Fatty acids, lipotoxicity and insulin secretion

Diabetologia

Volumn 42, Issue 2, 1999, Pages 128-138

  McGarry, J D ^a   Dobbins, R L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENOSINE TRIPHOSPHATE CITRATE LYASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIACYLGLYCEROL; FATTY ACID; GLUCOKINASE; OXALOACETIC ACID; PROTEIN KINASE C;

CALCIUM CELL LEVEL; CELL FUNCTION; CELL INTERACTION; FATTY ACID OXIDATION; FOOD DEPRIVATION; GLUCOSE TRANSPORT; HYPERINSULINEMIA; INSULIN RELEASE; INSULIN SENSITIVITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REVIEW; STARVATION; STIMULUS SECRETION COUPLING;

ANIMALS; FATTY ACIDS, NONESTERIFIED; HUMANS; HYPERINSULINISM; INSULIN; ISLETS OF LANGERHANS; STARVATION;

EID: 0032898667     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051130     Document Type: Review

References (84)

1. 1. Newgard CB, McGarry JD (1995) Metabolic coupling factors in pancreatic β-cell signal transduction. Ann Rev Biochem 64: 689-719
2. 2+. Diabetes 46: 1928-1938
3. 3. Greenough WB, Crespin SR, Steinberg D (1967) Hypoglycaemia and hyperinsulinaemia in response to raised free-fatty acid levels. Lancet ii:1334-1336
4. 4. Seyffert WA, Jr, Madison LL (1967) Physiologic effects of metabolic fuels on carbohydrate metabolism. I. Acute effect of elevation of plasma free fatty acids on hepatic glucose output, peripheral glucose utilization, serum insulin, and plasma glucagon levels. Diabetes 16: 765-776
5. 5. Crespin SR, Greenough WB, Steinberg D (1973) Stimulation of insulin secretion by long-chain free fatty acids. A direct pancreatic effect. J Clin Invest 52: 1979-1984
6. 6. Malaisse WJ, Malaisse-Lagae F (1968) Stimulation of insulin secretion by noncarbohydrate metabolites. J Lab Clin Med 72: 438-448
7. 7. Montague W, Taylor KW (1968) Regulation of insulin secretion by short chain fatty acids. Nature (Lond) 217: 853
8. 8. Balasse EO, Ooms HA (1973) Role of plasma from free fatty acids in the control of insulin secretion in man. Diabetologia 9: 145-151
9. 9. Pfeiffer EF (1974) Action of β-hydroxybutyrate, acetoacetate and palmitate on the insulin release in the perfused isolated rat pancreas. Horm Metab Res 6: 256-260
10. 10. Campillo JE, Luyckx AS, Torres MD, Lefebvre PJ (1979) Effect of oleic acid on insulin secretion by the isolated perfused rat pancreas. Diabetologia 16: 267-273
11. 11. Boden G (1997) Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46: 3-10
12. 12. Dobbins RL, Chester MW, Daniels MB, McGarry JD, Stein DT (1998) Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans. Diabetes 47: 1613-1618
13. 13. Boden G, Chen X, Iqbal N (1998) Acute lowering of plasma fatty acids lowers basal insulin secretion in diabetic and non-diabetic subjects. Diabetes 47: 1609-1612
14. 14. Berne C (1975) The metabolism of lipids in mouse pancreatic islets: the oxidation of fatty acids and ketone bodies. Biochem J 152: 661-666
15. 15. Tamarit-Rodriguez J, Vara E, Tamarit J (1984) Starvation-induced changes of palmitate metabolism and insulin secretion in isolated rat islets stimulated by glucose. Biochem J 221: 317-324
16. 16. Vara E, Tamarit-Rodriguez J (1986) Glucose stimulation of insulin secretion in islets of fed and starved rats and its dependence on lipid metabolism. Metabolism 35: 266-271
17. 17. McGarry JD, Woeltje KF, Kuwajima M, Foster DW (1989) Regulation of ketogenesis and the renaissance of carnitine palmitoyltransferase. Diabetes Metab Rev 5: 271-284
18. 18. McGarry JD, Brown NF (1997) The mitochondrial carnitine palmitoyltransferase system-from concept to molecular analysis. Eur J Biochem 244: 001-014
19. 19. Bliss CR, Sharp GWG (1992) Glucose-induced insulin release in islets of young rats: time-dependent potentiation and effects of 2-bromostearate. Am J Physiol 263: E890-E896
20. 20. Prentki M, Vischer S, Glennon MC, Regazzi R, Deeney JT, Corkey BE (1992) Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion. J Biol Chem 267: 5802-5810
21. 21. Bedoya FJ, Ramirez R, Arilla E, Goberna R (1984) Effect of 2-bromostearate on glucose-phosphorylating activities and the dynamics of insulin secretion in islets of Langerhans during fasting. Diabetes 33: 858-863
22. 22. Shrago E, MacDonald MJ, Woldegiorgis G, Bremer J, Schalinske K (1985) The role of carnitine palmitoyltransferase and carnitine in the metabolism of pancreatic islets. In: Borum P (ed) Clinical Aspects of Human Carnitine Deficiency. Pergamon, New York, pp 28-37
23. 23. Liang Y, Matschinsky FM (1991) Content of CoA-esters in perifused rat islets stimulated by glucose and other fuels. Diabetes 40: 327-333
24. 24. Corkey BE, Glennon MC, Chen KS, Deeney JT, Matschinsky FM, Prentki M (1989)A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic β-cells. J Biol Chem 264: 21608-21612
25. 25. Brun T, Roche E, Kim K, Prentki M (1993) Glucose regulates acetyl-CoA carboxylase gene expression in a pancreatic β-cell line (INS-1). J Biol Chem 268: 18905-18911
26. 2+-turnover in glucose stimulated rat islets. Diabetologia 31: 687-693
27. 27. Prentki M, Corkey BE (1996) Are the β-cell signaling molecules malonyl-CoA and cytosolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45: 273-283
28. 28. McGarry JD (1979) Lilly Lecture 1978. New perspectives in the regulation of ketogenesis. Diabetes 28: 517-523
29. 29. Wollheim CB, Regazzi R (1990) Protein kinase C in insulin releasing cells. Putative role in stimulus secretion coupling. FEBS Lett 268: 376-380
30. 30. Pfanner N, Orci L, Glick BS et al. (1989) Fatty acyl-coenzyme A is required for budding of transport vesicles from Golgi Cisternae. Cell 59: 95-102
31. 31. Chen S, Ogawa A, Ohneda M, Unger RH, Foster DW, McGarry JD (1994) More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic β-cell signaling. Diabetes 43: 878-883
32. 32. Zhang S, Kim K-H (1998) Essential role of acetyl-CoA carboxylase in the glucose-induced insulin secretion in a pancreatic β-cell line. Cell Signal 10: 35-42
33. 33. Sener A, Malaisse WJ (1991) Hexose metabolism in pancreatic islets. Effect of (-)-hydroxycitrate upon fatty acid synthesis and insulin release in glucose stimulated islets. Biochimie 73: 1287-1290
34. + channel by long chain acyl-CoA. A role in modulation of pancreatic β-cell glucose sensitivity. J Biol Chem 271: 10623-10626
35. 35. Antinozzi PA, Segall L, Prentki M, McGarry JD, Newgard CB (1998) Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. J Biol Chem 273: 16146-16154
36. 36. Malaisse WJ, Malaisse-Lagae F, Wright PH (1967) Effect of fasting upon insulin secretion in the rat. Am J Physiol 213: 843-848
37. 37. Burch PT, Trus MD, Berner DK, Leontire A, Zawalich KC, Matschinsky FM (1981) Adaptation of glycolytic enzymes: glucose use and insulin release in rat pancreatic islets during fasting and refeeding. Diabetes 30: 923-928
38. 38. Stein DT, Esser V, Stevenson BE et al. (1996) Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat. J Clin Invest 97: 2728-2735
39. 39. Mokuda O, Sakamoto Y, Hue H-Y, Kawagoe R, Shimizu N (1993) Effects of long chain free fatty acids on glucose-induced insulin secretion in the perfused rat pancreas. Horm Metab Res 25: 596-597
40. 40. Warnotte C, Gilon P, Nenquin M, Henquin J-C (1994) Mechanisms of the stimulation of insulin release by saturated fatty acids; A study of palmitate effects in mouse β-cells. Diabetes 43: 703-711
41. 41. Boden G, Chen X, Rosner J, Barton M (1995) Effects of a 48-h fat infusion on insulin secretion and glucose utilization. Diabetes 44: 1239-1242
42. 42. Madison LL, Mebane D, Unger RH, Lochner A (1964) The hypoglycemic action of ketones. II. Evidence or a stimulatory feedback of ketones on the pancreatic β-cell. J Clin Invest 43: 408-415
43. 43. Jenkins DJA, Hunter WM, Goff DV (1970) Ketone bodies and evidence for increased insulin secretion. Nature (Lond) 227: 384-385
44. 44. Balasse EO, Ooms HA, Lambilliotte JP (1970) Evidence for a stimulatory effect of ketone bodies on insulin secretion in man. Horm Metab Res 2: 371-372
45. 45. Stein DT, Stevenson BE, Chester MW et al. (1997) The insulinotropic potency of fatty acids is profoundly influenced by their chain length and degree of saturation. J Clin Invest 100: 398-403
46. 46. Liu YQ, Tornheim K, Leahy JL (1998) Fatty acid-induced β-cell hypersensitivity to glucose. Increased phosphofructokinase activity and lowered glucose-6-phosphate content. J Clin Invest 101: 1870-1875
47. 47. Dobbins RL, Chester MW, Stevenson BE, Daniels MB, Stein DT, McGarry JD (1998) A fatty acid-dependent step is critically important for both glucose and non-glucose stimulated insulin secretion. J Clin Invest 101: 2370-2376
48. 48. Malaisse WJ, Sener A, Levy J (1976) The stimulus-secretion coupling of glucose-induced insulin release. J Biol Chem 251: 1731-1737
49. 49. Zhou Y-P, Priestman DA, Randle PJ, Grill VE (1996) Fasting and decreased β-cell sensitivity: important role for fatty acid-induced inhibition of PDH activity. Am J Physiol 270: E988-E994
50. 50. Wolters GHJ, Konijnendijk W, Bouman PR (1977) Effects of fasting on insulin secretion, islet glucose metabolism, and the cyclic adenosine 3′, 5′-monophosphate content of rat pancreatic islets in vitro. Diabetes 26: 530-537
51. 51. Defronzo RA, Bonadonna RC, Ferrannini E (1992) Pathogenesis of NIDDM. A balanced overview. Diabetes Care 15: 318-368
52. 52. Reaven GM (1995) The fourth Musketeer-from Alexandre Dumas to Claude Bernard. Diabetologia 38: 3-13
53. 53. McGarry JD (1992) What if Minkowski had been ageusic? An alternative angle on diabetes. Science 258: 766-770
54. 54. McGarry JD (1994) Disordered metabolism in diabetes: Have we underemphasized the fat component? J Cell Biochem 55 [Suppl]: 29-38
55. 55. McGarry JD, Dobbins RL, Stein DT (1998) Role of fatty acids in the etiology of obesity/non-insulin dependent diabetes syndromes - a speculative view. In: Hanefeld M, Leonhardt W, Jaross W, Dude H (eds) Advances in Lipoprotein and Atherosclerosis Research, Diagnostics and Treatment. Gustav Fischer Verlag, Jena, Stuttgart, Lübeck, Ulm, pp 255-272
56. 56. McGarry JD, Dobbins RL, Stein DT (1998) Acides gras, insulinorésistance et fonction de la cellule β-pancréatique. In: Selam JL (ed) Journées de Diabétologie Hôtel-Dieu 1998. Médecine-Sciences Flammarion, Paris, pp 1-10
57. 57. Spraul M, Ravussin E, Fontvieille AM, Rising R, Larson DE, Anderson EA (1993) Reduced sympathetic nervous activity. A potential mechanism predisposing to body weight gain. J Clin Invest 92: 1730-1735
58. 58. Jeanrenaud B (1995) Insulin, corticosterone and the autonomic nervous system in animal obesities: a viewpoint. Diabetologia 38: 998-1002
59. 59. Haynes WG, Morgan DA, Walsh SA, Mark AL, Sivitz WI (1997) Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 100: 270-278
60. 60. Neel JV (1962) Diabetes mellitus: a thrifty genotype rendered detrimental by "progress"? Am J Hum Genet 14: 353-362
61. 61. Cusin I, Zakrzewska KE, Boss O et al. (1998) Chronic central leptin infusion enhances insulin-stimulated glucose metabolism and favors the expression of uncoupling proteins. Diabetes 47: 1014-1019
62. 62. Storlein LH, Baur LA, Kriketos AD et al. (1996) Dietary fats and insulin action. Diabetologia 39: 621-631
63. 63. Boden G and Chen X (1995) Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes. J Clin Invest 96: 1261-1268
64. 64. Phillips DIW, Caddy S, Llic V, Fielding BA, Frayn KN, Borthwick AC, Taylor R (1996) Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects. Metabolism 45: 947-950
65. 65. Hettiarachchi M, Watkinson A, Jenkins AB, Theos V, Ho KKY, Kraegen EW (1996) Growth hormone-induced insulin resistance and its relationship to lipid availability in the rat. Diabetes 45: 415-421
66. 66. Oakes ND, Cooney GJ, Camilleri S, Chisholm DJ, Kraegen EW (1997) Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 46: 1768-1774
67. 67. Pan DA, Lillioja S, Kriketos AD et al. (1997) Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46: 983-988
68. 68. Chen KS, Heydrick SJ, Brown ML, Friel JC, Ruderman NB (1994) Insulin increases a biochemically distinct pool of diacylglyerol in the rat soleus muscle. Am J Physiol 266: E479-E485
69. 69. Roust LR, Jensen MD (1993) Postprandial free fatty acid kinetics are abnormal in upper body obesity. Diabetes 42: 1567-1573
70. 70. Caprio S, Bronson M, Sherwin RS, Rife F, Tamborlane WV (1996) Co-existence of severe insulin resistance and hyperinsulinaemia in pre-adolescent obese children. Diabetologia 39: 1489-1497
71. 71. Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH (1994) β-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-β-cell relationships. Proc Natl Acad Sci 91: 10878-10882
72. 72. Koyama K, Chen G, Lee Y, Unger RH (1997) Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity. Am J Physiol 273: E708-E713
73. 73. Stein DT, Dobbins R, Szczepaniak L, Malloy C, McGarry, JD (1997) Skeletal muscle triglyceride stores are increased in insulin resistance. Diabetes 46 [Suppl]:A929
74. 74. Koyama K, Chen G, Wang MY et al. (1997) β-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy. Diabetes 46: 1276-1280
75. 75. Sako Y, Grill VE (1990) A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and β-cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 127: 1580-1589
76. 76. Elks ML (1993) Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release. Endocrinology 133: 208-214
77. 77. Zhou Y-P, Grill VE (1994) Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93: 870-876
78. 78. Bollheimer LC, Skelly RH, Chester JD, McGarry JD, Rhodes CJ (1998) Chronic exposure to free fatty acid reduces pancreatic β-cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. J Clin Invest 101: 1094-1101
79. 79. Waldhäusl W, Bratusch-Marrain P, Gasi S, Korn A, Nowotny P (1982) Insulin production rate, hepatic insulin retention and splanchnic carbohydrate metabolism after oral glucose ingestion in hyperinsulinaemic Type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 23: 6-15
80. 80. Zhou Y-P, Ling Z-C, Grill VE (1996) Inhibitory effects of fatty acids on glucose-regulated β-cell function: association with increased islet triglyceride stores and altered effect of fatty acid oxidation on glucose metabolism. Metabolism 45: 981-986
81. 81. Shimabukuro M, Ohneda M, Lee Y, Unger RH (1997) Role of nitric oxide in obesity-induced beta cell disease. J Clin Invest 100: 290-295
82. 82. Shimabukuro M, Koyama K, Lee Y, Unger RH (1997) Leptin-or Troglitazone-induced lipopenia protects islets from interleukin 1β cytotoxicity. J Clin Invest 100: 1750-1754
83. 83. Shimabukuro M, Zhou Y-T, Levi M, Unger RH (1998) Fatty acid-induced β-cell apoptosis: A link between obesity and diabetes. Proc Natl Acad Sci 95: 2498-2502
84. 84. Pick A, Clark J, Kubstrup C et al. (1998) Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker Diabetic Fatty rat. Diabetes 47: 358-364