메뉴 건너뛰기




Volumn 117, Issue 6, 2007, Pages 1679-1689

Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; DIACYLGLYCEROL ACYLTRANSFERASE; DIACYLGLYCEROL ACYLTRANSFERASE 1; FATTY ACID; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 34249894505     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI30565     Document Type: Article
Times cited : (281)

References (81)
  • 1
    • 0036182137 scopus 로고    scopus 로고
    • Lipotoxic diseases
    • Unger, R.H. 2002. Lipotoxic diseases. Annu. Rev. Med. 53:319-336.
    • (2002) Annu. Rev. Med , vol.53 , pp. 319-336
    • Unger, R.H.1
  • 2
    • 2942746793 scopus 로고    scopus 로고
    • The role of acyl-CoA:diacylglycerol acyltransferase (DGAT) in energy metabolism
    • Yu, Y.H., and Ginsberg, H.N. 2004. The role of acyl-CoA:diacylglycerol acyltransferase (DGAT) in energy metabolism. Ann. Med. 36:252-261.
    • (2004) Ann. Med , vol.36 , pp. 252-261
    • Yu, Y.H.1    Ginsberg, H.N.2
  • 3
    • 0029787329 scopus 로고    scopus 로고
    • Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects
    • Phillips, D.I., et al. 1996. Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism. 45:947-950.
    • (1996) Metabolism , vol.45 , pp. 947-950
    • Phillips, D.I.1
  • 4
    • 0031930724 scopus 로고    scopus 로고
    • Intramuscular triglyceride content is increased in IDDM
    • Ebeling, P., et al. 1998. Intramuscular triglyceride content is increased in IDDM. Diabetologia. 41:111-115.
    • (1998) Diabetologia , vol.41 , pp. 111-115
    • Ebeling, P.1
  • 5
    • 0033952722 scopus 로고    scopus 로고
    • Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides
    • Manco, M., et al. 2000. Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides. Metabolism. 49:220-224.
    • (2000) Metabolism , vol.49 , pp. 220-224
    • Manco, M.1
  • 6
    • 0027395358 scopus 로고
    • The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids
    • Borkman, M., et al. 1993. The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. N. Engl. J. Med. 328:238-244.
    • (1993) N. Engl. J. Med , vol.328 , pp. 238-244
    • Borkman, M.1
  • 7
    • 0030969532 scopus 로고    scopus 로고
    • Skeletal muscle triglyceride levels are inversely related to insulin action
    • Pan, D.A., et al. 1997. Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes. 46:983-988.
    • (1997) Diabetes , vol.46 , pp. 983-988
    • Pan, D.A.1
  • 8
    • 0032764784 scopus 로고    scopus 로고
    • Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: A 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents
    • Perseghin, G., et al. 1999. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes. 48:1600-1606.
    • (1999) Diabetes , vol.48 , pp. 1600-1606
    • Perseghin, G.1
  • 9
    • 0035487317 scopus 로고    scopus 로고
    • Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle
    • Virkamaki, A., et al. 2001. Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle. Diabetes. 50:2337-2343.
    • (2001) Diabetes , vol.50 , pp. 2337-2343
    • Virkamaki, A.1
  • 10
    • 0032934826 scopus 로고    scopus 로고
    • Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: A 1H NMR spectroscopy study
    • Krssak, M., et al. 1999. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia. 42:113-116.
    • (1999) Diabetologia , vol.42 , pp. 113-116
    • Krssak, M.1
  • 11
    • 1542440927 scopus 로고    scopus 로고
    • Decreased muscle acetyl-coenzyme A carboxylase 2 mRNA and insulin resistance in formerly obese subjects
    • Rosa, G., et al. 2003. Decreased muscle acetyl-coenzyme A carboxylase 2 mRNA and insulin resistance in formerly obese subjects. Obes. Res. 11:1306-1312.
    • (2003) Obes. Res , vol.11 , pp. 1306-1312
    • Rosa, G.1
  • 12
    • 4644305200 scopus 로고    scopus 로고
    • Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice
    • Heron-Milhavet, L., et al. 2004. Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice. Endocrinology. 145:4667-4676.
    • (2004) Endocrinology , vol.145 , pp. 4667-4676
    • Heron-Milhavet, L.1
  • 13
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • Shimomura, I., et al. 1999. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature. 401:73-76.
    • (1999) Nature , vol.401 , pp. 73-76
    • Shimomura, I.1
  • 14
    • 0037148928 scopus 로고    scopus 로고
    • Leptin-replacement therapy for lipodystrophy
    • Oral, E.A., et al. 2002. Leptin-replacement therapy for lipodystrophy. N. Engl. J. Med. 346:570-578.
    • (2002) N. Engl. J. Med , vol.346 , pp. 570-578
    • Oral, E.A.1
  • 15
    • 0032813243 scopus 로고    scopus 로고
    • Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats - effects of feeding
    • Qu, X., Seale, J.P., and Donnelly, R. 1999. Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats - effects of feeding. J. Endocrinol. 162:207-214.
    • (1999) J. Endocrinol , vol.162 , pp. 207-214
    • Qu, X.1    Seale, J.P.2    Donnelly, R.3
  • 16
    • 0033834079 scopus 로고    scopus 로고
    • Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle
    • Ellis, B.A., et al. 2000. Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle. Am. J. Physiol. Endocrinol. Metab. 279:E554-E560.
    • (2000) Am. J. Physiol. Endocrinol. Metab , vol.279
    • Ellis, B.A.1
  • 17
    • 0035912744 scopus 로고    scopus 로고
    • Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance
    • Kim, J.K., et al. 2001. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc. Natl. Acad. Sci. U. S. A. 98:7522-7527.
    • (2001) Proc. Natl. Acad. Sci. U. S. A , vol.98 , pp. 7522-7527
    • Kim, J.K.1
  • 18
    • 0036063842 scopus 로고    scopus 로고
    • Acyl-CoA binding protein expression is fiber type-specific and elevated in muscles from the obese insulin-resistant Zucker rat
    • Franch, J., et al. 2002. Acyl-CoA binding protein expression is fiber type-specific and elevated in muscles from the obese insulin-resistant Zucker rat. Diabetes. 51:449-454.
    • (2002) Diabetes , vol.51 , pp. 449-454
    • Franch, J.1
  • 19
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
    • Yu, C., et al. 2002. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J. Biol. Chem. 277:50230-50236.
    • (2002) J. Biol. Chem , vol.277 , pp. 50230-50236
    • Yu, C.1
  • 20
    • 33646394578 scopus 로고    scopus 로고
    • Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: Role of intramuscular accumulation of lipid metabolites
    • Lee, J.S., et al. 2006. Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites. J. Appl. Physiol. 100:1467-1474.
    • (2006) J. Appl. Physiol , vol.100 , pp. 1467-1474
    • Lee, J.S.1
  • 21
    • 0022260872 scopus 로고
    • Endurance training in humans: Aerobic capacity and structure of skeletal muscle
    • Hoppeler, H., et al. 1985. Endurance training in humans: aerobic capacity and structure of skeletal muscle. J. Appl. Physiol. 59:320-327.
    • (1985) J. Appl. Physiol , vol.59 , pp. 320-327
    • Hoppeler, H.1
  • 22
    • 0035217707 scopus 로고    scopus 로고
    • Skeletal muscle lipid content and insulin resistance: Evidence for a paradox in endurance-trained athletes
    • Goodpaster, B.H., et al. 2001. Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J. Clin. Endocrinol. Metab. 86:5755-5761.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 5755-5761
    • Goodpaster, B.H.1
  • 23
    • 13844250261 scopus 로고    scopus 로고
    • Postexercise insulin sensitivity is not impaired after an overnight lipid infusion
    • Schenk, S., et al. 2005. Postexercise insulin sensitivity is not impaired after an overnight lipid infusion. Am. J. Physiol. Endocrinol. Metab. 288:E519-E525.
    • (2005) Am. J. Physiol. Endocrinol. Metab , vol.288
    • Schenk, S.1
  • 24
    • 0034833901 scopus 로고    scopus 로고
    • Postexercise fat intake repletes intramyocellular lipids but no faster in trained than in sedentary subjects
    • Decombaz, J., et al. 2001. Postexercise fat intake repletes intramyocellular lipids but no faster in trained than in sedentary subjects. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281:R760-R769.
    • (2001) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.281
    • Decombaz, J.1
  • 25
    • 0021321296 scopus 로고
    • Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin-dependent diabetes mellitus
    • Bogardus, C., et al. 1984. Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin-dependent diabetes mellitus. Diabetes. 33:311-318.
    • (1984) Diabetes , vol.33 , pp. 311-318
    • Bogardus, C.1
  • 26
    • 0023604784 scopus 로고
    • Effect of physical training on insulin action in obesity
    • DeFronzo, R.A., Sherwin, R.S., and Kraemer, N. 1987. Effect of physical training on insulin action in obesity. Diabetes. 36:1379-1385.
    • (1987) Diabetes , vol.36 , pp. 1379-1385
    • DeFronzo, R.A.1    Sherwin, R.S.2    Kraemer, N.3
  • 27
    • 0024597695 scopus 로고
    • Effect of exercise on insulin action in human skeletal muscle
    • Richter, E.A., et al. 1989. Effect of exercise on insulin action in human skeletal muscle. J. Appl. Physiol. 66:876-885.
    • (1989) J. Appl. Physiol , vol.66 , pp. 876-885
    • Richter, E.A.1
  • 28
    • 0029849462 scopus 로고    scopus 로고
    • Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects
    • Perseghin, G., et al. 1996. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N. Engl. J. Med. 335:1357-1362.
    • (1996) N. Engl. J. Med , vol.335 , pp. 1357-1362
    • Perseghin, G.1
  • 29
    • 0028864373 scopus 로고
    • Insulin-stimulated muscle glucose clearance in patients with NIDDM. Effects of one-legged physical training
    • Dela, F., et al. 1995. Insulin-stimulated muscle glucose clearance in patients with NIDDM. Effects of one-legged physical training. Diabetes. 44:1010-1020.
    • (1995) Diabetes , vol.44 , pp. 1010-1020
    • Dela, F.1
  • 30
    • 0042321037 scopus 로고    scopus 로고
    • Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity
    • Goodpaster, B.H., Katsiaras, A., and Kelley, D.E. 2003. Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity. Diabetes. 52:2191-2197.
    • (2003) Diabetes , vol.52 , pp. 2191-2197
    • Goodpaster, B.H.1    Katsiaras, A.2    Kelley, D.E.3
  • 31
    • 0042266366 scopus 로고    scopus 로고
    • Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity
    • Short, K.R., et al. 2003. Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes. 52:1888-1896.
    • (2003) Diabetes , vol.52 , pp. 1888-1896
    • Short, K.R.1
  • 32
    • 33745841299 scopus 로고    scopus 로고
    • Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content
    • Bruce, C.R., et al. 2006. Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content. Am. J. Physiol. Endocrinol. Metab. 291:E99-E107.
    • (2006) Am. J. Physiol. Endocrinol. Metab , vol.291
    • Bruce, C.R.1
  • 33
    • 12444300209 scopus 로고    scopus 로고
    • Lipotoxicity: The obese and endurance-trained paradox
    • Russell, A.P. 2004. Lipotoxicity: the obese and endurance-trained paradox. Int. J. Obes. Relat. Metab. Disord. 28(Suppl. 4):S66-S71.
    • (2004) Int. J. Obes. Relat. Metab. Disord , vol.28 , Issue.SUPPL. 4
    • Russell, A.P.1
  • 34
    • 33746328957 scopus 로고    scopus 로고
    • Signaling pathways in skeletal muscle remodeling
    • Bassel-Duby, R., and Olson, E.N. 2006. Signaling pathways in skeletal muscle remodeling. Annu. Rev. Biochem. 75:19-37.
    • (2006) Annu. Rev. Biochem , vol.75 , pp. 19-37
    • Bassel-Duby, R.1    Olson, E.N.2
  • 35
    • 0009577154 scopus 로고    scopus 로고
    • Glucose transport and cell surface GLUT-4 protein in skeletal muscle of the obese Zucker rat
    • Etgen, G.J., Jr., et al. 1996. Glucose transport and cell surface GLUT-4 protein in skeletal muscle of the obese Zucker rat. Am. J. Physiol. 271:E294-E301.
    • (1996) Am. J. Physiol , vol.271
    • Etgen Jr., G.J.1
  • 36
    • 0029157866 scopus 로고
    • Skeletal muscle fiber composition is related to adiposity and in vitro glucose transport rate in humans
    • Hickey, M.S., et al. 1995. Skeletal muscle fiber composition is related to adiposity and in vitro glucose transport rate in humans. Am. J. Physiol. 268:E453-E457.
    • (1995) Am. J. Physiol , vol.268
    • Hickey, M.S.1
  • 37
    • 0010164060 scopus 로고    scopus 로고
    • Muscle fiber type specificity in insulin signal transduction
    • Song, X.M., et al. 1999. Muscle fiber type specificity in insulin signal transduction. Am. J. Physiol. 277:R1690-R1696.
    • (1999) Am. J. Physiol , vol.277
    • Song, X.M.1
  • 38
    • 0025187661 scopus 로고
    • Glucose transporter protein content and glucose transport capacity in rat skeletal muscles
    • Henriksen, E.J., et al. 1990. Glucose transporter protein content and glucose transport capacity in rat skeletal muscles. Am. J. Physiol. 259:E593-E598.
    • (1990) Am. J. Physiol , vol.259
    • Henriksen, E.J.1
  • 39
    • 0242582447 scopus 로고    scopus 로고
    • Skeletal muscle reprogramming by activation of calcineurin improves insulin action on metabolic pathways
    • Ryder, J.W., et al. 2003. Skeletal muscle reprogramming by activation of calcineurin improves insulin action on metabolic pathways. J. Biol. Chem. 278:44298-44304.
    • (2003) J. Biol. Chem , vol.278 , pp. 44298-44304
    • Ryder, J.W.1
  • 40
    • 0018846846 scopus 로고
    • Enzymes of glycerolipid synthesis in eukaryotes
    • Bell, R.M., and Coleman, R.A. 1980. Enzymes of glycerolipid synthesis in eukaryotes. Annu. Rev. Biochem. 49:459-487.
    • (1980) Annu. Rev. Biochem , vol.49 , pp. 459-487
    • Bell, R.M.1    Coleman, R.A.2
  • 41
    • 0030175841 scopus 로고    scopus 로고
    • Biosynthesis of triacylglycerols
    • Lehner, R., and Kuksis, A. 1996. Biosynthesis of triacylglycerols. Prog. Lipid Res. 35:169-201.
    • (1996) Prog. Lipid Res , vol.35 , pp. 169-201
    • Lehner, R.1    Kuksis, A.2
  • 42
    • 0347993103 scopus 로고    scopus 로고
    • Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblasts
    • Bagnato, C., and Igal, R.A. 2003. Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblasts. J. Biol. Chem. 278:52203-52211.
    • (2003) J. Biol. Chem , vol.278 , pp. 52203-52211
    • Bagnato, C.1    Igal, R.A.2
  • 43
    • 0032500641 scopus 로고    scopus 로고
    • Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes
    • Oelkers, P., et al. 1998. Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. J. Biol. Chem. 273:26765-26771.
    • (1998) J. Biol. Chem , vol.273 , pp. 26765-26771
    • Oelkers, P.1
  • 44
    • 13144281703 scopus 로고    scopus 로고
    • Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
    • Cases, S., et al. 1998. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc. Natl. Acad. Sci. U. S. A. 95:13018-13023.
    • (1998) Proc. Natl. Acad. Sci. U. S. A , vol.95 , pp. 13018-13023
    • Cases, S.1
  • 45
    • 0035914356 scopus 로고    scopus 로고
    • Cloning of dgat2, a second mammalian diacylglycerol acyltransferase, and related family members
    • Cases, S., et al. 2001. Cloning of dgat2, a second mammalian diacylglycerol acyltransferase, and related family members. J. Biol. Chem. 276:38870-38876.
    • (2001) J. Biol. Chem , vol.276 , pp. 38870-38876
    • Cases, S.1
  • 46
    • 0035914412 scopus 로고    scopus 로고
    • Dgat2 is a new diacylglycerol acyltransferase gene family: Purification, cloning, and expression in insect cells of two polypeptides from mortierella ramanniana with diacylglycerol acyltransferase activity
    • Lardizabal, K.D., et al. 2001. Dgat2 is a new diacylglycerol acyltransferase gene family: purification, cloning, and expression in insect cells of two polypeptides from mortierella ramanniana with diacylglycerol acyltransferase activity. J. Biol. Chem. 276:38862-38869.
    • (2001) J. Biol. Chem , vol.276 , pp. 38862-38869
    • Lardizabal, K.D.1
  • 47
    • 0036429189 scopus 로고    scopus 로고
    • Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin
    • Meegalla, R.L., Billheimer, J.T., and Cheng, D. 2002. Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin. Biochem. Biophys. Res. Commun. 298:317-323.
    • (2002) Biochem. Biophys. Res. Commun , vol.298 , pp. 317-323
    • Meegalla, R.L.1    Billheimer, J.T.2    Cheng, D.3
  • 48
    • 0034103658 scopus 로고    scopus 로고
    • Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat
    • Smith, S.J., et al. 2000. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat. Genet. 25:87-90.
    • (2000) Nat. Genet , vol.25 , pp. 87-90
    • Smith, S.J.1
  • 49
    • 1642523683 scopus 로고    scopus 로고
    • Lipopenia and skin barrier abnormalities in DGAT2-deficient mice
    • Stone, S.J., et al. 2004. Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. J. Biol. Chem. 279:11767-11776.
    • (2004) J. Biol. Chem , vol.279 , pp. 11767-11776
    • Stone, S.J.1
  • 50
    • 24744443740 scopus 로고    scopus 로고
    • The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters
    • Yen, C.L., et al. 2005. The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters. J. Lipid Res. 46:1502-1511.
    • (2005) J. Lipid Res , vol.46 , pp. 1502-1511
    • Yen, C.L.1
  • 51
    • 27644498093 scopus 로고    scopus 로고
    • Acyl coenzyme A dependent retinol esterification by acyl coenzyme A: Diacylglycerol acyltransferase 1
    • Orland, M.D., et al. 2005. Acyl coenzyme A dependent retinol esterification by acyl coenzyme A: diacylglycerol acyltransferase 1. Biochim. Biophys. Acta. 1737:76-82.
    • (2005) Biochim. Biophys. Acta , vol.1737 , pp. 76-82
    • Orland, M.D.1
  • 52
    • 0036391934 scopus 로고    scopus 로고
    • Up-regulation of SREBP-1c and lipogenic genes in skeletal muscles after exercise training
    • Ikeda, S., et al. 2002. Up-regulation of SREBP-1c and lipogenic genes in skeletal muscles after exercise training. Biochem. Biophys. Res. Commun. 296:395-400.
    • (2002) Biochem. Biophys. Res. Commun , vol.296 , pp. 395-400
    • Ikeda, S.1
  • 53
    • 0029742924 scopus 로고    scopus 로고
    • Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis
    • Avignon, A., et al. 1996. Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis. Diabetes. 45:1396-1404.
    • (1996) Diabetes , vol.45 , pp. 1396-1404
    • Avignon, A.1
  • 54
    • 0030914330 scopus 로고    scopus 로고
    • Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat
    • Schmitz-Peiffer, C., et al. 1997. Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat. Diabetes. 46:169-178.
    • (1997) Diabetes , vol.46 , pp. 169-178
    • Schmitz-Peiffer, C.1
  • 55
    • 0033861608 scopus 로고    scopus 로고
    • Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity
    • Itani, S.I., et al. 2000. Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity. Diabetes. 49:1353-1358.
    • (2000) Diabetes , vol.49 , pp. 1353-1358
    • Itani, S.I.1
  • 56
    • 0036300538 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    • Itani, S.I., et al. 2002. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes. 51:2005-2011.
    • (2002) Diabetes , vol.51 , pp. 2005-2011
    • Itani, S.I.1
  • 57
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
    • Griffin, M.E., et al. 1999. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes. 48:1270-1274.
    • (1999) Diabetes , vol.48 , pp. 1270-1274
    • Griffin, M.E.1
  • 58
    • 8544244084 scopus 로고    scopus 로고
    • PKC-theta knockout mice are protected from fat-induced insulin resistance
    • doi:10.1172/JCI200422230
    • Kim, J.K., et al. 2004. PKC-theta knockout mice are protected from fat-induced insulin resistance. J. Clin. Invest. 114:823-827. doi:10.1172/JCI200422230.
    • (2004) J. Clin. Invest , vol.114 , pp. 823-827
    • Kim, J.K.1
  • 59
    • 18044382930 scopus 로고    scopus 로고
    • Atypical protein kinase C in insulin action and insulin resistance
    • Farese, R.V., Sajan, M.P., and Standaert, M.L. 2005. Atypical protein kinase C in insulin action and insulin resistance. Biochem. Soc. Trans. 33:350-353.
    • (2005) Biochem. Soc. Trans , vol.33 , pp. 350-353
    • Farese, R.V.1    Sajan, M.P.2    Standaert, M.L.3
  • 60
    • 0032959890 scopus 로고    scopus 로고
    • Functional role for protein kinase Cbeta as a regulator of stress-activated protein kinase activation and monocytic differentiation of myeloid leukemia cells
    • Kaneki, M., et al. 1999. Functional role for protein kinase Cbeta as a regulator of stress-activated protein kinase activation and monocytic differentiation of myeloid leukemia cells. Mol. Cell. Biol. 19:461-470.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 461-470
    • Kaneki, M.1
  • 61
    • 0032101707 scopus 로고    scopus 로고
    • Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes
    • Werlen, G., et al. 1998. Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes. EMBO J. 17:3101-3111.
    • (1998) EMBO J , vol.17 , pp. 3101-3111
    • Werlen, G.1
  • 62
    • 0034708832 scopus 로고    scopus 로고
    • The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
    • Aguirre, V., et al. 2000. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J. Biol. Chem. 275:9047-9054.
    • (2000) J. Biol. Chem , vol.275 , pp. 9047-9054
    • Aguirre, V.1
  • 63
    • 0037059330 scopus 로고    scopus 로고
    • Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
    • Aguirre, V., et al. 2002. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J. Biol. Chem. 277:1531-1537.
    • (2002) J. Biol. Chem , vol.277 , pp. 1531-1537
    • Aguirre, V.1
  • 64
    • 0033551804 scopus 로고    scopus 로고
    • Protein kinase C and calcineurin synergize to activate IkappaB kinase and NF-kappaB in T lymphocytes
    • Trushin, S.A., et al. 1999. Protein kinase C and calcineurin synergize to activate IkappaB kinase and NF-kappaB in T lymphocytes. J. Biol. Chem. 274:22923-22931.
    • (1999) J. Biol. Chem , vol.274 , pp. 22923-22931
    • Trushin, S.A.1
  • 65
    • 0037073679 scopus 로고    scopus 로고
    • Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex
    • Gao, Z., et al. 2002. Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J. Biol. Chem. 277:48115-48121.
    • (2002) J. Biol. Chem , vol.277 , pp. 48115-48121
    • Gao, Z.1
  • 66
    • 0037229758 scopus 로고    scopus 로고
    • Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1
    • Chen, H.C., et al. 2002. Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1. Am. J. Physiol. Endocrinol. Metab. 284:E213-E218.
    • (2002) Am. J. Physiol. Endocrinol. Metab , vol.284
    • Chen, H.C.1
  • 67
    • 0036228339 scopus 로고    scopus 로고
    • Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1
    • doi:10.1172/JCI200214672
    • Chen, H.C., et al. 2002. Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. J. Clin. Invest. 109:1049-1055. doi:10.1172/JCI200214672.
    • (2002) J. Clin. Invest , vol.109 , pp. 1049-1055
    • Chen, H.C.1
  • 68
    • 2542610041 scopus 로고    scopus 로고
    • Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1
    • Chen, H.C., et al. 2004. Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1. Diabetes. 53:1445-1451.
    • (2004) Diabetes , vol.53 , pp. 1445-1451
    • Chen, H.C.1
  • 69
    • 0038481184 scopus 로고    scopus 로고
    • Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1
    • doi:10.1172/JCI200315859
    • Chen, H.C., et al. 2003. Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1. J. Clin. Invest. 111:1715-1722. doi:10.1172/JCI200315859.
    • (2003) J. Clin. Invest , vol.111 , pp. 1715-1722
    • Chen, H.C.1
  • 70
    • 0037453056 scopus 로고    scopus 로고
    • Triglyceride accumulation protects against fatty acid-induced lipotoxicity
    • Listenberger, L.L., et al. 2003. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc. Natl. Acad. Sci. U. S. A. 100:3077-3082.
    • (2003) Proc. Natl. Acad. Sci. U. S. A , vol.100 , pp. 3077-3082
    • Listenberger, L.L.1
  • 71
    • 33646462136 scopus 로고    scopus 로고
    • Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
    • Haemmerle, G., et al. 2006. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science. 312:734-737.
    • (2006) Science , vol.312 , pp. 734-737
    • Haemmerle, G.1
  • 72
    • 0037608687 scopus 로고    scopus 로고
    • Transgenic mice with dominant negative PKC-theta in skeletal muscle: A new model of insulin resistance and obesity
    • Serra, C., et al. 2003. Transgenic mice with dominant negative PKC-theta in skeletal muscle: a new model of insulin resistance and obesity. J. Cell. Physiol. 196:89-97.
    • (2003) J. Cell. Physiol , vol.196 , pp. 89-97
    • Serra, C.1
  • 73
    • 33845989841 scopus 로고    scopus 로고
    • Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice
    • Gao, Z., et al. 2007. Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice. Am. J. Physiol. Endocrinol. Metab. 292:E84-E91.
    • (2007) Am. J. Physiol. Endocrinol. Metab , vol.292
    • Gao, Z.1
  • 74
    • 0023951837 scopus 로고
    • Diacylglycerol activation of protein kinase C is modulated by long-chain acyl-CoA
    • Bronfman, M., Morales, M.N., and Orellana, A. 1988. Diacylglycerol activation of protein kinase C is modulated by long-chain acyl-CoA. Biochem. Biophys. Res. Commun. 152:987-992.
    • (1988) Biochem. Biophys. Res. Commun , vol.152 , pp. 987-992
    • Bronfman, M.1    Morales, M.N.2    Orellana, A.3
  • 75
    • 0031841949 scopus 로고    scopus 로고
    • Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide
    • Summers, S.A., et al. 1998. Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol. Cell. Biol. 18:5457-5464.
    • (1998) Mol. Cell. Biol , vol.18 , pp. 5457-5464
    • Summers, S.A.1
  • 76
    • 0033588253 scopus 로고    scopus 로고
    • Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
    • Schmitz-Peiffer, C., Craig, D.L., and Biden, T.J. 1999. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J. Biol. Chem. 274:24202-24210.
    • (1999) J. Biol. Chem , vol.274 , pp. 24202-24210
    • Schmitz-Peiffer, C.1    Craig, D.L.2    Biden, T.J.3
  • 77
    • 0037044809 scopus 로고    scopus 로고
    • High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their IIb fiber content
    • Couplan, E., et al. 2002. High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their IIb fiber content. J. Biol. Chem. 277:43079-43088.
    • (2002) J. Biol. Chem , vol.277 , pp. 43079-43088
    • Couplan, E.1
  • 78
    • 0037184929 scopus 로고    scopus 로고
    • Posttranscriptional control of the expression and function of diacylglycerol acyltransferase-1 in mouse adipocytes
    • Yu, Y.H., et al. 2002. Posttranscriptional control of the expression and function of diacylglycerol acyltransferase-1 in mouse adipocytes. J. Biol. Chem. 277:50876-50884.
    • (2002) J. Biol. Chem , vol.277 , pp. 50876-50884
    • Yu, Y.H.1
  • 79
    • 33644695684 scopus 로고    scopus 로고
    • Whole-body insulin resistance in the absence of obesity in FVB mice with overexpression of Dgat1 in adipose tissue
    • Chen, N., et al. 2005. Whole-body insulin resistance in the absence of obesity in FVB mice with overexpression of Dgat1 in adipose tissue. Diabetes. 54:3379-3386.
    • (2005) Diabetes , vol.54 , pp. 3379-3386
    • Chen, N.1
  • 80
    • 0025669894 scopus 로고
    • Radioimmunoassays for retinolbinding protein, cellular retinol-binding protein, and cellular retinoic acid-binding protein
    • Blaner, W.S. 1990. Radioimmunoassays for retinolbinding protein, cellular retinol-binding protein, and cellular retinoic acid-binding protein. Methods Enzymol. 189:270-281.
    • (1990) Methods Enzymol , vol.189 , pp. 270-281
    • Blaner, W.S.1
  • 81
    • 0035678878 scopus 로고    scopus 로고
    • Nuclear factor kappa B is involved in lipopolysaccharide-stimulated induction of interferon regulatory factor-1 and GAS/GAF DNA-binding in human umbilical vein endothelial cells
    • Liu, L., et al. 2001. Nuclear factor kappa B is involved in lipopolysaccharide-stimulated induction of interferon regulatory factor-1 and GAS/GAF DNA-binding in human umbilical vein endothelial cells. Br. J. Pharmacol. 134:1629-1638.
    • (2001) Br. J. Pharmacol , vol.134 , pp. 1629-1638
    • Liu, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.