NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations

Cancer Research

Volumn 68, Issue 19, 2008, Pages 8022-8030

  Serra, Violeta ^b   Markman, Ben ^b   Scaltriti, Maurizio ^b   Eichhorn, Pieter J A ^b   Valero, Vanesa ^b   Guzman, Marta ^b   Botero, Maria Luisa ^b   Llonch, Elisabeth ^b   Atzori, Francesco ^b   Di Cosimo, Serena ^b   Maira, Michel ^b   Garcia Echeverria, Carlos ^b   Parra, Josep Lluis ^b   Arribas, Joaquin ^b   Baselga, José ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EVEROLIMUS; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P110; PROTEIN S6; TRASTUZUMAB; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CELL CYCLE ARREST; CELL EXPANSION; CELL PROLIFERATION; CONTROLLED STUDY; GENE ACTIVATION; GENE MUTATION; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; FEMALE; HUMANS; IMIDAZOLES; MICE; MICE, NUDE; MUTATION; PROTEIN KINASES; QUINOLINES; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 51849111524     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-1385     Document Type: Article

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