Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci

Diabetes

Volumn 49, Issue 11, 2000, Pages 1946-1954

  Stoehr, Jonathan P ^a   Nadler, Samuel T ^a   Schueler, Kathryn L ^a   Rabaglia, Mary E ^a   Yandell, Brian S ^a,b   Metz, Stewart A ^c   Attie, Alan D ^a,d  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b University of Wisconsin Madison   (United States)

^c PACIFIC NORTHWEST RESEARCH INSTITUTE   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ALLELE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; GENE AMPLIFICATION; GENE LOCUS; GENETIC SUSCEPTIBILITY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; RISK FACTOR; STRAIN DIFFERENCE;

EID: 0033761365     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.11.1946     Document Type: Article

References (45)

1. Type 2 diabetes: When insulin secretion fails to compensate for insulin resistance
2. Deconstructing type 2 diabetes
3. Non-insulin-dependent diabetes mellitus: A genetically programmed failure of the beta cell to compensate for insulin resistance
4. The beta-cell in diabetes: From molecular genetics to clinical research
5. Genetics of non-insulin-dependent (type-II) diabetes mellitus
6. Insulin action, diabetogenes, and the cause of type II diabetes
7. Molecular genetics of maturity-onset diabetes of the young
8. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
9. Gene-environment interactions in the pathogenesis of type 2 diabetes mellitus: Lessons learned from the Pima Indians
10. The universality of diabetes: A survey of diabetes morbidity in Arizona
11. Effects of a traditional lifestyle on obesity in Pima Indians
12. Diabetes incidence in Pima Indians: Contributions of obesity and parental diabetes
13. The influence of genetic background on the expression of the obese (Ob) gene in the mouse
14. Genetic modifiers of Lepr(fa) associated with variability in insulin production and susceptibility to NIDDM
15. Interaction between BTBR and C57BL/6 genomes produces an insulin resistance syndrome in (BTBR x C57BL/6J) F1 mice
16. A comprehensive genetic map of the mouse genome
17. MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations
18. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps
19. Zmap: A QTL cartographer
20. Multiple trait analysis of genetic mapping for quantitative trait loci
21. An extension of the concept of partitioning hereditary variance for analysis of covariances among relatives when epistasis is present
22. NIDDM genes in mice: Deleterious synergism by both parental genomes contributes to diabetogenic thresholds
23. High-fat feeding impairs insulin-stimulated GLUT4 recruitment via an early insulin-signaling defect
24. Using markers in gene introgression breeding programs
25. The language of gene interaction
26. Selective DNA pooling for determination of linkage between a molecular marker and a quantitative trait locus
27. The effect of selective genotyping on QTL mapping accuracy
28. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
29. Hypertension in C57BL/6J mouse model of non-insulin-dependent diabetes mellitus
30. Molecular characterization of the mouse agouti locus
31. Theoretical basis for separation of multiple linked gene effects in mapping quantitative trait loci
32. Precision mapping of quantitative trait loci
33. Genetic dissection of 'OLETF,' a rat model of non-insulin-dependent diabetes mellitus: Quantitative trait locus analysis of (OLETF x BN) x OLETF
34. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat
35. Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat
36. Genetic dissection of 'OLETF', a rat model for non-insulin-dependent diabetes mellitus
37. Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model
38. 2+ signaling and insulin release
39. A fifth allelomorph in the agouti series of the house mouse
40. Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice
41. The adipoinsular axis: Effects of leptin on pancreatic β-cells
42. Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes