Identification of a tumour suppressor network opposing nuclear Akt function

Nature

Volumn 441, Issue 7092, 2006, Pages 523-527

  Trotman, Lloyd C ^a   Alimonti, Andrea ^a   Scaglioni, Pier Paolo ^a   Koutcher, Jason A ^a   Cordon Cardo, Carlos ^a   Pandolfi, Pier Paolo ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; GENES; TISSUE;

COMPARTMENTALIZATION; HUMAN CANCER PATHOGENESIS; NUCLEAR TUMOURS; TUMOUR SUPPRESSOR;

TUMORS;

BIM PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; PHOSPHATASE; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN KINASE B; TRANSCRIPTION FACTOR FOXO; NUCLEAR PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE; PML PROTEIN, MOUSE; TRANSCRIPTION FACTOR; TUMOR PROTEIN; TUMOR SUPPRESSOR PROTEIN;

CANCER; COMPARTMENTALIZATION; DISEASE TREATMENT; EXPERIMENTAL STUDY; RODENT; TUMOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER INCIDENCE; CANCER PREVENTION; CARCINOGENESIS; CELL NUCLEUS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME LOCALIZATION; FEMALE STERILITY; GENE INACTIVATION; HETEROZYGOTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN ANALYSIS; PROTEIN FUNCTION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; ENZYMOLOGY; FEMALE; GENETICS; METABOLISM; PHOSPHORYLATION; PROTEIN TRANSPORT;

ANIMALS; CELL NUCLEUS; CELLS, CULTURED; FEMALE; MICE; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 33745316089     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04809     Document Type: Article

References (30)

1. Luo, J., Manning, B. D. & Cantley, L. C. Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 4, 257-262 (2003).
2. Brenkman, A. B. & Burgering, B. M. FoxO3a eggs on fertility and aging. Trends Mol. Med. 9, 464-467 (2003).
3. Salomoni, P. & Pandolfi, P. P. The role of PML in tumor suppression. Cell 108, 165-170 (2002).
4. Gurrieri, C. et al. Loss of the tumour suppressor PML in human cancers of multiple histologic origins. J. Natl Cancer Inst. 96, 269-279 (2004).
5. Goel, A. et al. Frequent inactivation of PTEN by promoter hypermethylation in microsatellite instability-high sporadic colorectal cancers. Cancer Res. 64, 3014-3021 (2004).
6. Porkka, K. P. & Visakorpi, T. Molecular mechanisms of prostate cancer. Eur. Urol. 45, 683-691 (2004).
7. Di Cristofano, A., Pesce, B., Cordon-Cardo, C. & Pandolfi, P. P. Pten is essential for embryonic development and tumour suppression. Nature Genet. 19, 348-355 (1998).
8. Podsypanina, K. et al. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc. Natl Acad. Sci. USA 96, 1563-1568 (1999).
9. Suzuki, A. et al. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr. Biol. 8, 1169-1178 (1998).
10. +/- mice. Science 285, 2122-2125 (1999).
11. Trotman, L. C. et al. Pten dose dictates cancer progression in the prostate. PLoS Biol. 1, E59 (2003).
12. Wang, S. et al. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell 4, 209-221 (2003).
13. Di Cristofano, A., De Acetis, M., Koff, A., Cordon-Cardo, C. & Pandolfi, P. P. Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse. Nature Genet. 27, 222-224 (2001).
14. Maehama, T., Taylor, G. S. & Dixon, J. E. PTEN and myotubularin: novel phosphoinositide phosphatases. Annu. Rev. Biochem. 70, 247-279 (2001).
15. Stambolic, V. et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95, 29-39 (1998).
16. Sarbassov, D. D., Guertin, D. A., Ali, S. M. & Sabatini, D. M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101 (2005).
17. Brazil, D. P., Yang, Z. Z. & Hemmings, B. A. Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem. Sci. 29, 233-242 (2004).
18. Tran, H., Brunet, A., Griffith, E. C. & Greenberg, M. E. The many forks in FOXO's road. Sci. STKE 2003, RE5 (2003).
19. Brunet, A. et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868 (1999).
20. Castrillon, D. H., Miao, L., Kollipara, R., Horner, J. W. & DePinho, R. A. Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 301, 215-218 (2003).
21. Hosaka, T. et al. Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc. Natl Acad. Sci. USA 101, 2975-2980 (2004).
22. Millward, T. A., Zolnierowicz, S. & Hemmings, B. A. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem. Sci. 24, 186-191 (1999).
23. Gao, T., Furnari, F. & Newton, A. C. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol. Cell 18, 13-24 (2005).
24. Janssens, V., Goris, J. & Van Hoof, C. PP2A: the expected tumor suppressor. Curr. Opin. Genet. Dev. 15, 34-41 (2005).
25. Li, L., Ren, C. H., Tahir, S. A., Ren, C. & Thompson, T. C. Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A. Mol. Cell. Biol. 23, 9389-9404 (2003).
26. Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell 100, 57-70 (2000).
27. Chen, Z. et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436, 725-730 (2005).
28. Wang, Z. G. et al. PML is essential for multiple apoptotic pathways. Nature Genet. 20, 266-272 (1998).
29. Guo, A. et al. The function of PML in p53-dependent apoptosis. Nature Cell Biol. 2, 730-736 (2000).
30. Brunet, A. et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011-2015 (2004).