Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin α during G1 and prevents nuclear re-entry

Journal of Biological Chemistry

Volumn 280, Issue 7, 2005, Pages 6055-6063

  Shin, Incheol ^a   Rotty, Jeremy ^b   Wu, Frederick Y ^a   Arteaga, Carlos L ^a,c  

^a VANDERBILT INGRAM CANCER CENTER   (United States)

^b BEREA COLLEGE   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CELLS; CYTOLOGY; ENZYME INHIBITION; MUTAGENESIS;

CELL FUSIONS; CELLULAR LOCALIZATION; CYTOSOL; PHOSPHORYLATION;

ENZYMES;

ALKALINE PHOSPHATASE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; KARYOPHERIN ALPHA; LEPTOMYCIN B; PROTEIN KINASE B; PROTEIN P27; THREONINE; AKT1 PROTEIN, HUMAN; CDKN1B PROTEIN, MOUSE; CELL CYCLE PROTEIN; ONCOPROTEIN; PHOSPHOSERINE; PHOSPHOTHREONINE; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL FUSION; CELL NUCLEUS; CELL STRAIN 3T3; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; HELA CELL; HETEROKARYON; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; ACTIVE TRANSPORT; ANIMAL; BIOLOGICAL MODEL; CELL LINE; DRUG ANTAGONISM; GENETICS; METABOLISM; PROTEIN BINDING; TIME;

ANIMALIA;

ACTIVE TRANSPORT, CELL NUCLEUS; ALPHA KARYOPHERINS; ANIMALS; CELL CYCLE PROTEINS; CELL LINE; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYTOSOL; G1 PHASE; HUMANS; MICE; MODELS, BIOLOGICAL; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTHREONINE; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; TIME FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 14044276381     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M412367200     Document Type: Article

References (50)

1. Sherr, C. J., and Roberts, J. M. (1999) Genes Dev. 13, 1501-1512
2. Medema, R. H., Kops, G. J., Bos, J. L., and Burgering, B. M. (2000) Nature 404, 782-787
3. Montagnoli, A., Fiore, F., Eytan, E., Carrano, A. C., Draetta, G. F., Hershko, A., and Pagano, M. (1999) Genes Dev. 13, 1181-1189
4. Carrano, A. C., Eytan, E., Hershko, A., and Pagano, M. (1999) Nat. Cell Biol. 1, 193-199
5. Kara, T., Kamura, T., Nakayama, K., Oshikawa, K., Hatakeyama, S., and Nakayama, K. (2001) J. Biol. Chem. 276, 48937-48943
6. Malek, N. P., Sundberg, H., McGrew, S., Nakayama, K., Kyriakides, T. R., Roberts, J. M., and Kyriakidis, T. R. (2001) Nature 413, 323-327
7. Darbon, J. M., Devault, A., Taviaux, S., Fesquet, D., Martinez, A. M., Galas, S., Cavadore, J. C., Doree, M., and Blanchard, J. M. (1994) Oncogene 9, 3127-3138
8. Orend, G., Hunter, T., and Ruoslahti, E. (1998) Oncogene 16, 2575-2583
9. Ciaparrone, M., Yamamoto, H., Yao, Y., Sgambato, A., Cattoretti, G., Tomita, N., Monden, T., Rotterdam, H., and Weinstein, I. B. (1998) Cancer Res. 58, 114-122
10. Singh, S. P., Lipman, J., Goldman, H., Ellis, F. H., Jr., Aizenman, L., Cangi, M. G., Signoretti, S., Chiaur, D. S., Pagano, M., and Loda, M. (1998) Cancer Res. 58, 1730-1735
11. Liang, J., Zubovitz, J., Petrocelli, T., Kotchetkov, R., Connor, M. K., Han, K., Lee, J. H., Ciarallo, S., Catzavelos, C., Beniston, R., Franssen, E., and Slingerland, J. M. (2002) Nat. Med. 8, 1153-1160
12. Shin, I., Yakes, F. M., Rojo, F., Shin, N. Y., Bakin, A. V., Baselga, J., and Arteaga, C. L. (2002) Nat. Med. 8, 1145-1152
13. Viglietto, G., Motti, M. L., Bruni, P., Melillo, R. M., D'Aleseio, A., Califano, D., Vinci, F., Chiappetta, G., Tsichlis, P., Bellacosa, A., Fusco, A., and Santoro, M. (2002) Nat. Med. 8, 1136-1144
14. Ishida, N., Kitagawa, M., Hatakeyama, S., and Nakayama, K. (2000) J. Biol. Chem. 275, 25146-25154
15. Ishida, N., Hara, T., Kamura, T., Yoshida, M., Nakayama, K., and Nakayama, K. I. (2002) J. Biol. Chem. 277, 14355-14358
16. Rodier, G., Montagnoli, A., Di Marcotullio, L., Coulombe, P., Draetta, G. F., Pagano, M., and Meloche, S. (2001) EMBO J. 20, 6672-6682
17. Connor, M. K., Kotchetkov, R., Cariou, S., Resch, A., Lupetti, R., Beniston, R. G., Melchior, F., Hengst, L., and Slingerland, J. M. (2003) Mol. Biol. Cell 14, 201-213
18. Boehm, M., Yoshimoto, T., Crook, M. F., Nallamshetty, S., True, A., Nabel, G. J., and Nabel, E. G. (2002) EMBO J. 21, 3390-3401
19. Macara, I. G. (2001) Microbiol. Mol. Biol. Rev. 65, 570-594
20. Doye, V., and Hurt, E. (1997) Curr. Opin. Cell Biol. 9, 401-411
21. Gorlich, D., Vogel, F., Mills, A. D., Hartmann, E., and Laskey, R. A. (1995) Nature 377, 246-248
22. Gorlich, D., and Mattaj, I. W. (1996) Science 271, 1513-1518
23. Zeng, Y., Hirano, K., Hirano, M., Nishimura, J., and Kanaide, H. (2000) Biochem. Biophys. Res. Commun. 274, 37-42
24. Hutchinson, J., Jin, J., Cardiff, R. D., Woodgett, J. R., and Muller, W. J. (2001) Mol. Cell. Biol. 21, 2203-2212
25. Lenferink, A. E., Busse, D., Flanagan, W. M., Yakes, F. M., and Arteaga, C. L. (2001) Cancer Res. 61, 6583-6591
26. Hidalgo, M., Siu, L. L., Nemunaitis, J., Rizzo, J., Hammond, L. A., Takimoto, C., Eckhardt, S. G., Tolcher, A., Britten, C. D., Denis, L., Ferrante, K., Von Hoff, D. D., Silberman, S., and Rowinsky, E. K. (2001) J Clin. Oncol. 19, 3267-3279
27. Hernan, R., Fasheh, R., Calabrese, C., Frank, A. J., Maclean, K. H., Allard, D., Barraclough, R., and Gilbertson, R. J. (2003) Cancer Res. 63, 140-148
28. Alt, J. R., Cleveland, J. L., Hannink, M., and Diehl, J. A. (2000) Genes Dev. 14, 3102-3114
29. Sutterluty, H., Chatelain, E., Marti, A., Wirbelauer, C., Senften, M., Muller, U., and Krek, W. (1999) Nat. Cell Biol. 1, 207-214
30. Sekimoto, T., Fukumoto, M., and Yoneda, Y. (2004) EMBO J. 23, 1934-1942
31. Ahmed, N. N., Franke, T. F., Bellacosa, A., Datta, K., Gonzalez-Portal, M. E., Taguchi, T., Testa, J. R., and Tsichlis, P. N. (1993) Oncogene 8, 1957-1963
32. Andjelkovic, M., Alessi, D. R., Meier, R., Fernandez, A., Lamb, N. J., Frech, M., Cron, P., Cohen, P., Lucocq, J. M., and Hemmings, B. A. (1997) J. Biol. Chem. 272, 31515-31524
33. Borgatti, P., Martelli, A. M., Tabellini, G., Bellacosa, A., Capitani, S., and Neri, L. M. (2003) J. Cell. Physiol. 196, 79-88
34. Alessi, D. R., Andjelkovic, M., Caudwell, B., Cron, P., Morrice, N., Cohen, P., and Hemmings, B. A. (1996) EMBO J. 15, 6541-6551
35. Bellacosa, A., Chan, T. O., Ahmed, N. N., Datta, K., Malstrom, S., Stokoe, D., McCormick, F., Feng, J., and Tsichlis, P. (1998) Oncogene 17, 313-325
36. Chan, T. O., Rittenhouse, S. E., and Tsichlis, P. N. (1999) Annu. Rev. Biochem. 68, 965-1014
37. Chan, T. O., and Tsichlis, P. N. (2001) Science's STKE http://stke.sciencemag.org/cgi/content/full/sigtrans;2001/66/pe1
38. Moll, T., Tebb, G., Surana, U., Robitsch, H., and Nasmyth, K. (1991) Cell 66, 743-758
39. Hennekes, H., Peter, M., Weber, K., and Nigg, E. A. (1993) J. Cell Biol. 120, 1293-1304
40. Ohta, Y., Nishida, E., Sakai, H., and Miyamoto, E. (1989) J. Biol. Chem. 264, 16143-16148
41. Jans, D. A., and Jans, P. (1994) Oncogene 9, 2961-2968
42. Morris, J. L., and Manley, J. L. (1992) Genes Dev. 6, 1654-1667
43. Mosialos, G., Hamer, P., Capobianco, A. J., Laursen, R. A., and Gilmore, T. D. (1991) Mol. Cell. Biol. 11, 5867-5877
44. Tagawa, T., Kuroki, T., Vogt, P. K., and Chida, K. (1995) J. Cell Biol. 130, 255-263
45. Fujita, N., Sato, S., Katayama, K., and Tsuruo, T. (2002) J. Biol. Chem. 277, 28706-28713
46. Fujita, N., Sato, S., and Tsuruo, T. (2003) J. Biol. Chem. 278, 49254-49260
47. Muller, D., Thieke, K., Burgin, A., Dickmanns, A., and Eilers, M. (2000) EMBO J. 19, 2168-2180
48. Smitherman, M., Lee, K., Swanger, J., Kapur, R., and Clurman, B. E. (2000) Mol. Cell. Biol. 20, 5631-5642
49. Guan, T., Kehlenbach, R. H., Schirmer, E. C., Kehlenbach, A., Fan, F., Clurman, B. E., Arnheim, N., and Gerace, L. (2000) Mol. Cell Biol. 20, 5619-5630
50. Lindsay, M. E., Plafker, K., Smith, A. E., Clurman, B. E., and Macara, I. G. (2002) Cell 110, 349-360