vol.148 , pp. 1367-1375
    • Alquier, T.1    Kawashima, J.2    Tsuji, Y.3    Kahn, B.B.4
  • 10
    • 34248223285 scopus 로고    scopus 로고
    • Biology of Incretins: GLP-1 and GIP
    • DOI 10.1053/j.gastro.2007.03.054, PII S001650850700580X
    • Baggio LL, Drucker DJ (2007) Biology of incretins: GLP-1 and GIP. Gastroenterology 132: 2131-2157 (Pubitemid 46711096)
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 11
    • 27744446892 scopus 로고    scopus 로고
    • Treating insulin resistance in type 2 diabetes with metformin and thiazolidinediones
    • Bailey CJ (2005) Treating insulin resistance in type 2 diabetes with metformin and thiazolidinediones. Diabetes Obes Metab 7:675-691
    • (2005) Diabetes Obes Metab , vol.7 , pp. 675-691
    • Bailey, C.J.1
  • 12
    • 33644695097 scopus 로고    scopus 로고
    • Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty acyl-CoAs and insulin action in type 2 diabetic patients
    • DOI 10.2337/diabetes.54.11.3148
    • Bajaj M, Suraamornkul S, Romanelli A, Cline GW, Mandarino LJ, Shulman GI, DeFronzo RA (2005) Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients. Diabetes 54: 3148-3153 (Pubitemid 43334368)
    • (2005) Diabetes , vol.54 , Issue.11 , pp. 3148-3153
    • Bajaj, M.1    Suraamornkul, S.2    Romanelli, A.3    Cline, G.W.4    Mandarino, L.J.5    Shulman, G.I.6    DeFronzo, R.A.7
  • 13
    • 23644448924 scopus 로고    scopus 로고
    • Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle
    • DOI 10.2337/diabetes.54.8.2351
    • Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky JM (2005) Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle. Diabetes 54:2351-2359 (Pubitemid 41134262)
    • (2005) Diabetes , vol.54 , Issue.8 , pp. 2351-2359
    • Bandyopadhyay, G.K.1    Yu, J.G.2    Ofrecio, J.3    Olefsky, J.M.4
  • 14
    • 33749370466 scopus 로고    scopus 로고
    • Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects
    • DOI 10.2337/db06-0062
    • Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky JM (2006) Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. Diabetes 55:2277-2285 (Pubitemid 44743625)
    • (2006) Diabetes , vol.55 , Issue.8 , pp. 2277-2285
    • Bandyopadhyay, G.K.1    Yu, J.G.2    Ofrecio, J.3    Olefsky, J.M.4
  • 15
    • 67449103220 scopus 로고    scopus 로고
    • Redefining the role of thiazolidinediones in the management of type 2 diabetes
    • Barnett AH (2009) Redefining the role of thiazolidinediones in the management of type 2 diabetes. Vasc Health Risk Manag 5:141-151
    • (2009) Vasc Health Risk Manag , vol.5 , pp. 141-151
    • Barnett, A.H.1
  • 16
    • 17844373857 scopus 로고    scopus 로고
    • Genetics of Type 2 diabetes
    • Barroso I (2005) Genetics of Type 2 diabetes. Diabet Med 22:517-535
    • (2005) Diabet Med , vol.22 , pp. 517-535
    • Barroso, I.1
  • 19
    • 0346157290 scopus 로고    scopus 로고
    • Innate immunity: An overview
    • Beutler B (2004) Innate immunity: an overview. Mol Immunol 40:845-859
    • (2004) Mol Immunol , vol.40 , pp. 845-859
    • Beutler, B.1
  • 20
    • 0029084869 scopus 로고
    • Effects of fat on glucose uptake and utilization in patients with noninsulin- dependent diabetes
    • Boden G, Chen X (1995) Effects of fat on glucose uptake and utilization in patients with noninsulin- dependent diabetes. J Clin Invest 96:1261-1268
    • (1995) J Clin Invest , vol.96 , pp. 1261-1268
    • Boden, G.1    Chen, X.2
  • 21
    • 0035405847 scopus 로고    scopus 로고
    • Effects of Acute Changes of Plasma Free Fatty Acids on Intramyocellular Fat Content and Insulin Resistance in Healthy Subjects
    • Boden G, Lebed B, Schatz M, Homko C, Lemieux S (2001) Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes 50:1612-1617 (Pubitemid 33639602)
    • (2001) Diabetes , vol.50 , Issue.7 , pp. 1612-1617
    • Boden, G.1    Lebed, B.2    Schatz, M.3    Homko, C.4    Lemieux, S.5
  • 23
    • 0021360725 scopus 로고
    • Relationship between obesity and maximal insulin-stimulated glucose uptake in vivo and in vitro in Pima Indians
    • Bogardus C, Lillioja S, Mott D, Reaven GR, Kashiwagi A, Foley JE (1984) Relationship between obesity and maximal insulin-stimulated glucose uptake in vivo and in vitro in Pima Indians. J Clin Invest 73:800-805 (Pubitemid 14156863)
    • (1984) Journal of Clinical Investigation , vol.73 , Issue.3 , pp. 800-805
    • Bogardus, C.1    Lillioja, S.2    Mott, D.3
  • 24
    • 0042905763 scopus 로고    scopus 로고
    • Plasmalemmal fatty acid transport is regulated in heart and skeletal muscle by contraction, insulin and leptin, and in obesity and diabetes
    • DOI 10.1046/j.1365-201X.2003.01157.x
    • Bonen A, Benton CR, Campbell SE, Chabowski A, Clarke DC, Han XX, Glatz JF, Luiken JJ (2003) Plasmalemmal fatty acid transport is regulated in heart and skeletal muscle by contraction, insulin and leptin, and in obesity and diabetes. Acta Physiol Scand 178:347-356 (Pubitemid 36960425)
    • (2003) Acta Physiologica Scandinavica , vol.178 , Issue.4 , pp. 347-356
    • Bonen, A.1    Benton, C.R.2    Campbell, S.E.3    Chabowski, A.4    Clarke, D.C.5    Han, X.-X.6    Glatz, J.F.C.7    Luiken, J.J.F.P.8
  • 25
    • 4544355465 scopus 로고    scopus 로고
    • Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport increased sarcolemmal FAT/CD36
    • DOI 10.1096/fj.03-1065fje
    • Bonen A, Parolin ML, Steinberg GR, Calles-Escandon J, Tandon NN, Glatz JF, Luiken JJ, Heigenhauser GJ, Dyck DJ (2004) Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36. FASEB J 18:1144-1146 (Pubitemid 39561551)
    • (2004) FASEB Journal , vol.18 , Issue.10 , pp. 1144-1146
    • Bonen, A.1    Parolin, M.L.2    Steinberg, G.R.3    Calles-Escandon, J.4    Tandon, N.N.5    Glatz, J.F.C.6    Luiken, J.J.F.P.7    Heigenhauser, G.J.F.8    Dyck, D.J.9
  • 28
    • 79953783519 scopus 로고    scopus 로고
    • Effects of insulin on the vasculature
    • Sep 1 [Epub ahead of print]
    • Breen DM, Giacca A (2010) Effects of insulin on the vasculature. Curr Vasc Pharmacol. Sep 1 [Epub ahead of print]
    • (2010) Curr Vasc Pharmacol
    • Breen, D.M.1    Giacca, A.2
  • 31
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • DOI 10.1038/nm1166
    • Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE (2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 11:183-190 (Pubitemid 40321354)
    • (2005) Nature Medicine , vol.11 , Issue.2 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6    Shoelson, S.E.7
  • 33
    • 0028075299 scopus 로고
    • Regulatory effects of glucose on the catalytic activity and cellular content of glucokinase in the pancreatic beta cell. Study using cultured rat islets
    • Chen C, Hosokawa H, Bumbalo LM, Leahy JL (1994) Regulatory effects of glucose on the catalytic activity and cellular content of glucokinase in the pancreatic beta cell. Study using cultured rat islets. J Clin Invest 94:1616-1620
    • (1994) J Clin Invest , vol.94 , pp. 1616-1620
    • Chen, C.1    Hosokawa, H.2    Bumbalo, L.M.3    Leahy, J.L.4
  • 36
    • 0030754560 scopus 로고    scopus 로고
    • Bromocriptine/SKF38393 treatment ameliorates obesity and associated metabolic dysfunctions in obese (ob/ob) mice
    • DOI 10.1016/S0024-3205(97)00599-7, PII S0024320597005997
    • Cincotta AH, Tozzo E, Scislowski PW (1997) Bromocriptine/SKF38393 treatment ameliorates obesity and associated metabolic dysfunctions in obese (ob/ob) mice. Life Sci 61:951-956 (Pubitemid 27348663)
    • (1997) Life Sciences , vol.61 , Issue.10 , pp. 951-956
    • Cincotta, A.H.1    Tozzo, E.2    Scislowski, P.W.D.3
  • 39
    • 0345171460 scopus 로고    scopus 로고
    • Enzymes of triacylglycerol synthesis and their regulation
    • DOI 10.1016/S0163-7827(03)00051-1
    • Coleman RA, Lee DP (2004) Enzymes of triacylglycerol synthesis and their regulation. Prog Lipid Res 43:134-176 (Pubitemid 37492937)
    • (2004) Progress in Lipid Research , vol.43 , Issue.2 , pp. 134-176
    • Coleman, R.A.1    Lee, D.P.2
  • 43
    • 33644832891 scopus 로고    scopus 로고
    • Nutritional upregulation of p85alpha expression is an early molecular manifestation of insulin resistance
    • DOI 10.1007/s00125-006-0148-0
    • Cornier MA, Bessesen DH, Gurevich I, Leitner JW, Draznin B (2006) Nutritional upregulation of p85alpha expression is an early molecular manifestation of insulin resistance. Diabetologia 49:748-754 (Pubitemid 43357550)
    • (2006) Diabetologia , vol.49 , Issue.4 , pp. 748-754
    • Cornier, M.-A.1    Bessesen, D.H.2    Gurevich, I.3    Leitner, J.W.4    Draznin, B.5
  • 47
    • 74349122900 scopus 로고    scopus 로고
    • Advances in therapy for type 2 diabetes: GLP-1 receptor agonists and DPP-4 inhibitors
    • Davidson JA (2009) Advances in therapy for type 2 diabetes: GLP-1 receptor agonists and DPP-4 inhibitors. Cleve Clin J Med 76(Suppl 5):S28-S38
    • (2009) Cleve Clin J Med , vol.76 , Issue.SUPPL. 5
    • Davidson, J.A.1
  • 48
    • 0028953577 scopus 로고
    • Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo
    • Deacon CF, Johnsen AH, Holst JJ (1995a) Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo. J Clin Endocrinol Metab 80:952-957
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 952-957
    • Deacon, C.F.1    Johnsen, A.H.2    Holst, J.J.3
  • 49
    • 0028803336 scopus 로고
    • Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects
    • Deacon CF, Nauck MA, Toft-Nielsen M, Pridal L, Willms B, Holst JJ (1995b) Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects. Diabetes 44:1126-1131
    • (1995) Diabetes , vol.44 , pp. 1126-1131
    • Deacon, C.F.1    Nauck, M.A.2    Toft-Nielsen, M.3    Pridal, L.4    Willms, B.5    Holst, J.J.6
  • 50
    • 0024026298 scopus 로고
    • Lilly lecture 1987. The triumvirate: Beta-cell, muscle, liver. A collusion responsible for NIDDM
    • DeFronzo RA (1988) Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37:667-687
    • (1988) Diabetes , vol.37 , pp. 667-687
    • DeFronzo, R.A.1
  • 51
    • 0033578476 scopus 로고    scopus 로고
    • Pharmacologic therapy for type 2 diabetes mellitus
    • DeFronzo RA (1999) Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med 131:281-303
    • (1999) Ann Intern Med , vol.131 , pp. 281-303
    • DeFronzo, R.A.1
  • 52
    • 64649104158 scopus 로고    scopus 로고
    • Banting Lecture. From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus
    • Defronzo RA (2009) Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes 58:773-795
    • (2009) Diabetes , vol.58 , pp. 773-795
    • Defronzo, R.A.1
  • 53
    • 0029099086 scopus 로고
    • Efficacy of metformin in patients with non-insulindependent diabetes mellitus
    • The Multicenter Metformin Study Group
    • DeFronzo RA, Goodman AM (1995) Efficacy of metformin in patients with non-insulindependent diabetes mellitus. The Multicenter Metformin Study Group. N Engl J Med 333:541-549
    • (1995) N Engl J Med , vol.333 , pp. 541-549
    • DeFronzo, R.A.1    Goodman, A.M.2
  • 54
    • 0018192087 scopus 로고
    • Insulin binding to monocytes and insulin action in human obesity, starvation, and refeeding
    • DeFronzo RA, Soman V, Sherwin RS, Hendler R, Felig P (1978) Insulin binding to monocytes and insulin action in human obesity, starvation, and refeeding. J Clin Invest 62:204-213 (Pubitemid 8367354)
    • (1978) Journal of Clinical Investigation , vol.62 , Issue.1 , pp. 204-213
    • DeFronzo, R.A.1    Soman, V.2    Sherwin, R.S.3
  • 55
    • 0021994683 scopus 로고
    • Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus
    • DeFronzo RA, Gunnarsson R, Bjorkman O, Olsson M, Wahren J (1985) Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest 76:149-155 (Pubitemid 15240430)
    • (1985) Journal of Clinical Investigation , vol.76 , Issue.1 , pp. 149-155
    • DeFronzo, R.A.1    Gunnarsson, R.2    Bjorkman, O.3
  • 57
    • 23644446750 scopus 로고    scopus 로고
    • Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: Association with cytokine expression, insulin resistance, and reduction by pioglitazone
    • DOI 10.2337/diabetes.54.8.2305
    • Di Gregorio GB, Yao-Borengasser A, Rasouli N, Varma V, Lu T, Miles LM, Ranganathan G, Peterson CA, McGehee RE, Kern PA (2005) Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone. Diabetes 54:2305-2313 (Pubitemid 41134256)
    • (2005) Diabetes , vol.54 , Issue.8 , pp. 2305-2313
    • Di, G.G.B.1    Yao-Borengasser, A.2    Rasouli, N.3    Varma, V.4    Lu, T.5    Miles, L.M.6    Ranganathan, G.7    Peterson, C.A.8    McGehee, R.E.9    Kern, P.A.10
  • 58
    • 48149101434 scopus 로고    scopus 로고
    • The endocannabinoid system in obesity and type 2 diabetes
    • Di Marzo V (2008) The endocannabinoid system in obesity and type 2 diabetes. Diabetologia 51:1356-1367
    • (2008) Diabetologia , vol.51 , pp. 1356-1367
    • Di Marzo, V.1
  • 62
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • DOI 10.1016/S0140-6736(06)69705-5, PII S0140673606697055
    • Drucker DJ, Nauck MA (2006) The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368:1696-1705 (Pubitemid 46048557)
    • (2006) Lancet , vol.368 , Issue.9548 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 63
    • 39149104320 scopus 로고    scopus 로고
    • The role for endoplasmic reticulum stress in diabetes mellitus
    • DOI 10.1210/er.2007-0015
    • Eizirik DL, Cardozo AK, Cnop M (2008) The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 29:42-61 (Pubitemid 351252746)
    • (2008) Endocrine Reviews , vol.29 , Issue.1 , pp. 42-61
    • Eizirik, D.L.1    Cardozo, A.K.2    Cnop, M.3
  • 64
    • 0034614420 scopus 로고    scopus 로고
    • Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
    • DOI 10.1074/jbc.275.1.223
    • El-Mir MY, Nogueira V, Fontaine E, Averet N, Rigoulet M, Leverve X (2000) Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J Biol Chem 275:223-228 (Pubitemid 30038975)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.1 , pp. 223-228
    • El-Mir, M.-Y.1    Nogueira, V.2    Fontaine, E.3    Averet, N.4    Rigoulet, M.5    Leverve, X.6
  • 66
    • 0029043139 scopus 로고
    • Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide
    • Fehmann HC, Goke R, Goke B (1995) Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide. Endocr Rev 16:390-410
    • (1995) Endocr Rev , vol.16 , pp. 390-410
    • Fehmann, H.C.1    Goke, R.2    Goke, B.3
  • 67
    • 0032005005 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans
    • Flint A, Raben A, Astrup A, Holst JJ (1998) Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J Clin Invest 101:515-520 (Pubitemid 28084232)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.3 , pp. 515-520
    • Flint, A.1    Raben, A.2    Astrup, A.3    Holst, J.J.4
  • 69
    • 33847764645 scopus 로고    scopus 로고
    • Aging, adiposity, and calorie restriction
    • Fontana L, Klein S (2007) Aging, adiposity, and calorie restriction. JAMA 297:986-994
    • (2007) JAMA , vol.297 , pp. 986-994
    • Fontana, L.1    Klein, S.2
  • 70
    • 2342647592 scopus 로고    scopus 로고
    • Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
    • Fontana L, Meyer TE, Klein S, Holloszy JO (2004) Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci USA 101:6659-6663
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6659-6663
    • Fontana, L.1    Meyer, T.E.2    Klein, S.3    Holloszy, J.O.4
  • 71
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span - From yeast to humans
    • Fontana L, Partridge L, Longo VD (2010) Extending healthy life span - from yeast to humans. Science 328:321-326
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 74
    • 27744565691 scopus 로고    scopus 로고
    • Metformin revisited: Re-evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents
    • DOI 10.1111/j.1463-1326.2004.00448.x
    • Goodarzi MO, Bryer-Ash M(2005) Metformin revisited: re-evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents. Diabetes Obes Metab 7:654-665 (Pubitemid 41601070)
    • (2005) Diabetes, Obesity and Metabolism , vol.7 , Issue.6 , pp. 654-665
    • Goodarzi, M.O.1    Bryer-Ash, M.2
  • 75
    • 0035217707 scopus 로고    scopus 로고
    • Skeletal muscle lipid content and insulin resistance: Evidence for a paradox in endurance-trained athletes
    • DOI 10.1210/jc.86.12.5755
    • Goodpaster BH, He J, Watkins S, Kelley DE (2001) Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab 86:5755-5761 (Pubitemid 33152620)
    • (2001) Journal of Clinical Endocrinology and Metabolism , vol.86 , Issue.12 , pp. 5755-5761
    • Goodpaster, B.H.1    He, J.2    Watkins, S.3    Kelley, D.E.4
  • 77
    • 34548419344 scopus 로고    scopus 로고
    • Adipocyte stress: The endoplasmic reticulum and metabolic disease
    • DOI 10.1194/jlr.R700007-JLR200
    • Gregor MF, Hotamisligil GS (2007) Thematic review series: adipocyte biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease. J Lipid Res 48:1905-1914 (Pubitemid 47360610)
    • (2007) Journal of Lipid Research , vol.48 , Issue.9 , pp. 1905-1914
    • Gregor, M.F.1    Hotamisligil, G.S.2
  • 78
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
    • DOI 10.2337/diabetes.48.6.1270
    • Griffin ME, Marcucci MJ, Cline GW, Bell K, Barucci N, Lee D, Goodyear LJ, Kraegen EW, White MF, Shulman GI (1999) Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 48:1270-1274 (Pubitemid 29241025)
    • (1999) Diabetes , vol.48 , Issue.6 , pp. 1270-1274
    • Griffin, M.E.1    Marcucci, M.J.2    Cline, G.W.3    Bell, K.4    Barucci, N.5    Lee, D.6    Goodyear, L.J.7    Kraegen, E.W.8    White, M.F.9    Shulman, G.I.10
  • 79
    • 0034112405 scopus 로고    scopus 로고
    • + T-cell alterations in trichloroethylene-treated MRL+/+ mice
    • Griffin JM, Gilbert KM, Pumford NR (2000) Inhibition of CYP2E1 reverses CD4+ T-cell alterations in trichloroethylene-treated MRL+/+ mice. Toxicol Sci 54:384-389 (Pubitemid 30185960)
    • (2000) Toxicological Sciences , vol.54 , Issue.2 , pp. 384-389
    • Griffin, J.M.1    Gilbert, K.M.2    Pumford, N.R.3
  • 80
    • 14544271905 scopus 로고    scopus 로고
    • Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
    • DOI 10.1016/j.biochi.2004.10.019
    • Gual P, Le Marchand-Brustel Y, Tanti JF (2005) Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 87:99-109 (Pubitemid 40298772)
    • (2005) Biochimie , vol.87 , Issue.1 SPEC. ISS , pp. 99-109
    • Gual, P.1    Le, M.-B.Y.2    Tanti, J.-F.3
  • 81
    • 9644307899 scopus 로고    scopus 로고
    • Melanocortin-independent effects of leptin on hepatic glucose fluxes
    • DOI 10.1074/jbc.M408665200
    • Gutierrez-Juarez R, Obici S, Rossetti L (2004) Melanocortin-independent effects of leptin on hepatic glucose fluxes. J Biol Chem 279:49704-49715 (Pubitemid 39577774)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.48 , pp. 49704-49715
    • Gutierrez-Juarez, R.1    Obici, S.2    Rossetti, L.3
  • 82
    • 36248955063 scopus 로고    scopus 로고
    • ATP Channel Subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti-related protein in the hypothalami of zucker diabetic fatty rats
    • DOI 10.1111/j.1365-2826.2007.01607.x
    • Gyte A, Pritchard LE, Jones HB, Brennand JC, White A (2007) Reduced expression of the KATP channel subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti-related protein in the hypothalami of Zucker diabetic fatty rats. J Neuroendocrinol 19:941-951 (Pubitemid 350131080)
    • (2007) Journal of Neuroendocrinology , vol.19 , Issue.12 , pp. 941-951
    • Gyte, A.1    Pritchard, L.E.2    Jones, H.B.3    Brennand, J.C.4    White, A.5
  • 83
    • 0033303516 scopus 로고    scopus 로고
    • Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine
    • Hansen L, Deacon CF, Orskov C, Holst JJ (1999) Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine. Endocrinology 140:5356-5363
    • (1999) Endocrinology , vol.140 , pp. 5356-5363
    • Hansen, L.1    Deacon, C.F.2    Orskov, C.3    Holst, J.J.4
  • 84
    • 0034968330 scopus 로고    scopus 로고
    • Diabetes mellitus and exocrine pancreatic dysfunction in Perk-/- Mice reveals a role for translational control in secretory cell survival
    • DOI 10.1016/S1097-2765(01)00264-7
    • Harding HP, Zeng H, Zhang Y, Jungries R, Chung P, Plesken H, Sabatini DD, Ron D (2001) Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell 7:1153-1163 (Pubitemid 32607350)
    • (2001) Molecular Cell , vol.7 , Issue.6 , pp. 1153-1163
    • Harding, H.P.1    Zeng, H.2    Zhang, Y.3    Jungries, R.4    Chung, P.5    Plesken, H.6    Sabatini, D.D.7    Ron, D.8
  • 85
    • 31544465941 scopus 로고    scopus 로고
    • Molecular disruption of hypothalamic nutrient sensing induces obesity
    • DOI 10.1038/nn1626, PII NN1626
    • He W, Lam TK, Obici S, Rossetti L (2006) Molecular disruption of hypothalamic nutrient sensing induces obesity. Nat Neurosci 9:227-233 (Pubitemid 43164546)
    • (2006) Nature Neuroscience , vol.9 , Issue.2 , pp. 227-233
    • He, W.1    Lam, T.K.T.2    Obici, S.3    Rossetti, L.4
  • 90
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444:860-867
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 92
    • 33846264544 scopus 로고    scopus 로고
    • Acute effects of atypical antipsychotics on whole-body insulin resistance in rats: Implications for adverse metabolic effects
    • DOI 10.1038/sj.npp.1301209, PII 1301209
    • Houseknecht KL, Robertson AS, Zavadoski W, Gibbs EM, Johnson DE, Rollema H (2007) Acute effects of atypical antipsychotics on whole-body insulin resistance in rats: implications for adverse metabolic effects. Neuropsychopharmacology 32:289-297 (Pubitemid 46106936)
    • (2007) Neuropsychopharmacology , vol.32 , Issue.2 , pp. 289-297
    • Houseknecht, K.L.1    Robertson, A.S.2    Zavadoski, W.3    Gibbs, E.M.4    Johnson, D.E.5    Rollema, H.6
  • 93
    • 0033536236 scopus 로고    scopus 로고
    • Insulin signaling in the arterial wall
    • Hsueh WA, Law RE (1999) Insulin signaling in the arterial wall. Am J Cardiol 84:21J-24J
    • (1999) Am J Cardiol , vol.84
    • Hsueh, W.A.1    Law, R.E.2
  • 94
    • 15244363998 scopus 로고    scopus 로고
    • Effect of centrally administered C75, a fatty acid synthase inhibitor, on ghrelin secretion and its downstream effects
    • Hu Z, Cha SH, van Haasteren G, Wang J, Lane MD (2005) Effect of centrally administered C75, a fatty acid synthase inhibitor, on ghrelin secretion and its downstream effects. Proc Natl Acad Sci USA 102:3972-3977
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 3972-3977
    • Hu, Z.1    Cha, S.H.2    Van Haasteren, G.3    Wang, J.4    Lane, M.D.5
  • 96
    • 0037116638 scopus 로고    scopus 로고
    • Oral antihyperglycemic therapy for type 2 diabetes: Scientific review
    • Inzucchi SE (2002) Oral antihyperglycemic therapy for type 2 diabetes: scientific review. JAMA 287:360-372
    • (2002) JAMA , vol.287 , pp. 360-372
    • Inzucchi, S.E.1
  • 97
    • 20044379258 scopus 로고    scopus 로고
    • Synergistic effect of portal glucose and glucagon-like peptide-1 to lower systemic glucose and stimulate counter-regulatory hormones
    • DOI 10.1007/s00125-005-1709-3
    • Ionut V, Hucking K, Liberty IF, Bergman RN (2005) Synergistic effect of portal glucose and glucagon-like peptide-1 to lower systemic glucose and stimulate counter-regulatory hormones. Diabetologia 48:967-975 (Pubitemid 40767991)
    • (2005) Diabetologia , vol.48 , Issue.5 , pp. 967-975
    • Ionut, V.1    Hucking, K.2    Liberty, I.F.3    Bergman, R.N.4
  • 99
    • 0036300538 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    • Itani SI, Ruderman NB, Schmieder F, Boden G (2002) Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 51:2005-2011 (Pubitemid 34729001)
    • (2002) Diabetes , vol.51 , Issue.7 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 103
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • DOI 10.1038/nature05482, PII NATURE05482
    • Kahn SE, Hull RL, Utzschneider KM (2006b) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444:840-846 (Pubitemid 46024990)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 107
    • 3242718780 scopus 로고    scopus 로고
    • Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose
    • DOI 10.1152/ajpendo.00426.2003
    • Khaldi MZ, Guiot Y, Gilon P, Henquin JC, Jonas JC (2004) Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose. Am J Physiol Endocrinol Metab 287:E207-E217 (Pubitemid 38943884)
    • (2004) American Journal of Physiology - Endocrinology and Metabolism , vol.287 , Issue.2
    • Khaldi, M.Z.1    Guiot, Y.2    Gilon, P.3    Henquin, J.C.4    Jonas, J.C.5
  • 119
    • 23244458439 scopus 로고    scopus 로고
    • Medicine: Regulation of blood glucose by hypothalamic pyruvate metabolism
    • DOI 10.1126/science.1112085
    • Lam TK, Gutierrez-Juarez R, Pocai A, Rossetti L (2005a) Regulation of blood glucose by hypothalamic pyruvate metabolism. Science 309:943-947 (Pubitemid 41099933)
    • (2005) Science , vol.309 , Issue.5736 , pp. 943-947
    • Lam, T.K.T.1    Gutierrez-Juarez, R.2    Pocai, A.3    Rossetti, L.4
  • 121
    • 1642422755 scopus 로고    scopus 로고
    • The immune response of Drosophila melanogaster
    • DOI 10.1111/j.0105-2896.2004.0130.x
    • Leclerc V, Reichhart JM (2004) The immune response of Drosophila melanogaster. Immunol Rev 198:59-71 (Pubitemid 38406935)
    • (2004) Immunological Reviews , vol.198 , pp. 59-71
    • Leclerc, V.1    Reichhart, J.-M.2
  • 122
    • 67650233905 scopus 로고    scopus 로고
    • Rimonabant: An antagonist drug of the endocannabinoid system for the treatment of obesity
    • Leite CE, Mocelin CA, Petersen GO, Leal MB, Thiesen FV (2009) Rimonabant: an antagonist drug of the endocannabinoid system for the treatment of obesity. Pharmacol Rep 61:217-224
    • (2009) Pharmacol Rep , vol.61 , pp. 217-224
    • Leite, C.E.1    Mocelin, C.A.2    Petersen, G.O.3    Leal, M.B.4    Thiesen, F.V.5
  • 123
    • 4744356246 scopus 로고    scopus 로고
    • Reduced serum dipeptidyl peptidase-IV after metformin and pioglitazone treatments
    • DOI 10.1016/j.bbrc.2004.09.021, PII S0006291X04020649
    • Lenhard JM, Croom DK, Minnick DT (2004) Reduced serum dipeptidyl peptidase-IV after metformin and pioglitazone treatments. Biochem Biophys Res Commun 324:92-97 (Pubitemid 39311464)
    • (2004) Biochemical and Biophysical Research Communications , vol.324 , Issue.1 , pp. 92-97
    • Lenhard, J.M.1    Croom, D.K.2    Minnick, D.T.3
  • 124
    • 17844377908 scopus 로고    scopus 로고
    • ATP channels: Muscular impact on type 2 diabetes
    • DOI 10.2337/diabetes.54.5.1592
    • Li L, Shi Y, Wang X, Shi W, Jiang C (2005a) Single nucleotide polymorphisms in K(ATP) channels: muscular impact on type 2 diabetes. Diabetes 54:1592-1597 (Pubitemid 40586695)
    • (2005) Diabetes , vol.54 , Issue.5 , pp. 1592-1597
    • Li, L.1    Shi, Y.2    Wang, X.3    Shi, W.4    Jiang, C.5
  • 125
    • 20444461628 scopus 로고    scopus 로고
    • Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: Model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis
    • DOI 10.1074/jbc.M501759200
    • Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, Tall AR, Davis RJ, Flavell R, Brenner DA, Tabas I (2005b) Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem 280: 21763-21772 (Pubitemid 40827824)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.23 , pp. 21763-21772
    • Li, Y.1    Schwabe, R.F.2    DeVries-Seimon, T.3    Yao, P.M.4    Gerbod-Giannone, M.-C.5    Tall, A.R.6    Davis, R.J.7    Flavell, R.8    Brenner, D.A.9    Tabas, I.10
  • 128
    • 34249894505 scopus 로고    scopus 로고
    • Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance
    • DOI 10.1172/JCI30565
    • Liu L, Zhang Y, Chen N, Shi X, Tsang B, Yu YH (2007) Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. J Clin Invest 117: 1679-1689 (Pubitemid 46871352)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.6 , pp. 1679-1689
    • Liu, L.1    Zhang, Y.2    Chen, N.3    Shi, X.4    Tsang, B.5    Yu, Y.-H.6
  • 129
    • 0034733730 scopus 로고    scopus 로고
    • Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
    • DOI 10.1126/science.288.5475.2379
    • Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, Lane MD, Kuhajda FP (2000) Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288:2379-2381 (Pubitemid 30448165)
    • (2000) Science , vol.288 , Issue.5475 , pp. 2379-2381
    • Loftus, T.M.1    Jaworsky, D.E.2    Frehywot, C.L.3    Townsend, C.A.4    Ronnett, G.V.5    Daniel, L.M.6    Kuhajda, F.P.7
  • 130
    • 33847073149 scopus 로고    scopus 로고
    • Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
    • Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR (2007) Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 56:16-23
    • (2007) Diabetes , vol.56 , pp. 16-23
    • Lumeng, C.N.1    Deyoung, S.M.2    Bodzin, J.L.3    Saltiel, A.R.4
  • 132
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • DOI 10.1016/j.it.2004.09.015, PII S1471490604002959
    • Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, LocatiM(2004) The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 25:677-686 (Pubitemid 39457982)
    • (2004) Trends in Immunology , vol.25 , Issue.12 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3    Allavena, P.4    Vecchi, A.5    Locati, M.6
  • 133
    • 33845968872 scopus 로고    scopus 로고
    • Mathematical modeling shows exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin or metformin and a sulfonylurea
    • DOI 10.1055/s-2006-956505
    • Mari A, Nielsen LL, Nanayakkara N, DeFronzo RA, Ferrannini E, Halseth A (2006) Mathematical modeling shows exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin or metformin and a sulfonylurea. Horm Metab Res 38:838-844 (Pubitemid 46051506)
    • (2006) Hormone and Metabolic Research , vol.38 , Issue.12 , pp. 838-844
    • Mari, A.1    Nielsen, L.L.2    Nanayakkara, N.3    DeFronzo, R.A.4    Ferrannini, E.5    Halseth, A.6
  • 134
    • 34547684649 scopus 로고    scopus 로고
    • Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on beta-cell function in normal living conditions
    • DOI 10.2337/dc07-0310
    • Mari A, Degn K, Brock B, Rungby J, Ferrannini E, Schmitz O (2007) Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on beta-cell function in normal living conditions. Diab Care 30:2032-2033 (Pubitemid 47219415)
    • (2007) Diabetes Care , vol.30 , Issue.8 , pp. 2032-2033
    • Mari, A.1    Degn, K.2    Brock, B.3    Rungby, J.4    Ferrannini, E.L.E.5    Schmitz, O.6
  • 136
    • 0030658022 scopus 로고    scopus 로고
    • Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators
    • DOI 10.1074/jbc.272.45.28210
    • Martin G, Schoonjans K, Lefebvre AM, Staels B, Auwerx J (1997) Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators. J Biol Chem 272:28210-28217 (Pubitemid 27517759)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.45 , pp. 28210-28217
    • Martin, G.1    Schoonjans, K.2    Lefebvre, A.-M.3    Staels, B.4    Auwerx, J.5
  • 137
    • 33747055111 scopus 로고    scopus 로고
    • Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes
    • DOI 10.2337/db05-1672
    • Matveyenko AV, Butler PC (2006) Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat
    • (2006) Diabetes , vol.55 , Issue.7 , pp. 2106-2114
    • Matveyenko, A.V.1    Butler, P.C.2
  • 138
    • 17444432216 scopus 로고    scopus 로고
    • Calorie restriction increases the ratio of phosphatidylinositol 3-kinase catalytic to regulatory subunits in rat skeletal muscle
    • DOI 10.1152/ajpendo.00566.2004
    • McCurdy CE, Davidson RT, Cartee GD (2005) Calorie restriction increases the ratio of phosphatidylinositol 3-kinase catalytic to regulatory subunits in rat skeletal muscle. Am J Physiol Endocrinol Metab 288:E996-E1001 (Pubitemid 40547895)
    • (2005) American Journal of Physiology - Endocrinology and Metabolism , vol.288 , Issue.5
    • McCurdy, C.E.1    Davidson, R.T.2    Cartee, G.D.3
  • 139
    • 0032898667 scopus 로고    scopus 로고
    • Fatty acids, lipotoxicity and insulin secretion
    • DOI 10.1007/s001250051130
    • McGarry JD, Dobbins RL (1999) Fatty acids, lipotoxicity and insulin secretion. Diabetologia 42:128-138 (Pubitemid 29064233)
    • (1999) Diabetologia , vol.42 , Issue.2 , pp. 128-138
    • McGarry, J.D.1    Dobbins, R.L.2
  • 140
    • 38349192580 scopus 로고    scopus 로고
    • New drugs for the treatment of diabetes mellitus: Part I: Thiazolidinediones and their evolving cardiovascular implications
    • McGuire DK, Inzucchi SE (2008) New drugs for the treatment of diabetes mellitus: part I: Thiazolidinediones and their evolving cardiovascular implications. Circulation 117:440-449
    • (2008) Circulation , vol.117 , pp. 440-449
    • McGuire, D.K.1    Inzucchi, S.E.2
  • 141
    • 0034647947 scopus 로고    scopus 로고
    • Dopamine and serotonin VMN release is related to feeding status in obese and lean Zucker rats
    • Meguid MM, Fetissov SO, Blaha V, Yang ZJ (2000) Dopamine and serotonin VMN release is related to feeding status in obese and lean Zucker rats. NeuroReport 11:2069-2072 (Pubitemid 30485536)
    • (2000) NeuroReport , vol.11 , Issue.10 , pp. 2069-2072
    • Meguid, M.M.1    Fetissov, S.O.2    Blaha, V.3    Yang, Z.-J.4
  • 142
    • 0033619675 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV (CD26) - Role in the inactivation of regulatory peptides
    • Mentlein R (1999) Dipeptidyl-peptidase IV (CD26) - role in the inactivation of regulatory peptides. Regul Pept 85:9-24
    • (1999) Regul Pept , vol.85 , pp. 9-24
    • Mentlein, R.1
  • 143
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
    • Mentlein R, Gallwitz B, Schmidt WE (1993) Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem 214:829-835 (Pubitemid 23188160)
    • (1993) European Journal of Biochemistry , vol.214 , Issue.3 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 145
    • 12944261926 scopus 로고    scopus 로고
    • Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation
    • Mirshamsi S, Laidlaw HA, Ning K, Anderson E, Burgess LA, Gray A, Sutherland C, Ashford ML (2004) Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation. BMC Neurosci 5:54
    • (2004) BMC Neurosci , vol.5 , pp. 54
    • Mirshamsi, S.1    Laidlaw, H.A.2    Ning, K.3    Anderson, E.4    Burgess, L.A.5    Gray, A.6    Sutherland, C.7    Ashford, M.L.8
  • 147
    • 33845542745 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction
    • DOI 10.2337/db06-S002
    • Morino K, Petersen KF, Shulman GI (2006) Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes 55(Suppl 2): S9-S15 (Pubitemid 44927027)
    • (2006) Diabetes , vol.55 , Issue.SUPPL. 2
    • Morino, K.1    Petersen, K.F.2    Shulman, G.I.3
  • 149
    • 30044447631 scopus 로고    scopus 로고
    • Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons
    • Morton GJ, Gelling RW, Niswender KD, Morrison CD, Rhodes CJ, Schwartz MW (2005) Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab 2:11-20
    • (2005) Cell Metab , vol.2 , pp. 11-20
    • Morton, G.J.1    Gelling, R.W.2    Niswender, K.D.3    Morrison, C.D.4    Rhodes, C.J.5    Schwartz, M.W.6
  • 150
    • 39749147110 scopus 로고    scopus 로고
    • Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes
    • DOI 10.1038/nrm2327, PII NRM2327
    • Muoio DM, Newgard CB (2008) Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol 9:193-205 (Pubitemid 351301824)
    • (2008) Nature Reviews Molecular Cell Biology , vol.9 , Issue.3 , pp. 193-205
    • Muoio, D.M.1    Newgard, C.B.2
  • 151
    • 57349160286 scopus 로고    scopus 로고
    • Medical management of hyperglycaemia in type 2 diabetes mellitus: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, Zinman B (2009) Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 52:17-30
    • (2009) Diabetologia , vol.52 , pp. 17-30
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3    Ferrannini, E.4    Holman, R.R.5    Sherwin, R.6    Zinman, B.7
  • 152
    • 15044362439 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 and its derivatives in the treatment of diabetes
    • DOI 10.1016/j.regpep.2004.07.014, Proceedings from the GLP1 Meeting on the Occasion of the 80th Birthday of Prof.Dr. Med. Dr. hc (em) Werner Creutzfeltdt.
    • Nauck MA, Meier JJ (2005) Glucagon-like peptide 1 and its derivatives in the treatment of diabetes. Regul Pept 128:135-148 (Pubitemid 40380914)
    • (2005) Regulatory Peptides , vol.128 , Issue.2 , pp. 135-148
    • Nauck, M.A.1    Meier, J.J.2
  • 153
    • 0022617246 scopus 로고
    • Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes
    • DOI 10.1007/BF02427280
    • Nauck M, Stockmann F, Ebert R, Creutzfeldt W (1986) Reduced incretin effect in type 2 (noninsulin- dependent) diabetes. Diabetologia 29:46-52 (Pubitemid 16162741)
    • (1986) Diabetologia , vol.29 , Issue.1 , pp. 46-52
    • Nauck, M.1    Stockmann, F.2    Ebert, R.3    Creutzfeldt, W.4
  • 154
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, CreutzfeldtW(1993) Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 91:301-307
    • (1993) J Clin Invest , vol.91 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, M.M.2    Orskov, C.3    Holst, J.J.4    Ebert, R.5    Creutzfeldt, W.6
  • 159
    • 0036065628 scopus 로고    scopus 로고
    • Central administration of oleic acid inhibits glucose production and food intake
    • Obici S, Feng Z, Morgan K, Stein D, Karkanias G, Rossetti L (2002a) Central administration of oleic acid inhibits glucose production and food intake. Diabetes 51:271-275 (Pubitemid 34764780)
    • (2002) Diabetes , vol.51 , Issue.2 , pp. 271-275
    • Obici, S.1    Feng, Z.2    Morgan, K.3    Stein, D.4    Karkanias, G.5    Rossetti, L.6
  • 160
    • 0036913187 scopus 로고    scopus 로고
    • Hypothalamic insulin signaling is required for inhibition of glucose production
    • DOI 10.1038/nm798
    • Obici S, Zhang BB, Karkanias G, Rossetti L (2002b) Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 8:1376-1382 (Pubitemid 36019422)
    • (2002) Nature Medicine , vol.8 , Issue.12 , pp. 1376-1382
    • Obici, S.1    Zhang, B.B.2    Karkanias, G.3    Rossetti, L.4
  • 161
    • 0036267472 scopus 로고    scopus 로고
    • Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
    • DOI 10.1038/nn861
    • Obici S, Feng Z, Karkanias G, Baskin DG, Rossetti L (2002c) Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci 5:566-572 (Pubitemid 34568999)
    • (2002) Nature Neuroscience , vol.5 , Issue.6 , pp. 566-572
    • Obici, S.1    Feng, Z.2    Karkanias, G.3    Baskin, D.G.4    Rossetti, L.5
  • 162
    • 0038037734 scopus 로고    scopus 로고
    • Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production
    • DOI 10.1038/nm873
    • Obici S, Feng Z, Arduini A, Conti R, Rossetti L (2003) Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nat Med 9:756-761 (Pubitemid 36749226)
    • (2003) Nature Medicine , vol.9 , Issue.6 , pp. 756-761
    • Obici, S.1    Feng, Z.2    Arduini, A.3    Conti, R.4    Rossetti, L.5
  • 165
    • 0033857387 scopus 로고    scopus 로고
    • Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists
    • Olefsky JM (2000) Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. J Clin Invest 106:467-472
    • (2000) J Clin Invest , vol.106 , pp. 467-472
    • Olefsky, J.M.1
  • 166
    • 0028085284 scopus 로고
    • Effects of glucose and fatty acids on myocardial ischaemia and arrhythmias
    • Oliver MF, Opie LH (1994) Effects of glucose and fatty acids on myocardial ischaemia and arrhythmias. Lancet 343:155-158
    • (1994) Lancet , vol.343 , pp. 155-158
    • Oliver, M.F.1    Opie, L.H.2
  • 168
    • 70450193472 scopus 로고    scopus 로고
    • Human genetics illuminates the paths to metabolic disease
    • O'Rahilly S (2009) Human genetics illuminates the paths to metabolic disease. Nature 462:307-314
    • (2009) Nature , vol.462 , pp. 307-314
    • O'Rahilly, S.1
  • 169
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • DOI 10.1042/0264-6021:3480607
    • Owen MR, Doran E, Halestrap AP (2000) Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J 348(Pt 3):607-614 (Pubitemid 30410251)
    • (2000) Biochemical Journal , vol.348 , Issue.3 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 171
    • 33748069813 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    • DOI 10.1126/science.1128294
    • Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ, Hotamisligil GS (2006) Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313:1137-1140 (Pubitemid 44300242)
    • (2006) Science , vol.313 , Issue.5790 , pp. 1137-1140
    • Ozcan, U.1    Yilmaz, E.2    Ozcan, L.3    Furuhashi, M.4    Vaillancourt, E.5    Smith, R.O.6    Gorgun, C.Z.7    Hotamisligil, G.S.8
  • 174
    • 71449120759 scopus 로고    scopus 로고
    • Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitment
    • Patsouris D, Neels JG, Fan W, Li PP, Nguyen MT, Olefsky JM (2009) Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitment. J Biol Chem 284:31223-31235
    • (2009) J Biol Chem , vol.284 , pp. 31223-31235
    • Patsouris, D.1    Neels, J.G.2    Fan, W.3    Li, P.P.4    Nguyen, M.T.5    Olefsky, J.M.6
  • 177
    • 4344710646 scopus 로고    scopus 로고
    • Intracerebroventricular infusion of glucose, insulin, and the adenosine monophosphate-activated kinase activator, 5-aminoimidazole-4-carboxamide-1- beta-D-ribofuranoside, controls muscle glycogen synthesis
    • DOI 10.1210/en.2004-0270
    • Perrin C, Knauf C, Burcelin R (2004) Intracerebroventricular infusion of glucose, insulin, and the adenosine monophosphate-activated kinase activator, 5-aminoimidazole-4-carboxamide-1- beta-D-ribofuranoside, controls muscle glycogen synthesis. Endocrinology 145:4025-4033 (Pubitemid 39120547)
    • (2004) Endocrinology , vol.145 , Issue.9 , pp. 4025-4033
    • Perrin, C.1    Knauf, C.2    Burcelin, R.3
  • 178
    • 0032764784 scopus 로고    scopus 로고
    • 13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents
    • DOI 10.2337/diabetes.48.8.1600
    • Perseghin G, Scifo P, De Cobelli F, Pagliato E, Battezzati A, Arcelloni C, Vanzulli A, Testolin G, Pozza G, Del Maschio A, Luzi L (1999) Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 48:1600-1606 (Pubitemid 29356869)
    • (1999) Diabetes , vol.48 , Issue.8 , pp. 1600-1606
    • Perseghin, G.1    Scifo, P.2    De Cobelli, F.3    Pagliato, E.4    Battezzati, A.5    Arcelloni, C.6    Vanzulli, A.7    Testolin, G.8    Pozza, G.9    Del, M.A.10    Luzi, L.11
  • 183
    • 0036153256 scopus 로고    scopus 로고
    • Minireview: Secondary beta-cell failure in type 2 diabetes - A convergence of glucotoxicity and lipotoxicity
    • DOI 10.1210/en.143.2.339
    • Poitout V, Robertson RP (2002) Minireview: Secondary beta-cell failure in type 2 diabetes - a convergence of glucotoxicity and lipotoxicity. Endocrinology 143:339-342 (Pubitemid 34107184)
    • (2002) Endocrinology , vol.143 , Issue.2 , pp. 339-342
    • Poitout, V.1    Robertson, R.P.2
  • 184
    • 0042160132 scopus 로고    scopus 로고
    • Energy translocation across cell membranes and membrane models
    • DOI 10.1046/j.1365-201X.2003.01154.x
    • Pownall HJ, Hamilton JA (2003) Energy translocation across cell membranes and membrane models. Acta Physiol Scand 178:357-365 (Pubitemid 36960426)
    • (2003) Acta Physiologica Scandinavica , vol.178 , Issue.4 , pp. 357-365
    • Pownall, H.J.1    Hamilton, J.A.2
  • 185
    • 0036896505 scopus 로고    scopus 로고
    • Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: Role in beta-cell adaptation and failure in the etiology of diabetes
    • Prentki M, Joly E, El-Assaad W, Roduit R (2002) Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes. Diabetes 51(Suppl 3):S405-S413 (Pubitemid 35403424)
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 3
    • Prentki, M.1    Joly, E.2    El-Assaad, W.3    Roduit, R.4
  • 186
    • 58149330247 scopus 로고    scopus 로고
    • Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin complex 1 signaling in the central nervous system
    • Proulx K, Cota D, Woods SC, Seeley RJ (2008) Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin complex 1 signaling in the central nervous system. Diabetes 57:3231-3238
    • (2008) Diabetes , vol.57 , pp. 3231-3238
    • Proulx, K.1    Cota, D.2    Woods, S.C.3    Seeley, R.J.4
  • 187
    • 15444370639 scopus 로고    scopus 로고
    • Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle
    • DOI 10.1074/jbc.M408985200
    • Richardson DK, Kashyap S, Bajaj M, Cusi K, Mandarino SJ, Finlayson J, DeFronzo RA, Jenkinson CP, Mandarino LJ (2005) Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle. J Biol Chem 280:10290-10297 (Pubitemid 40395885)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.11 , pp. 10290-10297
    • Richardson, D.K.1    Kashyap, S.2    Bajaj, M.3    Cusi, K.4    Mandarino, S.J.5    Finlayson, J.6    DeFronzo, R.A.7    Jenkinson, C.P.8    Mandarino, L.J.9
  • 189
    • 77957662514 scopus 로고    scopus 로고
    • The American Association of Clinical Endocrinologists/American College of Endocrinology (AACE/ACE) algorithm for managing glycaemia in patients with type 2 diabetes mellitus: Comparison with the ADA/EASD algorithm
    • Rodbard HW, Jellinger PS (2010) The American Association of Clinical Endocrinologists/American College of Endocrinology (AACE/ACE) algorithm for managing glycaemia in patients with type 2 diabetes mellitus: comparison with the ADA/EASD algorithm. Diabetologia 53 (11):2458-2460
    • (2010) Diabetologia , vol.53 , Issue.11 , pp. 2458-2460
    • Rodbard, H.W.1    Jellinger, P.S.2
  • 191
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • DOI 10.1038/nrm2199, PII NRM2199
    • Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8:519-529 (Pubitemid 46985379)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.7 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 192
    • 33746068289 scopus 로고    scopus 로고
    • Metformin delays the manifestation of diabetes and vascular dysfunction in Goto-Kakizaki rats by reduction of mitochondrial oxidative stress
    • DOI 10.1002/dmrr.623
    • Rosen P, Wiernsperger NF (2006) Metformin delays the manifestation of diabetes and vascular dysfunction in Goto-Kakizaki rats by reduction of mitochondrial oxidative stress. Diabetes Metab Res Rev 22:323-330 (Pubitemid 44070509)
    • (2006) Diabetes/Metabolism Research and Reviews , vol.22 , Issue.4 , pp. 323-330
    • Rosen, P.1    Wiernsperger, N.F.2
  • 193
    • 33746983981 scopus 로고    scopus 로고
    • Specific protein kinase C isoforms as transducers and modulators of insulin signaling
    • DOI 10.1016/j.ymgme.2006.04.017, PII S1096719206001661
    • Sampson SR, Cooper DR (2006) Specific protein kinase C isoforms as transducers and modulators of insulin signaling. Mol Genet Metab 89:32-47 (Pubitemid 44205471)
    • (2006) Molecular Genetics and Metabolism , vol.89 , Issue.1-2 , pp. 32-47
    • Sampson, S.R.1    Cooper, D.R.2
  • 194
    • 77953868236 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance: Unravelling the mechanism
    • Samuel VT, Petersen KF, Shulman GI (2010) Lipid-induced insulin resistance: unravelling the mechanism. Lancet 375:2267-2277
    • (2010) Lancet , vol.375 , pp. 2267-2277
    • Samuel, V.T.1    Petersen, K.F.2    Shulman, G.I.3
  • 195
    • 50949094723 scopus 로고    scopus 로고
    • Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake
    • Sandoval DA, Bagnol D, Woods SC, D'Alessio DA, Seeley RJ (2008) Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake. Diabetes 57:2046-2054
    • (2008) Diabetes , vol.57 , pp. 2046-2054
    • Sandoval, D.A.1    Bagnol, D.2    Woods, S.C.3    D'Alessio, D.A.4    Seeley, R.J.5
  • 197
    • 0036924048 scopus 로고    scopus 로고
    • Activation of the Drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3
    • DOI 10.1016/S1097-2765(02)00734-7
    • Sathyanarayana P, Barthwal MK, Kundu CN, Lane ME, Bergmann A, Tzivion G, Rana A (2002) Activation of the Drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3. Mol Cell 10:1527-1533 (Pubitemid 36050893)
    • (2002) Molecular Cell , vol.10 , Issue.6 , pp. 1527-1533
    • Sathyanarayana, P.1    Barthwal, M.K.2    Kundu, C.N.3    Lane, M.E.4    Bergmann, A.5    Tzivion, G.6    Rana, A.7
  • 198
    • 51349156218 scopus 로고    scopus 로고
    • Insulin sensitivity: Modulation by nutrients and inflammation
    • Schenk S, Saberi M, Olefsky JM (2008) Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest 118:2992-3002
    • (2008) J Clin Invest , vol.118 , pp. 2992-3002
    • Schenk, S.1    Saberi, M.2    Olefsky, J.M.3
  • 200
    • 0030914330 scopus 로고    scopus 로고
    • Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat
    • Schmitz-Peiffer C, Browne CL, Oakes ND, Watkinson A, Chisholm DJ, Kraegen EW, Biden TJ (1997) Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat. Diabetes 46:169-178 (Pubitemid 27272248)
    • (1997) Diabetes , vol.46 , Issue.2 , pp. 169-178
    • Schmitz-Peiffer, C.1    Browne, C.L.2    Oakes, N.D.3    Watkinson, A.4    Chisholm, D.J.5    Kraegen, E.W.6    Biden, T.J.7
  • 201
    • 0036894268 scopus 로고    scopus 로고
    • Nucleotide sensitivity of pancreatic ATP-sensitive potassium channels and type 2 diabetes
    • Schwanstecher C, Schwanstecher M (2002) Nucleotide sensitivity of pancreatic ATP-sensitive potassium channels and type 2 diabetes. Diabetes 51(Suppl 3):S358-S362 (Pubitemid 35403416)
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 3
    • Schwanstecher, C.1    Schwanstecher, M.2
  • 202
    • 0036314298 scopus 로고    scopus 로고
    • + channels
    • Schwanstecher C, Meyer U, Schwanstecher M(2002) K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels. Diabetes 51:875-879 (Pubitemid 34760205)
    • (2002) Diabetes , vol.51 , Issue.3 , pp. 875-879
    • Schwanstecher, C.1    Meyer, U.2    Schwanstecher, M.3
  • 204
    • 33847198926 scopus 로고    scopus 로고
    • Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: A preliminary report
    • Shevah O, Laron Z (2007) Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: a preliminary report. Growth Horm IGF Res 17:54-57
    • (2007) Growth Horm IGF Res , vol.17 , pp. 54-57
    • Shevah, O.1    Laron, Z.2
  • 206
    • 33645083474 scopus 로고    scopus 로고
    • Pioglitazone increases circulating adiponectin levels and subsequently reduces TNF-alpha levels in Type 2 diabetic patients: A randomized study
    • Shimizu H, Oh IS, Tsuchiya T, Ohtani KI, Okada S, Mori M (2006) Pioglitazone increases circulating adiponectin levels and subsequently reduces TNF-alpha levels in Type 2 diabetic patients: a randomized study. Diabet Med 23:253-257
    • (2006) Diabet Med , vol.23 , pp. 253-257
    • Shimizu, H.1    Oh, I.S.2    Tsuchiya, T.3    Ohtani, K.I.4    Okada, S.5    Mori, M.6
  • 209
    • 0034804726 scopus 로고    scopus 로고
    • Pioglitazone: Mechanism of action
    • Smith U (2001) Pioglitazone: mechanism of action. Int J Clin Pract Suppl 121:13-18
    • (2001) Int J Clin Pract Suppl , vol.121 , pp. 13-18
    • Smith, U.1
  • 211
    • 0027168655 scopus 로고
    • Homology between the mammalian liver and the Drosophila fat body
    • Sondergaard L (1993) Homology between the mammalian liver and the Drosophila fat body. Trends Genet 9:193
    • (1993) Trends Genet , vol.9 , pp. 193
    • Sondergaard, L.1
  • 212
    • 33745187112 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
    • Song MJ, Kim KH, Yoon JM, Kim JB (2006) Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem Biophys Res Commun 346:739-745
    • (2006) Biochem Biophys Res Commun , vol.346 , pp. 739-745
    • Song, M.J.1    Kim, K.H.2    Yoon, J.M.3    Kim, J.B.4
  • 213
    • 0031898610 scopus 로고    scopus 로고
    • PPAR-gamma: Adipogenic regulator and thiazolidinedione receptor
    • Spiegelman BM (1998) PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. Diabetes 47:507-514
    • (1998) Diabetes , vol.47 , pp. 507-514
    • Spiegelman, B.M.1
  • 215
    • 0035281991 scopus 로고    scopus 로고
    • Ceramide dissociates 30-phosphoinositide production from pleckstrin homology domain translocation
    • DOI 10.1042/0264-6021:3540359
    • Stratford S, DeWald DB, Summers SA (2001) Ceramide dissociates 30-phosphoinositide production from pleckstrin homology domain translocation. Biochem J 354:359-368 (Pubitemid 32209874)
    • (2001) Biochemical Journal , vol.354 , Issue.2 , pp. 359-368
    • Stratford, S.1    DeWald, D.B.2    Summers, S.A.3
  • 217
    • 77952814507 scopus 로고    scopus 로고
    • Inhibition of multifunctional dipeptidyl peptidase-IV: Is there a risk of oncological and immunological adverse effects?
    • Stulc T, Sedo A (2010) Inhibition of multifunctional dipeptidyl peptidase-IV: is there a risk of oncological and immunological adverse effects? Diabetes Res Clin Pract 88:125-131
    • (2010) Diabetes Res Clin Pract , vol.88 , pp. 125-131
    • Stulc, T.1    Sedo, A.2
  • 218
    • 34548857700 scopus 로고    scopus 로고
    • SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B
    • DOI 10.1016/j.cmet.2007.08.014, PII S1550413107002598
    • Sun C, Zhang F, Ge X, Yan T, Chen X, Shi X, Zhai Q (2007) SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab 6:307-319 (Pubitemid 47468091)
    • (2007) Cell Metabolism , vol.6 , Issue.4 , pp. 307-319
    • Sun, C.1    Zhang, F.2    Ge, X.3    Yan, T.4    Chen, X.5    Shi, X.6    Zhai, Q.7
  • 219
    • 31644443192 scopus 로고    scopus 로고
    • Ceramides in insulin resistance and lipotoxicity
    • Summers SA (2006) Ceramides in insulin resistance and lipotoxicity. Prog Lipid Res 45:42-72
    • (2006) Prog Lipid Res , vol.45 , pp. 42-72
    • Summers, S.A.1
  • 220
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: Insights into insulin action
    • DOI 10.1038/nrm1837, PII NRM1837
    • Taniguchi CM, Emanuelli B, Kahn CR (2006) Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7:85-96 (Pubitemid 43278292)
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.2 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 221
    • 33644514920 scopus 로고    scopus 로고
    • Tissue-specific roles of IRS proteins in insulin signaling and glucose transport
    • Thirone AC, Huang C, Klip A (2006) Tissue-specific roles of IRS proteins in insulin signaling and glucose transport. Trends Endocrinol Metab 17:72-78
    • (2006) Trends Endocrinol Metab , vol.17 , pp. 72-78
    • Thirone, A.C.1    Huang, C.2    Klip, A.3
  • 222
    • 0345275811 scopus 로고    scopus 로고
    • Elevation of Free Fatty Acids Induces Inflammation and Impairs Vascular Reactivity in Healthy Subjects
    • DOI 10.2337/diabetes.52.12.2882
    • Tripathy D, Mohanty P, Dhindsa S, Syed T, Ghanim H, Aljada A, Dandona P (2003) Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects. Diabetes 52:2882-2887 (Pubitemid 37466856)
    • (2003) Diabetes , vol.52 , Issue.12 , pp. 2882-2887
    • Tripathy, D.1    Mohanty, P.2    Dhindsa, S.3    Syed, T.4    Ghanim, H.5    Aliada, A.6    Dandona, P.7
  • 224
    • 33644886769 scopus 로고    scopus 로고
    • Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
    • Tzatsos A, Kandror KV (2006) Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol 26:63-76
    • (2006) Mol Cell Biol , vol.26 , pp. 63-76
    • Tzatsos, A.1    Kandror, K.V.2
  • 225
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group (1998) Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 352:854-865
    • (1998) Lancet , vol.352 , pp. 854-865
  • 227
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
    • Unger RH (1995) Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 44:863-870
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 228
    • 66149138468 scopus 로고    scopus 로고
    • Bone metabolism in type 2 diabetes and role of thiazolidinediones
    • Vestergaard P (2009) Bone metabolism in type 2 diabetes and role of thiazolidinediones. Curr Opin Endocrinol Diabetes Obes 16:125-131
    • (2009) Curr Opin Endocrinol Diabetes Obes , vol.16 , pp. 125-131
    • Vestergaard, P.1
  • 229
    • 38449111332 scopus 로고    scopus 로고
    • Splanchnic regulation of glucose production
    • DOI 10.1146/annurev.nutr.27.061406.093806
    • Wahren J, Ekberg K (2007) Splanchnic regulation of glucose production. Annu Rev Nutr 27:329-345 (Pubitemid 351384373)
    • (2007) Annual Review of Nutrition , vol.27 , pp. 329-345
    • Wahren, J.1    Ekberg, K.2
  • 231
    • 35448934913 scopus 로고    scopus 로고
    • Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes
    • DOI 10.1007/s00424-007-0301-8
    • Wang B, Wood IS, Trayhurn P (2007) Dysregulation of the expression and secretion of inflammation- related adipokines by hypoxia in human adipocytes. Pflugers Arch 455:479-492 (Pubitemid 47624196)
    • (2007) Pflugers Archiv European Journal of Physiology , vol.455 , Issue.3 , pp. 479-492
    • Wang, B.1    Wood, I.S.2    Trayhurn, P.3
  • 234
    • 0023222388 scopus 로고
    • Islet amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone
    • Westermark P, Wernstedt C, O'Brien TD, Hayden DW, Johnson KH (1987) Islet amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone. Am J Pathol 127:414-417 (Pubitemid 17089802)
    • (1987) American Journal of Pathology , vol.127 , Issue.3 , pp. 414-417
    • Westermark, P.1    Wernstedt, C.2    O'Brien, T.D.3
  • 237
    • 33845998567 scopus 로고    scopus 로고
    • The role of hypothalamic malonyl-CoA in energy homeostasis
    • DOI 10.1074/jbc.R600016200
    • Wolfgang MJ, Lane MD (2006) The role of hypothalamic malonyl-CoA in energy homeostasis. J Biol Chem 281:37265-37269 (Pubitemid 46042029)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.49 , pp. 37265-37269
    • Wolfgang, M.J.1    Lane, M.D.2
  • 238
    • 0029125647 scopus 로고
    • Effects of duodenal and distal ileal infusions of glucose and oleic acid on meal patterns in rats
    • Woltman T, Reidelberger R (1995) Effects of duodenal and distal ileal infusions of glucose and oleic acid on meal patterns in rats. Am J Physiol 269:R7-R14
    • (1995) Am J Physiol , vol.269
    • Woltman, T.1    Reidelberger, R.2
  • 239
    • 55449096196 scopus 로고    scopus 로고
    • Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on beta-cell function in patients with type 2 diabetes: A model-based approach
    • Xu L, Man CD, Charbonnel B, Meninger G, Davies MJ, Williams-Herman D, Cobelli C, Stein PP (2008a) Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on beta-cell function in patients with type 2 diabetes: a model-based approach. Diabetes Obes Metab 10:1212-1220
    • (2008) Diabetes Obes Metab , vol.10 , pp. 1212-1220
    • Xu, L.1    Man, C.D.2    Charbonnel, B.3    Meninger, G.4    Davies, M.J.5    Williams-Herman, D.6    Cobelli, C.7    Stein, P.P.8
  • 242
    • 35148854599 scopus 로고    scopus 로고
    • Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
    • DOI 10.1152/ajpendo.00435.2007
    • Ye J, Gao Z, Yin J, He Q (2007) Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 293:E1118-E1128 (Pubitemid 47535846)
    • (2007) American Journal of Physiology - Endocrinology and Metabolism , vol.293 , Issue.4
    • Ye, J.1    Gao, Z.2    Yin, J.3    He, Q.4
  • 244
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    • DOI 10.1126/science.1061620
    • Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE (2001) Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 293:1673-1677 (Pubitemid 32807849)
    • (2001) Science , vol.293 , Issue.5535 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.-W.5    Karin, M.6    Shoelson, S.E.7
  • 245
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study
    • DOI 10.1016/S0140-6736(02)07952-7
    • Zander M, Madsbad S, Madsen JL, Holst JJ (2002) Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet 359:824-830 (Pubitemid 34233752)
    • (2002) Lancet , vol.359 , Issue.9309 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3    Holst, J.J.4
  • 246
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
    • Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D (2008) Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 135:61-73
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1    Zhang, G.2    Zhang, H.3    Karin, M.4    Bai, H.5    Cai, D.6
  • 248
    • 45849093655 scopus 로고    scopus 로고
    • Gastric relaxation induced by hyperglycemia is mediated by vagal afferent pathways in the rat
    • Zhou SY, Lu YX, Owyang C (2008) Gastric relaxation induced by hyperglycemia is mediated by vagal afferent pathways in the rat. Am J Physiol Gastrointest Liver Physiol 294:G1158-G1164
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294
    • Zhou, S.Y.1    Lu, Y.X.2    Owyang, C.3


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