AKT1E17K in human solid tumours

Oncogene

Volumn 27, Issue 42, 2008, Pages 5648-5650

  Bleeker, F E ^a,b   Felicioni, L ^c   Buttitta, F ^c   Lamba, S ^a   Cardone, L ^a   Rodolfo, M ^d   Scarpa, A ^e   Leenstra, S ^f   Frattini, M ^d,g   Barbareschi, M ^h   Grammastro, M Del ^c   Sciarrotta, M G ^c   Zanon, C ^a   Marchetti, A ^c   Bardelli, A ^a,i,j  

^a UNIVERSITY OF TURIN   (Italy)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF CHIETI   (Italy)

^d NATIONAL CANCER INSTITUTE   (Italy)

^e UNIVERSITY OF VERONA   (Italy)

^f CPRLab   (Netherlands)

^g OSPEDALE SAN GIOVANNI   (Switzerland)

^h SANTA CHIARA HOSPITAL   (Italy)

ⁱ FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^j UNIVERSITY OF TURIN   (Italy)

more..

Author keywords

AKT1; Cancer; Mutation; PIK3CA

Indexed keywords

AKT1 PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

AKT1 GENE; ALLELE; ARTICLE; BREAST CARCINOMA; COLORECTAL CARCINOMA; E17K GENE; GENE; GENE ACTIVATION; GENE MUTATION; GENE TARGETING; GENETIC IDENTIFICATION; GENETIC VARIABILITY; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; LUNG CARCINOMA; MELANOMA; MUTATION; NEOPLASM; OVARY CARCINOMA; PANCREAS CARCINOMA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SOLID TUMOR;

1-PHOSPHATIDYLINOSITOL 3-KINASE; HUMANS; MUTATION; NEOPLASMS; ORGAN SPECIFICITY; PROTO-ONCOGENE PROTEINS C-AKT;

MUS;

EID: 52149086562     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2008.170     Document Type: Article

References (14)

1. Balakrishnan A, Bleeker FE, Lamba S, Rodolfo M, Daniotti M, Scarpa A et al. (2007). Novel somatic and germline mutations in cancer candidate genesin glioblastoma, melanoma, and pancreatic carcinoma. Cancer Res 67: 3545-3550.
2. Barbareschi M, Buttitta F, Felicioni L, Cotrupi S, Barassi F, Del Grammastro M et al. (2007). Different prognostic roles of mutationsin the helical and kinase domains of the PIK3CA gene in breast carcinomas. Clin Cancer Res 13: 6064-6069.
3. Benvenuti S, Frattini M, Arena S, Zanon C, Cappelletti V, Coradini D et al. (2008). PIK3CA cancer mutations display gender and tissue specificity patterns. Hum Mutat 29: 284-288.
4. Brugge J, Hung MC, Mills GB. (2007). A new mutational AKTivation in the PI3K pathway. Cancer Cell 12: 104-107.
5. Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM et al. (2007). A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448: 439-444.
6. Frattini M, Signoroni S, Pilotti S, Bertario L, Benvenuti S, Zanon C et al. (2005). Phosphatase protein homologue to tensin expression and phosphatidylinositol-3 phosphate kinase mutations in colorectal cancer. Cancer Res 65: 11227.
7. Guldberg P, thor Straten P, Birck A, Ahrenkiel V, Kirkin AF, Zeuthen J. (1997). Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res 57: 3660-3663.
8. Karakas B, Bachman KE, Park BH. (2006). Mutation of the PIK3CA oncogene in human cancers. Br J Cancer 27: 455-459.
9. Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI et al. (1997). PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943-1947.
10. Malanga D, Scrima M, De Marco C, Fabiani F, De Rosa N, de Gisi S et al. (2008). Activating E17K mutation in the gene encoding the protein kinase AKT in a subset of squamous cell carcinoma of the lung. Cell Cycle 5: 665-669.
11. Saal LH, Holm K, Maurer M, Memeo L, Su T, Wang X et al. (2005). PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res 65: 2554-2559.
12. Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S et al. (2004). High frequency of mutations of the PIK3CA gene in human cancers. Science 304: 554.
13. Schonleben F, Qiu W, Ciau NT, Ho DJ, Li X, Allendorf JD et al. (2006). PIK3CA mutationsin intraductal papillary mucinous neoplasm/carcinoma of the pancreas. Clin Cancer Res 12: 3851-3885.
14. Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, Leary RJ et al. (2007). The genomic landscapes of human breast and colorectal cancers. Science 318: 1108-1113.