Activation of Akt/protein kinase B overcomes a G2/M cell cycle checkpoint induced by DNA damage

Molecular and Cellular Biology

Volumn 22, Issue 22, 2002, Pages 7831-7841

  Kandel, Eugene S ^a   Skeen, Jennifer ^a   Majewski, Nathan ^a   Di Cristofano, Antonio ^a   Pandolfi, Pier Paolo ^a   Feliciano, Claudine S ^a   Gartel, Andrei ^a   Hay, Nissim ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTAGENIC AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL 2; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN P53; THYMIDINE KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; DNA DAMAGE; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; GENE OVEREXPRESSION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; MISMATCH REPAIR; MITOSIS INDEX; MITOSIS INHIBITION; NONHUMAN; ONCOGENE MYC; PHENOTYPE; PRIORITY JOURNAL; STEM CELL; VIRUS GENE;

ANIMALIA; SIMPLEXVIRUS;

EID: 0036841293     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.22.7831-7841.2002     Document Type: Article

References (50)

1. Abuin, A., H. Zhang, and A. Bradley. 2000. Genetic analysis of mouse embryonic stem cells bearing Msh3 and Msh2 single and compound mutations. Mol. Cell. Biol. 20:149-157.
2. WAF1/CIP1 gene. Mol. Cell. Biol. 20:1291-1298.
3. Altiok, S., D. Batt, N. Altiok, A. Papautsky, J. Downward, T. M. Roberts, and H. Avraham. 1999. Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-kinase/AKT in breast cancer cells. J. Biol. Chem. 274:32274-32278.
4. Aoki, M., O. Batista, A. Bellacosa, P. Tsichlis, and P. K. Vogt. 1998. The akt kinase: Molecular determinants of oncogenicity. Proc. Natl. Acad. Sci. USA 95:14950-14955.
5. 2/M cell cycle arrest and lethality after DNA damage. Carcinogenesis 20:2317-2326.
6. Bellacosa, A. 2001. Functional interactions and signaling properties of mammalian DNA mismatch repair proteins. Cell Death Differ. 8:1076-1092.
7. Cantley, L. C., and B. G. Neel. 1999. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. USA 96: 4240-4245.
8. 1 CDKs in choroidal melanoma cells. FEBS Lett. 422:385-390.
9. Chen, W. S., P. Z. Xu, K. Gottlob, M. L. Chen, K. Sokol, T. Shiyanova, I. Roninson, W. Weng, R. Suzuki, K. Tobe, T. Kadowaki, and N. Hay. 2001. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 15:2203-2208.
10. Chernova, O. B., M. V. Chernov, Y. Ishizaka, M. L. Agarwal, and G. R. Stark. 1998. MYC abrogates p53-mediated cell cycle arrest in N-(phosphonacetyl)-L-aspartate-treated cells, permitting CAD gene amplification. Mol. Cell. Biol. 18:536-545.
11. 2-M cell cycle checkpoint arrest following ionizing radiation. Cancer Res. 58:767-778.
12. Di Cristofano, A., B. Pesce, C. Cordon-Cardo, and P. P. Pandolfi. 1998. Pten is essential for embryonic development and tumour suppression. Nat. Genet. 19:348-355.
13. Downward, J. 1998. Mechanisms and consequences of activation of protein kinase B/Akt. Curr. Opin. Cell Biol. 10:262-267.
14. Fenwick, R. G., Jr., and C. T. Caskey. 1975. Mutant Chinese hamster cells with a thermosensitive hypoxanthine-guanine phosphoribosyltransferase. Cell 5:115-122.
15. Gingras, A. C., S. G. Kennedy, M. A. O'Leary, N. Sonenberg, and N. Hay. 1998. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev. 12:502-513.
16. Gottlob, K., N. Majewski, S. Kennedy, E. S. Kandel, R. B. Robey, and N. Hay. 2001. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial metabolism. Genes Dev. 15:1406-1418.
17. Grand, R. J., P. S. Lecane, D. Owen, M. L. Grant, S. Roberts, A. J. Levine, and P. H. Gallimore. 1995. The high levels of p53 present in adenovirus early region 1-transformed human cells do not cause up-regulation of MDM2 expression. Virology 210:323-334.
18. Griffin, S., P. Branch, Y. Z. Xu, and P. Karran. 1994. DNA mismatch binding and incision at modified guanine bases by extracts of mammalian cells: Implications for tolerance to DNA methylation damage. Biochemistry 33: 4787-4793.
19. 2 cell cycle checkpoint. Cancer Res. 55:3721-3725.
20. Hirose, Y., M. S. Berger, and R. O. Pieper. 2001. Abrogation of the Chk1-mediated G(2) checkpoint pathway potentiates temozolomide-induced toxicity in a p53-independent manner in human glioblastoma cells. Cancer Res. 61:5843-5849.
21. Kandel, E. S., B. D. Chang, B. Schott, A. A. Shtil, A. V. Gudkov, and I. B. Roninson. 1997. Applications of green fluorescent protein as a marker of retroviral vectors. Somat. Cell Mol. Genet. 23:325-340.
22. Kandel, E. S., and N. Hay. 1999. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp. Cell Res. 253:210-229.
23. Kennedy, S. G., A. J. Wagner, S. D. Conzen, J. Jordan, A. Bellacosa, P. N. Tsichlis, and N. Hay. 1997. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 11:701-713.
24. Koi, M., A. Umar, D. P. Chauhan, S. P. Cherian, J. M. Carethers, T. A. Kunkel, and C. R. Boland. 1994. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N′-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res. 54:4308-4312. (Erratum, 55:201, 1995.)
25. 2 DNA damage checkpoint radiosensitizes p53 mutant human cells. Oncogene 20:7453-7463.
26. Le, X. F., R. Vadlamudi, A. McWatters, D. S. Bae, G. B. Mills, R. Kumar, and R. C. Bast, Jr. 2000. Differential signaling by an anti-p185(HER2) antibody and heregulin. Cancer Res. 60:3522-3531.
27. Lengauer, C., K. W. Kinzler, and B. Vogelstein. 1997. DNA methylation and genetic instability in colorectal cancer cells. Proc. Natl. Acad. Sci. USA 94:2545-2550.
28. 2/M DNA damage checkpoint. Genes Dev. 14:1448-1459.
29. 2 checkpoint specifically sensitizes p53 defective cells to cancer chemotherapeutic agents. Anticancer Res. 21:23-28.
30. MacLachlan, T. K., K. Somasundaram, M. Sgagias, Y. Shifman, R. J. Muschel, K. H. Cowan, and W. S. El-Deiry. 2000. BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression. J. Biol. Chem. 275:2777-2785.
31. Mailand, N., J. Falck, C. Lukas, R. G. Syljuasen, M. Welcker, J. Bartek, and J. Lukas. 2000. Rapid destruction of human Cdc25A in response to DNA damage. Science 288:1425-1429.
32. Mayo, L. D., and D. B. Donner. 2001. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc. Natl. Acad. Sci. USA 98:11598-11603.
33. Ossovskaya, V. S., I. A. Mazo, M. V. Chernov, O. B. Chernova, Z. Strezoska, R. Kondratov, G. R. Stark, P. M. Chumakov, and A. V. Gudkov. 1996. Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains. Proc. Natl. Acad. Sci. USA 93:10309-10314.
34. Podsypanina, K., L. H. Ellenson, A. Nemes, J. Gu, M. Tamura, K. M. Yamada, C. Cordon-Cardo, G. Catoretti, P. E. Fisher, and R. Parsons. 1999. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc. Natl. Acad. Sci. USA 96:1563-1568.
35. 2/M phase of the cell cycle. Curr. Biol. 12:919-924.
36. Simpson, L., and R. Parsons. 2001. Pten: Life as a tumor suppressor. Exp. Cell Res. 264:29-41.
37. Sun, H., R. Lesche, D. M. Li, J. Liliental, H. Zhang, J. Gao, N. Gavrilova, B. Mueller, X. Liu, and H. Wu. 1999. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc. Natl. Acad. Sci. USA 96:6199-6204.
38. Suzuki, A., J. L. de la Pompa, V. Stambolic, A. J. Elia, T. Sasaki, I. del Barco Barrantes, A. Ho, A. Wakeham, A. Itie, W. Khoo, M. Fukumoto, and T. W. Mak. 1998. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr. Biol. 8:1169-1178.
39. Swann, P. F., T. R. Waters, D. C. Moulton, Y. Z. Xu, Q. Zheng, M. Edwards, and R. Mace. 1996. Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine. Science 273:1109-1111.
40. Tran, H., A. Brunet, J. M. Grenier, S. R. Datta, A. J. Fornace, Jr., P. S. DiStefano, L. W. Chiang, and M. E. Greenberg. 2002. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296:530-534.
41. waf1/cip1. Genes Dev. 8:2817-2830.
42. Wagner, A. J., M. B. Small, and N. Hay. 1993. Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2. Mol. Cell. Biol. 13:2432-2440.
43. Wang, Q., H. Zhang, R. Fishel, and M. I. Greene. 2000. BRCA1 and cell signaling. Oncogene 19:6152-6158.
44. Wang, Q., H. Zhang, S. Guerrette, J. Chen, A. Mazurek, T. Wilson, A. Slupianek, T. Skorski, R. Fishel, and M. I. Greene. 2001. Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1. Oncogene 20:4640-4649.
45. Wang, Y., D. Cortez, P. Yazdi, N. Neff, S. J. Elledge, and J. Qin. 2000. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. Genes Dev. 14:927-939.
46. 2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol. Cell 3:389-395.
47. 2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat. Genet. 30:285-289.
48. Yew, P. R., and A. J. Berk. 1992. Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein. Nature 357:82-85.
49. Zhou, B. P., Y. Liao, W. Xia, B. Spohn, M. H. Lee, and M. C. Hung. 2001. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat. Cell Biol. 3:245-252.
50. Zhou, B. P., Y. Liao, W. Xia, Y. Zou, B. Spohn, and M. C. Hung. 2001. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat. Cell Biol. 3:973-982.