Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: Association with cytokine expression, insulin resistance, and reduction by pioglitazone

Diabetes

Volumn 54, Issue 8, 2005, Pages 2305-2313

  Di Gregorio, Gina B ^a,b   Yao Borengasser, Aiwei ^a,b   Rasouli, Neda ^a,b   Varma, Vijayalakshmi ^a,b   Lu, Tong ^a,b   Miles, Leslie M ^a,b   Ranganathan, Gouri ^a,b   Peterson, Charlotte A ^a,c   McGehee, Robert E ^b   Kern, Philip A ^a,b  

^a CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; CD68 ANTIGEN; CYTOKINE; GLUCOSE; INSULIN; INTERLEUKIN 6; METFORMIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PIOGLITAZONE; PROTEIN; TOLBUTAMIDE; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE; ADULT; AGED; ARTICLE; CHEMOLUMINESCENCE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; MALE; MUSCLE TISSUE; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADIPOSE TISSUE; ADULT; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CELL COUNT; CHEMOKINE CCL2; CYTOKINES; GENE EXPRESSION; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; MACROPHAGES; METFORMIN; MIDDLE AGED; MUSCLES; OBESITY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THIAZOLIDINEDIONES;

EID: 23644446750     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.54.8.2305     Document Type: Article

References (40)

1. Flegal KM, Carroll MD, Ogden CL, Johnson CL: Prevalence and trends in obesity among US adults, 1999-2000. JAMA 288:1723-1727, 2002
2. Mokdad A, Serdula MK, Dietz WH, Bowman B, Marks J, Koplan J: The spread of the obesity epidemic in the United States, 1991-1998. JAMA 282:1519-1522, 1999
3. Harris MI: Diabetes in America: epidemiology and scope of the problem. Diabetes Care 21 (Suppl. 3):C11-C14, 1998
4. Flier JS: The adipocyte: storage depot or node on the energy information superhighway? Cell 80:15-18, 1995
5. Flier JS: The missing rink with obesity? Nature 409:292-293, 2001
6. Kern PA: Potential role of TNF-alpha and lipoprotein lipase as candidate genes for obesity. J Nutr 127:19178-19228, 1997
7. Hotamisligil GS, Spiegelman BM: Tumor necrosis factor a: a key component of the obesity-diabetes link. Diabetes 43:1271-1278, 1994
8. Hotamisligil GS: Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord 27 (Suppl. 3):S53-S55, 2003
9. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H: Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821-1830, 2003
10. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr: Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796-1808, 2003
11. Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB: The expression of tumor necrosis factor in human adipose tissue: regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 95:2111-2119, 1995
12. Vidalpuig AJ, Considine RV, Jimenezlinan M, Werman A, Pories WJ, Caro JF, Flier JS: Peroxisome proliferator-activated receptor gene expression in human tissues: effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J Clin Invest 99:2416-2422, 1997
13. DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP: The effect of insulin on the disposal of intravenous glucose: results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30:1000-1007, 1981
14. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK: The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391:79-82, 1998
15. Chinetti G, Griglio S, Antonucci M, Torra IP, Delerive P, Majd Z, Fruchart JC, Chapman J, Najib J, Staels B: Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages. J Biol Chem 273:25573-25580, 1998
16. Castrillo A, Tontonoz P: Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation. Annu Rev Cell Dev Biol 20:455-480, 2004
17. Holness CL, Da Silva RP, Fawcett J, Gordon S, Simmons DL: Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family. J Biol Chem 268:9661-9666, 1993
18. Rodbell M: Metabolism of isolated fat cells. I. Effects of hormone on glucose metabolism and lipolysis. J Biol Chem 239:375-380, 1964
19. Van Harmelen V, Skurk T, Rohrig K, Lee YM, Halbleib M, Aprath-Husmann I, Hauner H: Effect of BMI and age on adipose tissue cellularity and differentiation capacity in women. Int J ObesRelat Metab Disord 27:889-895, 2003
20. Bergman RN, Finegood DT, Ader M: Assessment of insulin sensitivity in vivo. Endocr Rev 6:45-86, 1985
21. Bergman RN, Prager R, Volund A, Olefsky JM: Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest 79:790-800, 1987
22. Saad MF, Steil GM, Kades WW, Ayad MF, Elsewafy WA, Boyadjian R, Jinagouda SD, Bergman RN: Differences between the tolbutamide-boosted and the insulin-modified minimal model protocols. Diabetes 46:1167-1171, 1997
23. Bergman RN, Ider YZ, Bowden CR, Cobelli C: Quantitative estimation of insulin sensitivity. Am J Physiol 236:E667-E677, 1979
24. Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G: Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity-associated insulin resistance. Am J Physiol Endocrinol Metab 280:E745-E751, 2001
25. Olweus J, Thompson PA, Lund-Johansen F: Granulocytic and monocytic differentiation of CD34hi cells is associated with distinct changes in the expression of the PU 1-regulated molecules, CD64 and macrophage colony-stimulating factor receptor. Blood 88:3741-3754, 1996
26. Sartipy P, Loskutoff DJ: Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci U S A 100:7265-7270, 2003
27. Gerhardt CC, Romero IA, Cancello R, Camoin L, Strosberg AD: Chemokines control fat accumulation and leptin secretion by cultured human adipocytes. Mol Cell Endocrinol 175:81-92, 2001
28. Rajala MW, Scherer PE: Minireview: The adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144:3765-3773, 2003
29. Hsueh WA, Law R: The central role of fat and effect of peroxisome proliferator-activated receptor-gamma on progression of insulin resistance and cardiovascular disease. Am J Cardiol 92:3J-9J, 2003
30. Hotamisligil GS, Shargill NS, Spiegelman BM: Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259:87-91, 1993
31. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM: Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 95:2409-2415, 1995
32. Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS: Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389:610-614, 1997
33. Linton MF, Fazio S: Macrophages, inflammation, and atherosclerosis. Int J ObesRelat Metab Disord 27 (Suppl. 3):S35-S40, 2003
34. Christiansen T, Richelsen B, Bruun JM: Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects. Int J ObesRelat Metab Disord 29:146-150, 2005
35. Fasshauer M, Klein J, Kralisch S, Klier M, Lossner U, Bluher M, Paschke R: Monocyte chemoattractant protein 1 expression is stimulated by growth hormone and interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun 317:598-604, 2004
36. Wang B, Jenkins JR, Trayhurn P: Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-{alpha}. Am J Physiol Endocrinol Metab 288:E731-E740, 2005
37. Simeoni E, Hoffmann MM, Winkelmann BR, Ruiz J, Fleury S, Boehm BO, Marz W, Vassalli G: Association between the A-2518G polymorphism in the monocyte chemoattractant protein-1 gene and insulin resistance and type 2 diabetes mellitus. Diabetologia 47:1574-1580, 2004
38. Castrillo A, Tontonoz P: PPAR-s in atherosclerosis: the clot thickens. J Clin Invest 114:1538-1540, 2004
39. Maeda N, Takahashi M, Funahashi T, Kihara S, Nishizawa H, Kishida K, Nagaretani H, Matsuda M, Komuro R, Ouchi N, Kuriyama H, Hotta K, Nakamura T, Shimomura I, Matsuzawa Y: PPAR-gamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 50:2094-2099, 2001
40. Trayhurn P, Wood IS: Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92:347-355, 2004