Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors

Science

Volumn 288, Issue 5475, 2000, Pages 2379-2381

  Loftus, Thomas M ^a   Jaworsky, Donna E ^a   Frehywot, Cojeb L ^b   Townsend, Craig A ^b   Ronnett, Gabriele V ^a   Daniel Lane, M ^a   Kuhajda, Francis P ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOBESITY AGENT; C 75; CERULENIN; FAS ANTIGEN; FATTY ACID SYNTHASE; LEPTIN; MALONYL COENZYME A; NEUROPEPTIDE Y; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APPETITE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENERGY METABOLISM; FEEDING BEHAVIOR; FEMALE; FOOD INTAKE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; WEIGHT REDUCTION;

ACETYL-COA CARBOXYLASE; ANIMALS; APPETITE; APPETITE DEPRESSANTS; CERULENIN; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; ENZYME INHIBITORS; FASTING; FATTY ACID SYNTHETASE COMPLEX; FEMALE; HYPOTHALAMUS; INJECTIONS, INTRAVENTRICULAR; LEPTIN; LIVER; MALE; MALONYL COENZYME A; MICE; MICE, INBRED BALB C; NEURONS; NEUROPEPTIDE Y; RNA, MESSENGER; WEIGHT LOSS;

EID: 0034733730     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.288.5475.2379     Document Type: Article

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21. Experimental animals were treated in accordance with institutional animal usage guidelines. Except for where noted, all mice were obtained from Charles River Labs (Wilmington, MA). We thank R. Mains for the NPY probe. Supported by NIH grants DK09623 (T.M.L.) and DC02979 (G.V.R.), the NIDDK (M.D.L), the W. M. Keck Foundation (G.V.R.), the Stewart Trust, and the Department of Defense (F.P.K.).