Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ

Journal of Clinical Investigation

Volumn 112, Issue 2, 2003, Pages 197-208

  Garofalo, Robert S ^a   Orena, Stephen J ^a   Rafidi, Kristina ^a   Torchia, Anthony J ^a   Stock, Jeffrey L ^a   Hildebrandt, Audrey L ^a   Coskran, Timothy ^a   Black, Shawn C ^a   Brees, Dominique J ^a   Wicks, Joan R ^a,b   McNeish, John D ^a   Coleman, Kevin G ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b CHARLES RIVER LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE B; PROTEIN KINASE B BETA; PROTEIN SERINE KINASE; UNCLASSIFIED DRUG; AKT2 PROTEIN, MOUSE; CASP3 PROTEIN, MOUSE; CASPASE; CASPASE 3; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLYCOGEN SYNTHASE; INSULIN; ISOPROTEIN; ONCOPROTEIN; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CELL GROWTH; CELL METABOLISM; CELL SURVIVAL; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GROWTH REGULATION; GROWTH RETARDATION; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN RESISTANCE; LIPOATROPHY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; ADIPOSE TISSUE; AGING; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; BLOOD; BODY WEIGHT; CHEMISTRY; COMPUTER ASSISTED TOMOGRAPHY; EXPERIMENTAL DIABETES MELLITUS; GENE VECTOR; GENETICS; GLUCOSE TOLERANCE TEST; HYPERINSULINISM; IMMUNOHISTOCHEMISTRY; LIVER; METABOLISM; MUSCLE; ORGAN SIZE; PANCREAS ISLET; PATHOLOGY; PHENOTYPE; PHYSIOLOGY; POLYMERASE CHAIN REACTION; TIME; TRANSGENIC MOUSE;

ADIPOSE TISSUE; AGING; ANIMALS; BODY WEIGHT; CASPASE 3; CASPASES; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; GENETIC VECTORS; GLUCOSE; GLUCOSE TOLERANCE TEST; GLUCOSE-6-PHOSPHATASE; GLYCOGEN SYNTHASE; HYPERGLYCEMIA; HYPERINSULINISM; IMMUNOHISTOCHEMISTRY; INSULIN; ISLETS OF LANGERHANS; LIVER; MALE; MICE; MICE, TRANSGENIC; MODELS, GENETIC; MUSCLES; ORGAN SIZE; PHENOTYPE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); POLYMERASE CHAIN REACTION; PROTEIN ISOFORMS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 85047693348     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI16885     Document Type: Article

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