Ceramide dissociates 3′-phosphoinositide production from pleckstrin homology domain translocation

Biochemical Journal

Volumn 354, Issue 2, 2001, Pages 359-368

  Stratford, S ^a   DeWald, D B ^a   Summers, S A ^a  

^a Veterinary Dentistry and Oral Surgery   (United States)

Author keywords

Akt; GLUT4 translocation; Phosphoinositide 3 kinase; Protein kinase B; Sphingolipids

Indexed keywords

CERAMIDE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PLECKSTRIN;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; ENZYME ACTIVITY; GLUCOSE METABOLISM; NONHUMAN; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ANIMALS; BLOOD PROTEINS; CERAMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT ANTIBODY TECHNIQUE; GLUCOSE TRANSPORTER TYPE 4; ISOENZYMES; MICE; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPASE C; PHOSPHOPROTEINS; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SEQUENCE HOMOLOGY, AMINO ACID; SPHINGOLIPIDS; SPHINGOSINE; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0035281991     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3540359     Document Type: Article

References (53)

1. Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase
2. Requirement for phosphatidylinositol-3-kinase in the prevention of apoptosis by nerve growth factor
3. Phosphatidylinositol 3-kinase
4. Lipid signalling
5. Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate
6. ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1
7. Phosphorylation and activation of p70(S6K) by PDK1
8. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
9. Cellular survival: A play in three Akts
10. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains
11. Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B
12. Ceramide and the induction of apoptosis
13. Signal transduction of stress via ceramide
14. Ceramide in the eukaryotic stress response
15. Reply to Kolesnick and Hannun, and Perry and Hannun
16. The use of diglyceride kinase for quantifying ceramide
17. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
18. Fatty acid-induced β cell apoptosis: A link between obesity and diabetes
19. Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells
20. Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest
21. Role for ceramide in cell cycle arrest
22. Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide
23. Effects of cell-permeable ceramides and tumor necrosis factor-α on insulin signaling and glucose uptake in 3T3-L1 adipocytes
24. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
25. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis
26. Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells
27. Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473
28. Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport
29. Differentiation-dependent suppression of platelet-derived growth factor signaling in cultured adipocytes
30. Frequent inactivation of PTEN in prostate cancer cell lines and xenografts
31. The dynamics of protein kinase B regulation during B cell antigen receptor engagement
32. 3H]inositol-labeled phosphoinositide pools
33. Analysis of phosphoinositides in protein trafficking
34. The role of glycogen synthase kinase 3β in insulin-stimulated glucose metabolism
35. Polyoma middle T antigen activates the serine/threonine kinase Akt in a P13-kinase dependent manner
36. Cell cycle arrest induced by an inhibitor of glucosylceramide synthase. Correlation with cyclin-dependent kinases
37. Ceramide kinase
38. Stimulation of DNA synthesis by natural ceramide 1-phosphate
39. The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo
40. Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction
41. Confocal imaging of the subcellular distribution of phosphatidylinositol 3,4,5-trisphosphate in insulin- and PDGF-stimulated 3T3-L1 adipocytes
42. Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain
43. The sphingomyelin cycle and the second messenger function of ceramide
44. Signaling pathways mediating insulin-stimulated glucose transport
45. Regulation of phosphatidylinositol 3,4,5-trisphosphate 5′-phosphatase activity by insulin
46. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate
47. Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide
48. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
49. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site
50. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
51. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
52. Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
53. Cross-talk between phosphatidylinositol 3-kinase and sphingomyelinase pathways as a mechanism for cell survival/death decisions