Skeletal muscle triglyceride levels are inversely related to insulin action

Diabetes

Volumn 46, Issue 6, 1997, Pages 983-988

  Pan, D A ^a,b   Lillioja, S ^c   Kriketos, A D ^b   Milner, M R ^c   Baur, L A ^b   Bogardus, C ^c   Jenkins, A B ^a   Storlien, L H ^a,b  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; CONTROLLED STUDY; GLUCOSE OXIDATION; HUMAN; HUMAN EXPERIMENT; INSULIN RELEASE; INSULIN SENSITIVITY; LIPID METABOLISM; LIPID OXIDATION; MALE; MUSCLE METABOLISM; NORMAL HUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE;

EID: 0030969532     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.6.983     Document Type: Article

References (49)

1. Reaven GM: Role of insulin resistance in human disease (Syndrome X): an expanded definition. Annu Rev Med 44:121-131, 1993
2. DeFronzo RA, Jacot E, Jéquier E, Wahren J, Felber JP: The effect of insulin on the disposal of intravenous glucose: results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30:1000-1007, 1981
3. 13C nuclear magnetic resonance spectroscopy. N Engl J Med 322:223-228, 1990
4. Lillioja S, Bogardus C, Mott DM, Kennedy AL, Knowler WC, Howard BV: Relationship between insulin-mediated glucose disposal and lipid metabolism in man. J Clin Invest 75:1106-1115, 1985
5. Falholt K, Jensen I, Lindkaer Jensen S, Mortensen H, Volund A, Heding LG, Noerskov Petersen P, Falholt W: Carbohydrate and lipid metabolism of skeletal muscle in type 2 diabetic patients. Diabet Med 5:27-31, 1988
6. Jenkins AB, Storlien LH, Chisholm DJ, Kraegen EW: Effects of non-esterified fatty acid availability on tissue specific glucose utilization in rats in vivo. J Clin Invest 82:293-299, 1988
7. Ebeling P, Koivisto VA: Non-esterified fatty acids regulate lipid and glucose oxidation and glycogen synthesis in man. Diabetologia 37:202-209, 1994
8. Randle PJ, Garland PB, Hales CN, Newsholme EA: The glucose fatty-acid cycle, its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet i:785-789, 1963
9. Felley CP, Felley EM, van Melle GD, Frascarolo P, Jéquier E, Felber J-P: Impairment of glucose disposal by infusion of triglycerides in humans: role of glycemia. Am J Physiol 256:E747-E752, 1989
10. Storlien LH, Borkman M, Jenkins AB, Pan DA, Campbell LV: Dietary modification of insulin action in vivo. In Diabetes 1991. Rifkin H, Colwell JA, Taylor SI, Eds. Amsterdam, Elsevier, 1991, p. 25-28
11. McGarry JD: What if Minkowski had been ageusic? An alternative angle on diabetes. Science 258:766-770, 1992
12. Issekutz B Jr, Miller HI, Paul P, Rodahl K: Source of fat oxidation in exercising dogs. Am J Physiol 207:583-589, 1964
13. Carlson LA, Lujedahl S, Wirsén C: Blood and tissue changes in the dog during and after excessive free fatty acid mobilization. Acta Med Scand 178:81-102, 1965
14. Dagenais GR, Tancredi RG, Zierler KL: Free fatty acid oxidation by forearm muscle at rest, and evidence for an intramuscular lipid pool in the human forearm. J Clin Invest 58:421-431, 1976
15. Storlien LH, Jenkins AB, Chisholm DJ, Pascoe WS, Khouri S, Kraegen EW: Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and ω-3 fatty acids in muscle phospholipids. Diabetes 40:280-289, 1991
16. Lillioja S, Mott DM, Spraul M, Ferraro R, Foley JE, Ravussin E, Knowler WC, Bennett PH, Bogardus C: Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. N Engl J Med 329:1988-1992, 1993
17. World Health Organization: Diabetes Mellitus: Report of a WHO Study Group. Geneva, World Health Organization, 1985 (Tech. Rep. Ser. no. 727)
18. Goldman RF, Buskirk ER: A method for underwater weighing and the determination of body density. In Techniques for Measuring Body Composition. Brozek J, Herschel A, Eds. Washington, DC, Natl. Acad. Sci. Natl. Res. Council, 1961, p. 78-106
19. Keys A, Brozek J: Body fat in adult man. Physiol Rev 33:245-325, 1953
20. Lusk G: Animal calorimetry: analysis of the oxidation of mixtures of carbohydrate and fat. J Biol Chem 59:41-42, 1924
21. Pan DA, Storlien LH: Dietary lipid profile is a determinant of tissue phospholipid fatty acid composition and rate of weight gain in rats. J Nutr 123:512-519, 1993
22. Lillioja S, Bogardus C: Obesity and insulin resistance: lessons learned from the Pima Indians. Diabetes Metab Rev 4:517-540, 1987
23. Storlien LH, Kraegen EW, Chisholm DJ, Ford GL, Bruce DG, Pascoe WS: Fish oil prevents insulin resistance induced by high-fat feeding in rats. Science 237:885-888, 1987
24. Vaag A, Skott P, Damsbo P, Richter EA, Beck-Nielsen H: Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 88:1282-1290, 1991
25. Storlien LH, Oakes ND, Pan DA, Kusunoki M, Jenkins AB: "Syndromes of insulin resistance" in the rat: induction by diet and amelioration with benfluorex. Diabetes 42:457-462, 1993
26. Felber JP, Golay A, Felley C, Jequier E: Regulation of glucose storage in obesity and diabetes: metabolic aspects. Diabetes Metab Rev 4:691-700, 1988
27. Boden G, Chen X, Ruiz J, White JV, Rossetti L: Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 93:2438-2446, 1994
28. Dent on RM, Randle PJ: Concentrations of glycerides and phospholipids in rat heart and gastrocnemius muscles. Biochem J 104:416-422, 1967
29. Standl E, Lotz N, Dexel T, Janka H-U, Kolb HJ: Muscle triglycerides in diabetic subjects. Diabetologia 18:463-469, 1980
30. Groop LC, Bonadonna RC, Simonson DC, Petrides AS, Shank M, DeFronzo RA: Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity. Am J Physiol 263:E79-E84, 1992
31. Simoneau J-A, Colberg SR, Thaete FL, Kelley DE: Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women. FASEB J 9:273-278, 1995
32. Bogardus C, Lillioja S, Mott D, Reaven GR, Kashiwagi A, Foley JE: Relationship between obesity and maximal insulin-stimulated glucose uptake in vivo and in vitro in Pima Indians. J Clin Invest 73:800-805, 1984
33. Hurley BF, Nemeth PM, Martin WH III, Hagberg JM, Dalsky GP, Holloszy JO: Muscle triglyceride utilization during exercise: effect of training. J Appl Physiol 60:562-567, 1986
34. Essén-Gustavsson B, Tesch PA: Glycogen and triglyceride utilization in relation to muscle metabolic characteristics in men performing heavy-resistance exercise. Eur J Physiol 61:5-10, 1990
35. Brouns F, Saris WHM, Beckers E, Adlercreutz H, van der Vusse GJ, Keizer HA, Kuipers H, Menheere P, Wagenmakers AJM, ten Hoor F: Metabolic changes induced by sustained exhaustive cycling and diet manipulation. Int J Sports Med 10 (Suppl. 1):S49-S62, 1989
36. Kiens B, Essen-Gustavsson B, Gad P, Lithell H: Lipoprotein lipase activity and intramuscular triglyceride stores after long-term high-fat and high-carbohydrate diets in physically trained men. Clin Physiol 7:1-9, 1987
37. Taylor CR, Hoppeler H, Kennedy C, Valenski T, Roberts TJ, Weyand P: High fat diet improves aerobic performance by building mitochondria. Physiologist 37:A84, 1994
38. DeFronzo RA, Ferrannini E, Sato Y, Feiig P, Wahren J: Synergistic interaction between exercise and insulin on peripheral glucose uptake. J Clin Invest 68:1468-1474, 1981
39. Horton E: Exercise and decreased risk of NIDDM. N Engl J Med 325:196-198, 1991
40. Kayar SR, Hoppeler H, Howald H, Claassen H, Oberholzer F: Acute effects of endurance exercise on mitochondrial distribution and skeletal muscle morphology. Eur J Appl Physiol 54:578-584, 1986
41. Curtain C, Gordon L, Aloia R: Lipid domains in biological membranes: conceptual development and significance. In Lipid Domains and the Relationship to Membrane Function. Aloia RC, Curtain CC, Gordon LM, Eds. New York, Alan R Liss, 1988, p. 1-15
42. Sweet W, Schroeder F: Lipid domains and enzyme activity. In Lipid Domains and the Relationship to Membrane Function. Aloia RC, Curtain CC, Gordon LM, Eds. New York, Alan R Liss, 1988, p. 17-42
43. Berridge MJ: Intracellular signalling through inositol triphosphate and diacylglycerol. J Biol Chem 367:447-455, 1986
44. Tanti J, Rochet N, Gremeaux T, van Obbergghen E, le Marchand-Brustel Y: Insulin-stimulated glucose transport in muscle. Biochem J 258:141-146, 1989
45. Saad MJ, Araki E, Miralpeix M, Rothenberg PL, White MF, Kahn CR: Regulation of insulin receptor substrate-1 in liver and muscle of an animal model of insulin resistance. J Clin Invest 90:1839-1849, 1992
46. Saltiel AR: The paradoxical regulation of protein phosphorylation in insulin action. FASEB J 8:1034-1040, 1994
47. Pan DA, Ullioja S, Milner MR, Kriketos AD, Baur LA, Bogardus C, Storlien LH: Skeletal muscle membrane Upid composition is related to adiposity and insulin action. J Clin Invest 96:2802-2808, 1995
48. Else PL, Hulbert AJ: Evolution of mammalian endothermic metabolism: "leaky" membranes as a source of heat. Am J Physiol 253:R1-R7, 1987
49. Brand MD, Couture R Else PL, Withers KW, Hulbert AJ: Evolution of energy metabolism. Proton permeability of the inner membrane of liver mitochondria is greater in a mammal than in a reptile. Biochem J 275:81-86, 1991