PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model

Human Molecular Genetics

Volumn 10, Issue 6, 2001, Pages 605-616

  Weng, Liang Ping ^a   Smith, Wendy M ^a   Brown, Jessica L ^a   Eng, Charis ^a,b,c  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; GROWTH FACTOR; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN SHC; SOMATOMEDIN C; SOS PROTEIN; WORTMANNIN;

ARTICLE; BREAST CANCER; CANCER MODEL; CELL CYCLE; CELL GROWTH; CELL STRAIN MCF 7; COMPLEX FORMATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; STIMULATION; TUMOR SUPPRESSOR GENE;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0035869175     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.6.605     Document Type: Article

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