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Volumn 10, Issue 5, 2010, Pages 342-352

Phosphoinositide signalling in cancer: Beyond PI3K and PTEN

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATASE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE; PHOSPHOLIPASE C;

EID: 77951568703     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc2842     Document Type: Review
Times cited : (355)

References (123)
  • 1
    • 70350211473 scopus 로고    scopus 로고
    • Mammalian phosphoinositide kinases and phosphatases
    • Sasaki, T. et al. Mammalian phosphoinositide kinases and phosphatases. Prog. Lipid Res. 48, 307-343 (2009).
    • (2009) Prog. Lipid Res. , vol.48 , pp. 307-343
    • Sasaki, T.1
  • 2
    • 33644840483 scopus 로고    scopus 로고
    • New insights into the families of PLC enzymes: Looking back and going forward
    • Katan, M. New insights into the families of PLC enzymes: looking back and going forward. Biochem. J. 391, e7-e9 (2005).
    • (2005) Biochem. J. , vol.391
    • Katan, M.1
  • 3
    • 0038281249 scopus 로고    scopus 로고
    • Phosphoinositide recognition domains
    • Lemmon, M. A. Phosphoinositide recognition domains. Traffic 4, 201-213 (2003).
    • (2003) Traffic , vol.4 , pp. 201-213
    • Lemmon, M.A.1
  • 4
    • 38549092474 scopus 로고    scopus 로고
    • Membrane recognition by phospholipid-binding domains
    • Lemmon, M. A. Membrane recognition by phospholipid-binding domains. Nature Rev. Mol. Cell Biol. 9, 99-111 (2008).
    • (2008) Nature Rev. Mol. Cell Biol. , vol.9 , pp. 99-111
    • Lemmon, M.A.1
  • 5
    • 28444439900 scopus 로고    scopus 로고
    • Organelle identity and the signposts for membrane traffic
    • Behnia, R. & Munro, S. Organelle identity and the signposts for membrane traffic. Nature 438, 597-604 (2005).
    • (2005) Nature , vol.438 , pp. 597-604
    • Behnia, R.1    Munro, S.2
  • 6
    • 33749836234 scopus 로고    scopus 로고
    • Phosphoinositides in cell regulation and membrane dynamics
    • Di Paolo, G. & De Camilli, P. Phosphoinositides in cell regulation and membrane dynamics. Nature 443, 651-657 (2006).
    • (2006) Nature , vol.443 , pp. 651-657
    • Di Paolo, G.1    De Camilli, P.2
  • 8
    • 47649123929 scopus 로고    scopus 로고
    • The multiple roles of PtdIns(4)P\not just the precursor of PtdIns(4, 5)P2
    • D'Angelo, G., Vicinanza, M., Di Campli, A. & De Matteis, M. A. The multiple roles of PtdIns(4)P\not just the precursor of PtdIns(4, 5)P2. J. Cell Sci. 121, 1955-1963 (2008).
    • (2008) J. Cell Sci. , vol.121 , pp. 1955-1963
    • D'Angelo, G.1    Vicinanza, M.2    Di Campli, A.3    De Matteis, M.A.4
  • 9
    • 34247187332 scopus 로고    scopus 로고
    • Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4, 5-bisphosphate
    • Zoncu, R. et al. Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4, 5-bisphosphate. Proc. Natl Acad. Sci. USA 104, 3793-3798 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 3793-3798
    • Zoncu, R.1
  • 10
    • 0038311944 scopus 로고    scopus 로고
    • Phosphoinositide regulation of the actin cytoskeleton
    • Yin, H. L. & Janmey, P. A. Phosphoinositide regulation of the actin cytoskeleton. Annu. Rev. Physiol. 65, 761-789 (2003).
    • (2003) Annu. Rev. Physiol. , vol.65 , pp. 761-789
    • Yin, H.L.1    Janmey, P.A.2
  • 11
    • 4644262299 scopus 로고    scopus 로고
    • 2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking
    • 2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking. Nature 431, 415-422 (2004).
    • (2004) Nature , vol.431 , pp. 415-422
    • Di Paolo, G.1
  • 12
    • 0035190026 scopus 로고    scopus 로고
    • Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer
    • Katso, R. et al. Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu. Rev. Cell Dev. Biol. 17, 615-675 (2001).
    • (2001) Annu. Rev. Cell Dev. Biol. , vol.17 , pp. 615-675
    • Katso, R.1
  • 13
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Engelman, J. A., Luo, J. & Cantley, L. C. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nature Rev. Genet. 7, 606-619 (2006).
    • (2006) Nature Rev. Genet. , vol.7 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 14
    • 51849167782 scopus 로고    scopus 로고
    • Understanding PTEN regulation: PIP2, polarity and protein stability
    • Leslie, N. R., Batty, I. H., Maccario, H., Davidson, L. & Downes, C. P. Understanding PTEN regulation: PIP2, polarity and protein stability. Oncogene 27, 5464-5476 (2008).
    • (2008) Oncogene , vol.27 , pp. 5464-5476
    • Leslie, N.R.1    Batty, I.H.2    MacCario, H.3    Davidson, L.4    Downes, C.P.5
  • 15
    • 62749155738 scopus 로고    scopus 로고
    • The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease
    • Ooms, L. M. et al. The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease. Biochem. J. 419, 29-49 (2009).
    • (2009) Biochem. J. , vol.419 , pp. 29-49
    • Ooms, L.M.1
  • 16
    • 0033574526 scopus 로고    scopus 로고
    • The role of phosphatases in inositol signaling reactions
    • Majerus, P. W., Kisseleva, M. V. & Norris, F. A. The role of phosphatases in inositol signaling reactions. J. Biol. Chem. 274, 10669-10672 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 10669-10672
    • Majerus, P.W.1    Kisseleva, M.V.2    Norris, F.A.3
  • 17
    • 30944461203 scopus 로고    scopus 로고
    • Phosphatidylinositol 3,5-bisphosphate: Metabolism and cellular functions
    • Michell, R. H., Heath, V. L., Lemmon, M. A. & Dove, S. K. Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions. Trends Biochem. Sci. 31, 52-63 (2006).
    • (2006) Trends Biochem. Sci. , vol.31 , pp. 52-63
    • Michell, R.H.1    Heath, V.L.2    Lemmon, M.A.3    Dove, S.K.4
  • 19
    • 52549091027 scopus 로고    scopus 로고
    • Phosphoinositides as regulators of membrane trafficking in health and disease
    • Vicinanza, M., D'Angelo, G., Di Campli, A. & De Matteis, M. A. Phosphoinositides as regulators of membrane trafficking in health and disease. Cell. Mol. Life Sci. 65, 2833-2841 (2008).
    • (2008) Cell. Mol. Life Sci. , vol.65 , pp. 2833-2841
    • Vicinanza, M.1    D'Angelo, G.2    Di Campli, A.3    De Matteis, M.A.4
  • 20
    • 33847353371 scopus 로고    scopus 로고
    • Phosphoinositide-metabolizing enzymes at the interface between membrane traffic and cell signalling
    • Krauss, M. & Haucke, V. Phosphoinositide-metabolizing enzymes at the interface between membrane traffic and cell signalling. EMBO Rep. 8, 241-246 (2007).
    • (2007) EMBO Rep. , vol.8 , pp. 241-246
    • Krauss, M.1    Haucke, V.2
  • 22
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: Variations on a theme
    • Yuan, T. L. & Cantley, L. C. PI3K pathway alterations in cancer: variations on a theme. Oncogene 27, 5497-5510 (2008).
    • (2008) Oncogene , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 23
    • 68249093818 scopus 로고    scopus 로고
    • Targeting the phosphoinositide 3-kinase pathway in cancer
    • Liu, P., Cheng, H., Roberts, T. M. & Zhao, J. J. Targeting the phosphoinositide 3-kinase pathway in cancer. Nature Rev. Drug Discov. 8, 627-644 (2009).
    • (2009) Nature Rev. Drug Discov. , vol.8 , pp. 627-644
    • Liu, P.1    Cheng, H.2    Roberts, T.M.3    Zhao, J.J.4
  • 24
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman, J. A. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nature Rev. Cancer 9, 550-562 (2009).
    • (2009) Nature Rev. Cancer , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 25
    • 0033579163 scopus 로고    scopus 로고
    • Mutational spectra of PTEN/MMAC1 gene: A tumor suppressor with lipid phosphatase activity
    • Ali, I. U., Schriml, L. M. & Dean, M. Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity. J. Natl Cancer Inst. 91, 1922-1932 (1999).
    • (1999) J. Natl Cancer Inst. , vol.91 , pp. 1922-1932
    • Ali, I.U.1    Schriml, L.M.2    Dean, M.3
  • 27
    • 70749140937 scopus 로고    scopus 로고
    • Somatic mutations in p85α promote tumorigenesis through class IA PI3K activation
    • Jaiswal, B. S. et al. Somatic mutations in p85α promote tumorigenesis through class IA PI3K activation. Cancer Cell 16, 463-474 (2009).
    • (2009) Cancer Cell , vol.16 , pp. 463-474
    • Jaiswal, B.S.1
  • 28
    • 13944284494 scopus 로고    scopus 로고
    • Oncogenic mutations of PIK3CA in human cancers
    • Samuels, Y. & Velculescu, V. E. Oncogenic mutations of PIK3CA in human cancers. Cell Cycle 3, 1221-1224 (2004).
    • (2004) Cell Cycle , vol.3 , pp. 1221-1224
    • Samuels, Y.1    Velculescu, V.E.2
  • 29
    • 21144457217 scopus 로고    scopus 로고
    • Functional analysis of PIK3CA gene mutations in human colorectal cancer
    • Ikenoue, T. et al. Functional analysis of PIK3CA gene mutations in human colorectal cancer. Cancer Res. 65, 4562-4567 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 4562-4567
    • Ikenoue, T.1
  • 30
    • 14144252004 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
    • Kang, S., Bader, A. G. & Vogt, P. K. Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc. Natl Acad. Sci. USA 102, 802-807 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 802-807
    • Kang, S.1    Bader, A.G.2    Vogt, P.K.3
  • 31
    • 39049101676 scopus 로고    scopus 로고
    • Portrait of PTEN: Messages from mutant mice
    • Suzuki, A., Nakano, T., Mak, T. W. & Sasaki, T. Portrait of PTEN: messages from mutant mice. Cancer Sci. 99, 209-213 (2008).
    • (2008) Cancer Sci. , vol.99 , pp. 209-213
    • Suzuki, A.1    Nakano, T.2    Mak, T.W.3    Sasaki, T.4
  • 32
    • 66149141021 scopus 로고    scopus 로고
    • PTEN and the PI3-kinase pathway in cancer
    • Chalhoub, N. & Baker, S. J. PTEN and the PI3-kinase pathway in cancer. Annu. Rev. Pathol. 4, 127-150 (2009).
    • (2009) Annu. Rev. Pathol. , vol.4 , pp. 127-150
    • Chalhoub, N.1    Baker, S.J.2
  • 33
    • 34548646991 scopus 로고    scopus 로고
    • PTEN: Its deregulation and tumorigenesis
    • Maehama, T. PTEN: its deregulation and tumorigenesis. Biol. Pharm. Bull. 30, 1624-1627 (2007).
    • (2007) Biol. Pharm. Bull. , vol.30 , pp. 1624-1627
    • Maehama, T.1
  • 34
    • 0031039024 scopus 로고    scopus 로고
    • Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
    • Franke, T. F., Kaplan, D. R., Cantley, L. C. & Toker, A. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4- bisphosphate. Science 275, 665-668 (1997).
    • (1997) Science , vol.275 , pp. 665-668
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3    Toker, A.4
  • 36
    • 0037088681 scopus 로고    scopus 로고
    • 2 is required for PKB phosphorylation at Ser-473: Studies using cells from SH2-containing inositol-5-phosphatase knockout mice
    • 2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockout mice. J. Biol. Chem. 277, 9027-9035 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 9027-9035
    • Scheid, M.P.1
  • 37
    • 66449092234 scopus 로고    scopus 로고
    • Differential roles for the inositol phosphatase SHIP in the regulation of macrophages and lymphocytes
    • Leung, W. H., Tarasenko, T. & Bolland, S. Differential roles for the inositol phosphatase SHIP in the regulation of macrophages and lymphocytes. Immunol. Res. 43, 243-251 (2009).
    • (2009) Immunol. Res. , vol.43 , pp. 243-251
    • Leung, W.H.1    Tarasenko, T.2    Bolland, S.3
  • 39
    • 2642684541 scopus 로고    scopus 로고
    • Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span
    • Helgason, C. D. et al. Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span. Genes Dev. 12, 1610-1620 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 1610-1620
    • Helgason, C.D.1
  • 40
    • 0032745240 scopus 로고    scopus 로고
    • BCR/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis
    • Sattler, M. et al. BCR/ABL directly inhibits expression of SHIP, an SH2-containing polyinositol-5-phosphatase involved in the regulation of hematopoiesis. Mol. Cell. Biol. 19, 7473-7480 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 7473-7480
    • Sattler, M.1
  • 41
    • 8844258034 scopus 로고    scopus 로고
    • Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3β signaling and leads to an increased transit time through the G1 phase of the cell cycle
    • Horn, S. et al. Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3β signaling and leads to an increased transit time through the G1 phase of the cell cycle. Leukemia 18, 1839-1849 (2004).
    • (2004) Leukemia , vol.18 , pp. 1839-1849
    • Horn, S.1
  • 42
    • 27244438058 scopus 로고    scopus 로고
    • Alteration of phosphatidylinositol 3-kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL)
    • Fukuda, R. et al. Alteration of phosphatidylinositol 3-kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL). Proc. Natl Acad. Sci. USA 102, 15213-15218 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 15213-15218
    • Fukuda, R.1
  • 43
    • 34548330713 scopus 로고    scopus 로고
    • Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells
    • Ong, C. J. et al. Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells. Blood 11 0, 1942-1949 (2007).
    • (2007) Blood , vol.110 , pp. 1942-1949
    • Ong, C.J.1
  • 44
    • 70349826160 scopus 로고    scopus 로고
    • Activation of SHIP via a small molecule agonist kills multiple myeloma cells
    • Kennah, M. et al. Activation of SHIP via a small molecule agonist kills multiple myeloma cells. Exp. Hematol. 37, 1274-1283 (2009).
    • (2009) Exp. Hematol. , vol.37 , pp. 1274-1283
    • Kennah, M.1
  • 45
    • 33644815364 scopus 로고    scopus 로고
    • Up-regulation of the T cell quiescence factor KLF2 in a leukaemic T-cell line after expression of the inositol 5'-phosphatase SHIP-1
    • Garcia-Palma, L. et al. Up-regulation of the T cell quiescence factor KLF2 in a leukaemic T-cell line after expression of the inositol 5'-phosphatase SHIP-1. Br. J. Haematol. 131, 628-631 (2005).
    • (2005) Br. J. Haematol. , vol.131 , pp. 628-631
    • Garcia-Palma, L.1
  • 46
    • 16644402688 scopus 로고    scopus 로고
    • Mutation analysis of SHIP gene in acute leukemia
    • Luo, J. M. et al. Mutation analysis of SHIP gene in acute leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi 12, 420-426 (2004).
    • (2004) Zhongguo Shi Yan Xue Ye Xue Za Zhi , vol.12 , pp. 420-426
    • Luo, J.M.1
  • 47
    • 0037269497 scopus 로고    scopus 로고
    • Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia
    • Luo, J. M. et al. Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia. Leukemia 17, 1-8 (2003).
    • (2003) Leukemia , vol.17 , pp. 1-8
    • Luo, J.M.1
  • 48
    • 38849148269 scopus 로고    scopus 로고
    • Phosphoinositol phosphatase SHIP2 promotes cancer development and metastasis coupled with alterations in EGF receptor turnover
    • Prasad, N. K., Tandon, M., Badve, S., Snyder, P. W. & Nakshatri, H. Phosphoinositol phosphatase SHIP2 promotes cancer development and metastasis coupled with alterations in EGF receptor turnover. Carcinogenesis 29, 25-34 (2008).
    • (2008) Carcinogenesis , vol.29 , pp. 25-34
    • Prasad, N.K.1    Tandon, M.2    Badve, S.3    Snyder, P.W.4    Nakshatri, H.5
  • 49
    • 60749136137 scopus 로고    scopus 로고
    • SHIP2 phosphoinositol phosphatase positively regulates EGFR-Akt pathway CXCR4 expression, and cell migration in MDA-MB-231 breast cancer cells
    • Prasad, N. K. SHIP2 phosphoinositol phosphatase positively regulates EGFR-Akt pathway, CXCR4 expression, and cell migration in MDA-MB-231 breast cancer cells. Int. J. Oncol. 34, 97-105 (2009).
    • (2009) Int. J. Oncol. , vol.34 , pp. 97-105
    • Prasad, N.K.1
  • 50
    • 20044364159 scopus 로고    scopus 로고
    • Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity
    • Sleeman, M. W. et al. Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity. Nature Med. 11, 199-205 (2005).
    • (2005) Nature Med. , vol.11 , pp. 199-205
    • Sleeman, M.W.1
  • 51
    • 3543072186 scopus 로고    scopus 로고
    • Obesity and cancer: Epidemiological evidence and proposed mechanisms
    • Calle, E. E. & Kaaks, R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nature Rev. Cancer 4, 579-591 (2004).
    • (2004) Nature Rev. Cancer , vol.4 , pp. 579-591
    • Calle, E.E.1    Overweight, K.R.2
  • 52
    • 67650053875 scopus 로고    scopus 로고
    • Two diseases with one hit: Inhibiting a potential diabetes target to reduce cancer risk and to improve anti-cancer therapy
    • Prasad, N. Tw o diseases with one hit: inhibiting a potential diabetes target to reduce cancer risk and to improve anti-cancer therapy. Curr. Cancer Ther. Rev. 5, 111-121 (2009).
    • (2009) Curr. Cancer Ther. Rev. , vol.5 , pp. 111-121
    • Prasad, N.1
  • 53
    • 17744390515 scopus 로고    scopus 로고
    • CDNA microarray analysis of gene expression profiles associated with cervical cancer
    • Yoon, J. H. et al. cDNA microarray analysis of gene expression profiles associated with cervical cancer. Cancer Res. Treat 35, 451-459 (2003).
    • (2003) Cancer Res. Treat , vol.35 , pp. 451-459
    • Yoon, J.H.1
  • 54
    • 27744462150 scopus 로고    scopus 로고
    • In vivo drug-response in patients with leukemic non-Hodgkin's lymphomas is associated with in vitro chemosensitivity and gene expression profiling
    • Chow, K. U. et al. In vivo drug-response in patients with leukemic non-Hodgkin's lymphomas is associated with in vitro chemosensitivity and gene expression profiling. Pharmacol. Res. 53, 49-61 (2006).
    • (2006) Pharmacol. Res. , vol.53 , pp. 49-61
    • Chow, K.U.1
  • 55
    • 2342588851 scopus 로고    scopus 로고
    • Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling
    • Quade, B. J. et al. Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling. Genes Chromosom. Cancer 40, 97-108 (2004).
    • (2004) Genes Chromosom. Cancer , vol.40 , pp. 97-108
    • Quade, B.J.1
  • 56
    • 17144390205 scopus 로고    scopus 로고
    • Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer
    • Akada, M. et al. Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer. Clin. Cancer Res. 11, 3094-3101 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , pp. 3094-3101
    • Akada, M.1
  • 57
    • 10744229353 scopus 로고    scopus 로고
    • Expression profiling and subtype-specific expression of stomach cancer
    • Kim, B. et al. Expression profiling and subtype-specific expression of stomach cancer. Cancer Res. 63, 8248-8255 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 8248-8255
    • Kim, B.1
  • 58
    • 0037226593 scopus 로고    scopus 로고
    • A molecular signature of metastasis in primary solid tumors
    • Ramaswamy, S., Ross, K. N., Lander, E. S. & Golub, T. R. A molecular signature of metastasis in primary solid tumors. Nature Genet. 33, 49-54 (2003).
    • (2003) Nature Genet. , vol.33 , pp. 49-54
    • Ramaswamy, S.1    Ross, K.N.2    Lander, E.S.3    Golub, T.R.4
  • 59
    • 0035881617 scopus 로고    scopus 로고
    • Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns
    • Gruvberger, S. et al. Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns. Cancer Res. 61, 5979-5984 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 5979-5984
    • Gruvberger, S.1
  • 60
    • 18244409687 scopus 로고    scopus 로고
    • Gene expression profiling predicts clinical outcome of breast cancer
    • van 't Veer, L. J. et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415, 530-536 (2002).
    • (2002) Nature , vol.415 , pp. 530-536
    • Van'T Veer, L.J.1
  • 61
    • 31944442909 scopus 로고    scopus 로고
    • The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation
    • Ooms, L. M. et al. The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation. Mol. Biol. Cell 17, 607-622 (2006).
    • (2006) Mol. Biol. Cell , vol.17 , pp. 607-622
    • Ooms, L.M.1
  • 62
    • 0037155228 scopus 로고    scopus 로고
    • Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt/protein kinase B phosphorylation and leads to apoptotic cell death
    • Kisseleva, M. V., Cao, L. & Majerus, P. W. Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt/protein kinase B phosphorylation and leads to apoptotic cell death. J. Biol. Chem. 277, 6266-6272 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 6266-6272
    • Kisseleva, M.V.1    Cao, L.2    Majerus, P.W.3
  • 63
    • 67651148274 scopus 로고    scopus 로고
    • Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling
    • Gewinner, C. et al. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell 16, 115-125 (2009).
    • (2009) Cancer Cell , vol.16 , pp. 115-125
    • Gewinner, C.1
  • 64
    • 33644775504 scopus 로고    scopus 로고
    • Phosphatidylinositol 4-phosphatase type II is an erythropoietin- responsive gene
    • Barnache, S., Le Scolan, E., Kosmider, O., Denis, N. & Moreau-Gachelin, F. Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene. Oncogene 25, 1420-1423 (2006).
    • (2006) Oncogene , vol.25 , pp. 1420-1423
    • Barnache, S.1    Le Scolan, E.2    Kosmider, O.3    Denis, N.4    Moreau-Gachelin, F.5
  • 65
    • 34447650761 scopus 로고    scopus 로고
    • High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization
    • Naylor, T. L. et al. High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization. Breast Cancer Res. 7, R1186-R1198 (2005).
    • (2005) Breast Cancer Res. , vol.7
    • Naylor, T.L.1
  • 66
    • 33748939380 scopus 로고    scopus 로고
    • Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer
    • Bergamaschi, A. et al. Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer. Genes Chromosom. Cancer 45, 1033-1040 (2006).
    • (2006) Genes Chromosom. Cancer , vol.45 , pp. 1033-1040
    • Bergamaschi, A.1
  • 67
    • 33947529520 scopus 로고    scopus 로고
    • Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers
    • Chin, S. F. et al. Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers. Oncogene 26, 1959-1970 (2007).
    • (2007) Oncogene , vol.26 , pp. 1959-1970
    • Chin, S.F.1
  • 68
    • 6444240104 scopus 로고    scopus 로고
    • Deletions on chromosome 4 in sporadic and BRCA mutated tumors and association with pathological variables
    • Johannsdottir, H. K. et al. Deletions on chromosome 4 in sporadic and BRCA mutated tumors and association with pathological variables. Anticancer Res. 24, 2681-2687 (2004).
    • (2004) Anticancer Res. , vol.24 , pp. 2681-2687
    • Johannsdottir, H.K.1
  • 69
    • 67349239410 scopus 로고    scopus 로고
    • Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1
    • Ivetac, I. et al. Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1. EMBO Rep. 10, 487-493 (2009).
    • (2009) EMBO Rep. , vol.10 , pp. 487-493
    • Ivetac, I.1
  • 70
    • 0033537926 scopus 로고    scopus 로고
    • Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes
    • Anderson, R. A., Boronenkov, I. V., Doughman, S. D., Kunz, J. & Loijens, J. C. Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes. J. Biol. Chem. 274, 9907-9910 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 9907-9910
    • Anderson, R.A.1    Boronenkov, I.V.2    Doughman, S.D.3    Kunz, J.4    Loijens, J.C.5
  • 71
    • 33847772690 scopus 로고    scopus 로고
    • A conspicuous connection: Structure defines function for the phosphatidylinositol-phosphate kinase family
    • Heck, J. N. et al. A conspicuous connection: structure defines function for the phosphatidylinositol-phosphate kinase family. Crit. Rev. Biochem. Mol. Biol. 42, 15-39 (2007).
    • (2007) Crit. Rev. Biochem. Mol. Biol. , vol.42 , pp. 15-39
    • Heck, J.N.1
  • 73
    • 70450246902 scopus 로고    scopus 로고
    • 2 synthesis: Regulation and cellular functions
    • 2 synthesis: regulation and cellular functions. J. Cell Sci. 122, 3837-3850 (2009).
    • (2009) J. Cell Sci. , vol.122 , pp. 3837-3850
    • Van Den Bout, I.1    Divecha, N.2
  • 74
    • 34548636680 scopus 로고    scopus 로고
    • Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases
    • Mao, Y. S. & Yin, H. L. Regulation of the actin cytoskeleton by phosphatidylinositol 4-phosphate 5 kinases. Pflugers Arch. 455, 5-18 (2007).
    • (2007) Pflugers Arch. , vol.455 , pp. 5-18
    • Mao, Y.S.1    Yin, H.L.2
  • 76
    • 0037038412 scopus 로고    scopus 로고
    • Type i gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions
    • Ling, K., Doughman, R. L., Firestone, A. J., Bunce, M. W. & Anderson, R. A. Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature 420, 89-93 (2002).
    • (2002) Nature , vol.420 , pp. 89-93
    • Ling, K.1    Doughman, R.L.2    Firestone, A.J.3    Bunce, M.W.4    Anderson, R.A.5
  • 77
    • 18644371169 scopus 로고    scopus 로고
    • Recruitment and regulation of phosphatidylinositol phosphate kinase type 1γ by the FERM domain of talin
    • Di Paolo, G. et al. Recruitment and regulation of phosphatidylinositol phosphate kinase type 1γ by the FERM domain of talin. Nature 420, 85-89 (2002).
    • (2002) Nature , vol.420 , pp. 85-89
    • Di Paolo, G.1
  • 79
    • 35548958302 scopus 로고    scopus 로고
    • Making and breaking contacts: The cellular biology of cadherin regulation
    • Yap, A. S., Crampton, M. S. & Hardin, J. Making and breaking contacts: the cellular biology of cadherin regulation. Curr. Opin. Cell Biol. 19, 508-514 (2007).
    • (2007) Curr. Opin. Cell Biol. , vol.19 , pp. 508-514
    • Yap, A.S.1    Crampton, M.S.2    Hardin, J.3
  • 80
    • 0037123766 scopus 로고    scopus 로고
    • Molecular architecture and functional model of the endocytic AP2 complex
    • Collins, B. M., McCoy, A. J., Kent, H. M., Evans, P. R. & Owen, D. J. Molecular architecture and functional model of the endocytic AP2 complex. Cell 109, 523-535 (2002).
    • (2002) Cell , vol.109 , pp. 523-535
    • Collins, B.M.1    McCoy, A.J.2    Kent, H.M.3    Evans, P.R.4    Owen, D.J.5
  • 81
    • 33846611043 scopus 로고    scopus 로고
    • Type Iγ phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with μ1B adaptin
    • Ling, K. et al. Type Iγ phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with μ1B adaptin. J. Cell Biol. 176, 343-353 (2007).
    • (2007) J. Cell Biol. , vol.176 , pp. 343-353
    • Ling, K.1
  • 82
    • 23744446278 scopus 로고    scopus 로고
    • Phosphatidylinositol-4-phosphate 5-kinase γ is associated with cell-cell junction in A431 epithelial cells
    • Akiyama, C. et al. Phosphatidylinositol-4-phosphate 5-kinase γ is associated with cell-cell junction in A431 epithelial cells. Cell Biol. Int. 29, 514-520 (2005).
    • (2005) Cell Biol. Int. , vol.29 , pp. 514-520
    • Akiyama, C.1
  • 84
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak, K. & Weinberg, R. A. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nature Rev. Cancer 9, 265-273 (2009).
    • (2009) Nature Rev. Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 85
    • 0037057509 scopus 로고    scopus 로고
    • E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer
    • Yabuta, T. et al. E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer. Int. J. Cancer 101, 434-441 (2002).
    • (2002) Int. J. Cancer , vol.101 , pp. 434-441
    • Yabuta, T.1
  • 86
    • 0042337360 scopus 로고    scopus 로고
    • The intracellular E-cadherin germline mutation V832 M lacks the ability to mediate cell-cell adhesion and to suppress invasion
    • Suriano, G. et al. The intracellular E-cadherin germline mutation V832 M lacks the ability to mediate cell-cell adhesion and to suppress invasion. Oncogene 22, 5716-5719 (2003).
    • (2003) Oncogene , vol.22 , pp. 5716-5719
    • Suriano, G.1
  • 87
    • 34548295877 scopus 로고    scopus 로고
    • Cell polarity in development and cancer
    • Wodarz, A. & Nathke, I. Cell polarity in development and cancer. Nature Cell Biol. 9, 1016-1024 (2007).
    • (2007) Nature Cell Biol. , vol.9 , pp. 1016-1024
    • Wodarz, A.1    Nathke, I.2
  • 89
    • 4444296491 scopus 로고    scopus 로고
    • Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation
    • Mouneimne, G. et al. Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation. J. Cell Biol. 166, 697-708 (2004).
    • (2004) J. Cell Biol. , vol.166 , pp. 697-708
    • Mouneimne, G.1
  • 90
    • 33749046492 scopus 로고    scopus 로고
    • Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin
    • Andrianantoandro, E. & Pollard, T. D. Mechanism of actin filament turnover by severing and nucleation at different concentrations of ADF/cofilin. Mol. Cell 24, 13-23 (2006).
    • (2006) Mol. Cell , vol.24 , pp. 13-23
    • Andrianantoandro, E.1    Pollard, T.D.2
  • 91
    • 34249281332 scopus 로고    scopus 로고
    • The cofilin pathway in breast cancer invasion and metastasis
    • Wang, W., Eddy, R. & Condeelis, J. The cofilin pathway in breast cancer invasion and metastasis. Nature Rev. Cancer 7, 429-440 (2007).
    • (2007) Nature Rev. Cancer , vol.7 , pp. 429-440
    • Wang, W.1    Eddy, R.2    Condeelis, J.3
  • 92
    • 33746861083 scopus 로고    scopus 로고
    • Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells
    • Song, X. et al. Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells. J. Cell Sci. 11 9, 2871-2881 (2006).
    • (2006) J. Cell Sci. , vol.11 , Issue.9 , pp. 2871-2881
    • Song, X.1
  • 93
    • 37249000008 scopus 로고    scopus 로고
    • EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells
    • van Rheenen, J. et al. EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells. J. Cell Biol. 179, 1247-1259 (2007).
    • (2007) J. Cell Biol. , vol.179 , pp. 1247-1259
    • Van Rheenen, J.1
  • 94
    • 58149293622 scopus 로고    scopus 로고
    • Cofilin is a pH sensor for actin free barbed end formation: Role of phosphoinositide binding
    • Frantz, C. et al. Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding. J. Cell Biol. 183, 865-879 (2008).
    • (2008) J. Cell Biol. , vol.183 , pp. 865-879
    • Frantz, C.1
  • 95
    • 73949099768 scopus 로고    scopus 로고
    • Unbalancing the phosphatidylinositol-4, 5-bisphosphate-cofilin interaction impairs cell steering
    • Leyman, S. et al. Unbalancing the phosphatidylinositol-4, 5-bisphosphate-cofilin interaction impairs cell steering. Mol. Biol. Cell 20, 4509-4523 (2009).
    • (2009) Mol. Biol. Cell , vol.20 , pp. 4509-4523
    • Leyman, S.1
  • 96
    • 33750977562 scopus 로고    scopus 로고
    • Mapping the phosphoinositide-binding site on chick cofilin explains how PIP2 regulates the cofilin-actin interaction
    • Gorbatyuk, V. Y. et al. Mapping the phosphoinositide-binding site on chick cofilin explains how PIP2 regulates the cofilin-actin interaction. Mol. Cell 24, 511-522 (2006).
    • (2006) Mol. Cell , vol.24 , pp. 511-522
    • Gorbatyuk, V.Y.1
  • 97
    • 2342436150 scopus 로고    scopus 로고
    • Cofilin promotes actin polymerization and defines the direction of cell motility
    • Ghosh, M. et al. Cofilin promotes actin polymerization and defines the direction of cell motility. Science 304, 743-746 (2004).
    • (2004) Science , vol.304 , pp. 743-746
    • Ghosh, M.1
  • 98
    • 33750948427 scopus 로고    scopus 로고
    • Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis
    • Mouneimne, G. et al. Spatial and temporal control of cofilin activity is required for directional sensing during chemotaxis. Curr. Biol. 16, 2193-2205 (2006).
    • (2006) Curr. Biol. , vol.16 , pp. 2193-2205
    • Mouneimne, G.1
  • 99
    • 66949162019 scopus 로고    scopus 로고
    • Memo is a cofilin-interacting protein that influences PLCγ1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration
    • Meira, M. et al. Memo is a cofilin-interacting protein that influences PLCγ1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration. J. Cell Sci. 122, 787-797 (2009).
    • (2009) J. Cell Sci. , vol.122 , pp. 787-797
    • Meira, M.1
  • 100
    • 21644478210 scopus 로고    scopus 로고
    • PLCγ1 is essential for early events in integrin signalling required for cell motility
    • Jones, N. P., Peak, J., Brader, S., Eccles, S. A. & Katan, M. PLCγ1 is essential for early events in integrin signalling required for cell motility. J. Cell Sci. 11 8, 2695-2706 (2005).
    • (2005) J. Cell Sci. , vol.11 , Issue.8 , pp. 2695-2706
    • Jones, N.P.1    Peak, J.2    Brader, S.3    Eccles, S.A.4    Katan, M.5
  • 101
    • 34547866453 scopus 로고    scopus 로고
    • Role of phospholipase Cγ1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1
    • Jones, N. P. & Katan, M. Role of phospholipase Cγ1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1. Mol. Cell. Biol. 27, 5790-5805 (2007).
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 5790-5805
    • Jones, N.P.1    Katan, M.2
  • 102
    • 35548972598 scopus 로고    scopus 로고
    • Rac1 and Rac2 differentially regulate actin free barbed end formation downstream of the fMLP receptor
    • Sun, C. X., Magalhaes, M. A. & Glogauer, M. Rac1 and Rac2 differentially regulate actin free barbed end formation downstream of the fMLP receptor. J. Cell Biol. 179, 239-245 (2007).
    • (2007) J. Cell Biol. , vol.179 , pp. 239-245
    • Sun, C.X.1    Magalhaes, M.A.2    Glogauer, M.3
  • 103
    • 0028069363 scopus 로고
    • Elevated content of phospholipase C-γ 1 in colorectal cancer tissues
    • Noh, D. Y. et al. Elevated content of phospholipase C-γ 1 in colorectal cancer tissues. Cancer 73, 36-41 (1994).
    • (1994) Cancer , vol.73 , pp. 36-41
    • Noh, D.Y.1
  • 104
    • 0025880895 scopus 로고
    • Elevated content of the tyrosine kinase substrate phospholipase C-y 1 in primary human breast carcinomas
    • Arteaga, C. L. et al. Elevated content of the tyrosine kinase substrate phospholipase C-y 1 in primary human breast carcinomas. Proc. Natl Acad. Sci. USA 88, 10435-10439 (1991).
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 10435-10439
    • Arteaga, C.L.1
  • 105
    • 0028985929 scopus 로고
    • Expression of phospholipasesy1 ß 1, and o 1 in primary human colon carcinomas and colon carcinoma cell lines
    • Nomoto, K. et al. Expression of phospholipasesy1, ß 1, and o 1 in primary human colon carcinomas and colon carcinoma cell lines. Mol. Carcinog. 12, 146-152 (1995).
    • (1995) Mol. Carcinog. , vol.12 , pp. 146-152
    • Nomoto, K.1
  • 106
    • 0028083941 scopus 로고
    • Overexpression of phospholipase C-y 1 in familial adenomatous polyposis
    • Park, J. G. et al. Overexpression of phospholipase C-y 1 in familial adenomatous polyposis. Cancer Res. 54, 2240-2244 (1994).
    • (1994) Cancer Res. , vol.54 , pp. 2240-2244
    • Park, J.G.1
  • 107
    • 0141592701 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-stimulated activation of phospholipase Cy-1 promotes invasion of head and neck squamous cell carcinoma
    • Thomas, S. M. et al. Epidermal growth factor receptor-stimulated activation of phospholipase Cy-1 promotes invasion of head and neck squamous cell carcinoma. Cancer Res. 63, 5629-5635 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 5629-5635
    • Thomas, S.M.1
  • 108
    • 34248358157 scopus 로고    scopus 로고
    • PLCy contributes to metastasis of in situ-occurring mammary and prostate tumors
    • Shepard, C. R., Kassis, J., Whaley, D. L, Kim, H. G. & Wells, A. PLCy contributes to metastasis of in situ-occurring mammary and prostate tumors. Oncogene 26, 3020-3026 (2007).
    • (2007) Oncogene , vol.26 , pp. 3020-3026
    • Shepard, C.R.1    Kassis, J.2    Whaley, D.L.3    Kim, H.G.4    Wells, A.5
  • 109
    • 57749118818 scopus 로고    scopus 로고
    • Phospholipase Cy 1 is required for metastasis development and progression
    • Sala, G. et al. Phospholipase Cy 1 is required for metastasis development and progression. Cancer Res. 68, 10187-10196 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 10187-10196
    • Sala, G.1
  • 110
    • 20244380494 scopus 로고    scopus 로고
    • 2+ entry
    • 2+ entry. Immunity 22, 451-465 (2005).
    • (2005) Immunity , vol.22 , pp. 451-465
    • Yu, P.1
  • 111
    • 69249083630 scopus 로고    scopus 로고
    • Characterization of phospholipase Cy enzymes with gain-of-function mutations
    • Everett, K. L. et al. Characterization of phospholipase Cy enzymes with gain-of-function mutations. J. Biol. Chem. 284, 23083-23093 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 23083-23093
    • Everett, K.L.1
  • 112
    • 63749086305 scopus 로고    scopus 로고
    • ErbB receptors and signaling pathways in cancer
    • Hynes, N. E. & MacDonald, G. ErbB receptors and signaling pathways in cancer. Curr. Opin. Cell Biol. 21, 177-184 (2009).
    • (2009) Curr. Opin. Cell Biol. , vol.21 , pp. 177-184
    • Hynes, N.E.1    MacDonald, G.2
  • 113
    • 46249091922 scopus 로고    scopus 로고
    • Multiple roles of phosphoinositide-specific phospholipase C isozymes
    • Suh, P. G. et al. Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep. 41, 415-434 (2008).
    • (2008) BMB Rep. , vol.41 , pp. 415-434
    • Suh, P.G.1
  • 114
    • 33751315308 scopus 로고    scopus 로고
    • Phospholipase C epsilon: Linking second messengers and small GTPases
    • Bunney, T. D. & Katan, M. Phospholipase C epsilon: linking second messengers and small GTPases. Trends Cell Biol. 16, 640-648 (2006).
    • (2006) Trends Cell Biol. , vol.16 , pp. 640-648
    • Bunney, T.D.1    Katan, M.2
  • 115
    • 10844263476 scopus 로고    scopus 로고
    • Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development
    • Bai, Y. et al. Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development. Cancer Res. 64, 8808-8810 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 8808-8810
    • Bai, Y.1
  • 116
    • 39149113469 scopus 로고    scopus 로고
    • Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester
    • Ikuta, S., Edamatsu, H., Li, M., Hu, L. & Kataoka, T. Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester. Cancer Res. 68, 64-72 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 64-72
    • Ikuta, S.1    Edamatsu, H.2    Li, M.3    Hu, L.4    Kataoka, T.5
  • 117
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens, L. M. & Werb, Z. Inflammation and cancer. Nature 420, 860-867 (2002).
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 119
    • 47749118003 scopus 로고    scopus 로고
    • Class 1A PI3K regulates vessel integrity during development and tumorigenesis
    • Yuan, T. L. et al. Class 1A PI3K regulates vessel integrity during development and tumorigenesis. Proc. Natl Acad. Sci. USA 105, 9739-9744 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 9739-9744
    • Yuan, T.L.1
  • 120
    • 67651152910 scopus 로고    scopus 로고
    • Tumor suppression by phospholipase C-ß3 via SHP-1-mediated dephosphorylation of Stat5
    • Xiao, W. et al. Tumor suppression by phospholipase C-ß3 via SHP-1-mediated dephosphorylation of Stat5. Cancer Cell 16, 161-171 (2009).
    • (2009) Cancer Cell , vol.16 , pp. 161-171
    • Xiao, W.1
  • 121
    • 10944255947 scopus 로고    scopus 로고
    • Focus on myeloproliferative diseases and myelodysplastic syndromes
    • Van Etten, R. A. & Shannon, K. M. Focus on myeloproliferative diseases and myelodysplastic syndromes. Cancer Cell 6, 547-552 (2004).
    • (2004) Cancer Cell , vol.6 , pp. 547-552
    • Van Etten, R.A.1    Shannon, K.M.2
  • 122
    • 60149098150 scopus 로고    scopus 로고
    • Phosphoinositide-phospholipase C ß1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia
    • Follo, M. Y et al. Phosphoinositide-phospholipase C ß1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia. J. Clin. Oncol. 27, 782-790 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 782-790
    • Follo, M.Y.1
  • 123
    • 42149177825 scopus 로고    scopus 로고
    • The regulation of cell motility and chemotaxis by phospholipid signaling
    • Kolsch, V, Charest, P. G. & Firtel, R. A. The regulation of cell motility and chemotaxis by phospholipid signaling. J. Cell Sci. 121, 551-559 (2008).
    • (2008) J. Cell Sci. , vol.121 , pp. 551-559
    • Kolsch, V.1    Charest, P.G.2    Firtel, R.A.3


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