-
1
-
-
0031936353
-
Ras signalling and apoptosis
-
Downward J. Ras signalling and apoptosis. Curr. Opin. Genet. Dev. 8 (1998) 49-54
-
(1998)
Curr. Opin. Genet. Dev.
, vol.8
, pp. 49-54
-
-
Downward, J.1
-
2
-
-
0037075886
-
GTPase activating proteins: critical regulators of intracellular signaling
-
Donovan S., Shannon K.M., and Bollag G. GTPase activating proteins: critical regulators of intracellular signaling. Biochim. Biophys. Acta 1602 (2002) 23-45
-
(2002)
Biochim. Biophys. Acta
, vol.1602
, pp. 23-45
-
-
Donovan, S.1
Shannon, K.M.2
Bollag, G.3
-
3
-
-
0030920782
-
G protein mechanisms: insights from structural analysis
-
Sprang S.R. G protein mechanisms: insights from structural analysis. Annu. Rev. Biochem. 66 (1997) 639-678
-
(1997)
Annu. Rev. Biochem.
, vol.66
, pp. 639-678
-
-
Sprang, S.R.1
-
4
-
-
0026735063
-
Protein isoprenylation and methylation at carboxyl-terminal cysteine residues
-
Clarke S. Protein isoprenylation and methylation at carboxyl-terminal cysteine residues. Annu. Rev. Biochem. 61 (1992) 355-386
-
(1992)
Annu. Rev. Biochem.
, vol.61
, pp. 355-386
-
-
Clarke, S.1
-
6
-
-
33644864788
-
Compartmentalized Ras/MAPK signaling
-
Mor A., and Philips M.R. Compartmentalized Ras/MAPK signaling. Annu. Rev. Immunol. 24 (2006) 771-800
-
(2006)
Annu. Rev. Immunol.
, vol.24
, pp. 771-800
-
-
Mor, A.1
Philips, M.R.2
-
7
-
-
0023445442
-
Dynamic fatty acylation of p21N-ras
-
Magee A.I., Gutierrez L., McKay I.A., Marshall C.J., and Hall A. Dynamic fatty acylation of p21N-ras. EMBO J. 6 (1987) 3353-3357
-
(1987)
EMBO J.
, vol.6
, pp. 3353-3357
-
-
Magee, A.I.1
Gutierrez, L.2
McKay, I.A.3
Marshall, C.J.4
Hall, A.5
-
8
-
-
20144375061
-
An acylation cycle regulates localization and activity of palmitoylated Ras isoforms
-
Rocks O., Peyker A., Kahms M., Verveer P.J., Koerner C., Lumbierres M., Kuhlmann J., Waldmann H., Wittinghofer A., and Bastiaens P.I. An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. Science 307 (2005) 1746-1752
-
(2005)
Science
, vol.307
, pp. 1746-1752
-
-
Rocks, O.1
Peyker, A.2
Kahms, M.3
Verveer, P.J.4
Koerner, C.5
Lumbierres, M.6
Kuhlmann, J.7
Waldmann, H.8
Wittinghofer, A.9
Bastiaens, P.I.10
-
9
-
-
22944460791
-
Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway
-
Goodwin J.S., Drake K.R., Rogers C., Wright L., Lippincott-Schwartz J., Philips M.R., and Kenworthy A.K. Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway. J. Cell Biol. 170 (2005) 261-272
-
(2005)
J. Cell Biol.
, vol.170
, pp. 261-272
-
-
Goodwin, J.S.1
Drake, K.R.2
Rogers, C.3
Wright, L.4
Lippincott-Schwartz, J.5
Philips, M.R.6
Kenworthy, A.K.7
-
10
-
-
22144479017
-
Ras plasma membrane signalling platforms
-
Hancock J.F., and Parton R.G. Ras plasma membrane signalling platforms. Biochem. J. 389 (2005) 1-11
-
(2005)
Biochem. J.
, vol.389
, pp. 1-11
-
-
Hancock, J.F.1
Parton, R.G.2
-
11
-
-
33745745892
-
Spatio-temporal segregation of Ras signals: one ship, three anchors, many harbors
-
Rocks O., Peyker A., and Bastiaens P.I. Spatio-temporal segregation of Ras signals: one ship, three anchors, many harbors. Curr. Opin. Cell Biol. 18 (2006) 351-357
-
(2006)
Curr. Opin. Cell Biol.
, vol.18
, pp. 351-357
-
-
Rocks, O.1
Peyker, A.2
Bastiaens, P.I.3
-
12
-
-
0025193117
-
Stimulation of p21ras upon T-cell activation
-
Downward J., Graves J.D., Warne P.H., Rayter S., and Cantrell D.A. Stimulation of p21ras upon T-cell activation. Nature 346 (1990) 719-723
-
(1990)
Nature
, vol.346
, pp. 719-723
-
-
Downward, J.1
Graves, J.D.2
Warne, P.H.3
Rayter, S.4
Cantrell, D.A.5
-
13
-
-
0025195107
-
Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity
-
Satoh T., Endo M., Nakafuku M., Akiyama T., Yamamoto T., and Kaziro Y. Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity. Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 7926-7929
-
(1990)
Proc. Natl. Acad. Sci. U. S. A.
, vol.87
, pp. 7926-7929
-
-
Satoh, T.1
Endo, M.2
Nakafuku, M.3
Akiyama, T.4
Yamamoto, T.5
Kaziro, Y.6
-
14
-
-
0025337018
-
Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells
-
Satoh T., Endo M., Nakafuku M., Nakamura S., and Kaziro Y. Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells. Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 5993-5997
-
(1990)
Proc. Natl. Acad. Sci. U. S. A.
, vol.87
, pp. 5993-5997
-
-
Satoh, T.1
Endo, M.2
Nakafuku, M.3
Nakamura, S.4
Kaziro, Y.5
-
15
-
-
0025222844
-
Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)
-
Gibbs J.B., Marshall M.S., Scolnick E.M., Dixon R.A., and Vogel U.S. Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP). J. Biol. Chem. 265 (1990) 20437-20442
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 20437-20442
-
-
Gibbs, J.B.1
Marshall, M.S.2
Scolnick, E.M.3
Dixon, R.A.4
Vogel, U.S.5
-
16
-
-
0027153103
-
Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
-
Buday L., and Downward J. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 73 (1993) 611-620
-
(1993)
Cell
, vol.73
, pp. 611-620
-
-
Buday, L.1
Downward, J.2
-
17
-
-
0027931640
-
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway
-
Aronheim A., Engelberg D., Li N., al-Alawi N., Schlessinger J., and Karin M. Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. Cell 78 (1994) 949-961
-
(1994)
Cell
, vol.78
, pp. 949-961
-
-
Aronheim, A.1
Engelberg, D.2
Li, N.3
al-Alawi, N.4
Schlessinger, J.5
Karin, M.6
-
18
-
-
0029132697
-
Differential interactions of human Sos1 and Sos2 with Grb2
-
Yang S.S., Van Aelst L., and Bar-Sagi D. Differential interactions of human Sos1 and Sos2 with Grb2. J. Biol. Chem. 270 (1995) 18212-18215
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 18212-18215
-
-
Yang, S.S.1
Van Aelst, L.2
Bar-Sagi, D.3
-
19
-
-
0030666849
-
The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1
-
Nielsen K.H., Papageorge A.G., Vass W.C., Willumsen B.M., and Lowy D.R. The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1. Mol. Cell. Biol. 17 (1997) 7132-7138
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 7132-7138
-
-
Nielsen, K.H.1
Papageorge, A.G.2
Vass, W.C.3
Willumsen, B.M.4
Lowy, D.R.5
-
20
-
-
0034651705
-
The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties
-
Qian X., Esteban L., Vass W.C., Upadhyaya C., Papageorge A.G., Yienger K., Ward J.M., Lowy D.R., and Santos E. The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties. EMBO J. 19 (2000) 642-654
-
(2000)
EMBO J.
, vol.19
, pp. 642-654
-
-
Qian, X.1
Esteban, L.2
Vass, W.C.3
Upadhyaya, C.4
Papageorge, A.G.5
Yienger, K.6
Ward, J.M.7
Lowy, D.R.8
Santos, E.9
-
21
-
-
0009722399
-
Ras-guanine nucleotide exchange factor sos2 is dispensable for mouse growth and development
-
Esteban L.M., Fernandez-Medarde A., Lopez E., Yienger K., Guerrero C., Ward J.M., Tessarollo L., and Santos E. Ras-guanine nucleotide exchange factor sos2 is dispensable for mouse growth and development. Mol. Cell. Biol. 20 (2000) 6410-6413
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 6410-6413
-
-
Esteban, L.M.1
Fernandez-Medarde, A.2
Lopez, E.3
Yienger, K.4
Guerrero, C.5
Ward, J.M.6
Tessarollo, L.7
Santos, E.8
-
22
-
-
0029031112
-
The Grb2 binding domain of mSos1 is not required for downstream signal transduction
-
Wang W., Fisher E.M., Jia Q., Dunn J.M., Porfiri E., Downward J., and Egan S.E. The Grb2 binding domain of mSos1 is not required for downstream signal transduction. Nat. Genet. 10 (1995) 294-300
-
(1995)
Nat. Genet.
, vol.10
, pp. 294-300
-
-
Wang, W.1
Fisher, E.M.2
Jia, Q.3
Dunn, J.M.4
Porfiri, E.5
Downward, J.6
Egan, S.E.7
-
23
-
-
33746631240
-
Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1
-
Zarich N., Oliva J.L., Martinez N., Jorge R., Ballester A., Gutierrez-Eisman S., Garcia-Vargas S., and Rojas J.M. Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1. Mol. Biol. Cell 17 (2006) 3591-3597
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 3591-3597
-
-
Zarich, N.1
Oliva, J.L.2
Martinez, N.3
Jorge, R.4
Ballester, A.5
Gutierrez-Eisman, S.6
Garcia-Vargas, S.7
Rojas, J.M.8
-
24
-
-
0029029153
-
Functional roles for the pleckstrin and Dbl homology regions in the Ras exchange factor Son-of-sevenless
-
McCollam L., Bonfini L., Karlovich C.A., Conway B.R., Kozma L.M., Banerjee U., and Czech M.P. Functional roles for the pleckstrin and Dbl homology regions in the Ras exchange factor Son-of-sevenless. J. Biol. Chem. 270 (1995) 15954-15957
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 15954-15957
-
-
McCollam, L.1
Bonfini, L.2
Karlovich, C.A.3
Conway, B.R.4
Kozma, L.M.5
Banerjee, U.6
Czech, M.P.7
-
25
-
-
0029003471
-
In vivo functional analysis of the Ras exchange factor son of sevenless
-
Karlovich C.A., Bonfini L., McCollam L., Rogge R.D., Daga A., Czech M.P., and Banerjee U. In vivo functional analysis of the Ras exchange factor son of sevenless. Science 268 (1995) 576-579
-
(1995)
Science
, vol.268
, pp. 576-579
-
-
Karlovich, C.A.1
Bonfini, L.2
McCollam, L.3
Rogge, R.D.4
Daga, A.5
Czech, M.P.6
Banerjee, U.7
-
26
-
-
0029849810
-
p21Ras activation by the guanine nucleotide exchange factor Sos, requires the Sos/Grb2 interaction and a second ligand-dependent signal involving the Sos N-terminus
-
Byrne J.L., Paterson H.F., and Marshall C.J. p21Ras activation by the guanine nucleotide exchange factor Sos, requires the Sos/Grb2 interaction and a second ligand-dependent signal involving the Sos N-terminus. Oncogene 13 (1996) 2055-2065
-
(1996)
Oncogene
, vol.13
, pp. 2055-2065
-
-
Byrne, J.L.1
Paterson, H.F.2
Marshall, C.J.3
-
27
-
-
0031929680
-
N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains
-
Qian X., Vass W.C., Papageorge A.G., Anborgh P.H., and Lowy D.R. N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains. Mol. Cell. Biol. 18 (1998) 771-778
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 771-778
-
-
Qian, X.1
Vass, W.C.2
Papageorge, A.G.3
Anborgh, P.H.4
Lowy, D.R.5
-
28
-
-
0031882763
-
Regulation of Sos activity by intramolecular interactions
-
Corbalan-Garcia S., Margarit S.M., Galron D., Yang S.S., and Bar-Sagi D. Regulation of Sos activity by intramolecular interactions. Mol. Cell. Biol. 18 (1998) 880-886
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 880-886
-
-
Corbalan-Garcia, S.1
Margarit, S.M.2
Galron, D.3
Yang, S.S.4
Bar-Sagi, D.5
-
29
-
-
0031580202
-
The solution structure of the pleckstrin homology domain of mouse Son-of-sevenless 1 (mSos1)
-
Koshiba S., Kigawa T., Kim J.H., Shirouzu M., Bowtell D., and Yokoyama S. The solution structure of the pleckstrin homology domain of mouse Son-of-sevenless 1 (mSos1). J. Mol. Biol. 269 (1997) 579-591
-
(1997)
J. Mol. Biol.
, vol.269
, pp. 579-591
-
-
Koshiba, S.1
Kigawa, T.2
Kim, J.H.3
Shirouzu, M.4
Bowtell, D.5
Yokoyama, S.6
-
30
-
-
0031002348
-
The role of the PH domain in the signal-dependent membrane targeting of Sos
-
Chen R.H., Corbalan-Garcia S., and Bar-Sagi D. The role of the PH domain in the signal-dependent membrane targeting of Sos. EMBO J. 16 (1997) 1351-1359
-
(1997)
EMBO J.
, vol.16
, pp. 1351-1359
-
-
Chen, R.H.1
Corbalan-Garcia, S.2
Bar-Sagi, D.3
-
31
-
-
0032493134
-
Inhibition of mSOS-activity by binding of phosphatidylinositol 4,5-P2 to the mSOS pleckstrin homology domain
-
Jefferson A.B., Klippel A., and Williams L.T. Inhibition of mSOS-activity by binding of phosphatidylinositol 4,5-P2 to the mSOS pleckstrin homology domain. Oncogene 16 (1998) 2303-2310
-
(1998)
Oncogene
, vol.16
, pp. 2303-2310
-
-
Jefferson, A.B.1
Klippel, A.2
Williams, L.T.3
-
32
-
-
34447568476
-
Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos
-
Zhao C., Du G., Skowronek K., Frohman M.A., and Bar-Sagi D. Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos. Nat. Cell Biol. 9 (2007) 706-712
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 706-712
-
-
Zhao, C.1
Du, G.2
Skowronek, K.3
Frohman, M.A.4
Bar-Sagi, D.5
-
33
-
-
0344885558
-
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS
-
Margarit S.M., Sondermann H., Hall B.E., Nagar B., Hoelz A., Pirruccello M., Bar-Sagi D., and Kuriyan J. Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell 112 (2003) 685-695
-
(2003)
Cell
, vol.112
, pp. 685-695
-
-
Margarit, S.M.1
Sondermann, H.2
Hall, B.E.3
Nagar, B.4
Hoelz, A.5
Pirruccello, M.6
Bar-Sagi, D.7
Kuriyan, J.8
-
34
-
-
7044226349
-
Structural analysis of autoinhibition in the Ras activator Son of sevenless
-
Sondermann H., Soisson S.M., Boykevisch S., Yang S.S., Bar-Sagi D., and Kuriyan J. Structural analysis of autoinhibition in the Ras activator Son of sevenless. Cell 119 (2004) 393-405
-
(2004)
Cell
, vol.119
, pp. 393-405
-
-
Sondermann, H.1
Soisson, S.M.2
Boykevisch, S.3
Yang, S.S.4
Bar-Sagi, D.5
Kuriyan, J.6
-
35
-
-
33751102674
-
Regulation of ras signaling dynamics by Sos-mediated positive feedback
-
Boykevisch S., Zhao C., Sondermann H., Philippidou P., Halegoua S., Kuriyan J., and Bar-Sagi D. Regulation of ras signaling dynamics by Sos-mediated positive feedback. Curr. Biol. 16 (2006) 2173-2179
-
(2006)
Curr. Biol.
, vol.16
, pp. 2173-2179
-
-
Boykevisch, S.1
Zhao, C.2
Sondermann, H.3
Philippidou, P.4
Halegoua, S.5
Kuriyan, J.6
Bar-Sagi, D.7
-
36
-
-
28044449725
-
Computational docking and solution X-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless
-
Sondermann H., Nagar B., Bar-Sagi D., and Kuriyan J. Computational docking and solution X-ray scattering predict a membrane-interacting role for the histone domain of the Ras activator son of sevenless. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 16632-16637
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 16632-16637
-
-
Sondermann, H.1
Nagar, B.2
Bar-Sagi, D.3
Kuriyan, J.4
-
37
-
-
0026659515
-
Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21
-
Shou C., Farnsworth C.L., Neel B.G., and Feig L.A. Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21. Nature 358 (1992) 351-354
-
(1992)
Nature
, vol.358
, pp. 351-354
-
-
Shou, C.1
Farnsworth, C.L.2
Neel, B.G.3
Feig, L.A.4
-
38
-
-
0026523616
-
Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator
-
Martegani E., Vanoni M., Zippel R., Coccetti P., Brambilla R., Ferrari C., Sturani E., and Alberghina L. Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator. EMBO J. 11 (1992) 2151-2157
-
(1992)
EMBO J.
, vol.11
, pp. 2151-2157
-
-
Martegani, E.1
Vanoni, M.2
Zippel, R.3
Coccetti, P.4
Brambilla, R.5
Ferrari, C.6
Sturani, E.7
Alberghina, L.8
-
39
-
-
0026768072
-
Isolation of multiple mouse cDNAs with coding homology to Saccharomyces cerevisiae CDC25: identification of a region related to Bcr, Vav, Dbl and CDC24
-
Cen H., Papageorge A.G., Zippel R., Lowy D.R., and Zhang K. Isolation of multiple mouse cDNAs with coding homology to Saccharomyces cerevisiae CDC25: identification of a region related to Bcr, Vav, Dbl and CDC24. EMBO J. 11 (1992) 4007-4015
-
(1992)
EMBO J.
, vol.11
, pp. 4007-4015
-
-
Cen, H.1
Papageorge, A.G.2
Zippel, R.3
Lowy, D.R.4
Zhang, K.5
-
40
-
-
0028304947
-
Expression of two different products of CDC25Mm, a mammalian Ras activator, during development of mouse brain
-
Ferrari C., Zippel R., Martegani E., Gnesutta N., Carrera V., and Sturani E. Expression of two different products of CDC25Mm, a mammalian Ras activator, during development of mouse brain. Exp. Cell Res. 210 (1994) 353-357
-
(1994)
Exp. Cell Res.
, vol.210
, pp. 353-357
-
-
Ferrari, C.1
Zippel, R.2
Martegani, E.3
Gnesutta, N.4
Carrera, V.5
Sturani, E.6
-
41
-
-
0029865523
-
Expression of alternative forms of Ras exchange factors GRF and SOS1 in different human tissues and cell lines
-
Guerrero C., Rojas J.M., Chedid M., Esteban L.M., Zimonjic D.B., Popescu N.C., Font de Mora J., and Santos E. Expression of alternative forms of Ras exchange factors GRF and SOS1 in different human tissues and cell lines. Oncogene 12 (1996) 1097-1107
-
(1996)
Oncogene
, vol.12
, pp. 1097-1107
-
-
Guerrero, C.1
Rojas, J.M.2
Chedid, M.3
Esteban, L.M.4
Zimonjic, D.B.5
Popescu, N.C.6
Font de Mora, J.7
Santos, E.8
-
42
-
-
0038275831
-
Ras-GRF1 signaling is required for normal beta-cell development and glucose homeostasis
-
Font de Mora J., Esteban L.M., Burks D.J., Nunez A., Garces C., Garcia-Barrado M.J., Iglesias-Osma M.C., Moratinos J., Ward J.M., and Santos E. Ras-GRF1 signaling is required for normal beta-cell development and glucose homeostasis. EMBO J. 22 (2003) 3039-3049
-
(2003)
EMBO J.
, vol.22
, pp. 3039-3049
-
-
Font de Mora, J.1
Esteban, L.M.2
Burks, D.J.3
Nunez, A.4
Garces, C.5
Garcia-Barrado, M.J.6
Iglesias-Osma, M.C.7
Moratinos, J.8
Ward, J.M.9
Santos, E.10
-
43
-
-
0031026133
-
Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras
-
Fam N.P., Fan W.T., Wang Z., Zhang L.J., Chen H., and Moran M.F. Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras. Mol. Cell. Biol. 17 (1997) 1396-1406
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 1396-1406
-
-
Fam, N.P.1
Fan, W.T.2
Wang, Z.3
Zhang, L.J.4
Chen, H.5
Moran, M.F.6
-
44
-
-
0026315383
-
The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras
-
Jones S., Vignais M.L., and Broach J.R. The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras. Mol. Cell. Biol. 11 (1991) 2641-2646
-
(1991)
Mol. Cell. Biol.
, vol.11
, pp. 2641-2646
-
-
Jones, S.1
Vignais, M.L.2
Broach, J.R.3
-
45
-
-
0025190338
-
In vitro reconstitution of cdc25 regulated S. cerevisiae adenylyl cyclase and its kinetic properties
-
Engelberg D., Simchen G., and Levitzki A. In vitro reconstitution of cdc25 regulated S. cerevisiae adenylyl cyclase and its kinetic properties. EMBO J. 9 (1990) 641-651
-
(1990)
EMBO J.
, vol.9
, pp. 641-651
-
-
Engelberg, D.1
Simchen, G.2
Levitzki, A.3
-
46
-
-
0034733637
-
Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3
-
Ohba Y., Mochizuki N., Yamashita S., Chan A.M., Schrader J.W., Hattori S., Nagashima K., and Matsuda M. Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3. J. Biol. Chem. 275 (2000) 20020-20026
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 20020-20026
-
-
Ohba, Y.1
Mochizuki, N.2
Yamashita, S.3
Chan, A.M.4
Schrader, J.W.5
Hattori, S.6
Nagashima, K.7
Matsuda, M.8
-
47
-
-
0035861736
-
Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors
-
Tian X., and Feig L.A. Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors. J. Biol. Chem. 276 (2001) 47248-47256
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47248-47256
-
-
Tian, X.1
Feig, L.A.2
-
48
-
-
0035851150
-
Prenylation of target GTPases contributes to signaling specificity of Ras-guanine nucleotide exchange factors
-
Gotoh T., Tian X., and Feig L.A. Prenylation of target GTPases contributes to signaling specificity of Ras-guanine nucleotide exchange factors. J. Biol. Chem. 276 (2001) 38029-38035
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38029-38035
-
-
Gotoh, T.1
Tian, X.2
Feig, L.A.3
-
49
-
-
0033588299
-
M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6
-
Quilliam L.A., Castro A.F., Rogers-Graham K.S., Martin C.B., Der C.J., and Bi C. M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6. J. Biol. Chem. 274 (1999) 23850-23857
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 23850-23857
-
-
Quilliam, L.A.1
Castro, A.F.2
Rogers-Graham, K.S.3
Martin, C.B.4
Der, C.J.5
Bi, C.6
-
50
-
-
0026632813
-
Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator
-
Mistou M.Y., Jacquet E., Poullet P., Rensland H., Gideon P., Schlichting I., Wittinghofer A., and Parmeggiani A. Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator. EMBO J. 11 (1992) 2391-2397
-
(1992)
EMBO J.
, vol.11
, pp. 2391-2397
-
-
Mistou, M.Y.1
Jacquet, E.2
Poullet, P.3
Rensland, H.4
Gideon, P.5
Schlichting, I.6
Wittinghofer, A.7
Parmeggiani, A.8
-
51
-
-
0027208625
-
Identification of amino acids in p21ras involved in exchange factor interaction
-
Howe L.R., and Marshall C.J. Identification of amino acids in p21ras involved in exchange factor interaction. Oncogene 8 (1993) 2583-2590
-
(1993)
Oncogene
, vol.8
, pp. 2583-2590
-
-
Howe, L.R.1
Marshall, C.J.2
-
52
-
-
0027285320
-
Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target
-
Polakis P., and McCormick F. Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target. J. Biol. Chem. 268 (1993) 9157-9160
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 9157-9160
-
-
Polakis, P.1
McCormick, F.2
-
54
-
-
0028178179
-
Identification of residues of the H-ras protein critical for functional interaction with guanine nucleotide exchange factors
-
Mosteller R.D., Han J., and Broek D. Identification of residues of the H-ras protein critical for functional interaction with guanine nucleotide exchange factors. Mol. Cell. Biol. 14 (1994) 1104-1112
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 1104-1112
-
-
Mosteller, R.D.1
Han, J.2
Broek, D.3
-
55
-
-
0028147401
-
Identification of residues critical for Ras(17N) growth-inhibitory phenotype and for Ras interaction with guanine nucleotide exchange factors
-
Quilliam L.A., Kato K., Rabun K.M., Hisaka M.M., Huff S.Y., Campbell-Burk S., and Der C.J. Identification of residues critical for Ras(17N) growth-inhibitory phenotype and for Ras interaction with guanine nucleotide exchange factors. Mol. Cell. Biol. 14 (1994) 1113-1121
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 1113-1121
-
-
Quilliam, L.A.1
Kato, K.2
Rabun, K.M.3
Hisaka, M.M.4
Huff, S.Y.5
Campbell-Burk, S.6
Der, C.J.7
-
56
-
-
0029838770
-
Rasp21 sequences opposite the nucleotide binding pocket are required for GRF-mediated nucleotide release
-
Leonardsen L., DeClue J.E., Lybaek H., Lowy D.R., and Willumsen B.M. Rasp21 sequences opposite the nucleotide binding pocket are required for GRF-mediated nucleotide release. Oncogene 13 (1996) 2177-2187
-
(1996)
Oncogene
, vol.13
, pp. 2177-2187
-
-
Leonardsen, L.1
DeClue, J.E.2
Lybaek, H.3
Lowy, D.R.4
Willumsen, B.M.5
-
57
-
-
15844372678
-
Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors
-
Quilliam L.A., Hisaka M.M., Zhong S., Lowry A., Mosteller R.D., Han J., Drugan J.K., Broek D., Campbell S.L., and Der C.J. Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors. J. Biol. Chem. 271 (1996) 11076-11082
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 11076-11082
-
-
Quilliam, L.A.1
Hisaka, M.M.2
Zhong, S.3
Lowry, A.4
Mosteller, R.D.5
Han, J.6
Drugan, J.K.7
Broek, D.8
Campbell, S.L.9
Der, C.J.10
-
58
-
-
13144250140
-
The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways
-
Fan W.T., Koch C.A., de Hoog C.L., Fam N.P., and Moran M.F. The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways. Curr. Biol. 8 (1998) 935-938
-
(1998)
Curr. Biol.
, vol.8
, pp. 935-938
-
-
Fan, W.T.1
Koch, C.A.2
de Hoog, C.L.3
Fam, N.P.4
Moran, M.F.5
-
59
-
-
0032722971
-
CDC25(Mm)/Ras-GRF1 regulates both Ras and Rac signaling pathways
-
Innocenti M., Zippel R., Brambilla R., and Sturani E. CDC25(Mm)/Ras-GRF1 regulates both Ras and Rac signaling pathways. FEBS Lett. 460 (1999) 357-362
-
(1999)
FEBS Lett.
, vol.460
, pp. 357-362
-
-
Innocenti, M.1
Zippel, R.2
Brambilla, R.3
Sturani, E.4
-
60
-
-
0033608990
-
G protein beta gamma subunit-dependent Rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm)
-
Kiyono M., Satoh T., and Kaziro Y. G protein beta gamma subunit-dependent Rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm). Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 4826-4831
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 4826-4831
-
-
Kiyono, M.1
Satoh, T.2
Kaziro, Y.3
-
61
-
-
0034658333
-
RasGRP links T-cell receptor signaling to Ras
-
Ebinu J.O., Stang S.L., Teixeira C., Bottorff D.A., Hooton J., Blumberg P.M., Barry M., Bleakley R.C., Ostergaard H.L., and Stone J.C. RasGRP links T-cell receptor signaling to Ras. Blood 95 (2000) 3199-3203
-
(2000)
Blood
, vol.95
, pp. 3199-3203
-
-
Ebinu, J.O.1
Stang, S.L.2
Teixeira, C.3
Bottorff, D.A.4
Hooton, J.5
Blumberg, P.M.6
Barry, M.7
Bleakley, R.C.8
Ostergaard, H.L.9
Stone, J.C.10
-
62
-
-
3042750795
-
Distinct mechanisms determine the patterns of differential activation of H-Ras, N-Ras, K-Ras 4B, and M-Ras by receptors for growth factors or antigen
-
Ehrhardt A., David M.D., Ehrhardt G.R., and Schrader J.W. Distinct mechanisms determine the patterns of differential activation of H-Ras, N-Ras, K-Ras 4B, and M-Ras by receptors for growth factors or antigen. Mol. Cell. Biol. 24 (2004) 6311-6323
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 6311-6323
-
-
Ehrhardt, A.1
David, M.D.2
Ehrhardt, G.R.3
Schrader, J.W.4
-
63
-
-
0034644772
-
Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor
-
Clyde-Smith J., Silins G., Gartside M., Grimmond S., Etheridge M., Apolloni A., Hayward N., and Hancock J.F. Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor. J. Biol. Chem. 275 (2000) 32260-32267
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 32260-32267
-
-
Clyde-Smith, J.1
Silins, G.2
Gartside, M.3
Grimmond, S.4
Etheridge, M.5
Apolloni, A.6
Hayward, N.7
Hancock, J.F.8
-
64
-
-
13144282666
-
A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia
-
Kawasaki H., Springett G.M., Toki S., Canales J.J., Harlan P., Blumenstiel J.P., Chen E.J., Bany I.A., Mochizuki N., Ashbacher A., Matsuda M., Housman D.E., and Graybiel A.M. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 13278-13283
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 13278-13283
-
-
Kawasaki, H.1
Springett, G.M.2
Toki, S.3
Canales, J.J.4
Harlan, P.5
Blumenstiel, J.P.6
Chen, E.J.7
Bany, I.A.8
Mochizuki, N.9
Ashbacher, A.10
Matsuda, M.11
Housman, D.E.12
Graybiel, A.M.13
-
65
-
-
0037163027
-
RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia
-
Reuther G.W., Lambert Q.T., Rebhun J.F., Caligiuri M.A., Quilliam L.A., and Der C.J. RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia. J. Biol. Chem. 277 (2002) 30508-30514
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 30508-30514
-
-
Reuther, G.W.1
Lambert, Q.T.2
Rebhun, J.F.3
Caligiuri, M.A.4
Quilliam, L.A.5
Der, C.J.6
-
66
-
-
0034682779
-
CalDAG-GEFIII activation of Ras, R-ras, and Rap1
-
Yamashita S., Mochizuki N., Ohba Y., Tobiume M., Okada Y., Sawa H., Nagashima K., and Matsuda M. CalDAG-GEFIII activation of Ras, R-ras, and Rap1. J. Biol. Chem. 275 (2000) 25488-25493
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 25488-25493
-
-
Yamashita, S.1
Mochizuki, N.2
Ohba, Y.3
Tobiume, M.4
Okada, Y.5
Sawa, H.6
Nagashima, K.7
Matsuda, M.8
-
67
-
-
0035117119
-
Phorbol esters modulate the Ras exchange factor RasGRP3
-
Lorenzo P.S., Kung J.W., Bottorff D.A., Garfield S.H., Stone J.C., and Blumberg P.M. Phorbol esters modulate the Ras exchange factor RasGRP3. Cancer Res. 61 (2001) 943-949
-
(2001)
Cancer Res.
, vol.61
, pp. 943-949
-
-
Lorenzo, P.S.1
Kung, J.W.2
Bottorff, D.A.3
Garfield, S.H.4
Stone, J.C.5
Blumberg, P.M.6
-
68
-
-
38349150605
-
The diacylglycerol dependent translocation of Ras guanine nucleotide-releasing protein 4 (RASGRP4) inside a human mast cell line results in substantial phenotypic changes including expression of the interleukin 13 receptor alpha2
-
Katsoulotos G.P., Qi M., Qi J.C., Tanaka K., Hughes W.E., Molloy T.J., Adachi R., Stevens R.L., and Krilis S.A. The diacylglycerol dependent translocation of Ras guanine nucleotide-releasing protein 4 (RASGRP4) inside a human mast cell line results in substantial phenotypic changes including expression of the interleukin 13 receptor alpha2. J. Biol. Chem. 283 (2007) 1610-1621
-
(2007)
J. Biol. Chem.
, vol.283
, pp. 1610-1621
-
-
Katsoulotos, G.P.1
Qi, M.2
Qi, J.C.3
Tanaka, K.4
Hughes, W.E.5
Molloy, T.J.6
Adachi, R.7
Stevens, R.L.8
Krilis, S.A.9
-
69
-
-
0037067713
-
RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function
-
Yang Y., Li L., Wong G.W., Krilis S.A., Madhusudhan M.S., Sali A., and Stevens R.L. RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function. J. Biol. Chem. 277 (2002) 25756-25774
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 25756-25774
-
-
Yang, Y.1
Li, L.2
Wong, G.W.3
Krilis, S.A.4
Madhusudhan, M.S.5
Sali, A.6
Stevens, R.L.7
-
70
-
-
0035861640
-
Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF
-
Pham N., and Rotin D. Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF. J. Biol. Chem. 276 (2001) 46995-47003
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 46995-47003
-
-
Pham, N.1
Rotin, D.2
-
71
-
-
0035839496
-
Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling
-
Jin T.G., Satoh T., Liao Y., Song C., Gao X., Kariya K., Hu C.D., and Kataoka T. Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling. J. Biol. Chem. 276 (2001) 30301-30307
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 30301-30307
-
-
Jin, T.G.1
Satoh, T.2
Liao, Y.3
Song, C.4
Gao, X.5
Kariya, K.6
Hu, C.D.7
Kataoka, T.8
-
72
-
-
0035951882
-
A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway
-
Lopez I., Mak E.C., Ding J., Hamm H.E., and Lomasney J.W. A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway. J. Biol. Chem. 276 (2001) 2758-2765
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 2758-2765
-
-
Lopez, I.1
Mak, E.C.2
Ding, J.3
Hamm, H.E.4
Lomasney, J.W.5
-
73
-
-
0029017628
-
Differential response of the Ras exchange factor, Ras-GRF to tyrosine kinase and G protein mediated signals
-
Shou C., Wurmser A., Suen K.L., Barbacid M., Feig L.A., and Ling K. Differential response of the Ras exchange factor, Ras-GRF to tyrosine kinase and G protein mediated signals. Oncogene 10 (1995) 1887-1893
-
(1995)
Oncogene
, vol.10
, pp. 1887-1893
-
-
Shou, C.1
Wurmser, A.2
Suen, K.L.3
Barbacid, M.4
Feig, L.A.5
Ling, K.6
-
74
-
-
0029098537
-
Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF
-
Farnsworth C.L., Freshney N.W., Rosen L.B., Ghosh A., Greenberg M.E., and Feig L.A. Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF. Nature 376 (1995) 524-527
-
(1995)
Nature
, vol.376
, pp. 524-527
-
-
Farnsworth, C.L.1
Freshney, N.W.2
Rosen, L.B.3
Ghosh, A.4
Greenberg, M.E.5
Feig, L.A.6
-
75
-
-
0029664925
-
Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits
-
Mattingly R.R., and Macara I.G. Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits. Nature 382 (1996) 268-272
-
(1996)
Nature
, vol.382
, pp. 268-272
-
-
Mattingly, R.R.1
Macara, I.G.2
-
76
-
-
0033601374
-
Phosphorylation of serine 916 of Ras-GRF1 contributes to the activation of exchange factor activity by muscarinic receptors
-
Mattingly R.R. Phosphorylation of serine 916 of Ras-GRF1 contributes to the activation of exchange factor activity by muscarinic receptors. J. Biol. Chem. 274 (1999) 37379-37384
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37379-37384
-
-
Mattingly, R.R.1
-
77
-
-
18444415156
-
Endogenous expression and protein kinase A-dependent phosphorylation of the guanine nucleotide exchange factor Ras-GRF1 in human embryonic kidney 293 cells
-
Norum J.H., Methi T., Mattingly R.R., and Levy F.O. Endogenous expression and protein kinase A-dependent phosphorylation of the guanine nucleotide exchange factor Ras-GRF1 in human embryonic kidney 293 cells. Febs J 272 (2005) 2304-2316
-
(2005)
Febs J
, vol.272
, pp. 2304-2316
-
-
Norum, J.H.1
Methi, T.2
Mattingly, R.R.3
Levy, F.O.4
-
78
-
-
0037631371
-
Phosphorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortex
-
Yang H., Cooley D., Legakis J.E., Ge Q., Andrade R., and Mattingly R.R. Phosphorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortex. J. Biol. Chem. 278 (2003) 13278-13285
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 13278-13285
-
-
Yang, H.1
Cooley, D.2
Legakis, J.E.3
Ge, Q.4
Andrade, R.5
Mattingly, R.R.6
-
79
-
-
13944278759
-
Calmodulin-dependent kinase kinase/calmodulin kinase I activity gates extracellular-regulated kinase-dependent long-term potentiation
-
Schmitt J.M., Guire E.S., Saneyoshi T., and Soderling T.R. Calmodulin-dependent kinase kinase/calmodulin kinase I activity gates extracellular-regulated kinase-dependent long-term potentiation. J. Neurosci. 25 (2005) 1281-1290
-
(2005)
J. Neurosci.
, vol.25
, pp. 1281-1290
-
-
Schmitt, J.M.1
Guire, E.S.2
Saneyoshi, T.3
Soderling, T.R.4
-
80
-
-
0034703005
-
Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1
-
Kiyono M., Kato J., Kataoka T., Kaziro Y., and Satoh T. Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1. J. Biol. Chem. 275 (2000) 29788-29793
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 29788-29793
-
-
Kiyono, M.1
Kato, J.2
Kataoka, T.3
Kaziro, Y.4
Satoh, T.5
-
81
-
-
0034008403
-
Induction of rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) following phosphorylation by the nonreceptor tyrosine kinase Src
-
Kiyono M., Kaziro Y., and Satoh T. Induction of rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) following phosphorylation by the nonreceptor tyrosine kinase Src. J. Biol. Chem. 275 (2000) 5441-5446
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 5441-5446
-
-
Kiyono, M.1
Kaziro, Y.2
Satoh, T.3
-
82
-
-
0242573273
-
The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1
-
Krapivinsky G., Krapivinsky L., Manasian Y., Ivanov A., Tyzio R., Pellegrino C., Ben-Ari Y., Clapham D.E., and Medina I. The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron 40 (2003) 775-784
-
(2003)
Neuron
, vol.40
, pp. 775-784
-
-
Krapivinsky, G.1
Krapivinsky, L.2
Manasian, Y.3
Ivanov, A.4
Tyzio, R.5
Pellegrino, C.6
Ben-Ari, Y.7
Clapham, D.E.8
Medina, I.9
-
83
-
-
33646378915
-
Age-dependent participation of Ras-GRF proteins in coupling calcium-permeable AMPA glutamate receptors to Ras/Erk signaling in cortical neurons
-
Tian X., and Feig L.A. Age-dependent participation of Ras-GRF proteins in coupling calcium-permeable AMPA glutamate receptors to Ras/Erk signaling in cortical neurons. J. Biol. Chem. 281 (2006) 7578-7582
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 7578-7582
-
-
Tian, X.1
Feig, L.A.2
-
84
-
-
12844256397
-
Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA
-
Robinson K.N., Manto K., Buchsbaum R.J., MacDonald J.I., and Meakin S.O. Neurotrophin-dependent tyrosine phosphorylation of Ras guanine-releasing factor 1 and associated neurite outgrowth is dependent on the HIKE domain of TrkA. J. Biol. Chem. 280 (2005) 225-235
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 225-235
-
-
Robinson, K.N.1
Manto, K.2
Buchsbaum, R.J.3
MacDonald, J.I.4
Meakin, S.O.5
-
85
-
-
33646241782
-
The guanine nucleotide exchange factor RasGRF1 directly binds microtubules via DHPH2-mediated interaction
-
Forlani G., Baldassa S., Lavagni P., Sturani E., and Zippel R. The guanine nucleotide exchange factor RasGRF1 directly binds microtubules via DHPH2-mediated interaction. FEBS J. 273 (2006) 2127-2138
-
(2006)
FEBS J.
, vol.273
, pp. 2127-2138
-
-
Forlani, G.1
Baldassa, S.2
Lavagni, P.3
Sturani, E.4
Zippel, R.5
-
86
-
-
34047253948
-
SCLIP, a microtubule-destabilizing factor, interacts with RasGRF1 and inhibits its ability to promote Rac activation and neurite outgrowth
-
Baldassa S., Gnesutta N., Fascio U., Sturani E., and Zippel R. SCLIP, a microtubule-destabilizing factor, interacts with RasGRF1 and inhibits its ability to promote Rac activation and neurite outgrowth. J. Biol. Chem. 282 (2007) 2333-2345
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 2333-2345
-
-
Baldassa, S.1
Gnesutta, N.2
Fascio, U.3
Sturani, E.4
Zippel, R.5
-
87
-
-
0035014355
-
Ras binding triggers ubiquitination of the Ras exchange factror Ras-GRF2
-
de Hoog C.L., Koehler J.A., Goldstein M.D., Taylor P., Figeys D., and Moran M.F. Ras binding triggers ubiquitination of the Ras exchange factror Ras-GRF2. Mol. Biol. Cell 21 (2001) 2107-2117
-
(2001)
Mol. Biol. Cell
, vol.21
, pp. 2107-2117
-
-
de Hoog, C.L.1
Koehler, J.A.2
Goldstein, M.D.3
Taylor, P.4
Figeys, D.5
Moran, M.F.6
-
88
-
-
0027220836
-
Localization of the cellular expression pattern of cdc25NEF and ras in the juvenile rat brain
-
Wei W., Schreiber S.S., Baudry M., Tocco G., and Broek D. Localization of the cellular expression pattern of cdc25NEF and ras in the juvenile rat brain. Brain Res. Mol. Brain Res. 19 (1993) 339-344
-
(1993)
Brain Res. Mol. Brain Res.
, vol.19
, pp. 339-344
-
-
Wei, W.1
Schreiber, S.S.2
Baudry, M.3
Tocco, G.4
Broek, D.5
-
89
-
-
0031581209
-
A role for the Ras signalling pathway in synaptic transmission and long-term memory
-
Brambilla R., Gnesutta N., Minichiello L., White G., Roylance A.J., Herron C.E., Ramsey M., Wolfer D.P., Cestari V., Rossi-Arnaud C., Grant S.G., Chapman P.F., Lipp H.P., Sturani E., and Klein R. A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature 390 (1997) 281-286
-
(1997)
Nature
, vol.390
, pp. 281-286
-
-
Brambilla, R.1
Gnesutta, N.2
Minichiello, L.3
White, G.4
Roylance, A.J.5
Herron, C.E.6
Ramsey, M.7
Wolfer, D.P.8
Cestari, V.9
Rossi-Arnaud, C.10
Grant, S.G.11
Chapman, P.F.12
Lipp, H.P.13
Sturani, E.14
Klein, R.15
-
90
-
-
0034788432
-
Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1)
-
Giese K.P., Friedman E., Telliez J.B., Fedorov N.B., Wines M., Feig L.A., and Silva A.J. Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1). Neuropharmacology 41 (2001) 791-800
-
(2001)
Neuropharmacology
, vol.41
, pp. 791-800
-
-
Giese, K.P.1
Friedman, E.2
Telliez, J.B.3
Fedorov, N.B.4
Wines, M.5
Feig, L.A.6
Silva, A.J.7
-
91
-
-
2342561884
-
Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB
-
Tian X., Gotoh T., Tsuji K., Lo E.H., Huang S., and Feig L.A. Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB. EMBO J. 23 (2004) 1567-1575
-
(2004)
EMBO J.
, vol.23
, pp. 1567-1575
-
-
Tian, X.1
Gotoh, T.2
Tsuji, K.3
Lo, E.H.4
Huang, S.5
Feig, L.A.6
-
92
-
-
0033376412
-
Activity-dependent interaction of the intracellular domain of rat trkA with intermediate filament proteins, the beta-6 proteasomal subunit, Ras-GRF1, and the p162 subunit of eIF3
-
MacDonald J.I., Verdi J.M., and Meakin S.O. Activity-dependent interaction of the intracellular domain of rat trkA with intermediate filament proteins, the beta-6 proteasomal subunit, Ras-GRF1, and the p162 subunit of eIF3. J. Mol. Neurosci. 13 (1999) 141-158
-
(1999)
J. Mol. Neurosci.
, vol.13
, pp. 141-158
-
-
MacDonald, J.I.1
Verdi, J.M.2
Meakin, S.O.3
-
93
-
-
33750935902
-
Regulators of Rho GTPases in neuronal development
-
Watabe-Uchida M., Govek E.E., and Van Aelst L. Regulators of Rho GTPases in neuronal development. J. Neurosci. 26 (2006) 10633-10635
-
(2006)
J. Neurosci.
, vol.26
, pp. 10633-10635
-
-
Watabe-Uchida, M.1
Govek, E.E.2
Van Aelst, L.3
-
94
-
-
37149057142
-
Functions of Rac GTPases during neuronal development
-
de Curtis I. Functions of Rac GTPases during neuronal development. Dev. Neurosci. 30 (2008) 47-58
-
(2008)
Dev. Neurosci.
, vol.30
, pp. 47-58
-
-
de Curtis, I.1
-
95
-
-
33745745744
-
The Ras-GRF1 exchange factor coordinates activation of H-Ras and Rac1 to control neuronal morphology
-
Yang H., and Mattingly R.R. The Ras-GRF1 exchange factor coordinates activation of H-Ras and Rac1 to control neuronal morphology. Mol. Biol. Cell 17 (2006) 2177-2189
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 2177-2189
-
-
Yang, H.1
Mattingly, R.R.2
-
96
-
-
32544453670
-
Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression
-
Li S., Tian X., Hartley D.M., and Feig L.A. Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression. J. Neurosci. 26 (2006) 1721-1729
-
(2006)
J. Neurosci.
, vol.26
, pp. 1721-1729
-
-
Li, S.1
Tian, X.2
Hartley, D.M.3
Feig, L.A.4
-
97
-
-
34247486969
-
Laser microdissection and microarray analysis of the hippocampus of Ras-GRF1 knockout mice reveals gene expression changes affecting signal transduction pathways related to memory and learning
-
Fernandez-Medarde A., Porteros A., de las Rivas J., Nunez A., Fuster J.J., and Santos E. Laser microdissection and microarray analysis of the hippocampus of Ras-GRF1 knockout mice reveals gene expression changes affecting signal transduction pathways related to memory and learning. Neuroscience 146 (2007) 272-285
-
(2007)
Neuroscience
, vol.146
, pp. 272-285
-
-
Fernandez-Medarde, A.1
Porteros, A.2
de las Rivas, J.3
Nunez, A.4
Fuster, J.J.5
Santos, E.6
-
98
-
-
0028245832
-
A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells
-
Buday L., Egan S.E., Rodriguez Viciana P., Cantrell D.A., and Downward J. A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells. J. Biol. Chem. 269 (1994) 9019-9023
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 9019-9023
-
-
Buday, L.1
Egan, S.E.2
Rodriguez Viciana, P.3
Cantrell, D.A.4
Downward, J.5
-
99
-
-
0032498231
-
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
-
Zhang W., Sloan-Lancaster J., Kitchen J., Trible R.P., and Samelson L.E. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92 (1998) 83-92
-
(1998)
Cell
, vol.92
, pp. 83-92
-
-
Zhang, W.1
Sloan-Lancaster, J.2
Kitchen, J.3
Trible, R.P.4
Samelson, L.E.5
-
100
-
-
0032080391
-
The real LAT steps forward
-
Cantrell D. The real LAT steps forward. Trends Cell Biol. 8 (1998) 180-182
-
(1998)
Trends Cell Biol.
, vol.8
, pp. 180-182
-
-
Cantrell, D.1
-
101
-
-
0033047309
-
Integration of T cell receptor-dependent signaling pathways by adapter proteins
-
Clements J.L., Boerth N.J., Lee J.R., and Koretzky G.A. Integration of T cell receptor-dependent signaling pathways by adapter proteins. Annu. Rev. Immunol. 17 (1999) 89-108
-
(1999)
Annu. Rev. Immunol.
, vol.17
, pp. 89-108
-
-
Clements, J.L.1
Boerth, N.J.2
Lee, J.R.3
Koretzky, G.A.4
-
102
-
-
0032541062
-
Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell
-
Yablonski D., Kuhne M.R., Kadlecek T., and Weiss A. Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell. Science 281 (1998) 413-416
-
(1998)
Science
, vol.281
, pp. 413-416
-
-
Yablonski, D.1
Kuhne, M.R.2
Kadlecek, T.3
Weiss, A.4
-
103
-
-
0032524389
-
RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs
-
Ebinu J.O., Bottorff D.A., Chan E.Y., Stang S.L., Dunn R.J., and Stone J.C. RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Science 280 (1998) 1082-1086
-
(1998)
Science
, vol.280
, pp. 1082-1086
-
-
Ebinu, J.O.1
Bottorff, D.A.2
Chan, E.Y.3
Stang, S.L.4
Dunn, R.J.5
Stone, J.C.6
-
104
-
-
0034061660
-
The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters
-
Lorenzo P.S., Beheshti M., Pettit G.R., Stone J.C., and Blumberg P.M. The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters. Mol. Pharmacol. 57 (2000) 840-846
-
(2000)
Mol. Pharmacol.
, vol.57
, pp. 840-846
-
-
Lorenzo, P.S.1
Beheshti, M.2
Pettit, G.R.3
Stone, J.C.4
Blumberg, P.M.5
-
105
-
-
0031784267
-
Regulation of RasGRP via a phorbol ester-responsive C1 domain
-
Tognon C.E., Kirk H.E., Passmore L.A., Whitehead I.P., Der C.J., and Kay R.J. Regulation of RasGRP via a phorbol ester-responsive C1 domain. Mol. Cell. Biol. 18 (1998) 6995-7008
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 6995-7008
-
-
Tognon, C.E.1
Kirk, H.E.2
Passmore, L.A.3
Whitehead, I.P.4
Der, C.J.5
Kay, R.J.6
-
106
-
-
0034303371
-
RasGRP is essential for mouse thymocyte differentiation and TCR signaling
-
Dower N.A., Stang S.L., Bottorff D.A., Ebinu J.O., Dickie P., Ostergaard H.L., and Stone J.C. RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nat. Immunol. 1 (2000) 317-321
-
(2000)
Nat. Immunol.
, vol.1
, pp. 317-321
-
-
Dower, N.A.1
Stang, S.L.2
Bottorff, D.A.3
Ebinu, J.O.4
Dickie, P.5
Ostergaard, H.L.6
Stone, J.C.7
-
107
-
-
0035853782
-
Activation of the Rap1 guanine nucleotide exchange gene, CalDAG-GEF I, in BXH-2 murine myeloid leukemia
-
Dupuy A.J., Morgan K., von Lintig F.C., Shen H., Acar H., Hasz D.E., Jenkins N.A., Copeland N.G., Boss G.R., and Largaespada D.A. Activation of the Rap1 guanine nucleotide exchange gene, CalDAG-GEF I, in BXH-2 murine myeloid leukemia. J. Biol. Chem. 276 (2001) 11804-11811
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 11804-11811
-
-
Dupuy, A.J.1
Morgan, K.2
von Lintig, F.C.3
Shen, H.4
Acar, H.5
Hasz, D.E.6
Jenkins, N.A.7
Copeland, N.G.8
Boss, G.R.9
Largaespada, D.A.10
-
108
-
-
15044359236
-
Linking Rap to cell adhesion
-
Bos J.L. Linking Rap to cell adhesion. Curr. Opin. Cell Biol. 17 (2005) 123-128
-
(2005)
Curr. Opin. Cell Biol.
, vol.17
, pp. 123-128
-
-
Bos, J.L.1
-
109
-
-
34447327781
-
Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap1 effector molecules
-
Menasche G., Kliche S., Bezman N., and Schraven B. Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap1 effector molecules. Immunol. Rev. 218 (2007) 82-91
-
(2007)
Immunol. Rev.
, vol.218
, pp. 82-91
-
-
Menasche, G.1
Kliche, S.2
Bezman, N.3
Schraven, B.4
-
110
-
-
0036790996
-
Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling
-
Eto K., Murphy R., Kerrigan S.W., Bertoni A., Stuhlmann H., Nakano T., Leavitt A.D., and Shattil S.J. Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 12819-12824
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 12819-12824
-
-
Eto, K.1
Murphy, R.2
Kerrigan, S.W.3
Bertoni, A.4
Stuhlmann, H.5
Nakano, T.6
Leavitt, A.D.7
Shattil, S.J.8
-
111
-
-
4644221351
-
CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation
-
Crittenden J.R., Bergmeier W., Zhang Y., Piffath C.L., Liang Y., Wagner D.D., Housman D.E., and Graybiel A.M. CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat Med 10 (2004) 982-986
-
(2004)
Nat Med
, vol.10
, pp. 982-986
-
-
Crittenden, J.R.1
Bergmeier, W.2
Zhang, Y.3
Piffath, C.L.4
Liang, Y.5
Wagner, D.D.6
Housman, D.E.7
Graybiel, A.M.8
-
112
-
-
36349034646
-
Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion
-
Ghandour H., Cullere X., Alvarez A., Luscinskas F.W., and Mayadas T.N. Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion. Blood 110 (2007) 3682-3690
-
(2007)
Blood
, vol.110
, pp. 3682-3690
-
-
Ghandour, H.1
Cullere, X.2
Alvarez, A.3
Luscinskas, F.W.4
Mayadas, T.N.5
-
113
-
-
34447255182
-
A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets
-
Pasvolsky R., Feigelson S.W., Kilic S.S., Simon A.J., Tal-Lapidot G., Grabovsky V., Crittenden J.R., Amariglio N., Safran M., Graybiel A.M., Rechavi G., Ben-Dor S., Etzioni A., and Alon R. A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, neutrophils, and platelets. J. Exp. Med. 204 (2007) 1571-1582
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1571-1582
-
-
Pasvolsky, R.1
Feigelson, S.W.2
Kilic, S.S.3
Simon, A.J.4
Tal-Lapidot, G.5
Grabovsky, V.6
Crittenden, J.R.7
Amariglio, N.8
Safran, M.9
Graybiel, A.M.10
Rechavi, G.11
Ben-Dor, S.12
Etzioni, A.13
Alon, R.14
-
114
-
-
34249863368
-
Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III
-
Bergmeier W., Goerge T., Wang H.W., Crittenden J.R., Baldwin A.C., Cifuni S.M., Housman D.E., Graybiel A.M., and Wagner D.D. Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III. J. Clin. Invest. 117 (2007) 1699-1707
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1699-1707
-
-
Bergmeier, W.1
Goerge, T.2
Wang, H.W.3
Crittenden, J.R.4
Baldwin, A.C.5
Cifuni, S.M.6
Housman, D.E.7
Graybiel, A.M.8
Wagner, D.D.9
-
115
-
-
0042237772
-
Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3
-
Teixeira C., Stang S.L., Zheng Y., Beswick N.S., and Stone J.C. Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3. Blood 102 (2003) 1414-1420
-
(2003)
Blood
, vol.102
, pp. 1414-1420
-
-
Teixeira, C.1
Stang, S.L.2
Zheng, Y.3
Beswick, N.S.4
Stone, J.C.5
-
116
-
-
9344264018
-
Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation
-
Aiba Y., Oh-hora M., Kiyonaka S., Kimura Y., Hijikata A., Mori Y., and Kurosaki T. Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 16612-16617
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 16612-16617
-
-
Aiba, Y.1
Oh-hora, M.2
Kiyonaka, S.3
Kimura, Y.4
Hijikata, A.5
Mori, Y.6
Kurosaki, T.7
-
117
-
-
3042630992
-
PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters
-
Brodie C., Steinhart R., Kazimirsky G., Rubinfeld H., Hyman T., Ayres J.N., Hur G.M., Toth A., Yang D., Garfield S.H., Stone J.C., and Blumberg P.M. PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters. Mol. Pharmacol. 66 (2004) 76-84
-
(2004)
Mol. Pharmacol.
, vol.66
, pp. 76-84
-
-
Brodie, C.1
Steinhart, R.2
Kazimirsky, G.3
Rubinfeld, H.4
Hyman, T.5
Ayres, J.N.6
Hur, G.M.7
Toth, A.8
Yang, D.9
Garfield, S.H.10
Stone, J.C.11
Blumberg, P.M.12
-
118
-
-
18244409902
-
Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells
-
Zheng Y., Liu H., Coughlin J., Zheng J., Li L., and Stone J.C. Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells. Blood 105 (2005) 3648-3654
-
(2005)
Blood
, vol.105
, pp. 3648-3654
-
-
Zheng, Y.1
Liu, H.2
Coughlin, J.3
Zheng, J.4
Li, L.5
Stone, J.C.6
-
119
-
-
0037986267
-
RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines
-
Li L., Yang Y., and Stevens R.L. RasGRP4 regulates the expression of prostaglandin D2 in human and rat mast cell lines. J. Biol. Chem. 278 (2003) 4725-4729
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 4725-4729
-
-
Li, L.1
Yang, Y.2
Stevens, R.L.3
-
120
-
-
0028180585
-
GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation
-
Sieh M., Batzer A., Schlessinger J., and Weiss A. GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation. Mol. Cell. Biol. 14 (1994) 4435-4442
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 4435-4442
-
-
Sieh, M.1
Batzer, A.2
Schlessinger, J.3
Weiss, A.4
-
122
-
-
0032212728
-
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway
-
Finco T.S., Kadlecek T., Zhang W., Samelson L.E., and Weiss A. LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity 9 (1998) 617-626
-
(1998)
Immunity
, vol.9
, pp. 617-626
-
-
Finco, T.S.1
Kadlecek, T.2
Zhang, W.3
Samelson, L.E.4
Weiss, A.5
-
123
-
-
34147203741
-
Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes
-
Roose J.P., Mollenauer M., Ho M., Kurosaki T., and Weiss A. Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol. Cell. Biol. 27 (2007) 2732-2745
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 2732-2745
-
-
Roose, J.P.1
Mollenauer, M.2
Ho, M.3
Kurosaki, T.4
Weiss, A.5
-
124
-
-
0034192402
-
The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP
-
Pham N., Cheglakov I., Koch C.A., de Hoog C.L., Moran M.F., and Rotin D. The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP. Curr. Biol. 10 (2000) 555-558
-
(2000)
Curr. Biol.
, vol.10
, pp. 555-558
-
-
Pham, N.1
Cheglakov, I.2
Koch, C.A.3
de Hoog, C.L.4
Moran, M.F.5
Rotin, D.6
-
125
-
-
0033547353
-
nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM)
-
Ohtsuka T., Hata Y., Ide N., Yasuda T., Inoue E., Inoue T., Mizoguchi A., and Takai Y. nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM). Biochem. Biophys. Res. Commun. 265 (1999) 38-44
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.265
, pp. 38-44
-
-
Ohtsuka, T.1
Hata, Y.2
Ide, N.3
Yasuda, T.4
Inoue, E.5
Inoue, T.6
Mizoguchi, A.7
Takai, Y.8
-
126
-
-
0032480888
-
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
-
de Rooij J., Zwartkruis F.J., Verheijen M.H., Cool R.H., Nijman S.M., Wittinghofer A., and Bos J.L. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 396 (1998) 474-477
-
(1998)
Nature
, vol.396
, pp. 474-477
-
-
de Rooij, J.1
Zwartkruis, F.J.2
Verheijen, M.H.3
Cool, R.H.4
Nijman, S.M.5
Wittinghofer, A.6
Bos, J.L.7
-
127
-
-
0036607064
-
Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation
-
Stork P.J., and Schmitt J.M. Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol. 12 (2002) 258-266
-
(2002)
Trends Cell Biol.
, vol.12
, pp. 258-266
-
-
Stork, P.J.1
Schmitt, J.M.2
-
128
-
-
0030963439
-
cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
-
Vossler M.R., Yao H., York R.D., Pan M.G., Rim C.S., and Stork P.J. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell 89 (1997) 73-82
-
(1997)
Cell
, vol.89
, pp. 73-82
-
-
Vossler, M.R.1
Yao, H.2
York, R.D.3
Pan, M.G.4
Rim, C.S.5
Stork, P.J.6
-
129
-
-
0034659736
-
Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes
-
Busca R., Abbe P., Mantoux F., Aberdam E., Peyssonnaux C., Eychene A., Ortonne J.P., and Ballotti R. Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes. EMBO J. 19 (2000) 2900-2910
-
(2000)
EMBO J.
, vol.19
, pp. 2900-2910
-
-
Busca, R.1
Abbe, P.2
Mantoux, F.3
Aberdam, E.4
Peyssonnaux, C.5
Eychene, A.6
Ortonne, J.P.7
Ballotti, R.8
-
130
-
-
0036827005
-
Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation
-
Pak Y., Pham N., and Rotin D. Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation. Mol. Cell. Biol. 22 (2002) 7942-7952
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 7942-7952
-
-
Pak, Y.1
Pham, N.2
Rotin, D.3
-
131
-
-
33644859875
-
The guanine nucleotide exchange factor CNrasGEF regulates melanogenesis and cell survival in melanoma cells
-
Amsen E.M., Pham N., Pak Y., and Rotin D. The guanine nucleotide exchange factor CNrasGEF regulates melanogenesis and cell survival in melanoma cells. J. Biol. Chem. 281 (2006) 121-128
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 121-128
-
-
Amsen, E.M.1
Pham, N.2
Pak, Y.3
Rotin, D.4
-
132
-
-
0027965262
-
Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma
-
Di Guglielmo G.M., Baass P.C., Ou W.J., Posner B.I., and Bergeron J.J. Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma. EMBO J. 13 (1994) 4269-4277
-
(1994)
EMBO J.
, vol.13
, pp. 4269-4277
-
-
Di Guglielmo, G.M.1
Baass, P.C.2
Ou, W.J.3
Posner, B.I.4
Bergeron, J.J.5
-
133
-
-
0035963331
-
Spatio-temporal images of growth-factor-induced activation of Ras and Rap1
-
Mochizuki N., Yamashita S., Kurokawa K., Ohba Y., Nagai T., Miyawaki A., and Matsuda M. Spatio-temporal images of growth-factor-induced activation of Ras and Rap1. Nature 411 (2001) 1065-1068
-
(2001)
Nature
, vol.411
, pp. 1065-1068
-
-
Mochizuki, N.1
Yamashita, S.2
Kurokawa, K.3
Ohba, Y.4
Nagai, T.5
Miyawaki, A.6
Matsuda, M.7
-
134
-
-
0036091925
-
Ras signalling on the endoplasmic reticulum and the Golgi
-
Chiu V.K., Bivona T., Hach A., Sajous J.B., Silletti J., Wiener H., Johnson II R.L., Cox A.D., and Philips M.R. Ras signalling on the endoplasmic reticulum and the Golgi. Nat. Cell Biol. 4 (2002) 343-350
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 343-350
-
-
Chiu, V.K.1
Bivona, T.2
Hach, A.3
Sajous, J.B.4
Silletti, J.5
Wiener, H.6
Johnson II, R.L.7
Cox, A.D.8
Philips, M.R.9
-
136
-
-
0041488671
-
Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1
-
Bivona T.G., Perez De Castro I., Ahearn I.M., Grana T.M., Chiu V.K., Lockyer P.J., Cullen P.J., Pellicer A., Cox A.D., and Philips M.R. Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature 424 (2003) 694-698
-
(2003)
Nature
, vol.424
, pp. 694-698
-
-
Bivona, T.G.1
Perez De Castro, I.2
Ahearn, I.M.3
Grana, T.M.4
Chiu, V.K.5
Lockyer, P.J.6
Cullen, P.J.7
Pellicer, A.8
Cox, A.D.9
Philips, M.R.10
-
137
-
-
0042858184
-
Exchange factors of the RasGRP family mediate Ras activation in the Golgi
-
Caloca M.J., Zugaza J.L., and Bustelo X.R. Exchange factors of the RasGRP family mediate Ras activation in the Golgi. J. Biol. Chem. 278 (2003) 33465-33473
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 33465-33473
-
-
Caloca, M.J.1
Zugaza, J.L.2
Bustelo, X.R.3
-
138
-
-
0842304220
-
Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors
-
Arozarena I., Matallanas D., Berciano M.T., Sanz-Moreno V., Calvo F., Munoz M.T., Egea G., Lafarga M., and Crespo P. Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. Mol. Cell. Biol. 24 (2004) 1516-1530
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 1516-1530
-
-
Arozarena, I.1
Matallanas, D.2
Berciano, M.T.3
Sanz-Moreno, V.4
Calvo, F.5
Munoz, M.T.6
Egea, G.7
Lafarga, M.8
Crespo, P.9
-
139
-
-
4344614175
-
Visualizing Ras signalling in real-time
-
Walker S.A., and Lockyer P.J. Visualizing Ras signalling in real-time. J. Cell Sci. 117 (2004) 2879-2886
-
(2004)
J. Cell Sci.
, vol.117
, pp. 2879-2886
-
-
Walker, S.A.1
Lockyer, P.J.2
-
140
-
-
0037542854
-
Ras proteins: different signals from different locations
-
Hancock J.F. Ras proteins: different signals from different locations. Nat. Rev., Mol. Cell Biol. 4 (2003) 373-384
-
(2003)
Nat. Rev., Mol. Cell Biol.
, vol.4
, pp. 373-384
-
-
Hancock, J.F.1
-
141
-
-
33644852080
-
Live-cell imaging of endogenous Ras-GTP illustrates predominant Ras activation at the plasma membrane
-
Augsten M., Pusch R., Biskup C., Rennert K., Wittig U., Beyer K., Blume A., Wetzker R., Friedrich K., and Rubio I. Live-cell imaging of endogenous Ras-GTP illustrates predominant Ras activation at the plasma membrane. EMBO Rep. 7 (2006) 46-51
-
(2006)
EMBO Rep.
, vol.7
, pp. 46-51
-
-
Augsten, M.1
Pusch, R.2
Biskup, C.3
Rennert, K.4
Wittig, U.5
Beyer, K.6
Blume, A.7
Wetzker, R.8
Friedrich, K.9
Rubio, I.10
-
142
-
-
33751315308
-
Phospholipase C epsilon: linking second messengers and small GTPases
-
Bunney T.D., and Katan M. Phospholipase C epsilon: linking second messengers and small GTPases. Trends Cell Biol. 16 (2006) 640-648
-
(2006)
Trends Cell Biol.
, vol.16
, pp. 640-648
-
-
Bunney, T.D.1
Katan, M.2
-
143
-
-
33144456377
-
Regulation of phospholipase C isozymes by ras superfamily GTPases
-
Harden T.K., and Sondek J. Regulation of phospholipase C isozymes by ras superfamily GTPases. Annu. Rev. Pharmacol. Toxicol. 46 (2006) 355-379
-
(2006)
Annu. Rev. Pharmacol. Toxicol.
, vol.46
, pp. 355-379
-
-
Harden, T.K.1
Sondek, J.2
-
144
-
-
0035951771
-
Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras
-
Song C., Hu C.D., Masago M., Kariyai K., Yamawaki-Kataoka Y., Shibatohge M., Wu D., Satoh T., and Kataoka T. Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras. J. Biol. Chem. 276 (2001) 2752-2757
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 2752-2757
-
-
Song, C.1
Hu, C.D.2
Masago, M.3
Kariyai, K.4
Yamawaki-Kataoka, Y.5
Shibatohge, M.6
Wu, D.7
Satoh, T.8
Kataoka, T.9
-
146
-
-
1542344841
-
Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins
-
Kelley G.G., Reks S.E., and Smrcka A.V. Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins. Biochem. J. 378 (2004) 129-139
-
(2004)
Biochem. J.
, vol.378
, pp. 129-139
-
-
Kelley, G.G.1
Reks, S.E.2
Smrcka, A.V.3
-
147
-
-
10844263476
-
Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development
-
Bai Y., Edamatsu H., Maeda S., Saito H., Suzuki N., Satoh T., and Kataoka T. Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development. Cancer Res. 64 (2004) 8808-8810
-
(2004)
Cancer Res.
, vol.64
, pp. 8808-8810
-
-
Bai, Y.1
Edamatsu, H.2
Maeda, S.3
Saito, H.4
Suzuki, N.5
Satoh, T.6
Kataoka, T.7
-
148
-
-
33750286101
-
Signal transduction. Prelude to an anniversary for the RAS oncogene
-
Downward J. Signal transduction. Prelude to an anniversary for the RAS oncogene. Science 314 (2006) 433-434
-
(2006)
Science
, vol.314
, pp. 433-434
-
-
Downward, J.1
-
149
-
-
33947594129
-
Hyperactive Ras in developmental disorders and cancer
-
Schubbert S., Shannon K., and Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat. Rev., Cancer 7 (2007) 295-308
-
(2007)
Nat. Rev., Cancer
, vol.7
, pp. 295-308
-
-
Schubbert, S.1
Shannon, K.2
Bollag, G.3
-
150
-
-
33846207546
-
Deregulated Ras signaling in developmental disorders: new tricks for an old dog
-
Schubbert S., Bollag G., and Shannon K. Deregulated Ras signaling in developmental disorders: new tricks for an old dog. Curr. Opin. Genet. Dev. 17 (2007) 15-22
-
(2007)
Curr. Opin. Genet. Dev.
, vol.17
, pp. 15-22
-
-
Schubbert, S.1
Bollag, G.2
Shannon, K.3
-
151
-
-
27144531386
-
Germline mutations in HRAS proto-oncogene cause Costello syndrome
-
Aoki Y., Niihori T., Kawame H., Kurosawa K., Ohashi H., Tanaka Y., Filocamo M., Kato K., Suzuki Y., Kure S., and Matsubara Y. Germline mutations in HRAS proto-oncogene cause Costello syndrome. Nat. Genet. 37 (2005) 1038-1040
-
(2005)
Nat. Genet.
, vol.37
, pp. 1038-1040
-
-
Aoki, Y.1
Niihori, T.2
Kawame, H.3
Kurosawa, K.4
Ohashi, H.5
Tanaka, Y.6
Filocamo, M.7
Kato, K.8
Suzuki, Y.9
Kure, S.10
Matsubara, Y.11
-
152
-
-
33845884026
-
Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome
-
Tartaglia M., Pennacchio L.A., Zhao C., Yadav K.K., Fodale V., Sarkozy A., Pandit B., Oishi K., Martinelli S., Schackwitz W., Ustaszewska A., Martin J., Bristow J., Carta C., Lepri F., Neri C., Vasta I., Gibson K., Curry C.J., Siguero J.P., Digilio M.C., Zampino G., Dallapiccola B., Bar-Sagi D., and Gelb B.D. Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Nat. Genet. 39 (2007) 75-79
-
(2007)
Nat. Genet.
, vol.39
, pp. 75-79
-
-
Tartaglia, M.1
Pennacchio, L.A.2
Zhao, C.3
Yadav, K.K.4
Fodale, V.5
Sarkozy, A.6
Pandit, B.7
Oishi, K.8
Martinelli, S.9
Schackwitz, W.10
Ustaszewska, A.11
Martin, J.12
Bristow, J.13
Carta, C.14
Lepri, F.15
Neri, C.16
Vasta, I.17
Gibson, K.18
Curry, C.J.19
Siguero, J.P.20
Digilio, M.C.21
Zampino, G.22
Dallapiccola, B.23
Bar-Sagi, D.24
Gelb, B.D.25
more..
-
153
-
-
33845900943
-
Germline gain-of-function mutations in SOS1 cause Noonan syndrome
-
Roberts A.E., Araki T., Swanson K.D., Montgomery K.T., Schiripo T.A., Joshi V.A., Li L., Yassin Y., Tamburino A.M., Neel B.G., and Kucherlapati R.S. Germline gain-of-function mutations in SOS1 cause Noonan syndrome. Nat. Genet. 39 (2007) 70-74
-
(2007)
Nat. Genet.
, vol.39
, pp. 70-74
-
-
Roberts, A.E.1
Araki, T.2
Swanson, K.D.3
Montgomery, K.T.4
Schiripo, T.A.5
Joshi, V.A.6
Li, L.7
Yassin, Y.8
Tamburino, A.M.9
Neel, B.G.10
Kucherlapati, R.S.11
-
154
-
-
35348871857
-
SOS1 is the second most common Noonan gene but plays no major role in cardio-facio-cutaneous syndrome
-
Zenker M., Horn D., Wieczorek D., Allanson J., Pauli S., van der Burgt I., Doerr H.G., Gaspar H., Hofbeck M., Gillessen-Kaesbach G., Koch A., Meinecke P., Mundlos S., Nowka A., Rauch A., Reif S., von Schnakenburg C., Seidel H., Wehner L.E., Zweier C., Bauhuber S., Matejas V., Kratz C.P., Thomas C., and Kutsche K. SOS1 is the second most common Noonan gene but plays no major role in cardio-facio-cutaneous syndrome. J. Med. Genet. 44 (2007) 651-656
-
(2007)
J. Med. Genet.
, vol.44
, pp. 651-656
-
-
Zenker, M.1
Horn, D.2
Wieczorek, D.3
Allanson, J.4
Pauli, S.5
van der Burgt, I.6
Doerr, H.G.7
Gaspar, H.8
Hofbeck, M.9
Gillessen-Kaesbach, G.10
Koch, A.11
Meinecke, P.12
Mundlos, S.13
Nowka, A.14
Rauch, A.15
Reif, S.16
von Schnakenburg, C.17
Seidel, H.18
Wehner, L.E.19
Zweier, C.20
Bauhuber, S.21
Matejas, V.22
Kratz, C.P.23
Thomas, C.24
Kutsche, K.25
more..
|