PTEN expression is reduced in a subset of sporadic thyroid carcinomas: Evidence that PTEN-growth suppressing activity in thyroid cancer cells is mediated by p27(kip1)

Oncogene

Volumn 19, Issue 28, 2000, Pages 3146-3155

  Bruni, Paola ^a   Boccia, Angelo ^a   Baldassarre, Gustavo ^a   Trapasso, Francesco ^b   Santoro, Massimo ^c   Chiappetta, Gennaro ^a   Fusco, Alfredo ^b   Viglietto, Giuseppe ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c Campus Germaneto Viale Europa   (Italy)

Author keywords

AKT; Growth suppression; p27(kip1); PTEN; Thyroid cancer

Indexed keywords

COMPLEMENTARY DNA; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; PHOSPHATASE; PROTEIN P27;

ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CANCER CELL; CANCER GROWTH; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CONTROLLED STUDY; COWDEN SYNDROME; DNA TRANSFECTION; GENE DELETION; GENE FREQUENCY; GENE MUTATION; GERM LINE; HUMAN; HUMAN CELL; NORTHERN BLOTTING; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SOUTHERN BLOTTING; THYROID CARCINOMA; TUMOR SUPPRESSOR GENE;

EID: 0034729805     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1203633     Document Type: Article

References (35)

1. Baldassarre G, Belletti B, Bruni P, Boccia A, Trapasso F, Pentimalli F, Barone MV, Chiappetta G, Vento MT, Spiezia S, Fusco A and Viglietto G. (1999). J. Clin. Invest., 104, 865-874.
2. Bellacosa A, Testa JR, Staal SP and Tsichlis PN. (1991). Science, 254, 274-277.
3. Chalfie M, Tu Y, Euskirchen G, Ward WW and Prasher DC. (1994). Science, 263, 802-805.
4. Cheney IW, Johnson DE, Vaillancourt MT, Avanzini J, Morimoto A, Demers GW, Wills KN, Shabram PW, Bolen JB, Tavtigian SV and Bookstein R. (1998). Cancer Res., 58, 2331-2334.
5. Cheney IW, Neuteboom ST, Vaillancourt MT, Ramachandra M and Bookstein R. (1999). Cancer Res., 59, 2318-2323.
6. Dahia PL, Aguiar RC, Alberta J, Kum JB, Caron S, Sill H, Marsh DJ, Ritz J, Freedman A, Stiles C and Eng C. (1999). Hum. Mol. Genet., 8, 185-193.
7. Dahia PLM, Marsh DJ, Zheng Z, Zedenius J, Komminoth P, Frisk T, Wallin G, Parsons R, Longy M, Larsson C and Eng C. (1997). Cancer Res., 57, 4710-4713.
8. Da-Ming L and Hong S. (1998). Proc. Natl. Acad. Sci. USA, 95, 15406-15411.
9. Di Cristofano A, Pesce B, Cordon-Cardo C and Pandolfi PP. (1998). Nat. Genet., 19, 348-357.
10. Downward J. (1998). Science, 279, 673-674.
11. Eng C. (1998). Int. J. Oncol., 12, 701-710.
12. Furnari FB, Lin H, Huang HJS and Cavenee WK. (1997). Proc. Natl. Acad. Sci. USA, 9, 12479-12484.
13. Haas-Kogan D, Shalev N, Wong M, Mills G, Yount G and Stokoe D. (1998). Curr. Biol., 8, 1195-1198.
14. Halachmi N, Halachmi S, Evron E, Cairns P, Okami K, Saji M, Westra WH, Zeiger MA, Jen J and Sidransky D. (1998). Genes Chromosomes Cancer, 23, 239-243.
15. Hanssen A and Fryns JJ. (1995). Med. Genet., 32, 117-119.
16. Li J, Clifford J, Liaw D, Podsypanina K, Bose S, Wang S, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner S, Giovanella B, Ittmann M, Tycko B, Hibshoosh H, Wigler M and Parsons R. (1997). Science, 275, 1943-1947.
17. Liaw D, Marsh D, Li J, Dahia P, Wang S, Zheng Z, Bose S, Call K, Tsou H, Peacocke M, Eng C and Parson R. (1997). Nat. Genet., 16, 64-67.
18. Longy M and Lacombe D. (1996). Ann. Genet., 39, 35-42.
19. Maehama T and Dixon JE. (1998). J. Biol. Chem., 273, 13375-13378.
20. Marsh DJ, Coulon V, Lunetta KL, Rocca-Serra P, Dahia PLM, Zheng Z, Liaw D, Caron S, Duboue B and Lin AY. (1998). Hum. Mol. Genet., 7, 507-515.
21. Marte BM and Downward J. (1997). Trends Biochem. Sci., 22, 355-358.
22. Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP and Tonks NK. (1997). Proc. Natl. Acad. Sci. USA, 94, 9052-9057.
23. Myers MP, Stolarov JP, Eng C, Li J, Wang SI, Wigler MH, Parsons R and Tonks NK. (1998). Proc. Natl. Acad. Sci. USA, 95, 13515-13518.
24. Nelen M, Padberg G, Peeters E, Lyn A, van der Helm B, Frants R, Coulon V, Goldstein A, van Reen M, Easton D, Eeles R, Hogson S, Mulvihill J, Murday V, Tucker M, Mariman E, Starink T, Ponder B, Ropers H, Kremer H, Longy M and Eng C. (1996). Nat. Genet., 13, 114-116.
25. Podsypanina K, Ellenson LH, Nemes A, Gu J, Tamura M, Yamada K, Cordon-Carro C, Catoretti G, Fisher PE and Parsons R. (1999). Proc. Natl. Acad. Sci. USA, 96, 1563-1568.
26. Rasheed BKA, Stenzel TT, McLendon RE, Parsons R, Friedman AH, Fridman HS, Bigner DD and Bigner SH. (1997). Cancer Res., 57, 4187-4190.
27. Sambrook J, Fritsh E and Maniatis T. (1989). Molecular Cloning: A laboratory Manual, 2nd edn. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
28. Santoro M, Carlomagno F, Hay ID, Herrmann MA, Melillo RM, Bongarzone I, Pierotti MA, Della Porta G, Berger N, Peix JL, Paulin C, Fabien N, Grieco M, Vecchio G, Jenkins RB and Fusco A. (1992). J. Clin. Invest., 89, 1517-1522.
29. Scala S, Bruni P, Lo Muzio L, Mignogna M, Viglietto G and Fusco A. (1998). Int. J. Oncol., 13, 665-668.
30. Sherr CJ and Roberts JM. (1995). Genes Dev., 9, 1149-1163.
31. Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM, Siderovski DP and Mak TK. (1998). Cell, 95, 29-39.
32. Steck P, Pershouse M, Jasser S, Yung W, Lin H, Ligon A, Langford L, Baumgard M, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng D and Tavtigian S. (1997). Nat. Genet., 15, 356-362.
33. Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, Barrantes I, Ho A, Wakeham A, Itie A, Khoo W, Fukumoto M and Mak TK. (1998). Curr. Biol., 8, 1169-1178.
34. Tamura M, Gu J, Matsumoto K, Aota S, Parsons R and Yamada KM. (1998). Science, 280, 1614-1617.
35. Whang YE, Wu X, Suzuki H, Reiter RE, Tran C, Vessella R, Said JW, Isaacs WB and Sawiers CL. (1998). Proc. Natl. Acad. Sci. USA, 95, 5246-5250.