메뉴 건너뛰기




Volumn 198, Issue , 2004, Pages 59-71

The immune response of Drosophila melanogaster

Author keywords

[No Author keywords available]

Indexed keywords

MELANIN; PATTERN RECOGNITION RECEPTOR; PEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT; RECEPTOR; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

EID: 1642422755     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0105-2896.2004.0130.x     Document Type: Review
Times cited : (189)

References (103)
  • 1
    • 0031446642 scopus 로고    scopus 로고
    • Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms
    • Lemaitre B, Reichhart JM, Hoffmann JA. Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc Natl Acad Sci USA 1997;94: 14614-14619.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 14614-14619
    • Lemaitre, B.1    Reichhart, J.M.2    Hoffmann, J.A.3
  • 2
    • 0035940514 scopus 로고    scopus 로고
    • Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays
    • De Gregorio E, Spellman PT, Rubin GM, Lemaitre B. Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays. Proc Natl Acad Sci USA 2001;98:12590-12595.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12590-12595
    • De Gregorio, E.1    Spellman, P.T.2    Rubin, G.M.3    Lemaitre, B.4
  • 3
    • 0037013856 scopus 로고    scopus 로고
    • The Toll and Imd pathways are the major regulators of the immune response in Drosophila
    • De Gregorio E, Spellman PT, Tzou P, Rubin GM, Lemaitre B. The Toll and Imd pathways are the major regulators of the immune response in Drosophila. EMBO J 2002;21:2568-2579.
    • (2002) EMBO J , vol.21 , pp. 2568-2579
    • De Gregorio, E.1    Spellman, P.T.2    Tzou, P.3    Rubin, G.M.4    Lemaitre, B.5
  • 4
    • 0035909905 scopus 로고    scopus 로고
    • A genome-wide analysis of immune responses in Drosophila
    • Irving P, et al. A genome-wide analysis of immune responses in Drosophila. Proc Natl Acad Sci USA 2001;98:15119-15124.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 15119-15124
    • Irving, P.1
  • 5
    • 0034724440 scopus 로고    scopus 로고
    • The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response
    • Basset A, et al. The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response. Proc Natl Acad Sci USA 2000;97:3376-3381.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3376-3381
    • Basset, A.1
  • 6
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spaetzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spaetzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996;86:973-983.
    • (1996) Cell , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 7
    • 0037083557 scopus 로고    scopus 로고
    • The Toll pathway is required for resistance to gram-positive bacterial infections in Drosophila
    • Rutschmann S, Kilinc A, Ferrandon D. The Toll pathway is required for resistance to gram-positive bacterial infections in Drosophila. J Immunol 2002;168:1542-1546.
    • (2002) J Immunol , vol.168 , pp. 1542-1546
    • Rutschmann, S.1    Kilinc, A.2    Ferrandon, D.3
  • 8
    • 0028865526 scopus 로고
    • A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense
    • Lemaitre B, et al. A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense. Proc Natl Acad Sci USA 1995;92:9365-9469.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9365-9469
    • Lemaitre, B.1
  • 9
    • 0037133259 scopus 로고    scopus 로고
    • Constitutive expression of a single antimicrobial peptide can restore wild-type resistance to infection in immunodeficient Drosophila mutants
    • Tzou P, Reichhart JM, Lemaitre B. Constitutive expression of a single antimicrobial peptide can restore wild-type resistance to infection in immunodeficient Drosophila mutants. Proc Natl Acad Sci USA 2002;99:2152-2157.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 2152-2157
    • Tzou, P.1    Reichhart, J.M.2    Lemaitre, B.3
  • 10
  • 11
    • 0034610370 scopus 로고    scopus 로고
    • A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster
    • Werner T, Liu G, Kang D, Ekengren S, Steiner H, Hultmark D. A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster. Proc Natl Acad Sci USA 2000; 97:13772-13777.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 13772-13777
    • Werner, T.1    Liu, G.2    Kang, D.3    Ekengren, S.4    Steiner, H.5    Hultmark, D.6
  • 12
    • 0035856990 scopus 로고    scopus 로고
    • Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
    • Michel T, Reichhart JM, Hoffmann JA, Royet J. Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein. Nature 2001;414: 756-759.
    • (2001) Nature , vol.414 , pp. 756-759
    • Michel, T.1    Reichhart, J.M.2    Hoffmann, J.A.3    Royet, J.4
  • 13
    • 0037066464 scopus 로고    scopus 로고
    • Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila
    • Choe KM, Werner T, Stoven S, Hultmark D, Anderson KV. Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila. Science 2002;296:359-362.
    • (2002) Science , vol.296 , pp. 359-362
    • Choe, K.M.1    Werner, T.2    Stoven, S.3    Hultmark, D.4    Anderson, K.V.5
  • 14
    • 0037061450 scopus 로고    scopus 로고
    • The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein
    • Gottar M, et al. The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. Nature 2002;416:640-644.
    • (2002) Nature , vol.416 , pp. 640-644
    • Gottar, M.1
  • 15
    • 0037061482 scopus 로고    scopus 로고
    • Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli
    • Ramet M, Manfruelli P, Pearson A, Mathey-Prevot B, Ezekowitz RA. Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. Nature 2002;416:644-648.
    • (2002) Nature , vol.416 , pp. 644-648
    • Ramet, M.1    Manfruelli, P.2    Pearson, A.3    Mathey-Prevot, B.4    Ezekowitz, R.A.5
  • 16
    • 0037108754 scopus 로고    scopus 로고
    • Overexpression of a pattern-recognition receptor, peptidoglycan- recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae
    • Takehana A, et al. Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae. Proc Natl Acad Sci USA 2002;99: 13705-13710.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13705-13710
    • Takehana, A.1
  • 17
    • 0038664357 scopus 로고    scopus 로고
    • The Drosophila immune system detects bacteria through specific peptidoglycan recognition
    • Leulier F, et al. The Drosophila immune system detects bacteria through specific peptidoglycan recognition. Nat Immunol 2003;4:478-484.
    • (2003) Nat Immunol , vol.4 , pp. 478-484
    • Leulier, F.1
  • 18
    • 0038036294 scopus 로고    scopus 로고
    • Functional diversity of the Drosophila PGRP-LC gene cluster in the response to lipopolysaccharide and peptidoglycan
    • Werner T, Borge-Renberg K, Mellroth P, Steiner H, Hultmark D. Functional diversity of the Drosophila PGRP-LC gene cluster in the response to lipopolysaccharide and peptidoglycan. J Biol Chem 2003;278: 26319-26322.
    • (2003) J Biol Chem , vol.278 , pp. 26319-26322
    • Werner, T.1    Borge-Renberg, K.2    Mellroth, P.3    Steiner, H.4    Hultmark, D.5
  • 19
    • 0037317763 scopus 로고    scopus 로고
    • Innate immune sensing and its roots: The story of endotoxin
    • Beutler B, Rietschel ET. Innate immune sensing and its roots: the story of endotoxin. Nat Rev Immunol 2003;3:169-176.
    • (2003) Nat Rev Immunol , vol.3 , pp. 169-176
    • Beutler, B.1    Rietschel, E.T.2
  • 20
    • 0034693324 scopus 로고    scopus 로고
    • Gram-negative bacteria-binding protein, a pattern recognition receptor for lipopolysaccharide and beta-1,3-glucan that mediates the signaling for the induction of innate immune genes in Drosophila melanogaster cells
    • Kim YS, et al. Gram-negative bacteria-binding protein, a pattern recognition receptor for lipopolysaccharide and beta-1,3-glucan that mediates the signaling for the induction of innate immune genes in Drosophila melanogaster cells. J Biol Chem 2000;275:32721-32727.
    • (2000) J Biol Chem , vol.275 , pp. 32721-32727
    • Kim, Y.S.1
  • 21
    • 0037972466 scopus 로고    scopus 로고
    • The Drosophila melanogaster toll pathway participates in resistance to infection by the gram-negative human pathogen Pseudomonas aeruginosa
    • Lau GW, et al. The Drosophila melanogaster toll pathway participates in resistance to infection by the gram-negative human pathogen Pseudomonas aeruginosa. Infect Immun 2003; 71:4059-4066.
    • (2003) Infect Immun , vol.71 , pp. 4059-4066
    • Lau, G.W.1
  • 22
    • 0001310379 scopus 로고
    • Microbial activation of two serine enzymes and prophenoloxidase in the plasma fraction of hemolymph of the silkworm, Bombyx mori
    • Yoshida H, Ashida M. Microbial activation of two serine enzymes and prophenoloxidase in the plasma fraction of hemolymph of the silkworm, Bombyx mori. Insect Biochem 1986;16:539-545.
    • (1986) Insect Biochem , vol.16 , pp. 539-545
    • Yoshida, H.1    Ashida, M.2
  • 23
    • 0029846206 scopus 로고    scopus 로고
    • Purification and molecular cloning of an inducible gram-negative bacteria-binding protein from the silkworm, Bombyx mori
    • Lee WJ, Lee JD, Kravchenko VV, Ulevitch RJ, Brey PT. Purification and molecular cloning of an inducible gram-negative bacteria-binding protein from the silkworm, Bombyx mori. Proc Natl Acad Sci USA 1996;93: 7888-7893.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7888-7893
    • Lee, W.J.1    Lee, J.D.2    Kravchenko, V.V.3    Ulevitch, R.J.4    Brey, P.T.5
  • 24
    • 0034677596 scopus 로고    scopus 로고
    • A beta1,3-glucan recognition protein from an insect, Manduca sexta, agglutinates microorganisms and activates the phenoloxidase cascade
    • Ma C, Kanost MR. A beta1,3-glucan recognition protein from an insect, Manduca sexta, agglutinates microorganisms and activates the phenoloxidase cascade. J Biol Chem 2000;275:7505-7514.
    • (2000) J Biol Chem , vol.275 , pp. 7505-7514
    • Ma, C.1    Kanost, M.R.2
  • 25
    • 0034681346 scopus 로고    scopus 로고
    • A pattern-recognition protein for beta-1,3-glucan. The binding domain and the cDNA cloning of beta-1,3-glucan recognition protein from the silkworm, Bombyx mori
    • Ochiai M, Ashida M. A pattern-recognition protein for beta-1,3-glucan. The binding domain and the cDNA cloning of beta-1,3-glucan recognition protein from the silkworm, Bombyx mori. J Biol Chem 2000; 275:4995-5002.
    • (2000) J Biol Chem , vol.275 , pp. 4995-5002
    • Ochiai, M.1    Ashida, M.2
  • 26
    • 0036167107 scopus 로고    scopus 로고
    • Drosophila innate immunity: An evolutionary perspective
    • Hoffmann JA, Reichhart JM. Drosophila innate immunity: an evolutionary perspective. Nat Immunol 2002;3:121-126.
    • (2002) Nat Immunol , vol.3 , pp. 121-126
    • Hoffmann, J.A.1    Reichhart, J.M.2
  • 27
    • 0141532262 scopus 로고    scopus 로고
    • Toll-like receptor signaling
    • Akira S. Toll-like receptor signaling. J Biol Chem 2003;278:38105-38108.
    • (2003) J Biol Chem , vol.278 , pp. 38105-38108
    • Akira, S.1
  • 28
    • 0035883151 scopus 로고    scopus 로고
    • NF-kappaB signaling pathways in mammalian and insect innate immunity
    • Silverman N, Maniatis T. NF-kappaB signaling pathways in mammalian and insect innate immunity. Genes Dev 2001;15: 2321-2342.
    • (2001) Genes Dev , vol.15 , pp. 2321-2342
    • Silverman, N.1    Maniatis, T.2
  • 29
    • 0035940499 scopus 로고    scopus 로고
    • Drosophila MyD88 is an adapter in the Toll signaling pathway
    • Horng T, Medzhitov R. Drosophila MyD88 is an adapter in the Toll signaling pathway. Proc Natl Acad Sci USA 2001;98: 12654-12658.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 12654-12658
    • Horng, T.1    Medzhitov, R.2
  • 30
    • 0036141954 scopus 로고    scopus 로고
    • Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections
    • Tauszig-Delamasure S, Bilak H, Capovilla M, Hoffmann JA, Imler JL. Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections. Nat Immunol 2002;3:91-97.
    • (2002) Nat Immunol , vol.3 , pp. 91-97
    • Tauszig-Delamasure, S.1    Bilak, H.2    Capovilla, M.3    Hoffmann, J.A.4    Imler, J.L.5
  • 31
    • 0041989575 scopus 로고    scopus 로고
    • Binding of the Drosophila cytokine Spatzle to Toll is direct and establishes signaling
    • Weber AN, et al. Binding of the Drosophila cytokine Spatzle to Toll is direct and establishes signaling. Nat Immunol 2003;4:794-800.
    • (2003) Nat Immunol , vol.4 , pp. 794-800
    • Weber, A.N.1
  • 33
    • 16744364738 scopus 로고    scopus 로고
    • Structural complementarity of Toll/Interleukin1 receptor identity regions in toll-like receptors and the adaptors Mal and MyD88
    • Dunne A, Ejdeback M, Ludidi PL, O'Neill LA, Gay NJ. Structural complementarity of Toll/Interleukin1 receptor identity regions in toll-like receptors and the adaptors Mal and MyD88. J Biol Chem 2003;278: 41443-41451.
    • (2003) J Biol Chem , vol.278 , pp. 41443-41451
    • Dunne, A.1    Ejdeback, M.2    Ludidi, P.L.3    O'Neill, L.A.4    Gay, N.J.5
  • 34
    • 0026486817 scopus 로고
    • Cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the I kappa B gene family of vertebrates
    • Geisler R, Bergmann A, Hiromi Y, Nusslein-Volhard C. Cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the I kappa B gene family of vertebrates. Cell 1992;71:613-621.
    • (1992) Cell , vol.71 , pp. 613-621
    • Geisler, R.1    Bergmann, A.2    Hiromi, Y.3    Nusslein-Volhard, C.4
  • 35
    • 0018906664 scopus 로고
    • A dorso-ventral shift of embryonic primordia in a new maternal-effect mutant of Drosophila
    • Nusslein-Volhard C, Lohs-Schardin M, Sander K, Cremer C. A dorso-ventral shift of embryonic primordia in a new maternal-effect mutant of Drosophila. Nature 1980; 283:474-476.
    • (1980) Nature , vol.283 , pp. 474-476
    • Nusslein-Volhard, C.1    Lohs-Schardin, M.2    Sander, K.3    Cremer, C.4
  • 36
    • 0027443688 scopus 로고
    • Dif, a dorsal-related gene that mediates an immune response in Drosophila
    • Ip Y, et al. Dif, a dorsal-related gene that mediates an immune response in Drosophila. Cell 1993;75:753-763.
    • (1993) Cell , vol.75 , pp. 753-763
    • Ip, Y.1
  • 37
    • 0029840669 scopus 로고    scopus 로고
    • Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila
    • Dushay MS, Asling B, Hultmark D. Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila. Proc Natl Acad Sci USA 1996;93:10343-10347.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10343-10347
    • Dushay, M.S.1    Asling, B.2    Hultmark, D.3
  • 38
    • 0033231556 scopus 로고    scopus 로고
    • Relish, a central factor in the control of humoral but not cellular immunity in Drosophila
    • Hedengren M, et al. Relish, a central factor in the control of humoral but not cellular immunity in Drosophila. Mol Cell 1999;4:827-837.
    • (1999) Mol Cell , vol.4 , pp. 827-837
    • Hedengren, M.1
  • 39
    • 0033564614 scopus 로고    scopus 로고
    • A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF
    • Manfruelli P, Reichhart JM, Steward R, Hoffmann JA, Lemaitre B. A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF. EMBO J 1999; 18:3380-3391.
    • (1999) EMBO J , vol.18 , pp. 3380-3391
    • Manfruelli, P.1    Reichhart, J.M.2    Steward, R.3    Hoffmann, J.A.4    Lemaitre, B.5
  • 40
    • 0033711445 scopus 로고    scopus 로고
    • The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila
    • Rutschmann S, Jung AC, Hetru C, Reichhart JM, Hoffmann JA, Ferrandon D. The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila. Immunity 2000;12:569-580.
    • (2000) Immunity , vol.12 , pp. 569-580
    • Rutschmann, S.1    Jung, A.C.2    Hetru, C.3    Reichhart, J.M.4    Hoffmann, J.A.5    Ferrandon, D.6
  • 41
    • 0029730738 scopus 로고    scopus 로고
    • A conserved signaling pathway: The Drosophila toll-dorsal pathway
    • Belvin MP, Anderson KV. A conserved signaling pathway: the Drosophila toll-dorsal pathway. Annu Rev Cell Dev Biol 1996;12:393-416.
    • (1996) Annu Rev Cell Dev Biol , vol.12 , pp. 393-416
    • Belvin, M.P.1    Anderson, K.V.2
  • 42
    • 0032562285 scopus 로고    scopus 로고
    • In vivo regulation of the IκB homologue cactus during the immune response of Drosophila
    • Nicolas E, Reichhart J, Hoffmann J, Lemaitre B. In vivo regulation of the IκB homologue cactus during the immune response of Drosophila. J Biol Chem 1998;273:10463-10469.
    • (1998) J Biol Chem , vol.273 , pp. 10463-10469
    • Nicolas, E.1    Reichhart, J.2    Hoffmann, J.3    Lemaitre, B.4
  • 43
    • 0035208076 scopus 로고    scopus 로고
    • The protein kinase Pelle mediates feedback regulation in the Drosophila Toll signaling pathway
    • Towb P, Bergmann A, Wasserman SA. The protein kinase Pelle mediates feedback regulation in the Drosophila Toll signaling pathway. Development 2001;128: 4729-4736.
    • (2001) Development , vol.128 , pp. 4729-4736
    • Towb, P.1    Bergmann, A.2    Wasserman, S.A.3
  • 44
    • 0027441761 scopus 로고
    • Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo
    • Hecht PM, Anderson KV. Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in the specification of the dorsal-ventral pattern of the Drosophila embryo. Genetics 1993;135:405-417.
    • (1993) Genetics , vol.135 , pp. 405-417
    • Hecht, P.M.1    Anderson, K.V.2
  • 45
    • 0034893896 scopus 로고    scopus 로고
    • Separable and redundant regulatory determinants in Cactus mediate its dorsal group dependent degradation
    • Fernandez NQ, Grosshans J, Goltz JS, Stein D. Separable and redundant regulatory determinants in Cactus mediate its dorsal group dependent degradation. Development 2001;128:2963-2974.
    • (2001) Development , vol.128 , pp. 2963-2974
    • Fernandez, N.Q.1    Grosshans, J.2    Goltz, J.S.3    Stein, D.4
  • 46
    • 0035187882 scopus 로고    scopus 로고
    • The antibacterial arm of the Drosophila innate immune response requires an IkappaB kinase
    • Lu Y, Wu LP, Anderson KV. The antibacterial arm of the Drosophila innate immune response requires an IkappaB kinase. Genes Dev 2001; 15:104-110.
    • (2001) Genes Dev , vol.15 , pp. 104-110
    • Lu, Y.1    Wu, L.P.2    Anderson, K.V.3
  • 48
    • 0034287444 scopus 로고    scopus 로고
    • A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity
    • Silverman N, Zhou R, Stoven S, Pandey N, Hultmark D, Maniatis T. A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity. Genes Dev 2000;14:2461-2471.
    • (2000) Genes Dev , vol.14 , pp. 2461-2471
    • Silverman, N.1    Zhou, R.2    Stoven, S.3    Pandey, N.4    Hultmark, D.5    Maniatis, T.6
  • 49
    • 0242439335 scopus 로고    scopus 로고
    • Directed expression of the HIV-1 accessory protein Vpu in Drosophila fat-body cells inhibits Toll-dependent immune responses
    • Leulier F, Marchal C, Miletich I, Limbourg-Bouchon B, Benarous R, Lemaitre B. Directed expression of the HIV-1 accessory protein Vpu in Drosophila fat-body cells inhibits Toll-dependent immune responses. EMBO Rep 2003;4:976-981.
    • (2003) EMBO Rep , vol.4 , pp. 976-981
    • Leulier, F.1    Marchal, C.2    Miletich, I.3    Limbourg-Bouchon, B.4    Benarous, R.5    Lemaitre, B.6
  • 50
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-kappaB activity
    • Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-kappaB activity. Annu Rev Immunol 2000;18:621-663.
    • (2000) Annu Rev Immunol , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 51
    • 0031460697 scopus 로고    scopus 로고
    • A multimeric complex and the nuclear targeting of the Drosophila Rel protein Dorsal
    • Yang J, Steward R. A multimeric complex and the nuclear targeting of the Drosophila Rel protein Dorsal. Proc Natl Acad Sci USA 1997;94:14524-14529.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 14524-14529
    • Yang, J.1    Steward, R.2
  • 52
    • 0030815382 scopus 로고    scopus 로고
    • An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators
    • Edwards DN, Towb P, Wasserman SA. An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators. Development 1997;124:3855-3864.
    • (1997) Development , vol.124 , pp. 3855-3864
    • Edwards, D.N.1    Towb, P.2    Wasserman, S.A.3
  • 53
    • 0026491071 scopus 로고
    • Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins
    • Kidd S. Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins. Cell 1992;71:623-635.
    • (1992) Cell , vol.71 , pp. 623-635
    • Kidd, S.1
  • 54
    • 0035902486 scopus 로고    scopus 로고
    • Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation
    • Shen B, Liu H, Skolnik EY, Manley JL. Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation. Proc Natl Acad Sci USA 2001;98:8596-8601.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8596-8601
    • Shen, B.1    Liu, H.2    Skolnik, E.Y.3    Manley, J.L.4
  • 55
    • 18744372992 scopus 로고    scopus 로고
    • The Drosophila atypical protein kinase C-ref (2)p complex constitutes a conserved module for signaling in the toll pathway
    • Avila A, Silverman N, Diaz-Meco MT, Moscat J. The Drosophila atypical protein kinase C-ref (2)p complex constitutes a conserved module for signaling in the toll pathway. Mol Cell Biol 2002;22:8787-8795.
    • (2002) Mol Cell Biol , vol.22 , pp. 8787-8795
    • Avila, A.1    Silverman, N.2    Diaz-Meco, M.T.3    Moscat, J.4
  • 56
    • 0035942252 scopus 로고    scopus 로고
    • Activation of a protease cascade involved in patterning the Drosophila embryo
    • LeMosy EK, Tan YQ, Hashimoto C. Activation of a protease cascade involved in patterning the Drosophila embryo. Proc Natl Acad Sci USA 2001;98:5055-5060.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5055-5060
    • LeMosy, E.K.1    Tan, Y.Q.2    Hashimoto, C.3
  • 57
    • 0035873542 scopus 로고    scopus 로고
    • Autoproteolysis and feedback in a protease cascade directing Drosophila dorsal-ventral cell fate
    • Dissing M, Giordano H, DeLotto R. Autoproteolysis and feedback in a protease cascade directing Drosophila dorsal-ventral cell fate. EMBO J 2001;20:2387-2393.
    • (2001) EMBO J , vol.20 , pp. 2387-2393
    • Dissing, M.1    Giordano, H.2    DeLotto, R.3
  • 58
    • 0032033030 scopus 로고    scopus 로고
    • Proteolytic processing of the Drosophila Spatzle protein by easter generates a dimeric NGF-like molecule with ventralising activity
    • DeLotto Y, DeLotto R. Proteolytic processing of the Drosophila Spatzle protein by easter generates a dimeric NGF-like molecule with ventralising activity. Mech Dev 1998;72:141-148.
    • (1998) Mech Dev , vol.72 , pp. 141-148
    • DeLotto, Y.1    DeLotto, R.2
  • 59
    • 0033578917 scopus 로고    scopus 로고
    • Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila
    • Levashina EA, et al. Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila. Science 1999;285:1917-1919.
    • (1999) Science , vol.285 , pp. 1917-1919
    • Levashina, E.A.1
  • 60
    • 0037025213 scopus 로고    scopus 로고
    • Activation of Drosophila Toll during fungal infection by a blood serine protease
    • Ligoxygakis P, Pelte N, Hoffmann JA, Reichhart JM. Activation of Drosophila Toll during fungal infection by a blood serine protease. Science 2002;297:114-116.
    • (2002) Science , vol.297 , pp. 114-116
    • Ligoxygakis, P.1    Pelte, N.2    Hoffmann, J.A.3    Reichhart, J.M.4
  • 61
    • 0042405132 scopus 로고    scopus 로고
    • Recognition of microbial infection by Toll-like receptors
    • Kopp E, Medzhitov R. Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol 2003;15:396-401.
    • (2003) Curr Opin Immunol , vol.15 , pp. 396-401
    • Kopp, E.1    Medzhitov, R.2
  • 62
    • 0034641738 scopus 로고    scopus 로고
    • Toll-related receptors and the control of antimicrobial peptide expression in Drosophila
    • Tauszig S, Jouanguy E, Hoffmann JA, Imler JL. Toll-related receptors and the control of antimicrobial peptide expression in Drosophila. Proc Natl Acad Sci USA 2000;97:10520-10525.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10520-10525
    • Tauszig, S.1    Jouanguy, E.2    Hoffmann, J.A.3    Imler, J.L.4
  • 63
    • 0024003902 scopus 로고
    • Zygotic expression and activity of the Drosophila Toll gene, a gene required maternally for embryonic dorsal-ventral pattern formation
    • Gertulla S, Jin Y, Anderson KV. Zygotic expression and activity of the Drosophila Toll gene, a gene required maternally for embryonic dorsal-ventral pattern formation. Genetics 1988;119:123-133.
    • (1988) Genetics , vol.119 , pp. 123-133
    • Gertulla, S.1    Jin, Y.2    Anderson, K.V.3
  • 64
    • 0028326047 scopus 로고
    • The Drosophila 18 wheeler gene is required for morphogenesis and has striking similarities to Toll
    • Eldon E, et al. The Drosophila 18 wheeler gene is required for morphogenesis and has striking similarities to Toll. Development 1994;120:885-899.
    • (1994) Development , vol.120 , pp. 885-899
    • Eldon, E.1
  • 65
    • 0036023960 scopus 로고    scopus 로고
    • Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila
    • Ligoxygakis P, Bulet P, Reichhart JM. Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila. EMBO Rep 2002;3:666-673.
    • (2002) EMBO Rep , vol.3 , pp. 666-673
    • Ligoxygakis, P.1    Bulet, P.2    Reichhart, J.M.3
  • 66
    • 0036952124 scopus 로고    scopus 로고
    • Tissue and stage-specific expression of the Tolls in Drosophila embryos
    • Kambris Z, Hoffmann JA, Imler JL, Capovilla M. Tissue and stage-specific expression of the Tolls in Drosophila embryos. Gene Expr Patterns 2002;2:311-317.
    • (2002) Gene Expr Patterns , vol.2 , pp. 311-317
    • Kambris, Z.1    Hoffmann, J.A.2    Imler, J.L.3    Capovilla, M.4
  • 67
    • 0034777255 scopus 로고    scopus 로고
    • Tehao functions in the Toll pathway in Drosophila melanogaster: Possible roles in development and innate immunity
    • Luo C, Shen B, Manley JL, Zheng L. Tehao functions in the Toll pathway in Drosophila melanogaster: possible roles in development and innate immunity. Insect Mol Biol 2001; 10:457-464.
    • (2001) Insect Mol Biol , vol.10 , pp. 457-464
    • Luo, C.1    Shen, B.2    Manley, J.L.3    Zheng, L.4
  • 69
    • 0036166242 scopus 로고    scopus 로고
    • The Drosophila Toll-9 activates a constitutive antimicrobial defense
    • Ooi JY, Yagi Y, Hu X, Ip YT. The Drosophila Toll-9 activates a constitutive antimicrobial defense. EMBO Rep 2002;3:82-87.
    • (2002) EMBO Rep , vol.3 , pp. 82-87
    • Ooi, J.Y.1    Yagi, Y.2    Hu, X.3    Ip, Y.T.4
  • 70
    • 18044400563 scopus 로고    scopus 로고
    • Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis
    • Georgel P, et al. Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis. Dev Cell 2001;1:503-514.
    • (2001) Dev Cell , vol.1 , pp. 503-514
    • Georgel, P.1
  • 71
    • 0042066408 scopus 로고    scopus 로고
    • Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila
    • Kauppila S, et al. Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila. Oncogene 2003;22:4860-4867.
    • (2003) Oncogene , vol.22 , pp. 4860-4867
    • Kauppila, S.1
  • 72
    • 0037047362 scopus 로고    scopus 로고
    • Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling
    • Kanda H, Igaki T, KanukaH, Yagi T, Miura M. Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling. J Biol Chem 2002;277:28372-28375.
    • (2002) J Biol Chem , vol.277 , pp. 28372-28375
    • Kanda, H.1    Igaki, T.2    Kanuka, H.3    Yagi, T.4    Miura, M.5
  • 73
    • 0037124314 scopus 로고    scopus 로고
    • Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway
    • Igaki T, et al. Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. EMBO J 2002;21:3009-3018.
    • (2002) EMBO J , vol.21 , pp. 3009-3018
    • Igaki, T.1
  • 74
    • 0034303480 scopus 로고    scopus 로고
    • Activation of the Drosophila NF-kappaB factor Relish by rapid endoproteolytic cleavage
    • Stoven S, Ando I, Kadalayil L, Engstrom Y, Hultmark D. Activation of the Drosophila NF-kappaB factor Relish by rapid endoproteolytic cleavage. EMBO Rep 2000;1:347-352.
    • (2000) EMBO Rep , vol.1 , pp. 347-352
    • Stoven, S.1    Ando, I.2    Kadalayil, L.3    Engstrom, Y.4    Hultmark, D.5
  • 75
    • 0038284956 scopus 로고    scopus 로고
    • Caspase-mediated processing of the Drosophila NF-kappa B factor Relish
    • Stoven S, et al. Caspase-mediated processing of the Drosophila NF-kappa B factor Relish. Proc Natl Acad Sci USA 2003;100:5991-5996.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5991-5996
    • Stoven, S.1
  • 76
    • 0034613376 scopus 로고    scopus 로고
    • dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD
    • Hu S, Yang X. dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD. J Biol Chem 2000;275:30761-30764.
    • (2000) J Biol Chem , vol.275 , pp. 30761-30764
    • Hu, S.1    Yang, X.2
  • 77
    • 0037172656 scopus 로고    scopus 로고
    • Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults
    • Leulier F, Vidal S, Saigo K, Ueda R, Lemaitre B. Inducible expression of double-stranded RNA reveals a role for dFADD in the regulation of the antibacterial response in Drosophila adults. Curr Biol 2002;12:996-1000.
    • (2002) Curr Biol , vol.12 , pp. 996-1000
    • Leulier, F.1    Vidal, S.2    Saigo, K.3    Ueda, R.4    Lemaitre, B.5
  • 78
    • 0036850985 scopus 로고    scopus 로고
    • The Drosophila immune defense against gram-negative infection requires the death protein dFADD
    • Naitza S, et al. The Drosophila immune defense against gram-negative infection requires the death protein dFADD. Immunity 2002; 17:575-581.
    • (2002) Immunity , vol.17 , pp. 575-581
    • Naitza, S.1
  • 79
    • 0034305744 scopus 로고    scopus 로고
    • The Drosophila caspase Dredd is required to resist Gram-negative bacterial infection
    • Leulier F, Rodriguez A, Khush RS, Abrams JM, Lemaitre B. The Drosophila caspase Dredd is required to resist Gram-negative bacterial infection. EMBO Rep 2000;1:353-358.
    • (2000) EMBO Rep , vol.1 , pp. 353-358
    • Leulier, F.1    Rodriguez, A.2    Khush, R.S.3    Abrams, J.M.4    Lemaitre, B.5
  • 80
    • 0035423794 scopus 로고    scopus 로고
    • Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses
    • Vidal S, Khush RS, Leulier F, Tzou P, Nakamura M, Lemaitre B. Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses. Genes Dev 2001;15:1900-1912.
    • (2001) Genes Dev , vol.15 , pp. 1900-1912
    • Vidal, S.1    Khush, R.S.2    Leulier, F.3    Tzou, P.4    Nakamura, M.5    Lemaitre, B.6
  • 81
    • 0032005367 scopus 로고    scopus 로고
    • Role of the prophenoloxidase-activating system in invertebrate immunity
    • Soderhall K, Cerenius L. Role of the prophenoloxidase-activating system in invertebrate immunity. Curr Opin Immunol 1998;10:23-28.
    • (1998) Curr Opin Immunol , vol.10 , pp. 23-28
    • Soderhall, K.1    Cerenius, L.2
  • 82
    • 0036149337 scopus 로고    scopus 로고
    • JNK signaling pathway is required for efficient wound healing in Drosophila
    • Ramet M, Lanot R, Zachary D, Manfruelli P. JNK signaling pathway is required for efficient wound healing in Drosophila. Dev Biol 2002;241:145-156.
    • (2002) Dev Biol , vol.241 , pp. 145-156
    • Ramet, M.1    Lanot, R.2    Zachary, D.3    Manfruelli, P.4
  • 83
    • 0036848010 scopus 로고    scopus 로고
    • Sequential activation of signaling pathways during innate immune responses in Drosophila
    • Boutros M, Agaisse H, Perrimon N. Sequential activation of signaling pathways during innate immune responses in Drosophila. Dev Cell 2002;3:711-722.
    • (2002) Dev Cell , vol.3 , pp. 711-722
    • Boutros, M.1    Agaisse, H.2    Perrimon, N.3
  • 85
    • 0032473360 scopus 로고    scopus 로고
    • A drosomycin-GIP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway
    • Ferrandon D, et al. A drosomycin-GIP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway. EMBO J 1998;17: 1217-1227.
    • (1998) EMBO J , vol.17 , pp. 1217-1227
    • Ferrandon, D.1
  • 86
    • 0033638404 scopus 로고    scopus 로고
    • Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia
    • Tzou P, et al. Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia. Immunity 2000;13:737-748.
    • (2000) Immunity , vol.13 , pp. 737-748
    • Tzou, P.1
  • 88
    • 0032564398 scopus 로고    scopus 로고
    • Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes
    • Braun A, Hoffmann JA, Meister M. Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes. Proc Natl Acad Sci USA 1998;95:14337-14342.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14337-14342
    • Braun, A.1    Hoffmann, J.A.2    Meister, M.3
  • 89
    • 0034729655 scopus 로고    scopus 로고
    • Interactions between the cellular and humoral immune responses in Drosophila
    • Elrod-Erickson M, Mishra S, Schneider D. Interactions between the cellular and humoral immune responses in Drosophila. Curr Biol 2000;10:781-784.
    • (2000) Curr Biol , vol.10 , pp. 781-784
    • Elrod-Erickson, M.1    Mishra, S.2    Schneider, D.3
  • 90
    • 0042564535 scopus 로고    scopus 로고
    • Identification of cytoskeletal regulatory proteins required for efficient phagocytosis in Drosophila
    • Pearson AM, et al. Identification of cytoskeletal regulatory proteins required for efficient phagocytosis in Drosophila. Microbes Infect 2003;5:815-824.
    • (2003) Microbes Infect , vol.5 , pp. 815-824
    • Pearson, A.M.1
  • 91
    • 0030152160 scopus 로고    scopus 로고
    • Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells
    • Franc NC, Dimarcq JL, Lagueux M, Hoffmann J, Ezekowitz RA. Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells. Immunity 1996;4:431-443.
    • (1996) Immunity , vol.4 , pp. 431-443
    • Franc, N.C.1    Dimarcq, J.L.2    Lagueux, M.3    Hoffmann, J.4    Ezekowitz, R.A.5
  • 92
    • 0035690765 scopus 로고    scopus 로고
    • Drosophila scavenger receptor CI is a pattern recognition receptor for bacteria
    • Ramet M, et al. Drosophila scavenger receptor CI is a pattern recognition receptor for bacteria. Immunity 2001;15:1027-1038.
    • (2001) Immunity , vol.15 , pp. 1027-1038
    • Ramet, M.1
  • 93
    • 0034633786 scopus 로고    scopus 로고
    • Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila
    • Lagueux M, Perrodou E, Levashina EA, Capovilla M, Hoffmann JA. Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila. Proc Natl Acad Sci USA 2000;97:11427-11432.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11427-11432
    • Lagueux, M.1    Perrodou, E.2    Levashina, E.A.3    Capovilla, M.4    Hoffmann, J.A.5
  • 94
    • 0035831034 scopus 로고    scopus 로고
    • Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae
    • Levashina EA, Moita LF, Blandin S, Vriend G, Lagueux M, Kafatos FC. Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae. Cell 2001;104:709-718.
    • (2001) Cell , vol.104 , pp. 709-718
    • Levashina, E.A.1    Moita, L.F.2    Blandin, S.3    Vriend, G.4    Lagueux, M.5    Kafatos, F.C.6
  • 95
    • 0035865050 scopus 로고    scopus 로고
    • Postembryonic hematopoiesis in Drosophila
    • Lanot R, Zachary D, Holder F, Meister M. Postembryonic hematopoiesis in Drosophila. Dev Biol 2001;230:243-257.
    • (2001) Dev Biol , vol.230 , pp. 243-257
    • Lanot, R.1    Zachary, D.2    Holder, F.3    Meister, M.4
  • 96
    • 0042697323 scopus 로고    scopus 로고
    • Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury
    • Agaisse H, Petersen UM, Boutros M, Mathey-Prevot B, Perrimon N. Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Dev Cell 2003; 5:441-450.
    • (2003) Dev Cell , vol.5 , pp. 441-450
    • Agaisse, H.1    Petersen, U.M.2    Boutros, M.3    Mathey-Prevot, B.4    Perrimon, N.5
  • 97
    • 0037227097 scopus 로고    scopus 로고
    • Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila
    • Foley E, O'Farrell PH. Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila. Genes Dev 2003;17:115-125.
    • (2003) Genes Dev , vol.17 , pp. 115-125
    • Foley, E.1    O'Farrell, P.H.2
  • 99
    • 0000926038 scopus 로고    scopus 로고
    • Recent advances in research on the insect prophenoloxidase cascade
    • Brey PT, Hultmark D, eds. London: Chapman & Hall
    • Ashida M, Brey PT. Recent advances in research on the insect prophenoloxidase cascade. In: Brey PT, Hultmark D, eds. Molecular Mechanisms of Immune Response in Insects. London: Chapman & Hall, 1997: 135-172.
    • (1997) Molecular Mechanisms of Immune Response in Insects , pp. 135-172
    • Ashida, M.1    Brey, P.T.2
  • 100
    • 0018959836 scopus 로고
    • A mutant affecting crystal cells in Drosophila melanogaster
    • Rizki TM, Rizki RM, Grell EH. A mutant affecting crystal cells in Drosophila melanogaster. Roux Arch Dev Biol 1980; 188:91-99.
    • (1980) Roux Arch Dev Biol , vol.188 , pp. 91-99
    • Rizki, T.M.1    Rizki, R.M.2    Grell, E.H.3
  • 101
    • 18644376155 scopus 로고    scopus 로고
    • An immune-responsive Serpin regulates the melanization cascade in Drosophila
    • De Gregorio E, et al. An immune-responsive Serpin regulates the melanization cascade in Drosophila. Dev Cell 2002;3: 581-592.
    • (2002) Dev Cell , vol.3 , pp. 581-592
    • De Gregorio, E.1
  • 102
    • 0037011189 scopus 로고    scopus 로고
    • A serpin mutant links Toll activation to melanization in the host defence of Drosophila
    • Ligoxygakis P, et al. A serpin mutant links Toll activation to melanization in the host defence of Drosophila. EMBO J 2002;21:6330-6337.
    • (2002) EMBO J , vol.21 , pp. 6330-6337
    • Ligoxygakis, P.1
  • 103
    • 0041926711 scopus 로고    scopus 로고
    • Pherokine-2 and -3
    • Sabatier L, et al. Pherokine-2 and -3. Eur J Biochem 2003;270:3398-3407.
    • (2003) Eur J Biochem , vol.270 , pp. 3398-3407
    • Sabatier, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.