KIR6.2 Polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic β-cell ATP-sensitive K+ channels

Diabetes

Volumn 51, Issue 3, 2002, Pages 875-879

  Schwanstecher, Christina ^a   Meyer, Ulrike ^a   Schwanstecher, Mathias ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; POTASSIUM CHANNEL; POTASSIUM ION;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE FREQUENCY; GENETIC PREDISPOSITION; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; INSULIN RELEASE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 0036314298     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.3.875     Document Type: Article

References (22)

1. Non-insulin-dependent diabetes mellitus-a genetically programmed failure of the beta cell to compensate for insulin resistance
2. Genetics of type II diabetes
3. ATP channels induces profound neonatal diabetes
4. ATP channels
5. Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP- sensitive K-channel: No association with NIDDM in white Caucasian subjects or evidence of abnormal function when expressed in vitro
6. + channel Kir6.2 (Bir) gene: Identification and lack of role in Caucasian patients with NIDDM
7. Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM
8. + channel gene (KIR6.2/BIR): A meta-analysis suggests a role in the polygenic basis of type II diabetes mellitus in Caucasians
9. UK Prospective Diabetes Study (UKPDS 53): Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with type 2 diabetes mellitus (UKPDS 53)
10. ATP channels: Control of nucleotide sensitivity by the N-terminal domain of the Kir 6.2 subunit
11. ATP channels
12. + channel in mouse pancreatic beta-cells
13. ATP channel inhibition by ATP
14. Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians
15. Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians
16. Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene
17. Cloning of the promoters for the beta-cell ATP-sensitive K-channel subunits Kir 6.2 and SUR1
18. Insulin secretion and insulin sensitivity in diabetic subgroups: Studies in the prediabetic and diabetic state
19. Glucose-mediated glucose disposal in insulin-resistant normoglycemic relatives of type 2 diabetic patients
20. The "thrifty genotype" in 1998
21. The common PPARgamma Pro 12A1a polymorphism is associated with decreased risk of type 2 diabetes
22. 4- mediates closure of pancreatic beta-cell ATP-sensitive potassium channels by interaction with 1 of 4 identical sites