Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I

Journal of Biological Chemistry

Volumn 275, Issue 1, 2000, Pages 223-228

  El Mir, Mohamad Yehia ^a   Nogueira, Véronique ^a   Fontaine, Eric ^a   Avéret, Nicole ^b   Rigoulet, Michel ^b   Leverve, Xavier ^a  

^a UNIV GRENOBLE ALPES   (France)

^b Institut de Biochimie et Genetique Cellulaires   (France)

Author keywords

[No Author keywords available]

Indexed keywords

METFORMIN; MYXOTHIAZOL; ORAL ANTIDIABETIC AGENT; ROTENONE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ENERGY METABOLISM; LIVER CELL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CELL MEMBRANE PERMEABILITY; CELL RESPIRATION; ELECTRON TRANSPORT COMPLEX I; GLUTAMATES; HYPOGLYCEMIC AGENTS; MALATES; MEMBRANE POTENTIALS; METFORMIN; MITOCHONDRIA, LIVER; NADH, NADPH OXIDOREDUCTASES; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; RATS; SIGNAL TRANSDUCTION; SUCCINIC ACID; TEMPERATURE; TETRAMETHYLPHENYLENEDIAMINE;

ANIMALIA; LETHRINIDAE;

EID: 0034614420     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.1.223     Document Type: Article

References (53)

1. Kroemer, G., Petit, P., Zamzami, N., Vayssiere, J. L., and Mignotte, B. (1995) FASEB J. 9, 1277-1287
2. Green, D. R., and Reed, J. C. (1998) Science 281, 1309-1312
3. McCormack, J. G., Halestrap, A. P., and Denton, R. M. (1990) Physiol. Rev. 70, 391-425
4. Bolanos, J. P., Peuchen, S., Heales, S. J., Land, J. M., and Clark, J. B. (1994) J. Neurochem. 63, 910-916
5. Almeida, A., Heales, S. J. R., Bolanos, J. P., and Medina, J. M. (1998) Brain Res. 790, 209-216
6. Clementi, E., Brown, G. C., Feelisch, M., and Moncada, S. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 7631-7636
7. Bailey, C. J., and Turner, R. C. (1996) N. Engl. J. Med. 334, 574-579
8. Bailey, C. J. (1992) Diabetes Care 15, 755-772
9. Anonymous (1998) Diabetes Care 21, 87-92
10. Lee, A. J. (1996) Pharmacotherapy 16, 327-351
11. Argaud, D., Roth, H., Wiernsperger, N., and Leverve, X. M. (1993) Eur. J. Biochem. 213, 1341-1348
12. Schafer, G. (1969) Biochim. Biophys. Acta 172, 334-337
13. Schafer, G., and Bojanowski, D. (1972) Eur. J. Biochem. 27, 364-375
14. Schafer, G. (1983) Diabetes Metab. 9, 148-163
15. Jailing, O., and Olsen, C. (1984) Acta Pharmacol. Toxicol. (Copenh.) 54, 327-332
16. Bolanos, J. P., Almeida, A., Stewart, V., S., P., Land, J. M., Clark, J. B., and Heales, S. J. R. (1997) J. Neurochem. 68, 2227-2240
17. Pentikainen, P. J., Neuvonen, P. J., and Penttila, A. (1979) Eur. J. Clin. Pharmacol. 16, 195-202
18. Berry, M. N., and Friend, D. S. (1969) J. Cell Biol. 43, 506-520
19. Groen, A. K., Sips, H. J., Vervoorn, R. C., and Tager, J. M. (1982) Eur. J. Biochem. 122, 87-93
20. Fontaine, E. M., Keriel, C., Lantuejoul, S., Rigoulet, M., Leverve, X. M., and Saks, V. A. (1995) Biochem. Biophys. Res. Commun. 213, 138-146
21. Klingenberg, M., and Slenczka, W. (1959) Biochem. Z. 331, 486-495
22. Shoukry, M. I. (1980) J. Biochem. Biophys. Methods 3, 219-224
23. Kiselev, G. V., and Pavlinova, L. I. (1975) Ukr. Biokhim. Zh. 47, 389-392
24. Espie, P., Guerin, B., and Rigoulet, M. (1995) Biochim. Biophys. Acta 1230, 139-146
25. Bergmeyer, H. (1974) Methods of Enzymatic Analysis, 2nd Ed., Vols. 3 and 4, Academic Press, New York
26. Williamson, D. H., Lund, P., and Krebs, H. A. (1967) Biochem. J. 103, 514-527
27. Pison, C. M., Chauvin, C., Fontaine, E., Catelloni, F., Keriel, C., Paramelle, B., and Leverve, X. M. (1995) Am. J. Physiol. 268, E965-E973
28. Leverve, X. M., Fontaine, E., Putod Paramelle, F., and Rigoulet, M. (1994) Eur. J. Biochem. 224, 967-974
29. Rieske, J. S. (1967) Methods Enzymol. 10, 239-245
30. Wiernsperger, N. (1996) in Handbook of Experimental Pharmacology (Kuhlman, J., and Puls, W., eds) Vol. 119, pp. 305-358, Springer-Verlag, Berlin
31. Wiernsperger, N., and Rapin, J. R. (1995) Diabetes Metab. Rev. 11, Suppl. 1, S3-S12
32. Bailey, C. J., Wilcock, C., and Day, C. (1992) Br. J. Pharmacol. 105, 1009-1013
33. Stuehr, D. J., and Nathan, C. F. (1989) J. Exp. Med. 169, 1543-1555
34. Stadler, J., Bentz, B. G., Harbrecht, B. G., Di Silvio, M., Curran, R. D., Billiar, T. R., Hoffman, R. A., and Simmons, R. L. (1992) Ann. Surg. 216, 539-546
35. Stadler, J., Billiar, T. R., Curran, R. D., Stuehr, D. J., Ochoa, J. B., and Simmons, R. L. (1991) Am. J. Physiol. 260, C910-C916
36. Zhang, Y., Marcillat, O., Giulivi, C., Ernster, L., and Davies, K. J. (1990) J. Biol. Chem. 265, 16330-16336
37. Stith, B. J., Goalstone, M. L., Espinoza, R., Mossel, C., Roberts, D., and Wiernsperger, N. (1996) Endocrinology 137, 2990-2999
38. Stith, B. J., Woronoff, K., and Wiernsperger, N. (1998) Biochem. Pharmacol 55, 533-536
39. Santos, R. F., Nomizo, R., Bopsco, A., Wajchenberg, B. L., Reaven, G. M., and Azhar, S. (1997) Diabetes Metab. 23, 143-148
40. Grigorescu, F., Laurent, A., Chavanieu, A., and Capony, J. P. (1991) Diabetes Metab. 17, 146-149
41. White, M. F. (1997) Diabetologia 40, Suppl. 2, S2-S17
42. Shepherd, P. R., Nave, B. T., and O'Rahilly, S. (1996) J. Mol. Endocrinol. 17, 175-184
43. Ui, M., Okada, T., Hazeki, K., and Hazeki, O. (1995) Trends Biochem. Sci. 20, 303-307
44. Blommaart, E. F., Krause, U., Schellens, J. P., Vreeling-Sindelarova, H., and Meijer, A. J. (1997) Eur. J. Biochem. 243, 240-246
45. Kessler, A., Muller, G., Wied, S., Crecelius, A., and Eckel, J. (1998) Biochem. J. 330, 277-286
46. Carpenter, C. L., and Cantley, L. C. (1996) Curr. Opin. Cell Biol. 8, 153-158
47. Kaplan, D. R., Martin-Zanca, D., and Parada, L. F. (1991) Nature 350, 158-160
48. Ubl, J. J., Chen, S., and Stucki, J. W. (1994) Biochem. J. 304, 561-567
49. Dominguez, L. J., Davidoff, A. J., Srinivas, P. R., Standley, P. R., Walsh, M. F., and Sowers, J. R. (1996) Endocrinology 137, 113-121
50. Gudz, T. I., Tserng, K. Y., and Hoppel, C. L. (1997) J. Biol. Chem. 272, 24154-24158
51. Degli Esposti, M. (1998) Biochim. Biophys. Acta 1364, 222-235
52. Ewis, S. A., and Abdel-Rahman, M. S. (1995) J. Appl. Toxicol. 15, 387-390
53. Ewis, S. A., and Abdel-Rahman, M. S. (1997) J. Appl. Toxicol. 17, 409-413