Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

Biochemical Journal

Volumn 375, Issue 2, 2003, Pages 255-262

  Komander, David ^a   Kular, Gursant S ^a   Bain, Jennifer ^a   Elliott, Matthew ^a   Alessi, Dario R ^a   Van Aalten, Daan M F ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

3 phosphoinositide dependent protein kinase 1 (PDK1); 7 hydroxystaurosporine (UCN 01); Kinase alignment; Kinase inhibitor specificity

Indexed keywords

CRYSTAL STRUCTURE; ENZYMES; HYDROGEN BONDS; INSULIN; OPTIMIZATION;

GROWTH-FACTOR SIGNALING;

BIOCHEMISTRY;

3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; 7 HYDROXYSTAUROSPORINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE; HYDROXYL GROUP; PROTEIN KINASE; PROTEIN KINASE C; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG SPECIFICITY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CELL LINE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; SPODOPTERA; STAUROSPORINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0142231577     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20031119     Document Type: Article

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