Constitutive nuclear factor-κb-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells

Journal of Clinical Investigation

Volumn 100, Issue 12, 1997, Pages 2961-2969

  Bargou, Ralf C ^a,b   Emmerich, Florian ^a,b   Krappmann, Daniel ^a   Bommert, Kurt ^a   Mapara, Markus Y ^a,b   Arnold, Wolfgang ^a   Royer, Hans D ^a   Grinstein, E ^a   Greiner, Axel ^c   Scheidereit, Claus ^a   Dörken, Bernd ^a,b  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b Section of Pathology   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Apoptosis; Cell cycle; I B ; Lymphoma; Reed Sternberg cells Max Delbruck

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ARTICLE; CANCER CONTROL; CANCER GROWTH; CARCINOGENESIS; CELL SURVIVAL; CONTROLLED STUDY; HODGKIN DISEASE; HUMAN; HUMAN CELL; PATHOGENESIS; PRIORITY JOURNAL;

EID: 18844465632     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119849     Document Type: Article

References (51)

1. Kaufman, D., and D.L. Longo. 1992. Hodgkin's disease. Crit. Rev. Oncol-Hematol. 13:135-187.
2. Hsu, S.-M., and P.-L. Hsu. 1994. The nature of Reed-Sternberg cells: phenotype, genotype, and other properties. Crit. Rev. Oncog. 5:213-245.
3. Küppers, R., H. Kanzler, M.L. Hansmann, and K. Rajewsky. 1996. Single cell analysis of Hodgkin/Reed-Sternberg cells. Ann. Oncol. 7:S27-S30.
4. Bargou, R.C., M.Y. Mapara, C. Zugck, P.T. Daniel, M. Pawlita, H. Dohner, and B. Dörken. 1993. Characterization of a novel Hodgkin cell line, HD-MyZ, with myelomonocytic features mimicking Hodgkin's disease in severe combined immunodeficient mice. J. Exp. Med. 177:1257-1268.
5. Durkop, H., U. Latza, M. Hummel, F. Eitelbach, B. Seed, and H. Stein. 1992. Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease. Cell. 68:421-427.
6. Bilbe, G., J. Delabie, J. Bruggen, H. Richener, F.A. Asselbergs, N. Cerletti, C. Sorg, K. Odink, L. Tarcsay, W. Wiesendanger, C. DeWolf-Peeters, and R. Shipman. 1992. Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease. EMBO (Eur. Mol. Bio. Organ.) J. 11:2103-2113.
7. Kanzler, H., R. Kuppers, M.L. Hansmann, and K. Rajewsky. 1996. Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J. Exp. Med. 184:1495-1505.
8. Hummel, M., K. Ziemann, H. Lammert, S. Pileri, E. Sabattini, and H. Stein. 1995. Hodgkin's disease with monoclonal and polyclonal populations of Reed-Sternberg cells. N. Engl. J. Med. 333:901-906.
9. Bargou, R.C., C. Leng, D. Krappmann, M.Y. Mapara, F. Emmerich, K. Bommert, C. Scheidereit, and B. Dörken. 1996. High-level nuclear NF-κB and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells. Blood. 87:4340-4347.
10. Baeuerle, P.A., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141-179.
11. Verma, I.M., J.K. Stevenson, E.M. Schwarz, D. Van Antwerp, and S. Miyamoto. 1995. Rel/NF-κB/IκB family: intimate tales of association and dissociation. Genes Dev. 9:2723-2735.
12. Wulczyn, F.G., D. Krappmann, and C. Scheidereit. 1996. The NF-κB and IκB gene families: mediators of immune response and inflammation. J. Mol. Med. 74:749-769.
13. Kaltschmidt, C., B. Kaltschmidt, H. Neumann, H. Wekerle, and P.A. Baeuerle. 1994. Constitutive NF-κB activity in neurons. Mol. Cell. Biol. 14: 3981-3992.
14. Lernbecher, T., U. Müller, and T. Wirth. 1993. Distinct NF-κB/Rel transcription factors are responsible for tissue-specific and inducible gene activation. Nature. 365:767-770.
15. Liou, H.C., W.C. Sha, M.L. Scott, and D. Baltimore. 1994. Sequential induction of NF-κB/Rel family proteins during B-cell terminal differentiation. Mol. Cell. Biol. 14:5349-5359.
16. Miyamoto, S., M.J. Schmitt, and I.M. Verma. 1994. Qualitative changes in the subunit composition of κB-binding complexes during murine B-cell differentiation. Proc. Natl. Acad. Sci. USA. 91:5056-5060.
17. Siebenlist, U., G. Franzoso, and K. Brown. 1994. Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10:405-455.
18. Baldwin, A.S., Jr., J.C. Azizkhan, D.E. Jensen, A.A. Beg, and L.R. Coodly. 1991. Induction of NF-κB DNA-binding activity during the G0-to-G1 transition in mouse fibroblasts. Mol. Cell. Biol. 11:4943-4951.
19. Perkins, N.D., L.K. Felzien, J.C. Betts, K. Leung, D.H. Beach, and G.J. Nabel. 1997. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science. 275:523-527.
20. Beg, A.A., and D. Baltimore. 1996. An essential role for NF-κB in preventing TNF-α-induced cell death. Science. 274:782-784.
21. Van Antwerp, D.J., S.J. Martin, T. Kafri, D.R. Green, and I.M. Verma. 1996. Suppression of TNF-α-induced apoptosis by NF-κB. Science. 274:787-789.
22. Liu, Z.G., H. Hsu, D.V. Goeddel, and M. Karin. 1996. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell. 87:565-576.
23. Wang, C.-Y., M.W. Mayo, and A.S. Baldwin. 1996. TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science. 274: 784-787.
24. Wu, M., H. Lee, R.E. Bellas, S.L. Schauer, M. Arsura, D. Katz, M.J. FitzGerald, T.L. Rothstein, D.H. Sherr, and G.E. Sonenshein. 1996. Inhibition of NF-κB/Rel induces apoptosis of murine B cells. EMBO (Eur. Mol. Bio. Organ.) J. 15:4682-4690.
25. Grilli, M., M. Pizzi, M. Memo, and P. Spano. 1996. Neuroprotection by aspirin and sodium salicylate through blockade of NF-κB activation. Science. 274:1383-1385.
26. Cai, Z., M. Korner, N. Tarantino, and S. Chouaib. 1997. IκBα overexpression in human breast carcinoma MCF7 cells inhibits nuclear factor-κB activation but not tumor necrosis factor-α-induced apoptosis. J. Biol. Chem. 272: 96-101.
27. Krappmann, D., F.G. Wulczyn, and C. Scheidereit. 1996. Different mechanisms control signal-induced degradation and basal turnover of the NF-κB inhibitor IκBα in vivo. EMBO (Eur. Mol Bio. Organ.) J. 15:6716-6726.
28. Naumann, M., and C. Scheidereit. 1994. Activation of NF-κB in vivo is regulated by multiple phosphorylations. EMBO (Eur. Mol Bio. Organ.) J. 13: 4597-4607.
29. Muesing, M.A., D.H. Smith, and D.J. Capon. 1987. Regulation of mRNA accumulation by a human immunodeficiency virus Irans-activator protein. Cell. 48:691-701.
30. Vermes, I., C. Haanen, H. Steffens-Nakken, and C. Reutelingsperger. 1995. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled Annexin V.J. Immunol. Methods. 184:39-51.
31. Kaltschmidt, C., B. Kaltschmidt, T. Henkel, H. Stockinger, and P.A. Baeuerle. 1995. Selective recognition of the activated form of transcription factor NF-κB by a monoclonal antibody. Biol. Chem. Hoppe-Seyler. 376:9-16.
32. Brockman, J.A., D.C. Scherer, T.A. McKinsey, S.M. Hall, X. Qi, W.Y. Lee, and D.W. Ballard. 1995. Coupling of a signal response domain in IκBα to multiple pathways for NF-κB activation. mol. Cell. Biol. 15:2809-2818.
33. Brown, K., S. Gerstberger, L. Carlson, G. Franzoso, and U. Siebenlist. 1995. Control of IκBα proteolysis by site-specific, signal-induced phosphorylation. Science. 267:1485-1488.
34. Traenckner, E.B., H.L. Pahl, T. Henkel, K.N. Schmidt, S. Wilk, and P.A. Baeuerle. 1995. Phosphorylation of human IκBα on serines 32 and 36 controls IκBα proteolysis and NF-κB activation in response to diverse stimuli. EMBO (Eur. Mol. Bio. Organ.) J. 14:2876-2883.
35. Whiteside, S.T., M.K. Ernst, O. LeBail, C. Laurent-Winter, N. Rice, and A. Israel. 1995. N- and C-terminal sequences control degradation of MAD3/IκBα in response to inducers of NF-κB activity. Mol. Cell. Biol. 15:5339-5345.
36. Imbert, V., R.A. Rupec, A. Livolsi, H.J. Pahl, E.B. Traenckner, C. Mueller-Dieckmann, D. Farahifar, B. Rossi, P. Auberger, P.A. Baeuerle, and J.-F. Peyron. 1996. Tyrosine phosphorylation of IκBα activates NF-κB without proteolytic degradation of IκBα. Cell. 86:787-798.
37. Le Bail, O., R. Schmidt-Ullrich, and A. Israel. 1993. Promoter analysis of the gene encoding the IκB/MAD-3 inhibitor of NF-κB: positive regulation by members of the rel/NF-κB family. EMBO (Eur. Mol. Bio. Organ.) J. 12: 5043-5048.
38. Beg, A.A., W.C. Sha, R.T. Bronson, S. Ghosh, and D. Baltimore. 1995. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature. 376:167-170.
39. Diehl, V., M. Pfreundschuh, C. Fonatsch, H. Stein, M. Falk, H. Burrichter, and M. Schaadt. 1985. Phenotypic and genotypic analysis of Hodgkin's disease derived cell lines: histopathological and clinical implications. Cancer Surv. 4:399-419.
40. Laherty, C.D., H.M. Hu, A.W. Opipari, F. Wang, and V.M. Dixit. 1992. The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor κB. J. Biol. Chem. 267:24157-24160.
41. Biswas, P., C.A. Smith, D. Goletti, E.C. Hardy, R.W. Jackson, and A.S. Fauci. 1995. Cross-linking of CD30 induces HIV expression in chronically infected T cells. Immunity. 2:587-596.
42. Duckett, C.S., R.W. Gedrich, M.C. Gilfillan, and C.B. Thompson. 1997. Induction of nuclear factor κB by the CD30 receptor is mediated by TRAF1 and TRAF2. Mol. Cell. Biol. 17:1535-1542.
43. Perez, P., S.A. Lira, and R. Bravo. 1995. Overexpression of RelA in transgenic mouse thymocytes: specific increase in levels of the inhibitor protein IκBα. Mol. Cell. Biol. 15:3523-3530.
44. Doi, T.S., T. Takahashi, O. Taguchi, T. Azuma, and Y. Obata. 1997. NF-κB RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses. J. Exp. Med. 185:953-961.
45. Snapper, C.M., F.R. Rosas, P. Zelazowski, M.A. Moorman, M.R. Kehry, R. Bravo, and F. Weih. 1996. B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching. J. Exp. Med. 184:1537-1541.
46. Collins, T., M.A. Read, A.S. Neish, M.Z. Whitley, D. Thanos, and T. Maniatis. 1995. Transcriptional regulation of endothelial cell adhesion molecules: NF-κB and cytokine-inducible enhancers. FASEB (Fed. Am. Soc. Exp. Biol.) J. 9:899-909.
47. Higgins, K.A., J.R. Perez, T.A. Coleman, K. Dorshkind, W.A. McComas, U.M. Sarmiento, C.A. Rosen, and R. Narayanan. 1993. Antisense inhibition of the p65 subunit of NF-κB blocks tumorigenicity and causes tumor regression. Proc. Natl. Acad. Sci. USA. 90:9901-9905.
48. Kitajima, I., T. Shinohara, J. Bilakovics, D.A. Brown, X. Xu, and M. Nerenberg. 1992. Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-κB. Science. 258:1792-1795.
49. Opipari, A.W., Jr., H.M. Hu, R. Yabkowitz, and V.M. Dixit. 1992. The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. J. Biol. Chem. 267:12424-12427.
50. Wong, G.H., J.H. Elwell, L.W. Oberley, and D.V. Goeddel. 1989. Manganous Superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor. Cell. 58:923-931.
51. Krikos, A., C.D. Laherty, and V.M. Dixit. 1992. Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by κB elements. J. Biol. Chem. 267:17971-17976.