Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT)

Journal of Molecular Biology

Volumn 329, Issue 5, 2003, Pages 1021-1034

  Gaßel, Michael ^a   Breitenlechner, Christine B ^b   Rüger, Petra ^c   Jucknischke, Ute ^c   Schneider, Thorsten ^a   Huber, Robert ^b   Bossemeyer, Dirk ^a   Engh, Richard A ^b,c  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c ROCHE DIAGNOSTICS GMBH   (Germany)

Author keywords

Crystal structure; PKA; PKB; Point mutation; Protein kinase

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENZYME INHIBITOR; ISOENZYME; ISOQUINOLINE DERIVATIVE; LIGAND; MAGNESIUM ION; MUTANT PROTEIN; PROTEIN KINASE B;

ALPHA CHAIN; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME STRUCTURE; GEOMETRY; MOLECULAR MIMICRY; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SURFACE PLASMON RESONANCE;

EID: 0038206479     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(03)00518-7     Document Type: Article

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