Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

Molecular and Cellular Biology

Volumn 16, Issue 4, 1996, Pages 1722-1733

  Wymann, Matthias P ^a,d   Bulgarelli Leva, Ginette ^a   Zvelebil, Marketa J ^b   Pirola, Luciano ^a   Vanhaesebroeck, Bart ^b   Waterfield, Michael D ^b,c   Panayotou, George ^b  

^a UNIVERSITY OF FRIBOURG   (Switzerland)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d Division of Biochemistry   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; ARGININE; LYSINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PROTEIN KINASE INHIBITOR; RECOMBINANT PROTEIN; WORTMANNIN;

ARTICLE; ATAXIA TELANGIECTASIA; BINDING SITE; CATALYSIS; CONCENTRATION RESPONSE; EMBRYO; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; KIDNEY CELL; PHOSPHATE TRANSPORT; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

EID: 0029965452     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.4.1722     Document Type: Article

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