-
1
-
-
11344253462
-
Increased incidence of thyroid carcinoma in france: A true epidemic or thyroid nodule management effects? Report from the french thyroid cancer committee
-
DOI 10.1089/thy.2004.14.1056
-
L Leenhardt, P Grosclaude, L Chérié-Challine; Thyroid Cancer Committee: Increased incidence of thyroid carcinoma in france: a true epidemic or thyroid nodule management effects? Report from the French Thyroid Cancer Committee. Thyroid 14, 1056-60 (2004) (Pubitemid 40076130)
-
(2004)
Thyroid
, vol.14
, Issue.12
, pp. 1056-1060
-
-
Leenhardt, L.1
Grosclaude, P.2
Cherie-Challine, L.3
-
2
-
-
33646442046
-
Increasing incidence of thyroid cancer in the United States, 1973-2002
-
L Davies, HG Welch: Increasing incidence of thyroid cancer in the United States, 1973-2002. JAMA 295, 2164-7 (2006)
-
(2006)
JAMA
, vol.295
, pp. 2164-2167
-
-
Davies, L.1
Welch, H.G.2
-
4
-
-
33645465719
-
American thyroid association guidelines taskforce: Management guidelines for patients with thyroid nodules and differentiated thyroid cancer
-
S Cooper, GM Doherty, BR Haugen, RT Kloos, SL Lee, SJ Mandel, EL Mazzaferri, B McIver, SI Sherman, RM Tuttle; American Thyroid Association Guidelines Taskforce: Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 16, 109-42 (2006)
-
(2006)
Thyroid
, vol.16
, pp. 109-142
-
-
Cooper, S.1
Doherty, G.M.2
Haugen, B.R.3
Kloos, R.T.4
Lee, S.L.5
Mandel, S.J.6
Mazzaferri, E.L.7
McIver, B.8
Sherman, S.I.9
Tuttle, R.M.10
-
5
-
-
0035873951
-
Hürthle cell carcinoma: A critical histopathologic appraisal
-
A Stojadinovic, R Ghossein, A Hoos, MJ Urist, RH Spiro, JP Shah, MF Brennan, AR Shaha, B Singh: Hürthle cell carcinoma: a critical histopathological appraisal. J Clin Oncol 19, 2616-2625 (2001) (Pubitemid 32441366)
-
(2001)
Journal of Clinical Oncology
, vol.19
, Issue.10
, pp. 2616-2625
-
-
Stojadinovic, A.1
Ghossein, R.A.2
Hoos, A.3
Urist, M.J.4
Spiro, R.H.5
Shah, J.P.6
Brennan, M.F.7
Shaha, A.R.8
Singh, B.9
-
6
-
-
0001329347
-
Tumors of the thyroid gland
-
3rd series, fascicle. Eds: J. Rosai and L. H. Sobin
-
J Rosai, M Caracangui, R DeLellis: Tumors of the thyroid gland. In: Atlas of Tumor Pathology, 3rd series, fascicle. Eds: J. Rosai and L. H. Sobin (1992)
-
(1992)
Atlas of Tumor Pathology
-
-
Rosai, J.1
Caracangui, M.2
Delellis, R.3
-
8
-
-
33847397909
-
Anaplastic thyroid carcinoma: An overview
-
DOI 10.1007/s11912-007-0014-3
-
WR Cornett, AK Sharma, TA Day, MS Richardson, RS Hoda, JA van Heerden, J K Fernandes: Anaplastic thyroid carcinoma: an overview. Curr Oncol Rep 9, 152-8 (2007) (Pubitemid 46332389)
-
(2007)
Current Oncology Reports
, vol.9
, Issue.2
, pp. 152-158
-
-
Cornett, W.R.1
Sharma, A.K.2
Day, T.A.3
Richardson, M.S.4
Hoda, R.S.5
Van Heerden, J.A.6
Fernandes, J.K.7
-
9
-
-
38149036597
-
Molecular genetics of thyroid cancer: Implications for diagnosis, treatment and prognosis
-
MN Nikiforova, YE Nikiforov: Molecular genetics of thyroid cancer: implications for diagnosis, treatment and prognosis. Expert Rev Mol Diagn 8, 83-95 (2008)
-
(2008)
Expert Rev Mol Diagn
, vol.8
, pp. 83-95
-
-
Nikiforova, M.N.1
Nikiforov, Y.E.2
-
10
-
-
56449118024
-
Recent advances in molecular biology of thyroid cancer and their clinical implications
-
M Xing: Recent advances in molecular biology of thyroid cancer and their clinical implications. Otolaryngol Clin North Am 41, 1135-46 (2008)
-
(2008)
Otolaryngol Clin North Am
, vol.41
, pp. 1135-1146
-
-
Xing, M.1
-
11
-
-
77950961448
-
Signal transduction in the human thyrocyte and its perversion in thyroid tumors
-
PP Roger, WC van Staveren, K Coulonval, JE Dumont, C Maenhaut: Signal transduction in the human thyrocyte and its perversion in thyroid tumors. Mol Cell Endocrinol 321, 3-19 (2010)
-
(2010)
Mol Cell Endocrinol
, vol.321
, pp. 3-19
-
-
Roger, P.P.1
Van Staveren, W.C.2
Coulonval, K.3
Dumont, J.E.4
Maenhaut, C.5
-
12
-
-
75449095841
-
Potential utility and limitations of thyroid cancer cell lines as models for studying thyroid cancer
-
T Pilli, KV Prasad, S Jayarama, F Pacini, BS Prabhakar: Potential utility and limitations of thyroid cancer cell lines as models for studying thyroid cancer. Thyroid 19, 1333-42 (2009)
-
(2009)
Thyroid
, vol.19
, pp. 1333-1342
-
-
Pilli, T.1
Prasad, K.V.2
Jayarama, S.3
Pacini, F.4
Prabhakar, B.S.5
-
13
-
-
57349103343
-
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification
-
DOI 10.1210/jc.2008-1102
-
RE Schweppe, JP Klopper, C Korch, U Pugazhenthi, M Benezra, JA Knauf, JA Fagin, LA Marlow, JA Copland, RC Smallridge, BR Haugen: Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification. J Clin Endocrinol Metab 93, 4331-41 (2008) (Pubitemid 352789529)
-
(2008)
Journal of Clinical Endocrinology and Metabolism
, vol.93
, Issue.11
, pp. 4331-4341
-
-
Schweppe, R.E.1
Klopper, J.P.2
Korch, C.3
Pugazhenthi, U.4
Benezra, M.5
Knauf, J.A.6
Fagin, J.A.7
Marlow, L.A.8
Copland, J.A.9
Smallridge, R.C.10
Haugen, B.R.11
-
14
-
-
34548599774
-
Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype
-
DOI 10.1158/0008-5472.CAN-06-4026
-
WC van Staveren, DW Solís, L Delys, L Duprez, G Andry, B Franc, G Thomas, F Libert, JE Dumont, V Detours, C Maenhaut: Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype. Cancer Res 67, 8113-20 (2007) (Pubitemid 47395146)
-
(2007)
Cancer Research
, vol.67
, Issue.17
, pp. 8113-8120
-
-
Van Staveren, W.C.G.1
Solis, D.W.2
Delys, L.3
Duprez, L.4
Andry, G.5
Franc, B.6
Thomas, G.7
Libert, F.8
Dumont, J.E.9
Detours, V.10
Maenhaut, C.11
-
15
-
-
57349111372
-
"Thyroid cancer" cell line misidentification: A time for proactive change
-
DOI 10.1210/jc.2008-2008
-
MD Ringel: "Thyroid cancer" cell line misidentification: a time for proactive change. J Clin Endocrinol Metab 93, 4226-7 (2008) (Pubitemid 352789514)
-
(2008)
Journal of Clinical Endocrinology and Metabolism
, vol.93
, Issue.11
, pp. 4226-4227
-
-
Ringel, M.D.1
-
16
-
-
75449110719
-
Lessons from mouse models of thyroid cancer
-
CS Kim, X Zhu: Lessons from mouse models of thyroid cancer. Thyroid 9, 1317-31 (2009)
-
(2009)
Thyroid
, vol.9
, pp. 1317-1331
-
-
Kim, C.S.1
Zhu, X.2
-
17
-
-
0033604577
-
Signaling by distinct classes of phosphoinositide 3-kinases
-
B Vanhaesebroeck, MD Waterfield: Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res 253, 239-54 (1999)
-
(1999)
Exp Cell Res
, vol.253
, pp. 239-254
-
-
Vanhaesebroeck, B.1
Waterfield, M.D.2
-
19
-
-
0036632368
-
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
-
I Vivanco, CL Sawyers: The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2, 489-501 (2002) (Pubitemid 37328931)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.7
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
21
-
-
2342565881
-
Advances in protein kinase B signalling: AKTion on multiple fronts
-
DOI 10.1016/j.tibs.2004.03.006, PII S096800040400074X
-
DP Brazil, ZZYang, BA Hemmings: Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci 29, 233-42 (2004) (Pubitemid 38591317)
-
(2004)
Trends in Biochemical Sciences
, vol.29
, Issue.5
, pp. 233-242
-
-
Brazil, D.P.1
Yang, Z.-Z.2
Hemmings, B.A.3
-
22
-
-
0034613381
-
Akt/protein kinase B isoforms aredifferentially regulated by epidermal growth factor stimulation
-
J Okano, I Gaslightwala, MJ Birnbaum, AK Rustgi, H Nakagawa: Akt/protein kinase B isoforms aredifferentially regulated by epidermal growth factor stimulation. J Biol Chem 275, 30934-42 (2000)
-
(2000)
J Biol Chem
, vol.275
, pp. 30934-30942
-
-
Okano, J.1
Gaslightwala, I.2
Birnbaum, M.J.3
Rustgi, A.K.4
Nakagawa, H.5
-
23
-
-
0035448879
-
Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene
-
DOI 10.1101/gad.913901
-
WS Chen, PZ Xu, K Gottlob, ML Chen, K Sokol, T Shiyanova, I Roninson, W Weng, R Suzuki, K Tobe, T Kadowaki, N Hay: Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev 15, 2203-8 (2001) (Pubitemid 32843832)
-
(2001)
Genes and Development
, vol.15
, Issue.17
, pp. 2203-2208
-
-
Chen, W.S.1
Xu, P.-Z.2
Gottlob, K.3
Chen, M.-L.4
Sokol, K.5
Shiyanova, T.6
Roninson, I.7
Weng, W.8
Suzuki, R.9
Tobe, K.10
Kadowaki, T.11
Hay, N.12
-
24
-
-
0035914388
-
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
-
H Cho, JL Thorvaldsen, Q Chu, F Feng, MJ Birnbaum: Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 276, 38349-52 (2001)
-
(2001)
J Biol Chem
, vol.276
, pp. 38349-38352
-
-
Cho, H.1
Thorvaldsen, J.L.2
Chu, Q.3
Feng, F.4
Birnbaum, M.J.5
-
25
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBbeta)
-
DOI 10.1126/science.292.5522.1728
-
H Cho, J Mu, JK Kim, JL Thorvaldsen, Q Chu, EB Crenshaw 3rd, KH Kaestner, MS Bartolomei, GI Shulman, MJ Birnbaum: Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 292, 1728-31 (2001) (Pubitemid 32506248)
-
(2001)
Science
, vol.292
, Issue.5522
, pp. 1728-1731
-
-
Cho, H.1
Mu, J.2
Kim, J.K.3
Thorvaldsen, J.L.4
Chu, Q.5
Crenshaw III, E.B.6
Kaestner, K.H.7
Bartolomei, M.S.8
Shulman, G.I.9
Birnbaum, M.J.10
-
26
-
-
85047693348
-
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBbeta
-
DOI 10.1172/JCI200316885
-
RS Garofalo, SJ Orena, K Rafidi, AJ Torchia, JL Stock, AL Hildebrandt, T Coskran, SC Black, DJ Brees, JR Wicks, JD McNeish, KG Coleman: Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J Clin Invest 112, 197-208 (2003) (Pubitemid 38056356)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.2
, pp. 197-208
-
-
Garofalo, R.S.1
Orena, S.J.2
Rafidi, K.3
Torchia, A.J.4
Stock, J.L.5
Hildebrandt, A.L.6
Coskran, T.7
Black, S.C.8
Brees, D.J.9
Wicks, J.R.10
McNeish, J.D.11
Coleman, K.G.12
-
27
-
-
23144449547
-
Essential role of protein kinase Bγ (PKBγ/Akt3) in postnatal brain developmental but not in glucose homeostasis
-
DOI 10.1242/dev.01864
-
O Tschopp, ZZ Yang, D Brodbeck, BA Dummler, M Hemmings-Mieszczak, T Watanabe, T Michaelis, J Frahm, BA Hemmings: Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis. Development 132, 2943-54 (2005) (Pubitemid 41086730)
-
(2005)
Development
, vol.132
, Issue.13
, pp. 2943-2954
-
-
Tschopp, O.1
Yang, Z.-Z.2
Brodbeck, D.3
Dummler, B.A.4
Hemmings-Mieszczak, M.5
Watanabe, T.6
Michaelis, T.7
Frahm, J.8
Hemmings, B.A.9
-
28
-
-
0038624395
-
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
-
XD Peng, PZ Xu, ML Chen, A Hahn-Windgassen, J Skeen, J Jacobs, D Sundararajan, WS Chen, SE Crawford, KG Coleman, N Hay: Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev 17, 1352-65 (2003) (Pubitemid 36666005)
-
(2003)
Genes and Development
, vol.17
, Issue.11
, pp. 1352-1365
-
-
Peng, X.-D.1
Xu, P.-Z.2
Chen, M.-L.3
Hahn-Windgassen, A.4
Skeen, J.5
Jacobs, J.6
Sundararajan, D.7
Chen, W.S.8
Crawford, S.E.9
Coleman, K.G.10
Hay, N.11
-
29
-
-
27944493875
-
Dosage-dependent effects of Akt1/protein kinase Bα (PKBα) and Akt3/PKBγ on thymus, skin, and cardiovascular and nervous system development in mice
-
DOI 10.1128/MCB.25.23.10407-10418.2005
-
ZZ Yang, O Tschopp, N Di-Poï, E Bruder, A Baudry, B Dümmler, W Wahli, BA Hemmings: Dosagedependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice. Mol Cell Biol 25, 10407-18 (2005) (Pubitemid 41681964)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.23
, pp. 10407-10418
-
-
Yang, Z.-Z.1
Tschopp, O.2
Di-Poi, N.3
Bruder, E.4
Baudry, A.5
Dummler, B.6
Wahli, W.7
Hemmings, B.A.8
-
30
-
-
33750380920
-
Life with a single isoform of Akt: Mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies
-
DOI 10.1128/MCB.00722-06
-
B Dummler, O Tschopp, D Hynx, ZZ Yang, S Dirnhofer, BA Hemmings: Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies. Mol Cell Biol 26, 8042-51 (2006) (Pubitemid 44631003)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.21
, pp. 8042-8051
-
-
Dummler, B.1
Tschopp, O.2
Hynx, D.3
Yang, Z.-Z.4
Dirnhofer, S.5
Hemmings, B.A.6
-
31
-
-
20044382806
-
Role for Akt3/protein kinase by in attainment of normal brain size
-
DOI 10.1128/MCB.25.5.1869-1878.2005
-
RM Easton, H Cho, K Roovers, DW Shineman, M Mizrahi, MS Forman, VM Lee, M Szabolcs, R de Jong, T Oltersdorf, L Ludwig, A Efstratiadis, MJ Birnbaum: Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol 25, 1869-78 (2005) (Pubitemid 40280150)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.5
, pp. 1869-1878
-
-
Easton, R.M.1
Cho, H.2
Roovers, K.3
Shineman, D.W.4
Mizrahi, M.5
Forman, M.S.6
Lee, V.M.-Y.7
Szabolcs, M.8
De Jong, R.9
Oltersdorf, T.10
Ludwig, T.11
Efstratiadis, A.12
Birnbaum, M.J.13
-
32
-
-
29144488505
-
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition
-
DOI 10.1083/jcb.200505087
-
HY Irie, RV Pearline, D Grueneberg, M Hsia, P Ravichandran, N Kothari, S Natesan, JS Brugge: Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol 171, 1023-34 (2005) (Pubitemid 41815834)
-
(2005)
Journal of Cell Biology
, vol.171
, Issue.6
, pp. 1023-1034
-
-
Irie, H.Y.1
Pearline, R.V.2
Grueneberg, D.3
Hsia, M.4
Ravichandran, P.5
Kothari, N.6
Natesan, S.7
Brugge, J.S.8
-
33
-
-
33846416534
-
Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/Neu and MMTV-polyoma middle T transgenic mice
-
DOI 10.1158/0008-5472.CAN-06-3782
-
IG Maroulakou, W Oemler, SP Naber, PN Tsichlis: Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Cancer Res 67, 167-77 (2007) (Pubitemid 46142772)
-
(2007)
Cancer Research
, vol.67
, Issue.1
, pp. 167-177
-
-
Maroulakou, I.G.1
Oemler, W.2
Naber, S.P.3
Tsichlis, P.N.4
-
34
-
-
27944446105
-
Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT
-
DOI 10.1016/j.molcel.2005.10.033, PII S1097276505017284
-
M Yoeli-Lerner, GK Yiu, I Rabinovitz, P Erhardt, S Jauliac, A Toker: Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell 20, 539-50 (2005) (Pubitemid 41668639)
-
(2005)
Molecular Cell
, vol.20
, Issue.4
, pp. 539-550
-
-
Yoeli-Lerner, M.1
Yiu, G.K.2
Rabinovitz, I.3
Erhardt, P.4
Jauliac, S.5
Toker, A.6
-
35
-
-
68049144964
-
Loss of RhoB expression promotes migration and invasion of human bronchial cells Via activation of AKT1
-
E Bousquet, J Mazieres, M Privat, V Rizzati, A Casanova, A Ledoux, E Mery, B Couderc, G Favre, A Pradines: Loss of RhoB Expression Promotes Migration and Invasion of Human Bronchial Cells Via Activation of AKT1. Cancer Res 69, 6092-6099 (2009)
-
(2009)
Cancer Res
, vol.69
, pp. 6092-6099
-
-
Bousquet, E.1
Mazieres, J.2
Privat, M.3
Rizzati, V.4
Casanova, A.5
Ledoux, A.6
Mery, E.7
Couderc, B.8
Favre, G.9
Pradines, A.10
-
36
-
-
52249092644
-
Lysophosphatidic acid induces cell migration through the selective activation of AKT1
-
EK Kim, SJ Yun, KH Do, MS Kim, D Suh, CD Kim, JH Kim, MJ Birnbaum, SS Bae: Lysophosphatidic acid induces cell migration through the selective activation of AKT1. Exp Mol Med 40, 445-452 (2008)
-
(2008)
Exp Mol Med
, vol.40
, pp. 445-452
-
-
Kim, E.K.1
Yun, S.J.2
Do, K.H.3
Kim, M.S.4
Suh, D.5
Kim, C.D.6
Kim, J.H.7
Birnbaum, M.J.8
Bae, S.S.9
-
37
-
-
12144288657
-
Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer
-
V Vasko, M Saji, E Hardy, M Kruhlak, A Larin, V Savchenko, M Miyakawa, O Isozaki, H Murakami, T Tsushima, KD Burman, C De Micco, MD Ringel: Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer. J Med Genet 41, 161-70 (2004) (Pubitemid 38333792)
-
(2004)
Journal of Medical Genetics
, vol.41
, Issue.3
, pp. 161-170
-
-
Vasko, V.1
Saji, M.2
Hardy, E.3
Kruhlak, M.4
Larin, A.5
Savchenko, V.6
Miyakawa, M.7
Isozaki, O.8
Murakami, H.9
Tsushima, T.10
Burman, K.D.11
De Micco, C.12
Ringel, M.D.13
-
38
-
-
51449094934
-
Distinct roles of the three Akt isoforms in lactogenic differentiation and involution
-
IG Maroulakou, W Oemler, SP Naber, I Klebba, C Kuperwasser, PN Tsichlis: Distinct roles of the three Akt isoforms in lactogenic differentiation and involution. J Cell Physiol 217, 468-77 (2008)
-
(2008)
J Cell Physiol
, vol.217
, pp. 468-477
-
-
Maroulakou, I.G.1
Oemler, W.2
Naber, S.P.3
Klebba, I.4
Kuperwasser, C.5
Tsichlis, P.N.6
-
39
-
-
0028799420
-
Molecular cloning and characterization of a new member of the RAC protein kinase family: Association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins
-
H Konishi, S Kuroda, M Tanaka, H Matsuzaki, Y Ono, K Kameyama, T Haga, U Kikkawa: Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins. Biochem Biophys Res Commun 216, 526-34 (1995)
-
(1995)
Biochem Biophys Res Commun
, vol.216
, pp. 526-534
-
-
Konishi, H.1
Kuroda, S.2
Tanaka, M.3
Matsuzaki, H.4
Ono, Y.5
Kameyama, K.6
Haga, T.7
Kikkawa, U.8
-
40
-
-
0035881322
-
Overexpression and overactivation of Akt in thyroid carcinoma
-
MD Ringel, N Hayre, J Saito, B Saunier, F Schuppert, H Burch, V Bernet, KD Burman, LD Kohn, M Saji: Overexpression and overactivation of Akt in thyroid carcinoma. Cancer Res 61, 6105-11 (2001) (Pubitemid 32762546)
-
(2001)
Cancer Research
, vol.61
, Issue.16
, pp. 6105-6111
-
-
Ringel, M.D.1
Hayre, N.2
Saito, J.3
Saunier, B.4
Schuppert, F.5
Burch, H.6
Bernet, V.7
Burman, K.D.8
Kohn, L.D.9
Saji, M.10
-
41
-
-
0031039024
-
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
-
DOI 10.1126/science.275.5300.665
-
TF Franke, DR Kaplan, LC Cantley, A Toker: Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275, 665-8 (1997) (Pubitemid 27061333)
-
(1997)
Science
, vol.275
, Issue.5300
, pp. 665-668
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
Toker, A.4
-
42
-
-
85047681190
-
Discovery of PDKI, one of the missing links in insulin signal transduction
-
DOI 10.1042/0300-5127:0290001
-
DR Alessi: Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture. Biochem Soc Trans 29, 1-14 (2001) (Pubitemid 32587470)
-
(2001)
Biochemical Society Transactions
, vol.29
, Issue.2
, pp. 1-14
-
-
Alessi, D.R.1
-
43
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
DOI 10.1126/science.1106148
-
DD Sarbassov, DA Guertin, SM Ali, DM Sabatini: Phosphorylation and regulation of Akt/PKB by the rictormTOR complex. Science 307, 1098-101 (2005) (Pubitemid 40262113)
-
(2005)
Science
, vol.307
, Issue.5712
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
44
-
-
34250788809
-
AKT/PKB Signaling: Navigating Downstream
-
DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
-
BD Manning, LC Cantley: AKT/PKB signaling: navigating downstream. Cell 29, 1261-74 (2007) (Pubitemid 46962095)
-
(2007)
Cell
, vol.129
, Issue.7
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
45
-
-
15944406764
-
PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
-
DOI 10.1016/j.molcel.2005.03.008
-
T Gao, F Furnari, AC Newton: PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 18, 13-24 (2005) (Pubitemid 40444644)
-
(2005)
Molecular Cell
, vol.18
, Issue.1
, pp. 13-24
-
-
Gao, T.1
Furnari, F.2
Newton, A.C.3
-
46
-
-
33745316089
-
Identification of a tumour suppressor network opposing nuclear Akt function
-
DOI 10.1038/nature04809, PII NATURE04809
-
LC Trotman, A Alimonti, PP Scaglioni, JA Koutcher, C Cordon-Cardo, PP Pandolfi: Identification of a tumour suppressor network opposing nuclear Akt function. Nature 441, 523-7 (2006) (Pubitemid 44050155)
-
(2006)
Nature
, vol.441
, Issue.7092
, pp. 523-527
-
-
Trotman, L.C.1
Alimonti, A.2
Scaglioni, P.P.3
Koutcher, J.A.4
Cordon-Cardo, C.5
Pandolfi, P.P.6
-
47
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
DOI 10.1038/nrg1879, PII NRG1879
-
JA Engelman, J Luo, LC Cantley: The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 7, 606-19 (2006) (Pubitemid 44100518)
-
(2006)
Nature Reviews Genetics
, vol.7
, Issue.8
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
48
-
-
70350324640
-
Emerging common themes in regulation of PIKKs and PI3Ks
-
H Lempiäinen, TD Halazonetis: Emerging common themes in regulation of PIKKs and PI3Ks. EMBO J 28, 3067-73 (2009)
-
(2009)
EMBO J
, vol.28
, pp. 3067-3073
-
-
Lempiäinen, H.1
Halazonetis, T.D.2
-
49
-
-
70349335444
-
Form and flexibility in phosphoinositide 3-kinases
-
R Williams, A Berndt, S Miller, WC Hon, X Zhang: Form and flexibility in phosphoinositide 3-kinases. Biochem Soc Trans 37, 615-26 (2009)
-
(2009)
Biochem Soc Trans
, vol.37
, pp. 615-626
-
-
Williams, R.1
Berndt, A.2
Miller, S.3
Hon, W.C.4
Zhang, X.5
-
50
-
-
58149395054
-
Phosphoinositide 3-kinases in cell migration
-
RJ Cain, AJ Ridley: Phosphoinositide 3-kinases in cell migration. Biol Cell 101, 13-29 (2009)
-
(2009)
Biol Cell
, vol.101
, pp. 13-29
-
-
Cain, R.J.1
Ridley, A.J.2
-
51
-
-
0032590011
-
PlK3CA is implicated as an oncogene in ovarian cancer
-
DOI 10.1038/5042
-
L Shayesteh, Y Lu, WL Kuo, R Baldocchi, T Godfrey, C Collins, D Pinkel, B Powell, GB Mills, JW Gray: PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 21, 99-102 (1999) (Pubitemid 29036292)
-
(1999)
Nature Genetics
, vol.21
, Issue.1
, pp. 99-102
-
-
Shayesteh, L.1
Lu, Y.2
Kuo, W.-L.3
Baldocchi, R.4
Godfrey, T.5
Collins, C.6
Pinkel, D.7
Powell, B.8
Mills, G.B.9
Gray, J.W.10
-
52
-
-
34347370829
-
Cancer-specific mutations in phosphatidylinositol 3-kinase
-
DOI 10.1016/j.tibs.2007.05.005, PII S0968000407001429
-
PK Vogt, S Kang, MA Elsliger, M Gymnopoulos: Cancer-specific mutations in phosphatidylinositol 3-kinase. Trends Biochem Sci 32, 342-9 (2007) (Pubitemid 47021415)
-
(2007)
Trends in Biochemical Sciences
, vol.32
, Issue.7
, pp. 342-349
-
-
Vogt, P.K.1
Kang, S.2
Elsliger, M.-A.3
Gymnopoulos, M.4
-
53
-
-
62449130185
-
Knockin of mutant PIK3CA activates multiple oncogenic pathways
-
JP Gustin, B Karakas, MB Weiss, AM Abukhdeir, J Lauring, JP Garay, D Cosgrove, A Tamaki, H Konishi, Y Konishi, M Mohseni, G Wang, DM Rosen, SR Denmeade, MJ Higgins, MI Vitolo, KE Bachman, BH Park: Knockin of mutant PIK3CA activates multiple oncogenic pathways. Proc Natl Acad Sci U S A 106, 2835-40 (2009)
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 2835-2840
-
-
Gustin, J.P.1
Karakas, B.2
Weiss, M.B.3
Abukhdeir, A.M.4
Lauring, J.5
Garay, J.P.6
Cosgrove, D.7
Tamaki, A.8
Konishi, H.9
Konishi, Y.10
Mohseni, M.11
Wang, G.12
Rosen, D.M.13
Denmeade, S.R.14
Higgins, M.J.15
Vitolo, M.I.16
Bachman, K.E.17
Park, B.H.18
-
54
-
-
67649382929
-
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer
-
KM Vasudevan, DA Barbie, MA Davies, R Rabinovsky, CJ McNear, JJ Kim, BT Hennessy, H Tseng, P Pochanard, SY Kim, IF Dunn, AC Schinzel, P Sandy, S Hoersch, Q Sheng, PB Gupta, JS Boehm, JH Reiling, S Silver, Y Lu, K Stemke-Hale, B Dutta, C Joy, AA Sahin, AM Gonzalez-Angulo, A Lluch, LE Rameh, T Jacks, DE Root, ES Lander, GB Mills, WC Hahn, WR Sellers, LA Garraway: AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell 16, 21-32 (2009)
-
(2009)
Cancer Cell
, vol.16
, pp. 21-32
-
-
Vasudevan, K.M.1
Barbie, D.A.2
Davies, M.3
Rabinovsky, R.4
McNear, C.J.5
Kim, J.J.6
Hennessy, B.T.7
Tseng, H.8
Pochanard, P.9
Kim, S.Y.10
Dunn, I.F.11
Schinzel, A.C.12
Sandy, P.13
Hoersch, S.14
Sheng, Q.15
Gupta, P.B.16
Boehm, J.S.17
Reiling, J.H.18
Silver, S.19
Lu, Y.20
Stemke-Hale, K.21
Dutta, B.22
Joy, C.23
Sahin, A.A.24
Gonzalez-Angulo, A.M.25
Lluch, A.26
Rameh, L.E.27
Jacks, T.28
De Root29
Lander, E.S.30
Mills, G.B.31
Hahn, W.C.32
Sellers, W.R.33
Garraway, L.A.34
more..
-
55
-
-
0031001041
-
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta
-
DM Li, H Sun: TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res 57, 2124-9 (1997) (Pubitemid 27247025)
-
(1997)
Cancer Research
, vol.57
, Issue.11
, pp. 2124-2129
-
-
Li, D.-M.1
Sun, H.2
-
56
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
DOI 10.1126/science.275.5308.1943
-
J Li, C Yen, D Liaw, K Podsypanina, S Bose, SI Wang, J Puc, C Miliaresis, L Rodgers, R McCombie, SH Bigner, BC Giovanella, M Ittmann, B Tycko, H Hibshoosh, MH Wigler, R Parsons: PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275,1943-7(1997) (Pubitemid 27148818)
-
(1997)
Science
, vol.275
, Issue.5308
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
Bigner, S.H.11
Giovanella, B.C.12
Ittmann, M.13
Tycko, B.14
Hibshoosh, H.15
Wigler, M.H.16
Parsons, R.17
-
57
-
-
17144436629
-
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
-
DOI 10.1038/ng0497-356
-
PA Steck, MA Pershouse, SA Jasser, WK Yung, H Lin, AH Ligon, LA Langford, ML Baumgard, T Hattier, T Davis, C Frye, R Hu, B Swedlund, DH Teng, SV Tavtigian: Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15, 356-62 (1997) (Pubitemid 27147102)
-
(1997)
Nature Genetics
, vol.15
, Issue.4
, pp. 356-362
-
-
Steck, P.A.1
Pershouse, M.A.2
Jasser, S.A.3
Yung, W.K.A.4
Lin, H.5
Ligon, A.H.6
Langford, L.A.7
Baumgard, M.L.8
Hattier, T.9
Davis, T.10
Frye, C.11
Hu, R.12
Swedlund, B.13
Teng, D.H.F.14
Tavtigian, S.V.15
-
58
-
-
0033551070
-
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
-
DOI 10.1073/pnas.96.8.4240
-
LC Cantley, BG Neel: New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A 96, 4240-5 (1999) (Pubitemid 29190320)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.8
, pp. 4240-4245
-
-
Cantley, L.C.1
Neel, B.G.2
-
59
-
-
0033957661
-
The PTEN tumor suppressor protein: An antagonist of phosphoinositide 3-kinase signaling
-
M21-35
-
F Vazquez, WR Sellers: The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling. Biochim Biophys Acta 1470, M21-35 (2000)
-
(2000)
Biochim Biophys Acta
, vol.1470
-
-
Vazquez, F.1
Sellers, W.R.2
-
60
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
DOI 10.1074/jbc.273.22.13375
-
T Maehama, JE Dixon: The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273, 13375-8 (1998) (Pubitemid 28268370)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.22
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
61
-
-
0032475861
-
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
-
DOI 10.1016/S0092-8674(00)81780-8
-
V Stambolic, A Suzuki, JL de la Pompa, GM Brothers, C Mirtsos, T Sasaki, J Ruland, JM Penninger, DP Siderovski, TW Mak: Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95, 29-39 (1998) (Pubitemid 28458022)
-
(1998)
Cell
, vol.95
, Issue.1
, pp. 29-39
-
-
Stambolic, V.1
Suzuki, A.2
De La Pompa, J.L.3
Brothers, G.M.4
Mirtsos, C.5
Sasaki, T.6
Ruland, J.7
Penninger, J.M.8
Siderovski, D.P.9
Mak, T.W.10
-
62
-
-
13044305289
-
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway
-
DOI 10.1073/pnas.96.11.6199
-
H Sun, R Lesche, DM Li, J Liliental, H Zhang, J Gao, N Gavrilova, B Mueller, X Li, H Wu: PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A 96, 6199-204 (1999) (Pubitemid 29256643)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.11
, pp. 6199-6204
-
-
Sun, H.1
Lesche, R.2
Li, D.-M.3
Liliental, J.4
Zhang, H.5
Gao, J.6
Gavrilova, N.7
Mueller, B.8
Liu, X.9
Wu, H.10
-
63
-
-
0034681264
-
The multiple roles of PTEN in tumor suppression
-
A Di Cristofano and PP Pandolfi: The multiple roles of PTEN in tumor suppression. Cell 100, 387-90 (2000)
-
(2000)
Cell
, vol.100
, pp. 387-390
-
-
Di Cristofano, A.1
Pandolfi, P.P.2
-
64
-
-
70350238781
-
PTEN hamartoma tumor syndrome: An overview
-
JA Hobert, C Eng: PTEN hamartoma tumor syndrome: an overview. Genet Med 11, 687-94 (2009)
-
(2009)
Genet Med
, vol.11
, pp. 687-694
-
-
Hobert, J.A.1
Eng, C.2
-
65
-
-
77951568703
-
Phosphoinositide signalling in cancer: Beyond PI3K and PTEN
-
TD Bunney, M Katan: Phosphoinositide signalling in cancer: beyond PI3K and PTEN. Nat Rev Cancer 10, 342-52 (2010)
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 342-352
-
-
Bunney, T.D.1
Katan, M.2
-
66
-
-
34547524771
-
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
-
DOI 10.1053/j.gastro.2007.05.022, PII S0016508507010025
-
F Meng, R Henson, H Wehbe-Janek, K Ghoshal, ST Jacob, T Patel: MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133, 647-58 (2007) (Pubitemid 47187346)
-
(2007)
Gastroenterology
, vol.133
, Issue.2
, pp. 647-658
-
-
Meng, F.1
Henson, R.2
Wehbe-Janek, H.3
Ghoshal, K.4
Jacob, S.T.5
Patel, T.6
-
67
-
-
78149295998
-
Oncogenic role of NEDD4-1, a PTENnegative regulator, in non small lung carcinomas (NSCLC)
-
In press
-
N Amodio, M Scrima, L Palaia, A Naeem Salman, A Quintiero, R Franco, G Botti, P Pirozzi, G Rocco, N De Rosa, G Viglietto: Oncogenic role of NEDD4-1, a PTENnegative regulator, in non small lung carcinomas (NSCLC). Am J Pathol. In press (2010)
-
(2010)
Am J Pathol.
-
-
Amodio, N.1
Scrima, M.2
Palaia, L.3
Naeem Salman, A.4
Quintiero, A.5
Franco, R.6
Botti, G.7
Pirozzi, P.8
Rocco, G.9
De Rosa, N.10
Viglietto, G.11
-
68
-
-
0031870959
-
Pten is essential for embryonic development and tumour suppression
-
DOI 10.1038/1235
-
A Di Cristofano, B Pesce, C Cordon-Cardo, PP Pandolfi: Pten is essential for embryonic development and tumour suppression. Nat Genet 19, 348-55 (1998) (Pubitemid 28357906)
-
(1998)
Nature Genetics
, vol.19
, Issue.4
, pp. 348-355
-
-
Di Cristofano, A.1
Pesce, B.2
Cordon-Cardo, C.3
Pandolfi, P.P.4
-
69
-
-
13044250465
-
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
-
DOI 10.1073/pnas.96.4.1563
-
K Podsypanina, LH Ellenson, A Nemes, J Gu, M Tamura, KM Yamada, C Cordon-Cardo, G Catoretti, PE Fisher, R Parsons: Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci U S A 96, 1563-8 (1999) (Pubitemid 29098491)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.4
, pp. 1563-1568
-
-
Podsypanina, K.1
Ellenson, L.H.2
Nemes, A.3
Gu, J.4
Tamura, M.5
Yamada, K.M.6
Cordon-Cardo, C.7
Catoretti, G.8
Fisher, P.E.9
Parsons, R.10
-
70
-
-
13144249184
-
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
-
A Suzuki, JL de la Pompa, V Stambolic, AJ Elia, T Sasaki, I del Barco Barrantes, A Ho, A Wakeham, A Itie, W Khoo, M Fukumoto, TW Mak: High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol 8, 1169-78 (1998) (Pubitemid 28494715)
-
(1998)
Current Biology
, vol.8
, Issue.21
, pp. 1169-1178
-
-
Suzuki, A.1
De La Pompa, J.L.2
Stambolic, V.3
Elia, A.J.4
Sasaki, T.5
Del Barco Barrantes, I.6
Ho, A.7
Wakeham, A.8
Itie, A.9
Khoo, W.10
Fukumoto, M.11
Mak, T.W.12
-
71
-
-
0034234268
-
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten(+/-) mice
-
V Stambolic, MS Tsao, D Macpherson, A Suzuki, WB Chapman, TW Mak: High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/-mice. Cancer Res 60, 3605-11 (2000) (Pubitemid 30482183)
-
(2000)
Cancer Research
, vol.60
, Issue.13
, pp. 3605-3611
-
-
Stambolic, V.1
Tsao, M.-S.2
Macpherson, D.3
Suzuki, A.4
Chapman, W.B.5
Mak, T.W.6
-
73
-
-
65949117244
-
Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo
-
KA Miller, N Yeager, K Baker, XH Liao, S Refetoff, A Di Cristofano: Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo. Cancer Res 69, 3689-94 (2009)
-
(2009)
Cancer Res
, vol.69
, pp. 3689-3694
-
-
Miller, K.A.1
Yeager K Baker, N.2
Liao, X.H.3
Refetoff, S.4
Di Cristofano, A.5
-
74
-
-
0038413837
-
Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarcinoma
-
DOI 10.1200/JCO.2003.08.040
-
SJ Cohen, L Ho, S Ranganathan, JL Abbruzzese, RK Alpaugh, M Beard, NL Lewis, S McLaughlin, A Rogatko, JJ Perez-Ruixo, AM Thistle, T Verhaeghe, H Wang, LM Weiner, JJ Wright, GR Hudes, NJ Meropol: Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarcinoma. J Clin Oncol 21, 1301-6 (2003) (Pubitemid 46606407)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.7
, pp. 1301-1306
-
-
Cohen, S.J.1
Ho, L.2
Ranganathan, S.3
Abbruzzese, J.L.4
Alpaugh, R.K.5
Beard, M.6
Lewis, N.L.7
McLaughlin, S.8
Rogatko, A.9
Perez-Ruixo, J.J.10
Thistle, A.M.11
Verhaeghe, T.12
Wang, H.13
Weiner, L.M.14
Wright, J.J.15
Hudes, G.R.16
Meropol, N.J.17
-
75
-
-
36849031817
-
Selective growth inhibition in BRAF mutant thyroid cancer by the mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244
-
DOI 10.1210/jc.2007-1184
-
DW Ball, N Jin, DM Rosen, A Dackiw, D Sidransky, M Xing, BD Nelkin: Selective growth inhibition in BRAF mutant thyroid cancer by the mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244. J Clin Endocrinol Metab 92, 4712-8 (2007) (Pubitemid 350223448)
-
(2007)
Journal of Clinical Endocrinology and Metabolism
, vol.92
, Issue.12
, pp. 4712-4718
-
-
Ball, D.W.1
Jin, N.2
Rosen, D.M.3
Dackiw, A.4
Sidransky, D.5
Xing, M.6
Nelkin, B.D.7
-
76
-
-
0026661582
-
Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors
-
JE Dumont, F Lamy, P Roger, C Maenhaut: Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors. Physiol Rev 72, 667-697 (1992)
-
(1992)
Physiol Rev
, vol.72
, pp. 667-697
-
-
Dumont, J.E.1
Lamy, F.2
Roger, P.3
Maenhaut, C.4
-
77
-
-
0031768915
-
Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid
-
DOI 10.1210/en.139.3.852
-
K Tanaka, Y Nagayama, T Nakano, N Takamura, H Namba, S Fukada, K Kuma, S Yamashita, M Niwa: Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid. Endocrinology 139, 852-8 (1998) (Pubitemid 28510098)
-
(1998)
Endocrinology
, vol.139
, Issue.3
, pp. 852-858
-
-
Tanaka, K.1
Nagayama, Y.2
Nakano, T.3
Takamura, N.4
Namba, H.5
Fukada, S.6
Kuma, K.7
Yamashita, S.8
Niwa, M.9
-
78
-
-
0028287063
-
Autocrine growth factors produced in the thyroid
-
DOI 10.1016/0303-7207(94)90286-0
-
MC Eggo, MC Sheppard: Autocrine growth factors produced in the thyroid. Mol Cell Endocrinol 100, 97-102 (1994) (Pubitemid 24109534)
-
(1994)
Molecular and Cellular Endocrinology
, vol.100
, Issue.1-2
, pp. 97-102
-
-
Eggo, M.C.1
Sheppard, M.C.2
-
79
-
-
0028925355
-
Expression of growth factors and growth factor receptors in normal and tumorous human thyroid tissues
-
BF Van der Laan, JL Freeman, SL Asa: Expression of growth factors and growth factor receptors in normal and tumorous human thyroid tissues. Thyroid 5, 67-73 (1995)
-
(1995)
Thyroid
, vol.5
, pp. 67-73
-
-
Van Der Laan, B.F.1
Freeman, J.L.2
Asa, S.L.3
-
81
-
-
0032974382
-
Insulin and TSH promote growth in size of PC Cl3 rat thyroid cells, possibly via a pathway different from DNA synthesis: Comparison with FRTL-5 cells
-
DOI 10.1530/eje.0.1400094
-
T Kimura, JE Dumont, A Fusco, J Golstein: Insulin and TSH promote growth in size of PC Cl3 rat thyroid cells, possibly via a pathway different from DNA synthesis: comparison with FRTL-5 cells. Eur J Endocrinol 140, 94-103 (1999) (Pubitemid 29074774)
-
(1999)
European Journal of Endocrinology
, vol.140
, Issue.1
, pp. 94-103
-
-
Kimura, T.1
Dumont, J.E.2
Fusco, A.3
Golstein, J.4
-
82
-
-
0028334583
-
Mitogenic, dedifferentiating, and scattering effects of hepatocyte growth factor on dog thyroid cells
-
DOI 10.1210/en.135.1.135
-
S Dremier, M Taton, K Coulonval, T Nakamura, K Matsumoto, JE Dumont: Mitogenic, dedifferentiating, and scattering effects of hepatocyte growth factor on dog thyroid cells. Endocrinology 135, 135-140 (1994) (Pubitemid 24203809)
-
(1994)
Endocrinology
, vol.135
, Issue.1
, pp. 135-140
-
-
Dremier, S.1
Taton, M.2
Coulonval, K.3
Nakamura, T.4
Matsumoto, K.5
Dumont, J.E.6
-
83
-
-
0026763062
-
Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype
-
M Santoro, F Carlomagno, ID Hay, MA Herrmann, M Grieco, R Melillo, MA Pierotti, I Bongarzone, G Della Porta, N Berger, JL Peix, C Paulin, N Fabien, G Vecchio, RB Jenkins, A Fusco: Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype. J Clin Invest 89, 1517-22 (1992)
-
(1992)
J Clin Invest
, vol.89
, pp. 1517-1522
-
-
Santoro, M.1
Carlomagno, F.2
Hay, I.D.3
Herrmann, M.4
Grieco, M.5
Melillo, R.6
Pierotti, M.7
Bongarzone, I.8
Della Porta, G.9
Berger, N.10
Peix, J.L.11
Paulin, C.12
Fabien, N.13
Vecchio, G.14
Jenkins, R.B.15
Fusco, A.16
-
84
-
-
0030941779
-
Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children
-
YE Nikiforov, JM Rowland, KE Bove, H Monforte-Munoz, JA Fagin: Distinct pattern of ret oncogene rearrangements in morphological variants of radiationinduced and sporadic thyroid papillary carcinomas in children. Cancer Res 57, 1690-4 (1997) (Pubitemid 27199660)
-
(1997)
Cancer Research
, vol.57
, Issue.9
, pp. 1690-1694
-
-
Nikiforov, Y.E.1
Rowland, J.M.2
Bove, K.E.3
Monforte-Munoz, H.4
Fagin, J.A.5
-
85
-
-
0034453001
-
The ret/PTC mutations are common in sporadic papillary thyroid carcinoma of children and young adults
-
DOI 10.1210/jc.85.3.1170
-
CL Fenton, Y Lukes, D Nicholson, CA Dinauer, GL Francis, RM Tuttle: The ret/PTC mutations are common in sporadic papillary thyroid carcinoma of children and young adults. J Clin Endocrinol Metab 85, 1170-5 (2000) (Pubitemid 32269367)
-
(2000)
Journal of Clinical Endocrinology and Metabolism
, vol.85
, Issue.3
, pp. 1170-1175
-
-
Fenton, C.L.1
Lukes, Y.2
Nicholson, D.3
Dinauer, C.A.4
Francis, G.L.5
Tuttle, R.M.6
-
86
-
-
0031780414
-
Sporadic ret-rearranged papillary carcinoma of the thyroid: A subset of slow growing, less aggressive thyroid neoplasms?
-
DOI 10.1002/(SICI)1096-9896(199805)185:1<71::AID-PATH42>3.0.CO;2-S
-
P Soares, E Fonseca, D Wynford-Thomas, M Sobrinho-Simões: Sporadic ret-rearranged papillary carcinoma of the thyroid: a subset of slow growing, less aggressive thyroid neoplasms? J Pathol 18, 71-8 (1998) (Pubitemid 28266719)
-
(1998)
Journal of Pathology
, vol.185
, Issue.1
, pp. 71-78
-
-
Soares, P.1
Fonseca, E.2
Wynford-Thomas, D.3
Sobrinho-Simoes, M.4
-
87
-
-
0035837656
-
Chromosomal rearrangements in thyroid carcinomas: A recombination or death dilemma
-
DOI 10.1016/S0304-3835(01)00439-6, PII S0304383501004396
-
MA Pierotti: Chromosomal rearrangements in thyroid carcinomas: a recombination or death dilemma. Cancer Lett 166, 1-7 (2001) (Pubitemid 32274279)
-
(2001)
Cancer Letters
, vol.166
, Issue.1
, pp. 1-7
-
-
Pierotti, M.A.1
-
88
-
-
0031931662
-
RET/NTRK1 rearrangements in thyroid gland tumors of the papillary carcinoma family: Correlation with clinicopathological features
-
I Bongarzone, P Vigneri, L Mariani, P Collini, S Pilotti, MA Pierotti: RET/NTRK1 rearrangements in thyroid gland tumors of the papillary carcinoma family: correlation with clinicopathological features. Clin Cancer Res 4, 223-8 (1998) (Pubitemid 28062900)
-
(1998)
Clinical Cancer Research
, vol.4
, Issue.1
, pp. 223-228
-
-
Bongarzone, I.1
Vigneri, P.2
Mariani, L.3
Collini, P.4
Pilotti, S.5
Pierotti, M.A.6
-
89
-
-
5044234080
-
Chronic expression of RET/PTC 3 enhances basal and insulin-stimulated PI3 kinase/AKT signaling and increases IRS-2 expression in FRTL-5 thyroid cells
-
DOI 10.1002/mc.20042
-
E Miyagi, M Braga-Basaria, E Hardy, V Vasko, KD Burman, S Jhiang, M Saji, MD Ringel: Chronic expression of RET/PTC 3 enhances basal and insulin-stimulated PI3 kinase/AKT signaling and increases IRS-2 expression in FRTL-5 thyroid cells. Mol Carcinog 41, 98-107 (2004) (Pubitemid 39336759)
-
(2004)
Molecular Carcinogenesis
, vol.41
, Issue.2
, pp. 98-107
-
-
Miyagi, E.1
Braga-Basaria, M.2
Hardy, E.3
Vasko, V.4
Burman, K.D.5
Jhiang, S.6
Saji, M.7
Ringel, M.D.8
-
90
-
-
4344644698
-
Activation of the Hepatocyte Growth Factor (HGF)-Met system in papillary thyroid cancer: Biological effects of HGF in thyroid cancer cells depend on Met expression levels
-
DOI 10.1210/en.2003-1762
-
R Mineo, A Costantino, F Frasca, L Sciacca, S Russo, R Vigneri, A Belfiore: Activation of the hepatocyte growth factor (HGF)-Met system in papillary thyroid cancer: biological effects of HGF in thyroid cancer cells depend on Met expression levels. Endocrinology 145, 4355-65 (2004) (Pubitemid 39120585)
-
(2004)
Endocrinology
, vol.145
, Issue.9
, pp. 4355-4365
-
-
Mineo, R.1
Costantino, A.2
Frasca, F.3
Sciacca, L.4
Russo, S.5
Vigneri, R.6
Belfiore, A.7
-
91
-
-
0034729805
-
PTEN expression is reduced in a subset of sporadic thyroid carcinomas: Evidence that PTEN-growth suppressing activity in thyroid cancer cells is mediated by p27(kip1)
-
P Bruni, A Boccia, G Baldassarre, F Trapasso, M Santoro, G Chiappetta, A Fusco, G Viglietto: PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1. Oncogene 19, 3146-55 (2000) (Pubitemid 30455926)
-
(2000)
Oncogene
, vol.19
, Issue.28
, pp. 3146-3155
-
-
Bruni, P.1
Boccia, A.2
Baldassarre, G.3
Trapasso, F.4
Santoro, M.5
Chiappetta, G.6
Fusco, A.7
Viglietto, G.8
-
92
-
-
20044380158
-
kip1 expression and localization
-
ML Motti, D Califano, G Troncone, C De Marco, I Migliaccio, E Palmieri, L Pezzullo, L Palombini, A Fusco, G Viglietto: Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization. Am J Pathol 166, 737-49 (2005) (Pubitemid 40315631)
-
(2005)
American Journal of Pathology
, vol.166
, Issue.3
, pp. 737-749
-
-
Motti, M.L.1
Califano, D.2
Troncone, G.3
De Marco, C.4
Migliaccio, I.5
Palmieri, E.6
Pezzullo, L.7
Palombini, L.8
Fusco, A.9
Viglietto, G.10
-
93
-
-
28544452359
-
Mutation of the PIK3CA gene in anaplastic thyroid cancer
-
DOI 10.1158/0008-5472.CAN-04-4259
-
G García-Rostán, AM Costa, I Pereira-Castro, G Salvatore, R Hernandez, MJ Hermsem, A Herrero, A Fusco, J Cameselle-Teijeiro, M Santoro: Mutation of the PIK3CA gene in anaplastic thyroid cancer. Cancer Res 65, 10199-207 (2005) (Pubitemid 41743711)
-
(2005)
Cancer Research
, vol.65
, Issue.22
, pp. 10199-10207
-
-
Garcia-Rostan, G.1
Costa, A.M.2
Pereira-Castro, I.3
Salvatore, G.4
Hernandez, R.5
Hermsem, M.J.A.6
Herrero, A.7
Fusco, A.8
Cameselle-Teijeiro, J.9
Santoro, M.10
-
94
-
-
66349098309
-
Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1
-
JC Ricarte-Filho, M Ryder, DA Chitale, M Rivera, A Heguy, M Ladanyi, M Janakiraman, D Solit, JA Knauf, RM Tuttle, RA Ghossein, JA Fagin: Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1. Cancer Res 69, 4885-93 (2009)
-
(2009)
Cancer Res
, vol.69
, pp. 4885-4893
-
-
Ricarte-Filho, J.C.1
Ryder, M.2
Chitale, D.A.3
Rivera, M.4
Heguy, A.5
Ladanyi, M.6
Janakiraman, M.7
Solit, D.8
Knauf, J.A.9
Tuttle, R.M.10
Ghossein, R.A.11
Fagin, J.A.12
-
95
-
-
0037295455
-
Increased expression of phosphorylated p70S6 kinase and Akt in papillary thyroid cancer tissues
-
DOI 10.1507/endocrj.50.77
-
M Miyakawa, T Tsushima, H Murakami, K Wakai, O Isozaki, K Takano: Increased expression of phosphorylated p70S6 kinase and Akt in papillary thyroid cancer tissues. Endocr J 50, 77-83 (2003) (Pubitemid 36305850)
-
(2003)
Endocrine Journal
, vol.50
, Issue.1
, pp. 77-83
-
-
Miyakawa, M.1
Tsushima, T.2
Murakami, H.3
Wakai, K.4
Isozaki, O.5
Takano, K.6
-
96
-
-
39049169179
-
Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in a Middle Eastern population
-
DOI 10.1210/jc.2007-1717
-
J Abubaker, J Jehan, P Bavi, M Sultana, S Al-Harbi, M Ibrahim, A Al-Nuaim, M Ahmed, T Amin, M Al-Fehaily, O Al-Sanea, F Al-Dayel, S Uddin, KS Al-Kuraya: Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in a Middle Eastern population. J Clin Endocrinol Metab 93, 611-8 (2008) (Pubitemid 351240838)
-
(2008)
Journal of Clinical Endocrinology and Metabolism
, vol.93
, Issue.2
, pp. 611-618
-
-
Abubaker, J.1
Jehan, Z.2
Bavi, P.3
Sultana, M.4
Al-Harbi, S.5
Ibrahim, M.6
Al-Nuaim, A.7
Ahmed, M.8
Amin, T.9
Al-Fehaily, M.10
Al-Sanea, O.11
Al-Dayel, F.12
Uddin, S.13
Al-Kuraya, K.S.14
-
97
-
-
49249127826
-
Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers
-
Z Liu, P Hou, M Ji, H Guan, K Studeman, K Jensen, V Vasko, AK El-Naggar, M Xing: Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers. J Clin Endocrinol Metab 93, 3106-16 (2008)
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 3106-3116
-
-
Liu, Z.1
Hou, P.2
Ji, M.3
Guan, H.4
Studeman, K.5
Jensen, K.6
Vasko, V.7
El-Naggar, A.K.8
Xing, M.9
-
98
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
DOI 10.1038/nature05933, PII NATURE05933
-
JD Carpten, AL Faber, C Horn, GP Donoho, SL Briggs, CM Robbins, G Hostetter, S Boguslawski, TY Moses, S Savage, K Uhlik, A Lin, J Du, YW Qian, DJ Zeckner, G Tucker-Kellogg, J Touchman, K Patel, S Mousses, M Bittner, R Schevitz, MH Lai, KL Blanchard, JE Thomas: A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448, 439-44 (2007) (Pubitemid 47123510)
-
(2007)
Nature
, vol.448
, Issue.7152
, pp. 439-444
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
Donoho, G.P.4
Briggs, S.L.5
Robbins, C.M.6
Hostetter, G.7
Boguslawski, S.8
Moses, T.Y.9
Savage, S.10
Uhlik, M.11
Lin, A.12
Du, J.13
Qian, Y.-W.14
Zeckner, D.J.15
Tucker-Kellogg, G.16
Touchman, J.17
Patel, K.18
Mousses, S.19
Bittner, M.20
Schevitz, R.21
Lai, M.-H.T.22
Blanchard, K.L.23
Thomas, J.E.24
more..
-
99
-
-
53849132331
-
A novel AKT3 mutation in melanoma tumours and cell lines
-
MA Davies, K Stemke-Hale, C Tellez, CL Calderone, W Deng, VG Prieto, AJ Lazar, JE Gershenwald, GB Mills: A novel AKT3 mutation in melanoma tumours and cell lines. Br J Cancer 99, 1265-8 (2008)
-
(2008)
Br J Cancer
, vol.99
, pp. 1265-1268
-
-
Davies, M.1
Stemke-Hale, K.2
Tellez, C.3
Calderone, C.L.4
Deng, W.5
Prieto, V.G.6
Lazar, A.J.7
Gershenwald, J.E.8
Mills, G.B.9
-
100
-
-
41849132829
-
Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung
-
D Malanga, M Scrima, C De Marco, F Fabiani, N De Rosa, S De Gisi, N Malara, R Savino, G Rocco, G Chiappetta, R Franco, V Tirino, G Pirozzi, G Viglietto: Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung. Cell Cycle 7, 665-9 (2008) (Pubitemid 351499006)
-
(2008)
Cell Cycle
, vol.7
, Issue.5
, pp. 665-669
-
-
Malanga, D.1
Scrima, M.2
De Marco, C.3
Fabiani, F.4
De Rosa, N.5
De Gisi, S.6
Malara, N.7
Savino, R.8
Rocco, G.9
Chiappetta, G.10
Franco, R.11
Tirino, V.12
Pirozzi, G.13
Viglietto, G.14
-
101
-
-
52149086562
-
AKT1(E17K) in human solid tumours
-
FE Bleeker, L Felicioni, F Buttitta, S Lamba, L Cardone, M Rodolfo, A Scarpa, S Leenstra, M Frattini, M Barbareschi, MD Grammastro, MG Sciarrotta, C Zanon, A Marchetti, A Bardelli: AKT1(E17K) in human solid tumours. Oncogene 27, 5648-50 (2008)
-
(2008)
Oncogene
, vol.27
, pp. 5648-5650
-
-
Bleeker, F.E.1
Felicioni, L.2
Buttitta, F.3
Lamba, S.4
Cardone, L.5
Rodolfo, M.6
Scarpa, A.7
Leenstra, S.8
Frattini, M.9
Barbareschi, M.10
Grammastro, M.D.11
Sciarrotta, M.G.12
Zanon, C.13
Marchetti, A.14
Bardelli, A.15
-
102
-
-
67649868092
-
The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas
-
K Shoji, K Oda, S Nakagawa, S Hosokawa, G Nagae, Y Uehara, K Sone, Y Miyamoto, H Hiraike, O Hiraike-Wada, T Nei, K Kawana, H Kuramoto, H Aburatani, T Yano, Y Taketani: The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas. Br J Cancer 101, 145-8 (2009)
-
(2009)
Br J Cancer
, vol.101
, pp. 145-148
-
-
Shoji, K.1
Oda, K.2
Nakagawa, S.3
Hosokawa, S.4
Nagae, G.5
Uehara, Y.6
Sone, K.7
Miyamoto, Y.8
Hiraike, H.9
Hiraike-Wada, O.10
Nei, T.11
Kawana, K.12
Kuramoto, H.13
Aburatani, H.14
Yano, T.15
Taketani, Y.16
-
103
-
-
73849134249
-
AKT1 mutations in bladder cancer: Identification of a novel oncogenic mutation that can cooperate with E17K
-
JM Askham, F Platt, PA Chambers, H Snowden, CF Taylor, MA Knowles: AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can cooperate with E17K. Oncogene 29, 150-5 (2010)
-
(2010)
Oncogene
, vol.29
, pp. 150-155
-
-
Askham, J.M.1
Platt, F.2
Chambers, P.A.3
Snowden, H.4
Taylor, C.F.5
Knowles, M.6
-
104
-
-
77951586944
-
Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations
-
J Lauring, DP Cosgrove, S Fontana, JP Gustin, H Konishi, AM Abukhdeir, JP Garay, Mohseni, GM Wang, MJ Higgins, D Gorkin, M Reis, B Vogelstein, K Polyak, Cowherd, PJ Buckhaults, BH Park: Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations. Oncogene 29, 2337-2345 (2010)
-
(2010)
Oncogene
, vol.29
, pp. 2337-2345
-
-
Lauring, J.1
Cosgrove, D.P.2
Fontana, S.3
Gustin, J.P.4
Konishi, H.5
Abukhdeir, A.M.6
Garay, J.P.7
Mohseni8
Wang, G.M.9
Higgins, M.J.10
Gorkin, D.11
Reis, M.12
Vogelstein, B.13
Polyak, K.14
Cowherd15
Buckhaults, P.J.16
Park, B.H.17
-
105
-
-
23844446683
-
Uncommon mutation, but common amplifications, of the PIK3CA gene in thyroid tumors
-
DOI 10.1210/jc.2004-2281
-
G Wu, E Mambo, Z Guo, S Hu, X Huang, SM Gollin, B Trink, PW Ladenson, D Sidransky, M Xing: Uncommon mutation, but common amplifications, of the PIK3CA gene in thyroid tumors. J Clin Endocrinol Metab 90, 4688-93 (2005) (Pubitemid 41159359)
-
(2005)
Journal of Clinical Endocrinology and Metabolism
, vol.90
, Issue.8
, pp. 4688-4693
-
-
Wu, G.1
Mambo, E.2
Guo, Z.3
Hu, S.4
Huang, X.5
Gollin, S.M.6
Trink, B.7
Ladenson, P.W.8
Sidransky, D.9
Xing, M.10
-
106
-
-
33947284529
-
Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer
-
DOI 10.1158/1078-0432.CCR-06-1125
-
P Hou, D Liu, Y Shan, S Hu, K Studeman, S Condouris, Y Wang, A Trink, AK El-Naggar, G Tallini, V Vasko, M Xing: Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/Akt pathway in thyroid cancer. Clin Cancer Res 13, 1161-1170 (2007) (Pubitemid 46424056)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.4
, pp. 1161-1170
-
-
Hou, P.1
Liu, D.2
Shan, Y.3
Hu, S.4
Studeman, K.5
Condouris, S.6
Wang, Y.7
Trink, A.8
El-Naggar, A.K.9
Tallini, G.10
Vasko, V.11
Xing, M.12
-
107
-
-
34347251976
-
High prevalence and mutual exclusivity of genetic alterations in the phosphatidylinositol-3-kinase/Akt pathway in thyroid tumors
-
DOI 10.1210/jc.2006-2019
-
Y Wang, P Hou, H Yu, W Wang, M Ji, S Zhao, S Yan, X Sun, D Liu, B Shi, G Zhu, S Condouris, M Xing: High prevalence and mutual exclusivity of genetic alterations in the phosphatidylinositol-3-kinase/akt pathway in thyroid tumors. J Clin Endocrinol Metab 92, 2387-2390 (2007). (Pubitemid 46997152)
-
(2007)
Journal of Clinical Endocrinology and Metabolism
, vol.92
, Issue.6
, pp. 2387-2390
-
-
Wang, Y.1
Hou, P.2
Yu, H.3
Wang, W.4
Ji, M.5
Zhao, S.6
Yan, S.7
Sun, X.8
Liu, D.9
Shi, B.10
Zhu, G.11
Condouris, S.12
Xing, M.M.13
-
108
-
-
55549084534
-
Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3-kinase/AKT signaling pathway in thyroid tumors
-
P Hou, M Ji, M Xing: Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3-kinase/AKT signaling pathway in thyroid tumors. Cancer 113, 2440-7 (2008)
-
(2008)
Cancer
, vol.113
, pp. 2440-2447
-
-
Hou, P.1
Ji, M.2
Xing, M.3
-
109
-
-
38149115262
-
Phosphatidylinositol 3-kinase/akt and ras/rafmitogen-activated protein kinase pathway mutations in anaplastic thyroid cancer
-
L Santarpia, AK El-Naggar, GJ Cote, JN Myers, SI Sherman: Phosphatidylinositol 3-kinase/akt and ras/rafmitogen-activated protein kinase pathway mutations in anaplastic thyroid cancer. J Clin Endocrinol Metab 93, 278-84 (2008)
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 278-284
-
-
Santarpia, L.1
El-Naggar, A.K.2
Cote, G.J.3
Myers, J.N.4
Sherman, S.I.5
-
111
-
-
57349194139
-
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
-
JA Engelman, L Chen, X Tan, K Crosby, AR Guimaraes, R Upadhyay, M Maira, K McNamara, SA Perera, Y Song, LR Chirieac, R Kaur, A Lightbown, J Simendinger, T Li, RF Padera, C García-Echeverría, R Weissleder, U Mahmood, LC Cantley, KK Wong: Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 14, 1351-6 (2008)
-
(2008)
Nat Med
, vol.14
, pp. 1351-1356
-
-
Engelman, J.A.1
Chen, L.2
Tan, X.3
Crosby, K.4
Guimaraes, A.R.5
Upadhyay, R.6
Maira, M.7
McNamara, K.8
Perera, S.A.9
Song, Y.10
Chirieac, L.R.11
Kaur, R.12
Lightbown, A.13
Simendinger, J.14
Li, T.15
Padera, R.F.16
García-Echeverría, C.17
Weissleder, R.18
Mahmood, U.19
Cantley, L.C.20
Wong, K.K.21
more..
-
112
-
-
59349086663
-
Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation
-
S Liang, N Yang, Y Pan, S Deng, X Lin, X Yang, D Katsaros, KF Roby, TC Hamilton, DC Connolly, G Coukos, L Zhang: Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation. PLoS One 4, e4295 (2001)
-
(2001)
PLoS One
, vol.4
-
-
Liang, S.1
Yang, N.2
Pan, Y.3
Deng, S.4
Lin, X.5
Yang, X.6
Katsaros, D.7
Roby, K.F.8
Hamilton, T.C.9
Connolly, D.C.10
Coukos, G.11
Zhang, L.12
-
113
-
-
59149086040
-
PTEN deficiency accelerates tumour progression in a mouse model of thyroid cancer
-
CJ Guigon, L Zhao, MC Willingha, SY Cheng: PTEN deficiency accelerates tumour progression in a mouse model of thyroid cancer. Oncogene 28, 509-517 (2009)
-
(2009)
Oncogene
, vol.28
, pp. 509-517
-
-
Guigon, C.J.1
Zhao, L.2
Willingha, M.C.3
Cheng, S.Y.4
-
114
-
-
11144358645
-
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
-
DOI 10.1126/science.1096502
-
Y Samuels, Z Wang, A Bardelli, N Silliman, J Ptak, S Szabo, Y Yan, A Gazdar, SM Powell, GJ Riggins, JK Willson, S Markowitz, KW Kinzler, B Vogelstein, VE Velculescu: High frequency of mutations of the PIK3CA gene in human cancers. Science 304, 554 (2004) (Pubitemid 38541907)
-
(2004)
Science
, vol.304
, Issue.5670
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Yan, H.7
Gazdar, A.8
Powell, S.M.9
Riggins, G.J.10
Willson, J.K.V.11
Markowitz, S.12
Kinzler, K.W.13
Vogelstein, B.14
Velculescu, V.E.15
-
115
-
-
0031661833
-
Somatic mutations of the PTEN tumor suppressor gene in sporadic follicular thyroid tumors
-
DOI 10.1002/(SICI)1098-2264(199811)23:3<239::AID-GCC5>3.0.CO;2-2
-
N Halachmi, S Halachmi, E Evron, P Cairns, K Okami, M Saji, WH Westra, MA Zeiger, J Jen,D Sidransky: Somatic mutations of the PTEN tumor suppressor gene in sporadic follicular thyroid tumors. Genes Chromosomes Cancer 23, 239-43 (1998) (Pubitemid 28465640)
-
(1998)
Genes Chromosomes and Cancer
, vol.23
, Issue.3
, pp. 239-243
-
-
Halachmi, N.1
Halachmi, S.2
Evron, E.3
Cairns, P.4
Okami, K.5
Saji, M.6
Westra, W.H.7
Zeiger, M.A.8
Jen, J.9
Sidransky, D.10
-
116
-
-
0030730905
-
Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors
-
PL Dahia, DJ Marsh, Z Zheng, J Zedenius, P Komminoth, T Frisk, G Wallin, R Parsons, M Longy, C Larsson, C Eng: Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors. Cancer Res 57, 4710-3 (1997) (Pubitemid 27468972)
-
(1997)
Cancer Research
, vol.57
, Issue.21
, pp. 4710-4713
-
-
Dahia, P.L.M.1
Marsh, D.J.2
Zheng, Z.3
Zedenius, J.4
Komminoth, P.5
Frisk, T.6
Wallin, G.7
Parsons, R.8
Longy, M.9
Larsson, C.10
Eng, C.11
-
117
-
-
0032746790
-
Fine-structure deletion mapping of 10q22-24 identifies regions of loss of heterozygosity and suggests that sporadic follicular thyroid adenomas and follicular thyroid carcinomas develop along distinct neoplastic pathways
-
DOI 10.1002/(SICI)1098-2264(199912)26:4<322::AID-GCC6>3.0.CO;2-#
-
JJ Yeh, DJ Marsh, J Zedenius, T Dwight, L Delbridge, BG Robinson, C Eng: Fine-structure deletion mapping of 10q22-24 identifies regions of loss of heterozygosity and suggests that sporadic follicular thyroid adenomas and follicular thyroid carcinomas develop along distinct neoplastic pathways. Genes Chromosomes Cancer 26, 322-8 (1999) (Pubitemid 29529577)
-
(1999)
Genes Chromosomes and Cancer
, vol.26
, Issue.4
, pp. 322-328
-
-
Yeh, J.J.1
Marsh, D.J.2
Zedenius, J.3
Dwight, T.4
Delbridge, L.5
Robinson, B.G.6
Eng, C.7
-
118
-
-
0033843623
-
Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors
-
O Gimm, A Perren, LP Weng, DJ Marsh, JJ Yeh, U Ziebold, E Gil, R Hinze, L Delbridge, JA Lees, GL Mutter, BG Robinson, P Komminoth, H Dralle, C Eng: Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors. Am J Pathol 156, 1693-700 (2000) (Pubitemid 30646707)
-
(2000)
American Journal of Pathology
, vol.156
, Issue.5
, pp. 1693-1700
-
-
Gimm, O.1
Perren, A.2
Weng, L.-P.3
Marsh, D.J.4
Jen Jen Yeh5
Ziebold, U.6
Gil, E.7
Hinze, R.8
Delbridge, L.9
Lees, J.A.10
Mutter, G.L.11
Robinson, B.G.12
Komminoth, P.13
Dralle, H.14
Eng, C.15
-
119
-
-
0035869175
-
PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model
-
LP Weng, WM Smith, JL Brown, C Eng: PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model. Hum Mol Genet 10, 605-16 (2001) (Pubitemid 32229365)
-
(2001)
Human Molecular Genetics
, vol.10
, Issue.6
, pp. 605-616
-
-
Weng, L.-P.1
Smith, W.M.2
Brown, J.L.3
Eng, C.4
-
120
-
-
33644749218
-
PTEN promoter methylation in sporadic thyroid carcinomas
-
DOI 10.1089/thy.2006.16.17
-
F Alvarez-Nuñez, E Bussaglia, D Mauricio, J Ybarra, M Vilar, E Lerma, A de Leiva, X Matias-Guiu; Thyroid Neoplasia Study Group: PTEN promoter methylation in sporadic thyroid carcinomas. Thyroid 16, 17-23 (2006) (Pubitemid 43346499)
-
(2006)
Thyroid
, vol.16
, Issue.1
, pp. 17-23
-
-
Alvarez-Nunez, F.1
Bussaglia, E.2
Mauricio, D.3
Ybarra, J.4
Vilar, M.5
Lerma, E.6
De Leiva, A.7
Matias-Guiu, X.8
-
121
-
-
33747367221
-
CpG island methylation of tumor-related promoters occurs preferentially in undifferentiated carcinoma
-
U Schagdarsurengin, O Gimm, H Dralle, C Hoang-Vu, R Dammann: CpG island methylation of tumor-related promoters occurs preferentially in undifferentiated carcinoma. Thyroid 16(7), 633-42 (2006)
-
(2006)
Thyroid
, vol.16
, Issue.7
, pp. 633-642
-
-
Schagdarsurengin, U.1
Gimm, O.2
Dralle, H.3
Hoang-Vu, C.4
Dammann, R.5
-
122
-
-
0037564807
-
Specific pattern of RAS oncogene mutations in follicular thyroid tumors
-
V Vasko, M Ferrand, J Di Cristofaro, P Carayon, JF Henry, C de Micco: Specific pattern of RAS oncogene mutations in follicular thyroid tumors. J Clin Endocrinol Metab 88, 2745-52 (2003) (Pubitemid 36724451)
-
(2003)
Journal of Clinical Endocrinology and Metabolism
, vol.88
, Issue.6
, pp. 2745-2752
-
-
Vasko, V.1
Ferrand, M.2
Di Cristofaro, J.3
Carayon, P.4
Henry, J.F.5
De Micco, C.6
-
123
-
-
0034175984
-
Understanding ras: 'It ain't over 'til it's over'
-
DOI 10.1016/S0962-8924(00)01740-2, PII S0962892400017402
-
JM Shields, K Pruitt, A McFall, A Shaub, CJ Der: Understanding Ras: 'it ain't over 'til it's over'. Trends Cell Biol 10, 147-54 (2000) (Pubitemid 30171309)
-
(2000)
Trends in Cell Biology
, vol.10
, Issue.4
, pp. 147-154
-
-
Shields, J.M.1
Pruitt, K.2
McFall, A.3
Shaub, A.4
Der, C.J.5
-
124
-
-
0035504075
-
Enhanced sensitivity to apoptosis in Ras-transformed thyroid cells
-
DOI 10.1038/sj.onc.1204928
-
G Cheng, JL Meinkoth: Enhanced sensitivity to apoptosis in Ras-transformed thyroid cells. Oncogene 20, 7334-41 (2001) (Pubitemid 33078204)
-
(2001)
Oncogene
, vol.20
, Issue.50
, pp. 7334-7341
-
-
Cheng, G.1
Meinkoth, J.L.2
-
125
-
-
0034628416
-
RAS oncogene activation induces proliferation in normal human thyroid epithelial cells without loss of differentiation
-
V Gire and D Wynford-Thomas: RAS oncogene activation induces proliferation in normal human thyroid epithelial cells without loss of differentiation. Oncogene 9, 737-44 (2000) (Pubitemid 30107704)
-
(2000)
Oncogene
, vol.19
, Issue.6
, pp. 737-744
-
-
Gire, V.1
Wynford-Thomas, D.2
-
126
-
-
0034604041
-
PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS
-
V Gire, C Marshall, D Wynford-Thomas: PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS. Oncogene 19, 2269-76 (2000) (Pubitemid 30307202)
-
(2000)
Oncogene
, vol.19
, Issue.19
, pp. 2269-2276
-
-
Gire, V.1
Marshall, C.2
Wynford-Thomas, D.3
-
127
-
-
0035843142
-
The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: Evidence for a competition between Shc and IRS-1 for the binding to Ret
-
DOI 10.1038/sj.onc.1204049
-
RM Melillo, F Carlomagno, G De Vita, P Formisano, G Vecchio, A Fusco, M Billaud, M Santoro: The insulin receptor substrate (IRS)-1 recruits phosphatidylinositol 3-kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret. Oncogene 20, 209-18 (2001) (Pubitemid 32150266)
-
(2001)
Oncogene
, vol.20
, Issue.2
, pp. 209-218
-
-
Melillo, R.M.1
Carlomagno, F.2
De Vita, G.3
Formisano, P.4
Vecchio, G.5
Fusco, A.6
Billaud, M.7
Santoro, M.8
-
128
-
-
60549111185
-
XB130, a tissue-specific adaptor protein that couples the RET/PTC oncogenic kinase to PI 3-kinase pathway
-
M Lodyga, V De Falco, XH Bai, A Kapus, RM Melillo, M Santoro, M Liu: XB130, a tissue-specific adaptor protein that couples the RET/PTC oncogenic kinase to PI 3-kinase pathway. Oncogene 28, 937-49 (2009)
-
(2009)
Oncogene
, vol.28
, pp. 937-949
-
-
Lodyga, M.1
De Falco, V.2
Bai, X.H.3
Kapus, A.4
Melillo, R.M.5
Santoro, M.6
Liu, M.7
-
129
-
-
30544439694
-
RAI(ShcC/N-Shc)-dependent recruitment of GAB1 to RET oncoproteins potentiates PI3-K signalling in thyroid tumors
-
DOI 10.1038/sj.onc.1208776, PII 1208776
-
V De Falco, V Guarino, L Malorni, AM Cirafici, F Troglio, M Erreni, G Pelicci, M Santoro, RM Melillo: RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors. Oncogene 24, 6303-13 (2005) (Pubitemid 43080053)
-
(2005)
Oncogene
, vol.24
, Issue.41
, pp. 6303-6313
-
-
De Falco, V.1
Guarino, V.2
Malorni, L.3
Cirafici, A.M.4
Troglio, F.5
Erreni, M.6
Pelicci, G.7
Santoro, M.8
Melillo, R.M.9
-
130
-
-
12444299997
-
RET/PTC (rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): An alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1
-
DOI 10.1210/me.2002-0402
-
DW Kim, JH Hwang, JM Suh, H Kim, JH Song, ES Hwang, IY Hwang, KC Park, HK Chung, JM Kim, J Park, BA Hemmings, M Shong: RET/PTC (rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1. Mol Endocrinol 17, 1382-94 (2003) (Pubitemid 36819958)
-
(2003)
Molecular Endocrinology
, vol.17
, Issue.7
, pp. 1382-1394
-
-
Kim, D.W.1
Hwang, J.H.2
Suh, J.M.3
Kim, H.4
Song, J.H.5
Hwang, E.S.6
Hwang, I.Y.7
Park, K.C.8
Chung, H.K.9
Kim, J.M.10
Park, J.11
Hemmings, B.A.12
Shong, M.13
-
131
-
-
27644473154
-
Regulation of protein kinase B tyrosine phosphorylation by thyroid-specific oncogenic RET/PTC kinases
-
DOI 10.1210/me.2005-0122
-
HS Jung, DW Kim, YS Jo, HK Chung, JH Song, JS Park, KC Park, SH Park, JH Hwang, KW Jo, M. Shong: Regulation of protein kinase B tyrosine phosphorylation by thyroid-specific oncogenic RET/PTC kinases. Mol Endocrinol 19, 2748-59 (2005) (Pubitemid 41577247)
-
(2005)
Molecular Endocrinology
, vol.19
, Issue.11
, pp. 2748-2759
-
-
Hye, S.J.1
Dong, W.K.2
Young, S.J.3
Hyo, K.C.4
Jung, H.S.5
Jong, S.P.6
Ki, C.P.7
Su, H.P.8
Jung, H.H.9
Jo, K.-W.10
Shong, M.11
-
132
-
-
35349011718
-
Genome-wide expression analysis of Middle Eastern papillary thyroid cancer reveals c-MET as a novel target for cancer therapy
-
DOI 10.1002/path.2215
-
AK Siraj, P Bavi, J Abubaker, Z Jehan, M Sultana, F Al-Dayel, A Al-Nuaim, A Alzahrani, M Ahmed, O Al-Sanea, S Uddin, KS Al-Kuraya: Genome-wide expression analysis of Middle Eastern papillary thyroid cancer reveals c-MET as a novel target for cancer therapy. J Pathol 213, 190-9 (2007) (Pubitemid 47612241)
-
(2007)
Journal of Pathology
, vol.213
, Issue.2
, pp. 190-199
-
-
Siraj, A.K.1
Bavi, P.2
Abubaker, J.3
Jehan, Z.4
Sultana, M.5
Al-Dayel, F.6
Al-Nuaim, A.7
Alzahrani, A.8
Ahmed, M.9
Al-Sanea, O.10
Uddin, S.11
Al-Kuraya, K.S.12
-
133
-
-
0031470652
-
The structural basis for 14-3-3:phosphopeptide binding specificity
-
DOI 10.1016/S0092-8674(00)80487-0
-
MB Yaffe, K Rittinger, S Volinia, PR Caron, A Aitken, H Leffers, SJ Gamblin, SJ Smerdon, LCCantley: The structural basis for 14-3-3:phosphopeptide binding specificity. Cell 91, 961-71 (1997) (Pubitemid 28027829)
-
(1997)
Cell
, vol.91
, Issue.7
, pp. 961-971
-
-
Yaffe, M.B.1
Rittinger, K.2
Volinia, S.3
Caron, P.R.4
Aitken, A.5
Leffers, H.6
Gamblin, S.J.7
Smerdon, S.J.8
Cantley, L.C.9
-
134
-
-
32044465506
-
TOR signaling in growth and metabolism
-
DOI 10.1016/j.cell.2006.01.016, PII S0092867406001085
-
S Wullschleger, R Loewith, MN Hall: TOR signaling in growth and metabolism. Cell 124, 471-84 (2006) (Pubitemid 43199434)
-
(2006)
Cell
, vol.124
, Issue.3
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
135
-
-
27844515097
-
The Akt of translational control
-
DOI 10.1038/sj.onc.1209098, PII 1209098
-
D Ruggero, N Sonenberg: The Akt of translational control. Oncogene 24, 7426-34 (2005) (Pubitemid 41637982)
-
(2005)
Oncogene
, vol.24
, Issue.50
, pp. 7426-7434
-
-
Ruggero, D.1
Sonenberg, N.2
-
136
-
-
2942518250
-
Lost in translation: Dysregulation of cap-dependent translation and cancer
-
DOI 10.1016/j.ccr.2004.05.027, PII S1535610804001497
-
MA Bjornsti, PJ Houghton: Lost in translation: dysregulation of cap-dependent translation and cancer. Cancer Cell 5,519-23 (2004) (Pubitemid 38748913)
-
(2004)
Cancer Cell
, vol.5
, Issue.6
, pp. 519-523
-
-
Bjornsti, M.-A.1
Houghton, P.J.2
-
137
-
-
0037363075
-
Does the ribosome translate cancer?
-
DOI 10.1038/nrc1015
-
D Ruggero, PP Pandolfi: Does the ribosome translate cancer? Nat Rev Cancer 3, 179-92 (2003) (Pubitemid 37328870)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.3
, pp. 179-192
-
-
Ruggero, D.1
Pandolfi, P.P.2
-
138
-
-
27844526600
-
Akt-dependent transformation: There is more to growth than just surviving
-
DOI 10.1038/sj.onc.1209097, PII 1209097
-
DR Plas, CB Thompson: Akt-dependent transformation: there is more to growth than just surviving. Oncogene 24, 7435-42 (2005) (Pubitemid 41637983)
-
(2005)
Oncogene
, vol.24
, Issue.50
, pp. 7435-7442
-
-
Plas, D.R.1
Thompson, C.B.2
-
139
-
-
36148962868
-
Role of mTOR in solid tumor systems: A therapeutical target against primary tumor growth, metastases, and angiogenesis
-
DOI 10.1007/s10555-007-9077-8, Forty Years of Metastasis Research: A Tribute to Dr. Isaiah J. Fidler
-
H Seeliger, M Guba, A Kleespies, KW Jauch, CJ Bruns: Role of mTOR in solid tumor systems: a therapeutical target against primary tumor growth, metastases, and angiogenesis. Cancer Metastasis Rev 26, 611-21 (2007) (Pubitemid 350115107)
-
(2007)
Cancer and Metastasis Reviews
, vol.26
, Issue.3-4
, pp. 611-621
-
-
Seeliger, H.1
Guba, M.2
Kleespies, A.3
Jauch, K.-W.4
Bruns, C.J.5
-
140
-
-
27844562649
-
Tuberous sclerosis complex: Linking growth and energy signaling pathways with human disease
-
DOI 10.1038/sj.onc.1209090, PII 1209090
-
A Astrinidis, EP Henske: Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease. Oncogene 24, 7475-81 (2005) (Pubitemid 41637987)
-
(2005)
Oncogene
, vol.24
, Issue.50
, pp. 7475-7481
-
-
Astrinidis, A.1
Henske, E.P.2
-
141
-
-
34250619165
-
The mammalian target of rapamycin signaling pathway: Twists and turns in the road to cancer therapy
-
DOI 10.1158/1078-0432.CCR-06-2798
-
RT Abraham, JJ Gibbons: The mammalian target of rapamycin signaling pathway: twists and turns in the road to cancer therapy. Clin Cancer Res 13, 3109-14 (2007) (Pubitemid 46944891)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.11
, pp. 3109-3114
-
-
Abraham, R.T.1
Gibbons, J.J.2
-
142
-
-
34347220473
-
Defining the Role of mTOR in Cancer
-
DOI 10.1016/j.ccr.2007.05.008, PII S1535610807001511
-
DA Guertin, DM Sabatini: Defining the role of mTOR in cancer. Cancer Cell 12, 9-22 (2007) (Pubitemid 47001784)
-
(2007)
Cancer Cell
, vol.12
, Issue.1
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
143
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
DD Sarbassov, SM Ali, S Sengupta, JH Sheen, PP Hsu, AF Bagley, AL Markhard, DM Sabatini: Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 22, 159-68 (2006)
-
(2006)
Mol Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
144
-
-
34548580330
-
Thyroid-stimulating hormone-initiated proliferative signals converge in vivo on the mTOR kinase without activating AKT
-
DOI 10.1158/0008-5472.CAN-07-2471
-
C Brewer, N Yeager, A Di Cristofano: Thyroidstimulating hormone initiated proliferative signals converge in vivo on the mTOR kinase without activating AKT. Cancer Res 67, 8002-6 (2007) (Pubitemid 47395133)
-
(2007)
Cancer Research
, vol.67
, Issue.17
, pp. 8002-8006
-
-
Brewer, C.1
Yeager, N.2
Di Cristofano, A.3
-
145
-
-
33748756497
-
AKT-independent phosphorylation of TSC2 and activation of mTOR and ribosomal protein S6 kinase signaling by prostaglandin F2α
-
DOI 10.1074/jbc.M605371200
-
EW Arvisais, A Romanelli, X Hou, JS Davis: Tindependent phosphorylation of TSC2 and activation of mTOR and ribosomal protein S6 kinase signaling by prostaglandin F2{alpha}. J Biol Chem 281, 26904-13 (2006) (Pubitemid 44401719)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.37
, pp. 26904-26913
-
-
Arvisais, E.W.1
Romanelli, A.2
Hou, X.3
Davis, J.S.4
-
146
-
-
24744435392
-
Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase, insulin growth factor-1, and serum
-
DOI 10.1158/0008-5472.CAN-04-4180
-
P Wlodarski, M Kasprzycka, X Liu, M Marzec, ES Robertson, A Slupianek, MA Wasik: Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular signalregulated kinase kinase, insulin growth factor-I, and serum. Cancer Res 65, 7800-8 (2005) (Pubitemid 41297255)
-
(2005)
Cancer Research
, vol.65
, Issue.17
, pp. 7800-7808
-
-
Wlodarski, P.1
Kasprzycka, M.2
Liu, X.3
Marzec, M.4
Robertson, E.S.5
Slupianek, A.6
Wasik, M.A.7
-
147
-
-
21244486678
-
The mammalian target of rapamycin-p70 ribosomal S6 kinase but not phosphatidylinositol 3-kinase-Akt signaling is responsible for fibroblast growth factor-9-induced cell proliferation
-
LY Wing, HM Chen, PC Chuang, MH Wu, SJ Tsai: The mammalian target of rapamycin-p70 ribosomal S6 kinase but not phosphatidylinositol 3-kinase-Akt signaling is responsible for fibroblast growth factor-9-induced cell proliferation. J Biol Chem 280, 19937-47 (2005)
-
(2005)
J Biol Chem
, vol.280
, pp. 19937-19947
-
-
Wing, L.Y.1
Chen, H.M.2
Chuang, P.C.3
Wu, M.H.4
Tsai, S.J.5
-
148
-
-
77953857289
-
Mammaliam target of rapamycin (mTOR) down-regulates iodide uptake in thyrocytes
-
EC Souza, AS Figueiredo, WM Braga, BM Andrade, M Vaisman, LE Nasciutti, AC Ferreira, DP Carvalho: Mammaliam target of rapamycin (mTOR) down-regulates iodide uptake in thyrocytes. J Endocrinol 206, 113-20 (2010)
-
(2010)
J Endocrinol
, vol.206
, pp. 113-120
-
-
Souza, E.C.1
Figueiredo, A.S.2
Braga, W.M.3
Andrade, B.M.4
Vaisman, M.5
Nasciutti, L.E.6
Ferreira, A.C.7
Carvalho, D.P.8
-
149
-
-
39049086390
-
Mammalian target of rapamycin is the key effector of phosphatidylinositol- 3-OH-initiated proliferative signals in the thyroid follicular epithelium
-
DOI 10.1158/0008-5472.CAN-07-3030
-
N Yeager, C Brewer, KQ Cai, XX Xu, A Di Cristofano: Mammalian target of rapamycin is the key effector of phosphatidylinositol-3-OH-initiated proliferative signals in the thyroid follicular epithelium. Cancer Res, 68(2), 444-9 (2008) (Pubitemid 351380070)
-
(2008)
Cancer Research
, vol.68
, Issue.2
, pp. 444-449
-
-
Yeager, N.1
Brewer, C.2
Cai, K.Q.3
Xu, X.-X.4
Di Cristofano, A.5
-
150
-
-
36949013479
-
Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer
-
DOI 10.1093/carcin/bgm174
-
F Furuya, C Lu, MC Willingham, SY Cheng: Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer. Carcinogenesis 28, 2451-8 (2007) (Pubitemid 350238946)
-
(2007)
Carcinogenesis
, vol.28
, Issue.12
, pp. 2451-2458
-
-
Furuya, F.1
Lu, C.2
Willingham, M.C.3
Cheng, S.-Y.4
-
151
-
-
70349741010
-
Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin
-
D Liu, P Hou, Z Liu, G Wu, M Xing: Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin. Cancer Res 69, 7311-9 (2009)
-
(2009)
Cancer Res
, vol.69
, pp. 7311-7319
-
-
Liu, D.1
Hou, P.2
Liu, Z.3
Wu, G.4
Xing, M.5
-
152
-
-
70349909875
-
Dual inhibition of mitogen-activated protein kinase kinase and mammalian target of rapamycin in differentiated and anaplastic thyroid cancer
-
N Jin, T Jiang, DM Rosen, BD Nelkin, DW Ball: Dual inhibition of mitogen-activated protein kinase kinase and mammalian target of rapamycin in differentiated and anaplastic thyroid cancer. J Clin Endocrinol Metab 94, 4107-4112 (2009)
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 4107-4112
-
-
Jin, N.1
Jiang, T.2
Rosen, D.M.3
Nelkin, B.D.4
Ball, D.W.5
-
153
-
-
70350378811
-
Role of the novel mTOR inhibitor RAD001 (everolimus) in anaplastic thyroid cancer
-
C Papewalis, M Wuttke, S Schinner, HS Willenberg, AM Baran, WA Scherbaum, M Schott: Role of the novel mTOR inhibitor RAD001 (everolimus) in anaplastic thyroid cancer. Horm Metab Res 41, 752-6 (2009)
-
(2009)
Horm Metab Res
, vol.41
, pp. 752-756
-
-
Papewalis, C.1
Wuttke, M.2
Schinner, S.3
Willenberg, H.S.4
Baran, A.M.5
Scherbaum, W.A.6
Schott, M.7
-
154
-
-
0142117313
-
The Bcl-2 family: Roles in cell survival and oncogenesis
-
DOI 10.1038/sj.onc.1207102
-
S Cory, DC Huang, JM Adams: The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22, 8590-8607 (2003) (Pubitemid 38028528)
-
(2003)
Oncogene
, vol.22
, Issue.53 REV. ISS. 7
, pp. 8590-8607
-
-
Cory, S.1
Huang, D.C.S.2
Adams, J.M.3
-
155
-
-
0842281645
-
Cell death: Critical control points
-
DOI 10.1016/S0092-8674(04)00046-7
-
NN Danial, SJ Korsmeyer: Cell death: critical control points. Cell 116, 205-219 (2004) (Pubitemid 38167313)
-
(2004)
Cell
, vol.116
, Issue.2
, pp. 205-219
-
-
Danial, N.N.1
Korsmeyer, S.J.2
-
156
-
-
0033635235
-
14-3-3 proteins and survival kinasescooperate to inactivate BAD by BH3 domain phosphorylation
-
SR Datta, A Katsov, L Hu, A Petros, SW Fesik, MB Yaffe, ME Greenberg: 14-3-3 proteins and survival kinasescooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell 6, 41-51 (2000)
-
(2000)
Mol Cell
, vol.6
, pp. 41-51
-
-
Datta, S.R.1
Katsov, A.2
Hu, L.3
Petros, A.4
Fesik, S.W.5
Yaffe, M.B.6
Greenberg, M.E.7
-
157
-
-
1842333237
-
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
-
DOI 10.1126/science.278.5338.687
-
L del Peso, M González-García, C Page, R Herrera, G Nuñez: Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278, 687-9 (1997) (Pubitemid 27464966)
-
(1997)
Science
, vol.278
, Issue.5338
, pp. 687-689
-
-
Del Peso, L.1
Gonzalez-Garcia, M.2
Page, C.3
Herrera, R.4
Nunez, G.5
-
158
-
-
0032759047
-
Forkhead transcription factors: New insights into protein kinase B (c- akt) signaling
-
DOI 10.1007/s001099900050
-
GJ Kops, BM Burgering: Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling. J Mol Med 77, 656-65 (1999) (Pubitemid 29500958)
-
(1999)
Journal of Molecular Medicine
, vol.77
, Issue.9
, pp. 656-665
-
-
Kops, G.J.P.L.1
Burgering, B.M.T.2
-
159
-
-
0033560896
-
Direct control of the forkhead transcription faotor AFX by protein kinase B
-
DOI 10.1038/19328
-
GJ Kops, ND de Ruiter, AM De Vries-Smits, DR Powell, JL Bos, BM Burgering: Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398, 630-4 (1999) (Pubitemid 29183692)
-
(1999)
Nature
, vol.398
, Issue.6728
, pp. 630-634
-
-
Kops, G.J.P.L.1
De Ruiter, N.D.2
De Vries-Smits, A.M.M.3
Powell, D.R.4
Bos, J.L.5
Burgering, B.M.Th.6
-
160
-
-
0033595011
-
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
-
DOI 10.1073/pnas.96.13.7421
-
WH Biggs, J Meisenhelder, T Hunter, WK Cavenee, KC Arden: Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci U S A 96, 7421-6 (1999) (Pubitemid 29299677)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.13
, pp. 7421-7426
-
-
Biggs III, W.H.1
Meisenhelder, J.2
Hunter, T.3
Cavenee, W.K.4
Arden, K.C.5
-
161
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
-
A Brunet, A Bonni, MJ Zigmond, MZ Lin, P Juo, LS Hu, MJ Anderson, KC Arden, J Blenis, ME Greenberg: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-68 (1999) (Pubitemid 29165088)
-
(1999)
Cell
, vol.96
, Issue.6
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
162
-
-
0033546439
-
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
-
G Rena, S Guo, SC Cichy, TG Unterman, P Cohen: Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J Biol Chem 274, 17179-83 (1999)
-
(1999)
J Biol Chem
, vol.274
, pp. 17179-17183
-
-
Rena, G.1
Guo, S.2
Cichy, S.C.3
Unterman, T.G.4
Cohen, P.5
-
164
-
-
0034462121
-
Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN
-
DOI 10.1128/MCB.20.23.8969-8982.2000
-
N Nakamura, S Ramaswamy, F Vazquez, S Signoretti, M Loda, WR Sellers: Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol Cell Biol 20, 8969-82 (2000) (Pubitemid 32245927)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.23
, pp. 8969-8982
-
-
Nakamura, N.1
Ramaswamy, S.2
Vazquez, F.3
Signoretti, S.4
Loda, M.5
Sellers, W.R.6
-
165
-
-
0034643331
-
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27(kip1)
-
DOI 10.1038/35008115
-
RH Medema, GJ Kops, JL Bos, BM Burgering: AFXlike Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404, 782-7 (2000) (Pubitemid 30212408)
-
(2000)
Nature
, vol.404
, Issue.6779
, pp. 782-787
-
-
Medema, R.H.1
Kops, G.J.P.L.2
Bos, J.L.3
Burgering, B.M.T.4
-
166
-
-
0034609737
-
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
-
PF Dijkers, RH Medema, JW Lammers, L Koenderman, PJ Coffer: Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol 10, 1201-1204 (2000)
-
(2000)
Curr Biol
, vol.10
, pp. 1201-1204
-
-
Dijkers, P.F.1
Medema, R.H.2
Lammers, J.W.3
Koenderman, L.4
Coffer, P.J.5
-
167
-
-
0034660886
-
Akt/protein kinase B promotes survival and hormone-independent proliferation of thyroid cells in the absence of dedifferentiating and transforming effects
-
G De Vita, MT Berlingieri, R Visconti, MD Castellone, G Viglietto, G Baldassarre, M Zannini, A Bellacosa, PN Tsichlis, A Fusco, M Santoro: Akt/protein kinase B promotes survival and hormone-independent proliferation of thyroid cells in the absence of dedifferentiating and transforming effects. Cancer Res 60, 3916-20 (2000) (Pubitemid 32204587)
-
(2000)
Cancer Research
, vol.60
, Issue.14
, pp. 3916-3920
-
-
De Vita, G.1
Berlingieri, M.T.2
Visconti, R.3
Castellone, M.D.4
Viglietto, G.5
Baldassarre, G.6
Zannini, M.7
Bellacosa, A.8
Tsichlis, P.N.9
Fusco, A.10
Santoro, M.11
-
169
-
-
79959617444
-
HER-2/neu induces p53 ubiquitination via Aktmediated MDM2 phosphorylation
-
BP Zhou, Y Liao, W Xia, Y Zou, B Spohn, MC Hung: HER-2/neu induces p53 ubiquitination via Aktmediated MDM2 phosphorylation. Nat Cell Biol 4, 736 (2001)
-
(2001)
Nat Cell Biol
, vol.4
, pp. 736
-
-
Zhou, B.P.1
Liao, Y.2
Xia, W.3
Zou, Y.4
Spohn, B.5
Hung, M.C.6
-
170
-
-
0242410719
-
P53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
-
DOI 10.1126/science.1090072
-
A Villunger, EM Michalak, L Coultas, F Müllauer, G Böck, MJ Ausserlechner, JM Adams, A Strasser: p53-and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302, 1036-8 (2003) (Pubitemid 37386194)
-
(2003)
Science
, vol.302
, Issue.5647
, pp. 1036-1038
-
-
Villunger, A.1
Michalak, E.M.2
Coultas, L.3
Mullauer, F.4
Bock, G.5
Ausserlechner, M.J.6
Adams, J.M.7
Strasser, A.8
-
171
-
-
0033519453
-
Induction of NF-kappaB by the Akt/PKB kinase
-
LP Kane, VS Shapiro, D Stokoe, A Weiss: Induction of NF-kappaB by the Akt/PKB kinase. Curr Biol 9, 601-4 (1999)
-
(1999)
Curr Biol
, vol.9
, pp. 601-604
-
-
Kane, L.P.1
Shapiro, V.S.2
Stokoe, D.3
Weiss, A.4
-
172
-
-
0033517244
-
Akt is more than just a Bad kinase
-
A Khwaja: Akt is more than just a Bad kinase. Nature 401, 33-4 (1999)
-
(1999)
Nature
, vol.401
, pp. 33-34
-
-
Khwaja, A.1
-
173
-
-
0033517189
-
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
-
ON Ozes, LD Mayo, JA Gustin, SR Pfeffer, LM Pfeffer, DB Donner: NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401, 82-5 (1999)
-
(1999)
Nature
, vol.401
, pp. 82-85
-
-
Ozes, O.N.1
Mayo, L.D.2
Gustin, J.A.3
Pfeffer, S.R.4
Pfeffer, L.M.5
Donner, D.B.6
-
174
-
-
0033517190
-
NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
-
JA Romashkova, SS Makarov: NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 401, 86-90 (1999)
-
(1999)
Nature
, vol.401
, pp. 86-90
-
-
Romashkova, J.A.1
Makarov, S.S.2
-
175
-
-
0031897632
-
NF-κB and rel proteins: Evolutionarily conserved mediators of immune responses
-
DOI 10.1146/annurev.immunol.16.1.225
-
S Ghosh, MJ May, EB Kopp: NF-kB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16, 225-60 (1998) (Pubitemid 28183365)
-
(1998)
Annual Review of Immunology
, vol.16
, pp. 225-260
-
-
Ghosh, S.1
May, M.J.2
Kopp, E.B.3
-
176
-
-
0033002197
-
Bridging the gap: Composition, regulation, and physiological function of the IκB kinase complex
-
E Zandi, M Karin: Bridging the gap: composition, regulation, and physiological function of the IkB kinase complex. Mol Cell Biol 19, 4547-51 (1999) (Pubitemid 29289492)
-
(1999)
Molecular and Cellular Biology
, vol.19
, Issue.7
, pp. 4547-4551
-
-
Zandi, E.1
Karin, M.2
-
177
-
-
0033996762
-
The IκB kinase (IKK) and NF-κB: Key elements of proinflammatory signalling
-
DOI 10.1006/smim.2000.0210
-
M Karin, M Delhase: The IkB kinase (IKK) and NFkB: key elements of proinflammatory signalling. Semin Immunol 12, 85-98 (2000) (Pubitemid 30114019)
-
(2000)
Seminars in Immunology
, vol.12
, Issue.1
, pp. 85-98
-
-
Karin, M.1
Delhase, M.2
-
178
-
-
0032508414
-
NF-kB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
-
CY Wang, MW Mayo, RG Korneluk, DV Goeddel, AS Baldwin: NF-kB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281, 1680-3 (1998)
-
(1998)
Science
, vol.281
, pp. 1680-1683
-
-
Wang, C.Y.1
Mayo, M.W.2
Korneluk, R.G.3
Goeddel, D.V.4
Baldwin, A.S.5
-
179
-
-
0032516651
-
IEX-1L, an apoptosis inhibitor involved in NF-κB-mediated cell survival
-
MX Wu, Z Ao, KV Prasad, R Wu, SF Schlossman: IEX-1L, an apoptosis inhibitor involved in NF-kBmediated cell survival. Science 281, 998-1001 (1998) (Pubitemid 28399251)
-
(1998)
Science
, vol.281
, Issue.5379
, pp. 998-1001
-
-
Wu, M.X.1
Ao, Z.2
Prasad, K.V.S.3
Wu, R.4
Schlossman, S.F.5
-
180
-
-
18844465632
-
Constitutive nuclear factor-κb-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells
-
RC Bargou, F Emmerich, D Krappmann, K Bommert, MY Mapara, W Arnold, HD Royer, E Grinstein, A Greiner, C Scheidereit, B Dorken: Constitutive nuclear factor-kBRelA activation is required for proliferation and survival of Hodgkins disease tumor cells. J Clin Invest 100, 2961-9 (1997) (Pubitemid 28022832)
-
(1997)
Journal of Clinical Investigation
, vol.100
, Issue.12
, pp. 2961-2969
-
-
Bargou, R.C.1
Emmerich, F.2
Krappmann, D.3
Bommert, K.4
Mapara, M.Y.5
Arnold, W.6
Royer, H.D.7
Grinstein, E.8
Greiner, A.9
Scheidereit, C.10
Dorken, B.11
-
181
-
-
0033565217
-
Expression of a dominant-negative mutant inhibitor-κBα of nuclear factor-κB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo
-
DC Duffey, Z Chen, G Dong, FG Ondrey, JS Wolf, K Brown, U Siebenlist, C van Waes: Expression of a dominant-negative mutant inhibitor-kBa of nuclear factorkB in human head and neck squamous cell carcinomainhibits survival, proinflammatory cytokine expression, and tumor growth in vivo. Cancer Res 59, 3468-74 (1999) (Pubitemid 29334510)
-
(1999)
Cancer Research
, vol.59
, Issue.14
, pp. 3468-3474
-
-
Duffey, D.C.1
Chen, Z.2
Dong, G.3
Ondrey, F.G.4
Wolf, J.S.5
Brown, K.6
Siebenlist, U.7
Van Waes, C.8
-
182
-
-
0035849720
-
Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
-
DOI 10.1038/sj.onc.1204535
-
S Huang, CA Pettaway, H Uehara, CD Bucana and IJ Fidler: Blockade of NF-kB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene 20, 4188-97 (2001) (Pubitemid 32762193)
-
(2001)
Oncogene
, vol.20
, Issue.31
, pp. 4188-4197
-
-
Huang, S.1
Pettaway, C.A.2
Uehara, H.3
Bucana, C.D.4
Fidler, I.J.5
-
183
-
-
0033517190
-
NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
-
JA Romashkova, SS Makarov: NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 401, 86-90 (1999)
-
(1999)
Nature
, vol.401
, pp. 86-90
-
-
Romashkova, J.A.1
Makarov, S.S.2
-
184
-
-
72449194919
-
Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt
-
D Bai, L Ueno, PK Vogt: Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt. Int J Cancer 125, 2863-70 (2009)
-
(2009)
Int J Cancer
, vol.125
, pp. 2863-2870
-
-
Bai, D.1
Ueno, L.2
Vogt, P.K.3
-
185
-
-
27644541470
-
P38 mitogen-activated protein kinase/Hog1p regulates translation of the AU-rich-element-bearing MFA2 transcript
-
DOI 10.1128/MCB.25.22.9753-9763.2005
-
S Vasudevan, N Garneau, D Tu Khounh, SW Peltz: p38 mitogen-activated protein kinase/Hog1p regulates translation of the AU-rich-element-bearing MFA2 transcript. Mol Cell Biol 25, 9753-63 (2005) (Pubitemid 41572726)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.22
, pp. 9753-9763
-
-
Vasudevan, S.1
Garneau, N.2
Khounh, D.T.3
Peltz, S.W.4
-
186
-
-
0036840369
-
Tumor necrosis factor alpha induces three-dimensional cytomorphologic differentiation of human anaplastic thyroid carcinoma cells through activation of nuclear factor kappaB
-
CY Wang, WB Zhong, TC Chang, SM Lai, YF Tsai: Tumor necrosis factor alpha induces three-dimensional cytomorphologic differentiation of human anaplastic thyroid carcinoma cells through activation of nuclear factor kappaB. Cancer 95, 1827-33 (2002)
-
(2002)
Cancer
, vol.95
, pp. 1827-1833
-
-
Wang, C.Y.1
Zhong, W.B.2
Chang, T.C.3
Lai, S.M.4
Tsai, Y.F.5
-
187
-
-
33751549248
-
V600E promotes invasiveness of thyroid cancer cells through nuclear factor κB activation
-
DOI 10.1210/en.2006-0400
-
I Palona, H Namba, N Mitsutake, D Starenki, A Podtcheko, I Sedliarou, A Ohtsuru, V Saenko, Y Nagayama, K Umezawa, S Yamashita: BRAFV600E promotes invasiveness of thyroid cancer cells through nuclear factor kB activation. Endocrinology 147, 5699-707 (2006) (Pubitemid 44833486)
-
(2006)
Endocrinology
, vol.147
, Issue.12
, pp. 5699-5707
-
-
Palona, I.1
Namba, H.2
Mitsutake, N.3
Starenki, D.4
Podtcheko, A.5
Sedliarou, I.6
Ohtsuru, A.7
Saenko, V.8
Nagayama, Y.9
Umezawa, K.10
Yamashita, S.11
-
188
-
-
35348816753
-
Nuclear factor-kB in thyroid carcinogenesis and progression: A novel therapeutic target for advanced thyroid cancer
-
H Namba, V Saenko, S Yamashita: Nuclear factor-kB in thyroid carcinogenesis and progression: a novel therapeutic target for advanced thyroid cancer. Arq Bras Endocrinol Metab 51, 843-851 (2007)
-
(2007)
Arq Bras Endocrinol Metab
, vol.51
, pp. 843-851
-
-
Namba, H.1
Saenko, V.2
Yamashita, S.3
-
189
-
-
0030666532
-
Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkB p65 protein expression
-
R Visconti, J Cerutti, S Battista, M Fedele, F Trapasso, K Zeki, MP Miano, F de Nigris, L Casalino, F Curcio, M Santoro, A Fusco: Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkB p65 protein expression. Oncogene 15, 1987-94 (1997)
-
(1997)
Oncogene
, vol.15
, pp. 1987-1994
-
-
Visconti, R.1
Cerutti, J.2
Battista, S.3
Fedele, M.4
Trapasso, F.5
Zeki, K.6
Miano, M.P.7
De Nigris, F.8
Casalino, L.9
Curcio, F.10
Santoro, M.11
Fusco, A.12
-
190
-
-
0842334493
-
Inhibition of Nuclear Factor-κB Cascade Potentiates the Effect of a Combination Treatment of Anaplastic Thyroid Cancer Cells
-
DOI 10.1210/jc.2003-031216
-
D Starenki, H Namba, V Saenko, A Ohtsuru, S Yamashita: Inhibition of nuclear factor-kB cascade potentiates the effect of a combination treatment of anaplastic thyroid cancer cells. J Clin Endocrinol Metab 89, 410-8 (2004) (Pubitemid 38183911)
-
(2004)
Journal of Clinical Endocrinology and Metabolism
, vol.89
, Issue.1
, pp. 410-418
-
-
Starenki, D.1
Namba, H.2
Saenko, V.3
Ohtsuru, A.4
Yamashita, S.5
-
191
-
-
19944426112
-
Oncogenic and anti-apoptotic activity of NF-κB in human thyroid carcinomas
-
DOI 10.1074/jbc.M403492200
-
F Pacifico, C Mauro, C Barone, E Crescenzi, S Mellone, M Monaco, G Chiappetta, G Terrazzano, D Liguoro, P Vito, E Consiglio, S Formisano, A Leonardi: Oncogenic and anti-apoptotic activity of NF-kB in human thyroid carcinomas. J Biol Chem 279, 54610-9 (2004) (Pubitemid 40053204)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.52
, pp. 54610-54619
-
-
Pacifico, F.1
Mauro, C.2
Barone, C.3
Crescenzi, E.4
Mellone, S.5
Monaco, M.6
Chiappetta, G.7
Terrazzano, G.8
Liguoro, D.9
Vito, P.10
Consiglio, E.11
Formisano, S.12
Leonardi, A.13
-
192
-
-
33748741639
-
Epidermal growth factor receptor as a therapeutic target in human thyroid carcinoma: Mutational and functional analysis
-
DOI 10.1210/jc.2006-0055
-
CS Mitsiades, V Kotoula, V Poulaki, E Sozopoulos, J Negri, E Charalambous, G Fanourakis, G Voutsinas, S Tseleni-Balafouta, N Mitsiades: Epidermal growth factor receptor as a therapeutic target in human thyroid carcinoma: mutational and functional analysis. J Clin Endocrinol Metab 91, 3662-6 (2006) (Pubitemid 44402152)
-
(2006)
Journal of Clinical Endocrinology and Metabolism
, vol.91
, Issue.9
, pp. 3662-3666
-
-
Mitsiades, C.S.1
Kotoula, V.2
Poulaki, V.3
Sozopoulos, E.4
Negri, J.5
Charalambous, E.6
Fanourakis, G.7
Voutsinas, G.8
Tseleni-Balafouta, S.9
Mitsiades, N.10
-
193
-
-
77952452393
-
Inhibition of nuclear factor-kappa B differentially affects thyroid cancer cell growth, apoptosis, and invasion
-
T Bauerle, RE Schweppe, BR Haugen: Inhibition of nuclear factor-kappa B differentially affects thyroid cancer cell growth, apoptosis, and invasion. Mol Cancer 9, 117 (2010)
-
(2010)
Mol Cancer
, vol.9
, pp. 117
-
-
Bauerle, T.1
Schweppe, R.E.2
Haugen, B.R.3
-
194
-
-
64249131546
-
Rroscovitine sensitizes anaplastic thyroid carcinoma cells to TRAIL-induced apoptosis via regulation of IKK/NFkappaB pathway
-
M Festa, A Petrella, S Alfano, L Parente: Rroscovitine sensitizes anaplastic thyroid carcinoma cells to TRAIL-induced apoptosis via regulation of IKK/NFkappaB pathway. Int J Cancer 124, 2728-36 (2009)
-
(2009)
Int J Cancer
, vol.124
, pp. 2728-2736
-
-
Festa, M.1
Petrella, A.2
Alfano, S.3
Parente, L.4
-
195
-
-
54349105133
-
Dehydroxymethylepoxyquinomicin, a novel nuclear Factor-kappaB inhibitor, enhances antitumor activity of taxanes in anaplastic thyroid cancer cells
-
Z Meng, N Mitsutake, M Nakashima, D Starenki, M Matsuse, S Takakura, H Namba, V Saenko, K Umezawa, A Ohtsuru, S Yamashita: Dehydroxymethylepoxyquinomicin, a novel nuclear Factor-kappaB inhibitor, enhances antitumor activity of taxanes in anaplastic thyroid cancer cells. Endocrinology 149, 5357-65 (2008)
-
(2008)
Endocrinology
, vol.149
, pp. 5357-5365
-
-
Meng, Z.1
Mitsutake, N.2
Nakashima, M.3
Starenki, D.4
Matsuse, M.5
Takakura, S.6
Namba, H.7
Saenko, V.8
Umezawa, K.9
Ohtsuru, A.10
Yamashita, S.11
-
196
-
-
63849258626
-
A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factorkappa B pathway
-
W Zhu, Y Ou, Y Li, R Xiao, M Shu, Y Zhou, J Xie, S He, P Qiu, G Yan. A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factorkappa B pathway. Mol Pharmacol 75, 812-9 (2009)
-
(2009)
Mol Pharmacol
, vol.75
, pp. 812-819
-
-
Zhu, W.1
Ou, Y.2
Li, Y.3
Xiao, R.4
Shu, M.5
Zhou, Y.6
Xie, J.7
He, S.8
Qiu, P.9
Yan, G.10
-
197
-
-
0035011548
-
Regulation of FRTL-5 thyroid cell growth by phosphatidylinositol (OH) 3 kinase-dependent Akt-mediated signaling
-
J Saito, AD Kohn, RA Roth, Y Noguchi, I Tatsumo, A Hirai, K Suzuki, LD Kohn, M Saji, MD Ringel: Regulation of FRTL-5 thyroid cell growth by phosphatidylinositol (OH) 3 kinase-dependent Aktmediated signaling. Thyroid 11, 339-351 (2001) (Pubitemid 32422626)
-
(2001)
Thyroid
, vol.11
, Issue.4
, pp. 339-351
-
-
Saito, J.1
Kohn, A.D.2
Roth, R.A.3
Noguchi, Y.4
Tatsumo, I.5
Hirai, A.6
Suuki, K.7
Kohn, L.D.8
Saji, M.9
Ringel, M.D.10
-
198
-
-
0035253503
-
Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death
-
LP Weng, O Gimm, JB Kum, WM Smith, XP Zhou, D Wynford-Thomas, G Leone, C Eng: Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death. Hum Mol Genet, 10(3), 251-8 (2001) (Pubitemid 32123984)
-
(2001)
Human Molecular Genetics
, vol.10
, Issue.3
, pp. 251-258
-
-
Weng, L.-P.1
Gimm, O.2
Kum, J.B.3
Smith, W.M.4
Zhou, X.-P.5
Wynford-Thomas, D.6
Leone, G.7
Eng, C.8
-
199
-
-
18644376449
-
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
-
DOI 10.1038/nm761
-
J Liang, J Zubovitz, T Petrocelli, R Kotchetkov, MK Connor, K Han, JH Lee, S Ciarallo, S Catzavelos, R Beniston, E Franssen, JM Slingerland: PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med 8, 1153-60 (2002) (Pubitemid 35175971)
-
(2002)
Nature Medicine
, vol.8
, Issue.10
, pp. 1153-1160
-
-
Liang, J.1
Zubovitz, J.2
Petrocelli, T.3
Kotchetkov, R.4
Connor, M.K.5
Han, K.6
Lee, J.-H.7
Ciarallo, S.8
Catzavelos, C.9
Beniston, R.10
Franssen, E.11
Slingerland, J.M.12
-
200
-
-
18644370396
-
kip1 by PKB/Akt-mediated phosphorylation in breast cancer
-
DOI 10.1038/nm762
-
G Viglietto, ML Motti, P Bruni, RM Melillo, A D'Alessio, D Califano, F Vinci, G Chiappetta, P Tsichlis, A Bellacosa, A Fusco, M Santoro: Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Nat Med 8, 1136-44 (2002) (Pubitemid 35175969)
-
(2002)
Nature Medicine
, vol.8
, Issue.10
, pp. 1136-1144
-
-
Viglietto, G.1
Motti, M.L.2
Bruni, P.3
Melillo, R.M.4
D'Alessio, A.5
Califano, D.6
Vinci, F.7
Chiappetta, G.8
Tsichliss, P.9
Bellacosa, A.10
Fusco, A.11
Santoro, M.12
-
201
-
-
0037047268
-
Aktdependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization
-
N Fujita, S Sato, K Katayama, T Tsuruo: Aktdependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J Biol Chem 277, 28706-13 (2002)
-
(2002)
J Biol Chem
, vol.277
, pp. 28706-28713
-
-
Fujita, N.1
Sato, S.2
Katayama, K.3
Tsuruo, T.4
-
202
-
-
10044244277
-
kip1 in breast cancer
-
ML Motti, C De Marco, D Califano, A Fusco, G Viglietto: Akt-dependent T198 phosphorylation ofcyclin-dependent kinase inhibitor p27kip1 in breast cancer. Cell Cycle 3, 1074-80 (2004) (Pubitemid 40268668)
-
(2004)
Cell Cycle
, vol.3
, Issue.8
, pp. 1074-1080
-
-
Motti, M.L.1
De Marco, C.2
Califano, D.3
Fusco, A.4
Viglietto, G.5
-
203
-
-
14044276381
-
1 and prevents nuclear re-entry
-
DOI 10.1074/jbc.M412367200
-
I Shin, J Rotty, FY Wu, CL Arteaga: Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry. J Biol Chem 280, 6055-63 (2005) (Pubitemid 40280089)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.7
, pp. 6055-6063
-
-
Shin, I.1
Rotty, J.2
Wu, F.Y.3
Arteaga, C.L.4
-
204
-
-
3142512358
-
Kip1
-
DOI 10.1038/sj.emboj.7600198
-
T Sekimoto, M Fukumoto, Y Yoneda: 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). EMBO J 23, 1934-42 (2004) (Pubitemid 38902071)
-
(2004)
EMBO Journal
, vol.23
, Issue.9
, pp. 1934-1942
-
-
Sekimoto, T.1
Fukumoto, M.2
Yoneda, Y.3
-
205
-
-
0042532260
-
Understanding p27(kip1) deregulation in cancer: Down-regulation or mislocalization
-
G Viglietto, ML Motti, A Fusco: Understanding p27(kip1) deregulation in cancer: down-regulation or mislocalization. Cell Cycle 1, 394-400 (2002)
-
(2002)
Cell Cycle
, vol.1
, pp. 394-400
-
-
Viglietto, G.1
Motti, M.L.2
Fusco, A.3
-
206
-
-
34447544650
-
Kip1 that causes stem cell expansion and a multiple tumor phenotype
-
DOI 10.1101/gad.1556607
-
A Besson, HC Hwang, S Cicero, SL Donovan, M Gurian-West, D Johnson, BE Clurman, MA Dyer, JM Roberts: Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes Dev 21, 1731-46 (2007) (Pubitemid 47076473)
-
(2007)
Genes and Development
, vol.21
, Issue.14
, pp. 1731-1746
-
-
Besson, A.1
Hwang, H.C.2
Cicero, S.3
Donovan, S.L.4
Gurian-West, M.5
Johnson, D.6
Clurman, B.E.7
Dyer, M.A.8
Roberts, J.M.9
-
207
-
-
1942466518
-
Kip1 modulates cell migration through the regulation of RhoA activation
-
DOI 10.1101/gad.1185504
-
A Besson, M Gurian-West, A Schmidt, A Hall, JM Roberts: p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev 18, 862-76 (2004) (Pubitemid 38529656)
-
(2004)
Genes and Development
, vol.18
, Issue.8
, pp. 862-876
-
-
Besson, A.1
Gurian-West, M.2
Schmidt, A.3
Hall, A.4
Roberts, J.M.5
-
208
-
-
65549116919
-
FOXO3a: A novel player in thyroid carcinogenesis?
-
S Karger, C Weidinger, K Krause, SY Sheu, T Aigner, O Gimm, KW Schmid, H Dralle, D Fuhrer: FOXO3a: a novel player in thyroid carcinogenesis? Endocr Relat Cancer 16, 189-99 (2009)
-
(2009)
Endocr Relat Cancer
, vol.16
, pp. 189-199
-
-
Karger, S.1
Weidinger, C.2
Krause, K.3
Sheu, S.Y.4
Aigner, T.5
Gimm, O.6
Schmid, K.W.7
Dralle, H.8
Fuhrer, D.9
-
209
-
-
34547820267
-
Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer
-
DOI 10.1677/ERC-06-0030
-
G Chiappetta, C De Marco, A Quintiero, D Califano, S Gherardi, D Malanga, M Scrima, C Montero-Conde, L Cito, M Monaco, ML Motti, R Pasquinelli, V Agosti, M Robledo, A Fusco, G Viglietto: Overexpression of the Sphase kinase-associated protein 2 in thyroid cancer. Endocr Relat Cancer 14, 405-20 (2007) (Pubitemid 47242639)
-
(2007)
Endocrine-Related Cancer
, vol.14
, Issue.2
, pp. 405-420
-
-
Chiappetta, G.1
De Marco, C.2
Quintiero, A.3
Califano, D.4
Gherardi, S.5
Malanga, D.6
Scrima, M.7
Montero-Conde, C.8
Cito, L.9
Monaco, M.10
Motti, M.L.11
Pasquinelli, R.12
Agosti, V.13
Robledo, M.14
Fusco, A.15
Viglietto, G.16
-
210
-
-
37249061098
-
Loss of p27 expression through RAS>BRAF>MAP kinase-dependent pathway in human thyroid carcinomas
-
ML Motti, C De Marco, D Califano, S De Gisi, D Malanga, G Troncone, A Persico, S Losito, F Fabiani, M Santoro, G Chiappetta, A Fusco, G Viglietto: Loss of p27 expression through RAS->BRAF->MAP kinase-dependent pathway in human thyroid carcinomas. Cell Cycle 6, 2817-25 (2007) (Pubitemid 350277175)
-
(2007)
Cell Cycle
, vol.6
, Issue.22
, pp. 2817-2825
-
-
Motti, M.L.1
De Marco, C.2
Califano, D.3
De Gisi, S.4
Malanga, D.5
Troncone, G.6
Persico, A.7
Losito, S.8
Fabiani, F.9
Santoro, M.10
Chiappetta, G.11
Fusco, A.12
Viglietto, G.13
-
211
-
-
2542591571
-
Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells
-
DOI 10.1158/0008-5472.CAN-03-3918
-
D Vitagliano, F Carlomagno, ML Motti, G Viglietto, YE Nikiforov, MN Nikiforova, JM Hershman, AJ Ryan, A Fusco, RM Melillo, M Santoro: Regulation of p27Kip1 protein levels contributes to mitogenic effects of the RET/PTC kinase in thyroid carcinoma cells. Cancer Res 64, 3823-9 (2004) (Pubitemid 38697291)
-
(2004)
Cancer Research
, vol.64
, Issue.11
, pp. 3823-3829
-
-
Vitagliano, D.1
Carlomagno, F.2
Motti, M.L.3
Viglietto, G.4
Nikiforov, Y.E.5
Nikiforova, M.N.6
Hershman, J.M.7
Ryan, A.J.8
Fusco, A.9
Melillo, R.M.10
Santoro, M.11
-
212
-
-
67650468323
-
Impairment of the p27kip1 function enhances thyroid carcinogenesis in TRK-T1 transgenic mice
-
M Fedele, D Palmieri, G Chiappetta, R Pasquinelli, I De Martino, C Arra, G Palma, T Valentino, GM Pierantoni, G Viglietto, JL Rothstein, M Santoro, A Fusco: Impairment of the p27kip1 function enhances thyroid carcinogenesis in TRK-T1 transgenic mice. Endocr Relat Cancer 16, 483-90 (2009)
-
(2009)
Endocr Relat Cancer
, vol.16
, pp. 483-490
-
-
Fedele, M.1
Palmieri, D.2
Chiappetta, G.3
Pasquinelli, R.4
De Martino, I.5
Arra, C.6
Palma, G.7
Valentino, T.8
Pierantoni, G.M.9
Viglietto, G.10
Rothstein, J.L.11
Santoro, M.12
Fusco, A.13
-
213
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
DOI 10.1038/378785a0
-
DA Cross, DR Alessi, P Cohen, M Andjelkovich, BA Hemmings: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378, 785-9 (1995) (Pubitemid 26004411)
-
(1995)
Nature
, vol.378
, Issue.6559
, pp. 785-789
-
-
Cross, D.A.E.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
214
-
-
0032533225
-
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
-
JA Diehl, M Cheng, MF Roussel, CJ Sherr: Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 12, 3499-511 (1998) (Pubitemid 28553242)
-
(1998)
Genes and Development
, vol.12
, Issue.22
, pp. 3499-3511
-
-
Diehl, J.A.1
Cheng, M.2
Roussel, M.F.3
Sherr, C.J.4
-
215
-
-
0141591688
-
Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation
-
DOI 10.1016/S1097-2765(03)00287-9
-
M Welcker, J Singer, KR Loeb, J Grim, A Bloecher, M Gurien-West, BE Clurman, JM Roberts: Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation. Mol Cell 12, 381-92 (2003) (Pubitemid 37238925)
-
(2003)
Molecular Cell
, vol.12
, Issue.2
, pp. 381-392
-
-
Welcker, M.1
Singer, J.2
Loeb, K.R.3
Grim, J.4
Bloecher, A.5
Gurien-West, M.6
Clurman, B.E.7
Roberts, J.M.8
-
216
-
-
0036841293
-
2/M cell cycle checkpoint induced by DNA damage
-
DOI 10.1128/MCB.22.22.7831-7841.2002
-
ES Kandel, J Skeen, N Majewski, A Di Cristofano, PP Pandolfi, CS Feliciano, A Gartel, N Hay: Activation of Akt/protein kinase B overcomes a G(2)/M cell cycle checkpoint induced by DNA damage. Mol Cell Biol 22, 7831-41 (2002) (Pubitemid 35217294)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.22
, pp. 7831-7841
-
-
Kandel, E.S.1
Skeen, J.2
Majewski, N.3
Di Cristofano, A.4
Pandolfi, P.P.5
Feliciano, C.S.6
Gartel, A.7
Hay, N.8
-
217
-
-
0037018847
-
A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle
-
DOI 10.1016/S0960-9822(02)00843-6, PII S0960982202008436
-
E Shtivelman, J Sussman, D Stokoe: A role for PI 3-kinase and PKB activity in the G2/M phase of the cell cycle. Curr Biol 12, 919-24 (2002) (Pubitemid 34689227)
-
(2002)
Current Biology
, vol.12
, Issue.11
, pp. 919-924
-
-
Shtivelman, E.1
Sussman, J.2
Stokoe, D.3
-
218
-
-
4644241295
-
Inhibition of Chk1 by activated PKB/Akt
-
FW King, J Skeen, N Hay, E Shtivelman: Inhibition of Chk1 by activated PKB/Akt. Cell Cycle 3, 34-7 (2004)
-
(2004)
Cell Cycle
, vol.3
, pp. 34-37
-
-
King, F.W.1
Skeen, J.2
Hay, N.3
Shtivelman, E.4
-
219
-
-
13844251972
-
Lack of PTEN sequesters CHK1 and initiates genetic instability
-
DOI 10.1016/j.ccr.2005.01.009
-
J Puc, M Keniry, HS Li, TK Pandita, AD Choudhury, L Memeo, M Mansukhani, VV Murty, Z Gaciong, SE Meek, H Piwnica-Worms, H Hibshoosh, R. Parsons: Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell 7, 193-204 (2005) (Pubitemid 40248344)
-
(2005)
Cancer Cell
, vol.7
, Issue.2
, pp. 193-204
-
-
Puc, J.1
Keniry, M.2
Li, H.S.3
Pandita, T.K.4
Choudhury, A.D.5
Memeo, L.6
Mansukhani, M.7
Murty, V.V.V.S.8
Gaciong, Z.9
Meek, S.E.M.10
Piwnica-Worms, H.11
Hibshoosh, H.12
Parsons, R.13
-
220
-
-
33751278260
-
Ras induces chromosome instability and abrogation of the DNA damage response
-
DOI 10.1158/0008-5472.CAN-06-2351
-
A Abulaiti, AJ Fikaris, OM Tsygankova, JL. Meinkoth: Ras induces chromosome instability and abrogation of the DNA damage response. Cancer Res 66, 10505-12 (2006) (Pubitemid 44799772)
-
(2006)
Cancer Research
, vol.66
, Issue.21
, pp. 10505-10512
-
-
Abulaiti, A.1
Fikaris, A.J.2
Tsygankova, O.M.3
Meinkoth, J.L.4
-
221
-
-
0037232108
-
Small molecule tyrosine kinase inhibitors: Clinical development of anticancer agents
-
DOI 10.1517/13543784.12.1.51
-
AD Laird, JM Cherrington: Small molecule tyrosine kinase inhibitors: clinical development of anticancer agents. Expert Opin Investig Drugs 12, 51-64 (2003) (Pubitemid 36104643)
-
(2003)
Expert Opinion on Investigational Drugs
, vol.12
, Issue.1
, pp. 51-64
-
-
Laird, A.D.1
Cherrington, J.M.2
-
223
-
-
77954219743
-
Targeted therapy of thyroid cancer
-
SI Sherman: Targeted therapy of thyroid cancer. Biochem Pharmacol 80, 592-601 (2010)
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 592-601
-
-
Sherman, S.I.1
-
224
-
-
51849098272
-
Drug discovery approaches targeting the PI3K/Akt pathway in cancer
-
C Garcia-Echeverria, WR Sellers: Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene 27, 5511-5526 (2008)
-
(2008)
Oncogene
, vol.27
, pp. 5511-5526
-
-
Garcia-Echeverria, C.1
Sellers, W.R.2
-
225
-
-
46449117698
-
Motesanib diphosphate in progressive differentiated thyroid cancer
-
DOI 10.1056/NEJMoa075853
-
SI Sherman, LJ Wirth, JP Droz, M Hofmann, L Bastholt, RG Martins, L Licitra, MJ Eschenberg, YN Sun, T Juan, DE Stepan and MJ Schlumberger: Motesanib diphosphate in progressive differentiated thyroid cancer. N Engl J Med 359, 31-42 (2008) (Pubitemid 351931094)
-
(2008)
New England Journal of Medicine
, vol.359
, Issue.1
, pp. 31-42
-
-
Sherman, S.I.1
Wirth, L.J.2
Droz, J.-P.3
Hofmann, M.4
Bastholt, L.5
Martins, R.G.6
Licitra, L.7
Eschenberg, M.J.8
Sun, Y.-N.9
Juan, T.10
Stepan, D.E.11
Schlumberger, M.J.12
-
226
-
-
50649095801
-
Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: Results from a phase II study
-
EE Cohen, LS Rosen, EE Vokes, MS Kies, AA Forastiere, FP Worden, MA Kane, E Sherman, S Kim, PBycott, M Tortorici, DR Shalinsky, KF Liau, RB Cohen: Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a phase II study. J Clin Oncol 26, 4708-4713 (2008)
-
(2008)
J Clin Oncol
, vol.26
, pp. 4708-4713
-
-
Cohen, E.E.1
Rosen, L.S.2
Vokes, E.E.3
Kies, M.S.4
Forastiere, A.A.5
Worden, F.P.6
Kane, M.7
Sherman, E.8
Kim, S.9
Tortorici, P.M.10
Shalinsky, D.R.11
Liau, K.F.12
Cohen, R.B.13
-
227
-
-
77949430065
-
The Akt/PKB family of protein kinases: A review of small molecule inhibitors and progress towards target validation: A 2009 update
-
CW Lindsley: The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation: a 2009 update. Curr Top Med Chem 10, 458-77 (2010)
-
(2010)
Curr Top Med Chem
, vol.10
, pp. 458-477
-
-
Lindsley, C.W.1
-
228
-
-
0036718911
-
Targeting serine/threonine protein kinase B/Akt and cell-cycle checkpoint kinases for treating cancer
-
Q Li, GD Zhu: Targeting serine/threonine protein kinase B/Akt and cell-cycle checkpoint kinases for treating cancer. Curr Top Med Chem 2, 939-971 (2002)
-
(2002)
Curr Top Med Chem
, vol.2
, pp. 939-971
-
-
Li, Q.1
Zhu, G.D.2
-
229
-
-
0038206479
-
Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT)
-
DOI 10.1016/S0022-2836(03)00518-7
-
M Gassel, CB Breitenlechner, P Ruger, U Jucknischke, T Schneider, R Huber, D Bossemeyer, RA Engh: Mutants of protein kinase A that mimic the ATPbinding site of protein kinase B (Akt). J Mol Biol 329, 1021-1034 (2003) (Pubitemid 36683158)
-
(2003)
Journal of Molecular Biology
, vol.329
, Issue.5
, pp. 1021-1034
-
-
Gassel, M.1
Breitenlechner, C.B.2
Ruger, P.3
Jucknischke, U.4
Schneider, T.5
Huber, R.6
Bossemeyer, D.7
Engh, R.A.8
-
230
-
-
19944426184
-
Design and Crystal Structures of Protein Kinase B-Selective Inhibitors in Complex with Protein Kinase a and Mutants
-
DOI 10.1021/jm049701n
-
CB Breitenlechner, WG Friebe, E Brunet, G Werner, K Graul, U Thomas, KP Kunkele, W Schafer, M Gassel, D Bossemeyer, R Huber, RA Engh, B Masjost: Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants. J Med Chem 48, 163-170 (2005) (Pubitemid 40105257)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.1
, pp. 163-170
-
-
Breitenlechner, C.B.1
Friebe, W.-G.2
Brunet, E.3
Werner, G.4
Graul, K.5
Thomas, U.6
Kunkele, K.-P.7
Schafer, W.8
Gassel, M.9
Bossemeyer, D.10
Huber, R.11
Engh, R.A.12
Masjost, B.13
-
231
-
-
12144287555
-
Structure-Based Optimization of Novel Azepane Derivatives as PKB Inhibitors
-
DOI 10.1021/jm0310479
-
CB Breitenlechner, T Wegge, L Berillon, K Graul, K Marzenell, WG Friebe, U Thomas, R Schumacher, R Huber, RA Engh, B. Masjost: Structure-based optimization of novel azepane derivatives as PKB inhibitors. J Med Chem 47, 1375-1390 (2004) (Pubitemid 38327465)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.6
, pp. 1375-1390
-
-
Breitenlechner, C.B.1
Wegge, T.2
Berillon, L.3
Graul, K.4
Marzenell, K.5
Friebe, W.-G.6
Thomas, U.7
Schumacher, R.8
Huber, R.9
Engh, R.A.10
Masjost, B.11
-
232
-
-
20344384859
-
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo
-
DOI 10.1158/1535-7163.MCT-05-0005
-
Y Luo, AR Shoemaker, X Liu, KW Woods, SA Thomas, R de Jong, EK Han, T Li, VS Stoll, JA Powlas, A Oleksijew, MJ Mitten, Y Shi, R Guan, TP McGonigal, V Klinghofer, EF Johnson, JD Leverson, JJ Bouska, M Mamo, RA Smith, EE Gramling-Evans, BA Zinker, AK Mika, PT Nguyen, T Oltersdorf, SH Rosenberg, Q Li, VL Giranda: Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Res 4, 977-986 (2005) (Pubitemid 40909080)
-
(2005)
Molecular Cancer Therapeutics
, vol.4
, Issue.6
, pp. 977-986
-
-
Luo, Y.1
Shoemaker, A.R.2
Liu, X.3
Woods, K.W.4
Thomas, S.A.5
De Jong, R.6
Han, E.K.7
Li, T.8
Stoll, V.S.9
Powlas, J.A.10
Oleksijew, A.11
Mitten, M.J.12
Shi, Y.13
Guan, R.14
McGonigal, T.P.15
Klinghofer, V.16
Johnson, E.F.17
Leverson, J.D.18
Bouska, J.J.19
Mamo, M.20
Smith, R.A.21
Gramling-Evans, E.E.22
Zinker, B.A.23
Mika, A.K.24
Nguyen, P.T.25
Oltersdorf, T.26
Rosenberg, S.H.27
Li, Q.28
Giranda, V.L.29
more..
-
233
-
-
33644830649
-
Optimal classes of chemotherapeutic agents sensitized by specific small-molecule inhibitors of akt in vitro and in vivo
-
Y Shi, X Liu, E Han, R Guan, AR Shoemaker, A Oleksijew, KW Woods, JP Fisher, V Klinghofer, L Lasko, T McGonigal, Q Li, SH Rosenberg, VL Giranda, Y Luo: Optimal classes of chemotherapeutic agents sensitized by specific small-molecule inhibitors of akt in vitro and in vivo. Neoplasia 7, 992-1000 (2005)
-
(2005)
Neoplasia
, vol.7
, pp. 992-1000
-
-
Shi, Y.1
Liu, X.2
Han, E.3
Guan, R.4
Shoemaker, A.R.5
Oleksijew, A.6
Woods, K.W.7
Fisher, J.P.8
Klinghofer, V.9
Lasko, L.10
McGonigal, T.11
Li, Q.12
Rosenberg, S.H.13
Giranda, V.L.14
Luo, Y.15
-
234
-
-
42049115641
-
Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity
-
DOI 10.1158/0008-5472.CAN-07-5783
-
N Rhodes, DA Heerding, DR Duckett, DJ Eberwein, VB Knick, TJ Lansing, RT McConnell, TM Gilmer, SY Zhang, K Robell, JA Kahana, RS Geske, EV Kleymenova, AE Choudhry, Z Lai, JD Leber, EA Minthorn, SL Strum, ER Wood, PS Huang, RA Copeland, R Kumar: Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res 68, 2366-2374 (2008) (Pubitemid 351521811)
-
(2008)
Cancer Research
, vol.68
, Issue.7
, pp. 2366-2374
-
-
Rhodes, N.1
Heerding, D.A.2
Duckett, D.R.3
Eberwein, D.J.4
Knick, V.B.5
Lansing, T.J.6
McConnell, R.T.7
Gilmer, T.M.8
Zhang, S.-Y.9
Robell, K.10
Kahana, J.A.11
Geske, R.S.12
Kleymenova, E.V.13
Choudhry, A.E.14
Lai, Z.15
Leber, J.D.16
Minthorn, E.A.17
Strum, S.L.18
Wood, E.R.19
Huang, P.S.20
Copeland, R.A.21
Kumar, R.22
more..
-
235
-
-
37549010727
-
Pharmacodynamic markers of perifosine efficacy
-
BT Hennessy, Y Lu, E Poradosu, Q Yu, S Yu, H Hall, MS Carey, M Ravoori, AM Gonzalez-Angulo, R Birch, IC Henderson, V Kundra, GB Mills: Pharmacodynamic markers of perifosine efficacy. Clin Cancer Res 13, 7421-31 (2007)
-
(2007)
Clin Cancer Res
, vol.13
, pp. 7421-7431
-
-
Hennessy, B.T.1
Lu, Y.2
Poradosu, E.3
Yu, Q.4
Yu, S.5
Hall, H.6
Carey, M.S.7
Ravoori, M.8
Gonzalez-Angulo, A.M.9
Birch, R.10
Henderson, I.C.11
Kundra, V.12
Mills, G.B.13
-
236
-
-
43049131769
-
Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations
-
J LoPiccolo, GM Blumenthal, WB Bernstein, PA Dennis: Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist Updat 11, 32-50 (2008)
-
(2008)
Drug Resist Updat
, vol.11
, pp. 32-50
-
-
Lopiccolo, J.1
Blumenthal, G.M.2
Bernstein, W.B.3
Dennis, P.A.4
-
237
-
-
0029965452
-
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction
-
MP Wymann, G Bulgarelli-Leva, MJ Zvelebil, L Pirola, B Vanhaesebroeck, MD Waterfield, G Panayotou: Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. Mol Cell Biol 16, 1722-1733 (1996) (Pubitemid 26095645)
-
(1996)
Molecular and Cellular Biology
, vol.16
, Issue.4
, pp. 1722-1733
-
-
Wymann, M.P.1
Bulgarelli-Leva, G.2
Zvelebil, M.J.3
Pirola, L.4
Vanhaesebroeck, B.5
Waterfield, M.D.6
Panayotou, G.7
-
238
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
-
CJ Vlahos, WF Matter, KY Hui, RF Brown: A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269, 5241-5248 (1994)
-
(1994)
J Biol Chem
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
239
-
-
23644451118
-
PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors
-
K Yu, J Lucas, T Zhu, A Zask, C Gaydos, L Toral-Barza, J Gu, F Li, I Chaudhary, P Cai, J Lotvin, R Petersen, M Ruppen, M Fawzi, S Ayral-Kaloustian, J Skotnicki, T Mansour, P Frost, J Gibbons: PWT-458, a novel pegylated-17- dydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors. Cancer Biol Ther 4, 538-545 (2005) (Pubitemid 41351227)
-
(2005)
Cancer Biology and Therapy
, vol.4
, Issue.5
, pp. 538-545
-
-
Yu, K.1
Lucas, J.2
Zhu, T.3
Zask, A.4
Gaydos, C.5
Toral-Barza, L.6
Gu, J.7
Li, F.8
Chaudhary, I.9
Cai, P.10
Lotvin, J.11
Petersen, R.12
Ruppen, M.13
Fawzi, M.14
Ayral-Kaloustian, S.15
Skotnicki, J.16
Mansour, T.17
Frost, P.18
Gibbons, J.19
-
240
-
-
33644685228
-
The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts
-
NT Ihle, G Paine-Murrieta, MI Berggren, A Baker, WRTate, P Wipf, RT Abraham, DL Kirkpatrick, G Powis: The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts. Mol Cancer Ther 4, 1349-1357 (2005)
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 1349-1357
-
-
Ihle, N.T.1
Paine-Murrieta, G.2
Berggren, M.I.3
Baker, A.4
Wipf, W.P.5
Abraham, R.T.6
Kirkpatrick, D.L.7
Powis, G.8
-
241
-
-
34748840281
-
The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures
-
DOI 10.1158/1535-7163.MCT-06-0698
-
AL Howes, GG Chiang, ES Lang, CB Ho, G Powis, K Vuori, RT Abraham: The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures. Mol Cancer Ther 6, 2505-2514 (2007) (Pubitemid 47480416)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.9
, pp. 2505-2514
-
-
Howes, A.L.1
Chiang, G.G.2
Lang, E.S.3
Ho, C.B.4
Powis, G.5
Vuori, K.6
Abraham, R.T.7
-
242
-
-
63749106157
-
Should individual PI3 kinase isoforms be targeted in cancer?
-
S Jia, TM Roberts, JJ Zhao: Should individual PI3 kinase isoforms be targeted in cancer? Curr Opin Cell Biol 21, 199-208 (2009)
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 199-208
-
-
Jia, S.1
Roberts, T.M.2
Zhao, J.J.3
-
243
-
-
58249120506
-
Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance
-
NT Ihle, R Lemos, P Wipf, A Yacoub, C Mitchell, D Siwak, GB Mills, P Dent, DL Kirkpatrick, G Powis: Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance. Cancer Res 69, 143-50 (2009)
-
(2009)
Cancer Res
, vol.69
, pp. 143-150
-
-
Ihle, N.T.1
Lemos, R.2
Wipf, P.3
Yacoub, A.4
Mitchell, C.5
Siwak, D.6
Mills, G.B.7
Dent, P.8
Kirkpatrick, D.L.9
Powis, G.10
-
244
-
-
51849111524
-
NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations
-
V Serra, B Markman, M Scaltriti, PJ Eichhorn, V Valero, M Guzman, ML Botero, E Llonch, F Atzori, S Di Cosimo, M Maira, C Garcia-Echeverria, JL Parra, J Arribas, J Baselga: NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. Cancer Res 68, 8022-30 (2008)
-
(2008)
Cancer Res
, vol.68
, pp. 8022-8030
-
-
Serra, V.1
Markman, B.2
Scaltriti, M.3
Eichhorn, P.J.4
Valero, V.5
Guzman, M.6
Botero, M.L.7
Llonch, E.8
Atzori, F.9
Di Cosimo, S.10
Maira, M.11
Garcia-Echeverria, C.12
Parra, J.L.13
Arribas, J.14
Baselga, J.15
-
245
-
-
0037034928
-
Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine)
-
DOI 10.1038/sj/onc/1205225
-
S Sato, N Fujita, T Tsuruo: Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine). Oncogene 21, 1727-1738 (2002) (Pubitemid 34259036)
-
(2002)
Oncogene
, vol.21
, Issue.11
, pp. 1727-1738
-
-
Sato, S.1
Fujita, N.2
Tsuruo, T.3
-
246
-
-
0142231577
-
Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition
-
DOI 10.1042/BJ20031119
-
D Komander, GS Kular, J Bain, M Elliott, DR Alessi, DM Van Aalten: Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition. Biochem J 375, 255-262 (2003) (Pubitemid 37315433)
-
(2003)
Biochemical Journal
, vol.375
, Issue.2
, pp. 255-262
-
-
Komander, D.1
Kular, G.S.2
Bain, J.3
Elliott, M.4
Alessi, D.R.5
Van Aalten, D.M.F.6
-
247
-
-
34547094373
-
UCN-01 in combination with topotecan in patients with advanced recurrent ovarian cancer: A study of the Princess Margaret Hospital Phase II consortium
-
DOI 10.1016/j.ygyno.2007.02.018, PII S0090825807001461
-
S Welch, HW Hirte, MS Carey, SJ Hotte, MS Tsao, S Brown, GR Pond, JE Dancey, AM Oza: UCN-01 in combination with topotecan in patients with advanced recurrent ovarian cancer: a study of the Princess Margaret Hospital Phase II consortium. Gynecol Oncol 106, 305-310 (2007) (Pubitemid 47096653)
-
(2007)
Gynecologic Oncology
, vol.106
, Issue.2
, pp. 305-310
-
-
Welch, S.1
Hirte, H.W.2
Carey, M.S.3
Hotte, S.J.4
Tsao, M.-S.5
Brown, S.6
Pond, G.R.7
Dancey, J.E.8
Oza, A.M.9
-
248
-
-
21244435590
-
Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1
-
DOI 10.1074/jbc.M501367200
-
RI Feldman, JM Wu, MA Polokoff, MJ Kochanny, H Dinter, D Zhu, SL Biroc, B Alicke, J Bryant, S Yuan, BO Buckman, D Lentz, M Ferrer, M Whitlow, M Adler, S Finster, Z Chang, DO Arnaiz: Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem 280, 19867-19874 (2005) (Pubitemid 41379514)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.20
, pp. 19867-19874
-
-
Feldman, R.I.1
Wu, J.M.2
Polokoff, M.A.3
Kochanny, M.J.4
Dinter, H.5
Zhu, D.6
Biroc, S.L.7
Alicke, B.8
Bryant, J.9
Yuan, S.10
Buckman, B.O.11
Lentz, D.12
Ferrer, M.13
Whitlow, M.14
Adler, M.15
Finster, S.16
Chang, Z.17
Arnaiz, D.O.18
-
249
-
-
34250322969
-
Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX-517
-
DOI 10.1016/j.bmcl.2007.05.060, PII S0960894X07006282
-
I Islam, G Brown, J Bryant, P Hrvatin, MJ Kochanny, GB Phillips, S Yuan, M Adler, M Whitlow, D Lentz, MA Polokoff, J Wu, J Shen, J Walters, E Ho, B Subramanyam, D Zhu, RI Feldman, DO Arnaiz: Indolinone based phosphoinositide- dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517. Bioorg Med Chem Lett 17, 3819-3825 (2007) (Pubitemid 46920958)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.14
, pp. 3819-3825
-
-
Islam, I.1
Brown, G.2
Bryant, J.3
Hrvatin, P.4
Kochanny, M.J.5
Phillips, G.B.6
Yuan, S.7
Adler, M.8
Whitlow, M.9
Lentz, D.10
Polokoff, M.A.11
Wu, J.12
Shen, J.13
Walters, J.14
Ho, E.15
Subramanyam, B.16
Zhu, D.17
Feldman, R.I.18
Arnaiz, D.O.19
-
250
-
-
34250329460
-
Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity
-
DOI 10.1016/j.bmcl.2007.04.071, PII S0960894X07005033
-
I Islam, J Bryant, YL Chou, MJ Kochanny, W Lee, GB Phillips, H Yu, M Adler, M Whitlow, E Ho, D Lentz, MA Polokoff, B Subramanyam, JM Wu, D Zhu, RI Feldman, DO Arnaiz: Indolinone based phosphoinositidedependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. Bioorg Med Chem Lett 17, 3814-3818 (2007) (Pubitemid 46920915)
-
(2007)
Bioorganic and Medicinal Chemistry Letters
, vol.17
, Issue.14
, pp. 3814-3818
-
-
Islam, I.1
Bryant, J.2
Chou, Y.-L.3
Kochanny, M.J.4
Lee, W.5
Phillips, G.B.6
Yu, H.7
Adler, M.8
Whitlow, M.9
Ho, E.10
Lentz, D.11
Polokoff, M.A.12
Subramanyam, B.13
Wu, J.M.14
Zhu, D.15
Feldman, R.I.16
Arnaiz, D.O.17
-
251
-
-
0037008686
-
Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line
-
DOI 10.1074/jbc.M201119200
-
S Arico, S Pattingre, C Bauvy, P Gane, A Barbat, P Codogno, E Ogier-Denis: Celecoxib induces apoptosis by inhibiting 3-phosphoinositide- dependent protein kinase-1 activity in the human colon cancer HT-29 cell line. J Biol Chem 277, 27613-27621 (2002) (Pubitemid 34966703)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.31
, pp. 27613-27621
-
-
Arico, S.1
Pattingre, S.2
Bauvy, C.3
Gane, P.4
Barbat, A.5
Codogno, P.6
Ogier-Denis, E.7
-
252
-
-
54949144410
-
MTOR inhibitors in the treatment of cancer
-
A Fasolo, C Sessa: mTOR inhibitors in the treatment of cancer. Expert Opin Investig Drugs 17, 1717-34 (2008)
-
(2008)
Expert Opin Investig Drugs
, vol.17
, pp. 1717-1734
-
-
Fasolo, A.1
Sessa, C.2
-
253
-
-
57349194139
-
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
-
JA Engelman, L Chen, X Tan, K Crosby, AR Guimaraes, R Upadhyay, M Maira, K McNamara, SA Perera, Y Song, LR Chirieac, R Kaur, A Lightbown, J Simendinger, T Li, RF Padera, C García-Echeverría, R Weissleder, U Mahmood, LC Cantley, KK Wong. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 14, 1351-6 (2008)
-
(2008)
Nat Med
, vol.14
, pp. 1351-1356
-
-
Engelman, J.A.1
Chen, L.2
Tan, X.3
Crosby, K.4
Guimaraes, A.R.5
Upadhyay, R.6
Maira, M.7
McNamara, K.8
Perera, S.A.9
Song, Y.10
Chirieac, L.R.11
Kaur, R.12
Lightbown, A.13
Simendinger, J.14
Li, T.15
Padera, R.F.16
García-Echeverría, C.17
Weissleder, R.18
Mahmood, U.19
Cantley, L.C.20
Wong, K.K.21
more..
-
254
-
-
68049085887
-
In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basallike breast cancer models
-
KP Hoeflich, C O'Brien, Z Boyd, G Cavet, S Guerrero, K Jung, T Januario, H Savage, E Punnoose, T Truong, W Zhou, L Berry, L Murray, L Amler, M Belvin, LS Friedman, MR Lackner: In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basallike breast cancer models. Clin Cancer Res 15, 4649-64 (2009)
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4649-4664
-
-
Hoeflich, K.1
O'brien, C.2
Boyd, Z.3
Cavet, G.4
Guerrero, S.5
Jung, K.6
Januario, T.7
Savage, H.8
Punnoose, E.9
Truong, T.10
Zhou, W.11
Berry, L.12
Murray, L.13
Amler, L.14
Belvin, M.15
Friedman, L.S.16
Lackner, M.R.17
-
255
-
-
33847011426
-
Pten loss in the mouse thyroid causes goiter and follicular adenomas: Insights into thyroid function and Cowden disease pathogenesis
-
N Yeager, A Klein-Szanto, S Kimura, A Di Cristofano: Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis. Cancer Res 67, 959-66 (2007)
-
(2007)
Cancer Res
, vol.67
, pp. 959-966
-
-
Yeager, N.1
Klein-Szanto, A.2
Kimura, S.3
Di Cristofano, A.4
|