메뉴 건너뛰기




Volumn 206, Issue 1, 2010, Pages 113-120

MTOR downregulates iodide uptake in thyrocytes

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; EVEROLIMUS; INSULIN; IODIDE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P70; PROTEIN S6; RAPAMYCIN; SODIUM IODIDE SYMPORTER; THYROTROPIN;

EID: 77953857289     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-09-0436     Document Type: Article
Times cited : (54)

References (35)
  • 3
    • 34548580330 scopus 로고    scopus 로고
    • Thyroid-stimulating hormone-initiated proliferative signals converge in vivo on the mTOR kinase without activating Akt
    • Brewer C, Yeager N & Di Cristofano A 2007 Thyroid-stimulating hormone-initiated proliferative signals converge in vivo on the mTOR kinase without activating Akt. Cancer Research 67 8002-8006.
    • (2007) Cancer Research , vol.67 , pp. 8002-8006
    • Brewer, C.1    Yeager, N.2    Di Cristofano, A.3
  • 5
    • 0034214102 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin
    • Coulonval K, Vandeput F, Stein RC, Kozma SC, Lamy F & Dumont JE 2000 Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin. Biochemical Journal 348 351-358.
    • (2000) Biochemical Journal , vol.348 , pp. 351-358
    • Coulonval, K.1    Vandeput, F.2    Stein, R.C.3    Kozma, S.C.4    Lamy, F.5    Dumont, J.E.6
  • 6
    • 0030053759 scopus 로고    scopus 로고
    • Cloning and characterization of the thyroid iodide transporter
    • Dai G, Levy O & Carrasco N 1996 Cloning and characterization of the thyroid iodide transporter. Nature 379 458-460.
    • (1996) Nature , vol.379 , pp. 458-460
    • Dai, G.1    Levy, O.2    Carrasco, N.3
  • 9
    • 0036159928 scopus 로고    scopus 로고
    • PI3K is involved in the IGF-1 inhibition of TSH-induced sodium/iodide symporter gene expression
    • Garcia B & Santisteban P 2002 PI3K is involved in the IGF-1 inhibition of TSH-induced sodium/iodide symporter gene expression. Journal of Endocrinology 16 342-352.
    • (2002) Journal of Endocrinology , vol.16 , pp. 342-352
    • Garcia, B.1    Santisteban, P.2
  • 11
    • 28844434558 scopus 로고    scopus 로고
    • mTOR.RICTOR is the Ser 473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
    • Hresko RC & Mueckler M 2005 mTOR.RICTOR is the Ser 473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. Journal of Biological Chemistry 280 40406-40416.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 40406-40416
    • Hresko, R.C.1    Mueckler, M.2
  • 12
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling
    • Inoki K, Li Y, Zhu T, Wu J & Guan KL 2002 TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nature Cell Biology 4 648-657.
    • (2002) Nature Cell Biology , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 14
    • 0034793849 scopus 로고    scopus 로고
    • Regulation of thyroid cell proliferation by TSH and other factors: A critical evaluation of in vitro models
    • Kimura T, Van Keymeulen A, Golstein J, Fusco A, Dumont JE & Roger PP 2001 Regulation of thyroid cell proliferation by TSH and other factors: a critical evaluation of in vitro models. Endocrine Reviews 22 631-656.
    • (2001) Endocrine Reviews , vol.22 , pp. 631-656
    • Kimura, T.1    Van Keymeulen, A.2    Golstein, J.3    Fusco, A.4    Dumont, J.E.5    Roger, P.P.6
  • 15
    • 56849115726 scopus 로고    scopus 로고
    • Phosphoinositide-3-kinase (PI3K) inhibition induces sodium/iodide symporter expression (NIS) in rat thyroid cells and human pappilary cancer cells
    • Kogai T, Sajid-Crockett S, Newmarch LS, Liu YY & Brent GA 2008 Phosphoinositide-3-kinase (PI3K) inhibition induces sodium/iodide symporter expression (NIS) in rat thyroid cells and human pappilary cancer cells. Journal of Endocrinology 199 243-252.
    • (2008) Journal of Endocrinology , vol.199 , pp. 243-252
    • Kogai, T.1    Sajid-Crockett, S.2    Newmarch, L.S.3    Liu, Y.Y.4    Brent, G.A.5
  • 16
    • 0030006858 scopus 로고    scopus 로고
    • Increased cyclic adenosine 3′,5′-monophosphate inhibits G protein-coupled activation of phospholipase C in rat FRTL-5 thyroid cells
    • Laglia G, Zeiger MA, Leipricht A, Caturegli P, Levine MA, Kohn LD & Saji M 1996 Increased cyclic adenosine 3′,5′-monophosphate inhibits G protein-coupled activation of phospholipase C in rat FRTL-5 thyroid cells. Endocrinology 137 3170-3176.
    • (1996) Endocrinology , vol.137 , pp. 3170-3176
    • Laglia, G.1    Zeiger, M.A.2    Leipricht, A.3    Caturegli, P.4    Levine, M.A.5    Kohn, L.D.6    Saji, M.7
  • 17
    • 70349741010 scopus 로고    scopus 로고
    • Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin
    • Liu D, Hou P, Liu Z, Wu G & Xing M 2009 Genetic alterations in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of rapamycin. Cancer Research 69 7311-7319.
    • (2009) Cancer Research , vol.69 , pp. 7311-7319
    • Liu, D.1    Hou, P.2    Liu, Z.3    Wu, G.4    Xing, M.5
  • 18
    • 0036342294 scopus 로고    scopus 로고
    • Identification of the tuberous slerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway
    • Manning BD, Tee AR, Longsdon MN, Blenis J & Cantley LC 2002 Identification of the tuberous slerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt pathway. Molecular Cell 10 151-162.
    • (2002) Molecular Cell , vol.10 , pp. 151-162
    • Manning, B.D.1    Tee, A.R.2    Longsdon, M.N.3    Blenis, J.4    Cantley, L.C.5
  • 19
    • 0002083634 scopus 로고    scopus 로고
    • Carcinoma of the follicular epithelium
    • edn 8, Eds L Braverman & RUtiger. New York: Lippincott Williams & Wilkins
    • Mazaferri EL 2000 Carcinoma of the follicular epithelium. In Thyroid: a Fundamental and Clinical Text. edn 8, pp 904-930. Eds L Braverman & RUtiger. New York: Lippincott Williams & Wilkins.
    • (2000) Thyroid: A Fundamental and Clinical Text , pp. 904-930
    • Mazaferri, E.L.1
  • 20
    • 0034685546 scopus 로고    scopus 로고
    • Somatostatin interferes with thyrotropin-induced G1-S transition mediated by cAMP-dependent protein kinase and phosphatidylinositol 3-kinase. Involvement of RhoA and cyclin E cyclin dependent kinase 2 complexes
    • Medina DL, Toro MJ & Santisteban P 2000 Somatostatin interferes with thyrotropin-induced G1-S transition mediated by cAMP-dependent protein kinase and phosphatidylinositol 3-kinase. Involvement of RhoA and cyclin E cyclin dependent kinase 2 complexes. Journal of Biological Chemistry 275 15549-15556.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 15549-15556
    • Medina, D.L.1    Toro, M.J.2    Santisteban, P.3
  • 21
    • 0033429554 scopus 로고    scopus 로고
    • Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
    • Navé BT, Ouwens M, Withers DJ, Alessi DR & Shepherd PR 1999 Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochemical Journal 344 421-431.
    • (1999) Biochemical Journal , vol.344 , pp. 421-431
    • Navé, B.T.1    Ouwens, M.2    Withers, D.J.3    Alessi, D.R.4    Shepherd, P.R.5
  • 23
    • 0035877782 scopus 로고    scopus 로고
    • Post-transcriptional regulation of the sodium/iodide symporter by thyrotropin
    • Riedel C, Levy O & Carrasco N 2001 Post-transcriptional regulation of the sodium/iodide symporter by thyrotropin. Journal of Biological Chemistry 276 21458-21463.
    • (2001) Journal of Biological Chemistry , vol.276 , pp. 21458-21463
    • Riedel, C.1    Levy, O.2    Carrasco, N.3
  • 24
    • 0023112111 scopus 로고
    • Induction of DNA synthesis in dog thyrocytes in primary culture: Synergistic effects of thyrotropin and cyclic AMP with epidermal growth factor and insulin
    • Roger PP, Servais P & Dumont JE 1987 Induction of DNA synthesis in dog thyrocytes in primary culture: synergistic effects of thyrotropin and cyclic AMP with epidermal growth factor and insulin. Journal of Cellular Physiology 130 58-67.
    • (1987) Journal of Cellular Physiology , vol.130 , pp. 58-67
    • Roger, P.P.1    Servais, P.2    Dumont, J.E.3
  • 27
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Quertin DA, Ali SM & Sabatini DM 2005b Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307 1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Quertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 29
    • 0037821647 scopus 로고    scopus 로고
    • Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and stimulating type TSH receptor antibodies in the thyroid gland
    • Suh JM, Song JH, Kim DH, Kim H, Chung HK, Hwang JH, Kim JM, Hwang ES, Chung J, Han JH et al. 2003 Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and stimulating type TSH receptor antibodies in the thyroid gland. Journal of Biological Chemistry 278 21960-21971.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 21960-21971
    • Suh, J.M.1    Song, J.H.2    Kim, D.H.3    Kim, H.4    Chung, H.K.5    Hwang, J.H.6    Kim, J.M.7    Hwang, E.S.8    Chung, J.9    Han, J.H.10
  • 31
    • 0026743033 scopus 로고
    • The thyrotropin receptor and the regulation of thyrocyte function and growth
    • Vassart G & Dumont JE 1992 The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocrine Reviews 13 596-611.
    • (1992) Endocrine Reviews , vol.13 , pp. 596-611
    • Vassart, G.1    Dumont, J.E.2
  • 33
    • 0021252128 scopus 로고
    • Thyrotropin stimulated iodide transport mediated by adenosine 3′,5′-monophosphate and dependent on protein synthesis
    • Weiss SJ, Philp NJ, Ambesi-Impiobato FS & Grollman EF 1984 Thyrotropin stimulated iodide transport mediated by adenosine 3′,5′-monophosphate and dependent on protein synthesis. Endocrinology 114 1099-1107.
    • (1984) Endocrinology , vol.114 , pp. 1099-1107
    • Weiss, S.J.1    Philp, N.J.2    Ambesi-Impiobato, F.S.3    Grollman, E.F.4
  • 34
    • 39049086390 scopus 로고    scopus 로고
    • Mammalian target of rapamycin is the key effector of phosphatidyliositol- 3- OH-initiated proliferative signals in the thyroid follicular epithelium
    • Yeager N, Brewer C, Cai KQ, Xu XX & Di Cristofano A 2008 Mammalian target of rapamycin is the key effector of phosphatidyliositol-3- OH-initiated proliferative signals in the thyroid follicular epithelium. Cancer Research 68 444-449.
    • (2008) Cancer Research , vol.68 , pp. 444-449
    • Yeager, N.1    Brewer, C.2    Cai, K.Q.3    Xu, X.X.4    Di Cristofano, A.5
  • 35
    • 43049137345 scopus 로고    scopus 로고
    • Gβγ dimers released in response to thyrotropin activate phosphoinositide 3-kinase and regulate gene expression in thyroid cells
    • Zaballos MA, Garcia B & Santisteban P 2008 Gβγ dimers released in response to thyrotropin activate phosphoinositide 3-kinase and regulate gene expression in thyroid cells. Molecular Endocrinology 22 1183-1199.
    • (2008) Molecular Endocrinology , vol.22 , pp. 1183-1199
    • Zaballos, M.A.1    Garcia, B.2    Santisteban, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.