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Volumn 28, Issue 4, 2008, Pages 301-324

Gene therapy in type 1 diabetes

Author keywords

Autoimmunity; Immunomodulation; Islet; T cells; Tolerance

Indexed keywords

ADENOVIRUS VECTOR; ANGIOGENIC FACTOR; ANGIOPOIETIN 1; AUTOANTIBODY; AUTOANTIGEN; CYTOKINE; EXENDIN 4; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 65 IMMUNOGLOBULIN G; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HIRUDIN; IMMUNOGLOBULIN G; INSULIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PARVOVIRUS VECTOR; PLASMID DNA; SOMATOMEDIN C; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR PDX 1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN; VASCULOTROPIN C; VEGF C165S;

EID: 55349102003     PISSN: 10408401     EISSN: None     Source Type: Journal    
DOI: 10.1615/critrevimmunol.v28.i4.30     Document Type: Review
Times cited : (9)

References (225)
  • 1
    • 0012431804 scopus 로고    scopus 로고
    • Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
    • Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2003;26:S5-20.
    • (2003) Diabetes Care , vol.26
  • 2
    • 0027370108 scopus 로고    scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med. 1993;329:977-86
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med. 1993;329:977-86.
  • 8
    • 49549102057 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Biology and clinical potential in type 1 diabetes therapy
    • Epub Feb 24
    • Liu M, Han ZC. Mesenchymal stem cells: biology and clinical potential in type 1 diabetes therapy. J Cell Mol Med. 2008;12:1155-68. Epub 2008 Feb 24.
    • (2008) J Cell Mol Med. 2008 , vol.12 , pp. 1155-1168
    • Liu, M.1    Han, Z.C.2
  • 9
    • 0033001488 scopus 로고    scopus 로고
    • The NOD mouse model of type 1 diabetes: As good as it gets?
    • Atkinson MA, Leiter EH. The NOD mouse model of type 1 diabetes: as good as it gets? Nat Med. 1999;5:601-4.
    • (1999) Nat Med , vol.5 , pp. 601-604
    • Atkinson, M.A.1    Leiter, E.H.2
  • 10
    • 17644361955 scopus 로고    scopus 로고
    • The NOD mouse: A model of immune dysregulation
    • Anderson MS, Bluestone JA. The NOD mouse: a model of immune dysregulation. Annu Rev Immunol. 2005;23:447-85.
    • (2005) Annu Rev Immunol , vol.23 , pp. 447-485
    • Anderson, M.S.1    Bluestone, J.A.2
  • 11
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol. 1989;7:145-73.
    • (1989) Annu Rev Immunol , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 12
    • 0242416575 scopus 로고    scopus 로고
    • Cytokines and transcription factors that regulate T helper cell differentiation: New players and new insights
    • Agnello D, Lankford CS, Bream J, Morinobu A, Gadina M, O'Shea JJ, Frucht DM. Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. J Clin Immunol. 2003;23:147-61.
    • (2003) J Clin Immunol , vol.23 , pp. 147-161
    • Agnello, D.1    Lankford, C.S.2    Bream, J.3    Morinobu, A.4    Gadina, M.5    O'Shea, J.J.6    Frucht, D.M.7
  • 13
    • 9644262463 scopus 로고    scopus 로고
    • Signaling pathways in Th2 development
    • Mowen KA, Glimcher LH. Signaling pathways in Th2 development. Immunol Rev. 2004;202:203-22.
    • (2004) Immunol Rev , vol.202 , pp. 203-222
    • Mowen, K.A.1    Glimcher, L.H.2
  • 15
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005;6:1123-32.
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6    Weaver, C.T.7
  • 17
    • 34247555353 scopus 로고    scopus 로고
    • Differentiation and function of Th17 T cells
    • Stockinger B, Veldhoen M. Differentiation and function of Th17 T cells. Curr Opin Immunol. 2007;19:281-6.
    • (2007) Curr Opin Immunol , vol.19 , pp. 281-286
    • Stockinger, B.1    Veldhoen, M.2
  • 18
    • 35348960243 scopus 로고    scopus 로고
    • Th17: The third member of the effector T cell trilogy
    • Bettelli E, Korn T, Kuchroo VK. Th17: the third member of the effector T cell trilogy. Curr Opin Immunol. 2007;19:652-7.
    • (2007) Curr Opin Immunol , vol.19 , pp. 652-657
    • Bettelli, E.1    Korn, T.2    Kuchroo, V.K.3
  • 19
    • 41549134361 scopus 로고    scopus 로고
    • Th17 cell differentiation: The long and winding road
    • McGeachy MJ, Cua DJ. Th17 cell differentiation: the long and winding road. Immunity. 2008;28:445-53.
    • (2008) Immunity , vol.28 , pp. 445-453
    • McGeachy, M.J.1    Cua, D.J.2
  • 20
    • 41549135632 scopus 로고    scopus 로고
    • The biological functions of T helper 17 cell effector cytokines in inflammation
    • Ouyang W, Kolls JK, Zheng Y. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity. 2008;28:454-67.
    • (2008) Immunity , vol.28 , pp. 454-467
    • Ouyang, W.1    Kolls, J.K.2    Zheng, Y.3
  • 21
    • 42649115767 scopus 로고    scopus 로고
    • TH17 cells in development: An updated view of their molecular identity and genetic programming
    • Dong C. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat Rev Immunol. 2008;8:337-48.
    • (2008) Nat Rev Immunol , vol.8 , pp. 337-348
    • Dong, C.1
  • 22
    • 35548994594 scopus 로고    scopus 로고
    • Recent advancement of understanding pathogenesis of type 1 diabetes and potential relevance to diabetic nephropathy
    • Ichinose K, Kawasaki E, Eguchi K. Recent advancement of understanding pathogenesis of type 1 diabetes and potential relevance to diabetic nephropathy. Am J Nephrol. 2007;27:554-64.
    • (2007) Am J Nephrol , vol.27 , pp. 554-564
    • Ichinose, K.1    Kawasaki, E.2    Eguchi, K.3
  • 23
    • 85056045610 scopus 로고    scopus 로고
    • Imbalance in Th cell polarization and its relevance in type 1 diabetes mellitus
    • Sia C. Imbalance in Th cell polarization and its relevance in type 1 diabetes mellitus. Rev Diabet Stud. 2005;2:182-6.
    • (2005) Rev Diabet Stud , vol.2 , pp. 182-186
    • Sia, C.1
  • 24
    • 0037094032 scopus 로고    scopus 로고
    • Molecular mechanisms for gender differences in susceptibility to T cell-mediated autoimmune diabetes in nonobese diabetic mice
    • Bao M, Yang Y, Jun HS, Yoon JW. Molecular mechanisms for gender differences in susceptibility to T cell-mediated autoimmune diabetes in nonobese diabetic mice. J Immunol. 2002;168:5369-75.
    • (2002) J Immunol , vol.168 , pp. 5369-5375
    • Bao, M.1    Yang, Y.2    Jun, H.S.3    Yoon, J.W.4
  • 25
    • 30944455075 scopus 로고    scopus 로고
    • IL-23 leads to diabetes induction after subdiabetogenic treatment with multiple low doses of streptozotocin
    • Mensah-Brown EP, Shahin A, Al-Shamisi M, Wei X, Lukic ML. IL-23 leads to diabetes induction after subdiabetogenic treatment with multiple low doses of streptozotocin. Eur J Immunol. 2006;36:216-23.
    • (2006) Eur J Immunol , vol.36 , pp. 216-223
    • Mensah-Brown, E.P.1    Shahin, A.2    Al-Shamisi, M.3    Wei, X.4    Lukic, M.L.5
  • 27
    • 0035061536 scopus 로고    scopus 로고
    • Tolerance to islet autoantigens in type 1 diabetes
    • Bach JF, Chatenoud L. Tolerance to islet autoantigens in type 1 diabetes. Annu Rev Immunol. 2001;19:131-61.
    • (2001) Annu Rev Immunol , vol.19 , pp. 131-161
    • Bach, J.F.1    Chatenoud, L.2
  • 28
    • 34548361965 scopus 로고    scopus 로고
    • Roles of cytokines in the pathogenesis and therapy of type 1 diabetes
    • Rabinovitch A, Suarez-Pinzon WL. Roles of cytokines in the pathogenesis and therapy of type 1 diabetes. Cell Biochem Biophys. 2007;48:159-63.
    • (2007) Cell Biochem Biophys , vol.48 , pp. 159-163
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2
  • 29
    • 0031573072 scopus 로고    scopus 로고
    • IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function
    • Cameron MJ, Arreaza GA, Zucker P, Chensue SW, Strieter RM, Chakrabarti S, Delovitch TL. IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function. J Immunol. 1997;159:4686-92.
    • (1997) J Immunol , vol.159 , pp. 4686-4692
    • Cameron, M.J.1    Arreaza, G.A.2    Zucker, P.3    Chensue, S.W.4    Strieter, R.M.5    Chakrabarti, S.6    Delovitch, T.L.7
  • 30
    • 0033179229 scopus 로고    scopus 로고
    • Pancreatic IL-4 expression results in islet-reactive Th2 cells that inhibit diabetogenic lymphocytes in the nonobese diabetic mouse
    • Gallichan WS, Balasa B, Davies JD, Sarvetnick N. Pancreatic IL-4 expression results in islet-reactive Th2 cells that inhibit diabetogenic lymphocytes in the nonobese diabetic mouse. J Immunol. 1999;163:1696-703.
    • (1999) J Immunol , vol.163 , pp. 1696-1703
    • Gallichan, W.S.1    Balasa, B.2    Davies, J.D.3    Sarvetnick, N.4
  • 31
    • 0029838995 scopus 로고    scopus 로고
    • Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice
    • Mueller R, Krahl T, Sarvetnick N. Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice. J Exp Med. 1996;184:1093-9.
    • (1996) J Exp Med , vol.184 , pp. 1093-1099
    • Mueller, R.1    Krahl, T.2    Sarvetnick, N.3
  • 33
    • 0036198813 scopus 로고    scopus 로고
    • Prevention of autoimmune insulitis by delivery of interleukin-4 plasmid using a soluble and bio-degradable polymeric carrier
    • Lee M, Koh JJ, Han SO, Ko KS, Ki SW. Prevention of autoimmune insulitis by delivery of interleukin-4 plasmid using a soluble and bio-degradable polymeric carrier. Pharm Res. 2002;19:246-9.
    • (2002) Pharm Res , vol.19 , pp. 246-249
    • Lee, M.1    Koh, J.J.2    Han, S.O.3    Ko, K.S.4    Ki, S.W.5
  • 34
    • 0035871805 scopus 로고    scopus 로고
    • The activity of immunoregulatory T cells mediating active tolerance is potentiated in nonobese diabetic mice by an IL-4-based retroviral gene therapy
    • Yamamoto AM, Chernajovsky Y, Lepault F, Podhajcer O, Feldmann M, Bach JF, Chatenoud L. The activity of immunoregulatory T cells mediating active tolerance is potentiated in nonobese diabetic mice by an IL-4-based retroviral gene therapy. J Immunol. 2001;166:4973-80.
    • (2001) J Immunol , vol.166 , pp. 4973-4980
    • Yamamoto, A.M.1    Chernajovsky, Y.2    Lepault, F.3    Podhajcer, O.4    Feldmann, M.5    Bach, J.F.6    Chatenoud, L.7
  • 35
    • 0033721160 scopus 로고    scopus 로고
    • Immunotherapy of spontaneous type 1 diabetes in nonobese diabetic mice by systemic interleukin-4 treatment employing adenovirus vector-mediated gene transfer
    • Cameron MJ, Arreaza GA, Waldhauser L, Gauldie J, Delovitch TL. Immunotherapy of spontaneous type 1 diabetes in nonobese diabetic mice by systemic interleukin-4 treatment employing adenovirus vector-mediated gene transfer. Gene Ther. 2000;7:1840-6.
    • (2000) Gene Ther , vol.7 , pp. 1840-1846
    • Cameron, M.J.1    Arreaza, G.A.2    Waldhauser, L.3    Gauldie, J.4    Delovitch, T.L.5
  • 37
    • 0036584901 scopus 로고    scopus 로고
    • A single treatment with IL-4 via retrovirally transduced lymphocytes partially protects against diabetes in BioBreeding (BB) rats. JOP
    • Zipris D, Karnieli E. A single treatment with IL-4 via retrovirally transduced lymphocytes partially protects against diabetes in BioBreeding (BB) rats. JOP. 2002;3:76-82.
    • (2002) , vol.3 , pp. 76-82
    • Zipris, D.1    Karnieli, E.2
  • 40
    • 0037899021 scopus 로고    scopus 로고
    • Hayashi T, Yasutomi Y, Hasegawa K, Sasaki Y, Onodera T. Interleukin-4-expressing plasmid DNA inhibits reovirus type-2-triggered autoimmune insulitis in DBA/1 J suckling mice. Int J Exp Pathol. 2003;84:101-6.
    • Hayashi T, Yasutomi Y, Hasegawa K, Sasaki Y, Onodera T. Interleukin-4-expressing plasmid DNA inhibits reovirus type-2-triggered autoimmune insulitis in DBA/1 J suckling mice. Int J Exp Pathol. 2003;84:101-6.
  • 41
    • 0037347652 scopus 로고    scopus 로고
    • High-level expression of interleukin-4 following electroporation-mediated gene transfer accelerates type 1 diabetes in NOD mice
    • Horiki M, Yamato E, Noso S, Ikegami H, Ogihara T, Miyazaki J. High-level expression of interleukin-4 following electroporation-mediated gene transfer accelerates type 1 diabetes in NOD mice. J Autoimmun. 2003;20:111-7.
    • (2003) J Autoimmun , vol.20 , pp. 111-117
    • Horiki, M.1    Yamato, E.2    Noso, S.3    Ikegami, H.4    Ogihara, T.5    Miyazaki, J.6
  • 42
    • 1842864843 scopus 로고    scopus 로고
    • A murine interleukin-4-Ig fusion protein regulates the expression of Th1- and Th2-specific cytokines in the pancreas of NOD mice
    • Walz M, Overbergh L, Mathieu C, Kolb H, Martin S. A murine interleukin-4-Ig fusion protein regulates the expression of Th1- and Th2-specific cytokines in the pancreas of NOD mice. Horm Metab Res. 2002;34:561-9.
    • (2002) Horm Metab Res , vol.34 , pp. 561-569
    • Walz, M.1    Overbergh, L.2    Mathieu, C.3    Kolb, H.4    Martin, S.5
  • 43
    • 0030879734 scopus 로고    scopus 로고
    • Mechanism underlying counterregulation of autoimmune diabetes by IL-4
    • Mueller R, Bradley LM, Krahl T, Sarvetnick N. Mechanism underlying counterregulation of autoimmune diabetes by IL-4. Immunity. 1997;7:411-8.
    • (1997) Immunity , vol.7 , pp. 411-418
    • Mueller, R.1    Bradley, L.M.2    Krahl, T.3    Sarvetnick, N.4
  • 44
    • 0035122538 scopus 로고    scopus 로고
    • Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses
    • King C, Mueller Hoenger R, Malo Cleary M, Murali-Krishna K, Ahmed R, King E, Sarvetnick N. Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses. Nat Med. 2001;7:206-14.
    • (2001) Nat Med , vol.7 , pp. 206-214
    • King, C.1    Mueller Hoenger, R.2    Malo Cleary, M.3    Murali-Krishna, K.4    Ahmed, R.5    King, E.6    Sarvetnick, N.7
  • 45
    • 0031571310 scopus 로고    scopus 로고
    • IL-4 expression by grafts from transgenic mice fails to prevent allograft rejection
    • Mueller R, Davies JD, Krahl T, Sarvetnick N. IL-4 expression by grafts from transgenic mice fails to prevent allograft rejection. J Immunol. 1997;159:1599-603.
    • (1997) J Immunol , vol.159 , pp. 1599-1603
    • Mueller, R.1    Davies, J.D.2    Krahl, T.3    Sarvetnick, N.4
  • 46
    • 0030773969 scopus 로고    scopus 로고
    • Interleukin-4 or interleukin-10 expressed from adenovirus-transduced syngeneic islet grafts fails to prevent beta cell destruction in diabetic NOD mice
    • Smith DK, Korbutt GS, Suarez-Pinzon WL, Kao D, Rajotte RV, Elliott JF. Interleukin-4 or interleukin-10 expressed from adenovirus-transduced syngeneic islet grafts fails to prevent beta cell destruction in diabetic NOD mice. Transplantation. 1997;64:1040-9.
    • (1997) Transplantation , vol.64 , pp. 1040-1049
    • Smith, D.K.1    Korbutt, G.S.2    Suarez-Pinzon, W.L.3    Kao, D.4    Rajotte, R.V.5    Elliott, J.F.6
  • 47
    • 44449096726 scopus 로고    scopus 로고
    • IL-10: The master regulator of immunity to infection
    • Couper KN, Blount DG, Riley EM. IL-10: the master regulator of immunity to infection. J Immunol. 2008;180:5771-7.
    • (2008) J Immunol , vol.180 , pp. 5771-5777
    • Couper, K.N.1    Blount, D.G.2    Riley, E.M.3
  • 52
    • 0032504602 scopus 로고    scopus 로고
    • Systemic delivery of interleukin 10 by intramuscular injection of expression plasmid DNA prevents autoimmune diabetes in nonobese diabetic mice
    • Nitta Y, Tashiro F, Tokui M, Shimada A, Takei I, Tabayashi K, Miyazaki J. Systemic delivery of interleukin 10 by intramuscular injection of expression plasmid DNA prevents autoimmune diabetes in nonobese diabetic mice. Hum Gene Ther. 1998;9:1701-7.
    • (1998) Hum Gene Ther , vol.9 , pp. 1701-1707
    • Nitta, Y.1    Tashiro, F.2    Tokui, M.3    Shimada, A.4    Takei, I.5    Tabayashi, K.6    Miyazaki, J.7
  • 54
    • 0034504234 scopus 로고    scopus 로고
    • Degradable polymeric carrier for the delivery of IL-10 plasmid DNA to prevent autoimmune insulitis of NOD mice
    • Koh JJ, Ko KS, Lee M, Han S, Park JS, Kim SW. Degradable polymeric carrier for the delivery of IL-10 plasmid DNA to prevent autoimmune insulitis of NOD mice. Gene Ther. 2000;7:2099-104.
    • (2000) Gene Ther , vol.7 , pp. 2099-2104
    • Koh, J.J.1    Ko, K.S.2    Lee, M.3    Han, S.4    Park, J.S.5    Kim, S.W.6
  • 55
    • 33845709923 scopus 로고    scopus 로고
    • Interleukin-10 plasmid construction and delivery for the prevention of type 1 diabetes
    • Lee M, Park H, Youn J, Oh ET, Ko K, Kim S, Park Y. Interleukin-10 plasmid construction and delivery for the prevention of type 1 diabetes. Ann N Y Acad Sci. 2006;1079:313-9.
    • (2006) Ann N Y Acad Sci , vol.1079 , pp. 313-319
    • Lee, M.1    Park, H.2    Youn, J.3    Oh, E.T.4    Ko, K.5    Kim, S.6    Park, Y.7
  • 56
    • 0034760333 scopus 로고    scopus 로고
    • Combined administration of plasmids encoding IL-4 and IL-10 prevents the development of autoimmune diabetes in nonobese diabetic mice
    • Ko KS, Lee M, Koh JJ, Kim SW. Combined administration of plasmids encoding IL-4 and IL-10 prevents the development of autoimmune diabetes in nonobese diabetic mice. Mol Ther. 2001;4:313-6.
    • (2001) Mol Ther , vol.4 , pp. 313-316
    • Ko, K.S.1    Lee, M.2    Koh, J.J.3    Kim, S.W.4
  • 59
    • 34548156165 scopus 로고    scopus 로고
    • Ex vivo gene transfer of viral interleukin-10 to BB rat islets: No protection after transplantation to diabetic BB rats
    • Kuttler B, Wanka H, Kloting N, Gerstmayer B, Volk HD, Sawitzki B, Ritter T. Ex vivo gene transfer of viral interleukin-10 to BB rat islets: no protection after transplantation to diabetic BB rats. J Cell Mol Med. 2007;11:868-80.
    • (2007) J Cell Mol Med , vol.11 , pp. 868-880
    • Kuttler, B.1    Wanka, H.2    Kloting, N.3    Gerstmayer, B.4    Volk, H.D.5    Sawitzki, B.6    Ritter, T.7
  • 60
    • 27544513432 scopus 로고    scopus 로고
    • Interleukin-10 gene transfection of donor pancreas grafts protects against rejection after heterotopic pancreas transplantation in a rat model
    • Ozden H, Kabay B, Guven G, Acikalin MF, Erbis H, Alatas O. Interleukin-10 gene transfection of donor pancreas grafts protects against rejection after heterotopic pancreas transplantation in a rat model. Eur Surg Res. 2005;37:220-7.
    • (2005) Eur Surg Res , vol.37 , pp. 220-227
    • Ozden, H.1    Kabay, B.2    Guven, G.3    Acikalin, M.F.4    Erbis, H.5    Alatas, O.6
  • 61
    • 34249678653 scopus 로고    scopus 로고
    • TGFbeta signalling in control of T-cell-mediated self-reactivity
    • Rubtsov YP, Rudensky AY. TGFbeta signalling in control of T-cell-mediated self-reactivity. Nat Rev Immunol. 2007;7:443-53.
    • (2007) Nat Rev Immunol , vol.7 , pp. 443-453
    • Rubtsov, Y.P.1    Rudensky, A.Y.2
  • 62
    • 0032531423 scopus 로고    scopus 로고
    • TGF-beta1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice
    • Piccirillo CA, Chang Y, Prud'homme GJ. TGF-beta1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice. J Immunol. 1998;161:3950-6.
    • (1998) J Immunol , vol.161 , pp. 3950-3956
    • Piccirillo, C.A.1    Chang, Y.2    Prud'homme, G.J.3
  • 63
    • 20844446146 scopus 로고    scopus 로고
    • Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice
    • Luo X, Yang H, Kim IS, Saint-Hilaire F, Thomas DA, De BP, Ozkaynak E, Muthukumar T, Hancock WW, Crystal RG, Suthanthiran M. Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice. Transplantation. 2005;79:1091-6.
    • (2005) Transplantation , vol.79 , pp. 1091-1096
    • Luo, X.1    Yang, H.2    Kim, I.S.3    Saint-Hilaire, F.4    Thomas, D.A.5    De, B.P.6    Ozkaynak, E.7    Muthukumar, T.8    Hancock, W.W.9    Crystal, R.G.10    Suthanthiran, M.11
  • 64
    • 0036408818 scopus 로고    scopus 로고
    • Gene transfection and expression of transforming growth factor-beta1 in nonobese diabetic mouse islets protects betacells in syngeneic islet grafts from autoimmune destruction
    • Suarez-Pinzon WL, Marcoux Y, Ghahary A, Rabinovitch A. Gene transfection and expression of transforming growth factor-beta1 in nonobese diabetic mouse islets protects betacells in syngeneic islet grafts from autoimmune destruction. Cell Transplant. 2002;11:519-28.
    • (2002) Cell Transplant , vol.11 , pp. 519-528
    • Suarez-Pinzon, W.L.1    Marcoux, Y.2    Ghahary, A.3    Rabinovitch, A.4
  • 68
    • 46749117207 scopus 로고    scopus 로고
    • Determination of T-cell fate by dendritic cells
    • Epub Apr 1
    • Diebold SS. Determination of T-cell fate by dendritic cells. Immunol Cell Biol. 2008;86:389-97. Epub 2008 Apr 1.
    • (2008) Immunol Cell Biol. 2008 , vol.86 , pp. 389-397
    • Diebold, S.S.1
  • 70
    • 0033939942 scopus 로고    scopus 로고
    • Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo
    • Lutz MB, Suri RM, Niimi M, Ogilvie AL, Kukutsch NA, Rossner S, Schuler G, Austyn JM. Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur J Immunol. 2000;30:1813-22.
    • (2000) Eur J Immunol , vol.30 , pp. 1813-1822
    • Lutz, M.B.1    Suri, R.M.2    Niimi, M.3    Ogilvie, A.L.4    Kukutsch, N.A.5    Rossner, S.6    Schuler, G.7    Austyn, J.M.8
  • 71
    • 0036145202 scopus 로고    scopus 로고
    • Granulocyte macrophagecolony stimulating factor (GM-CSF) recruits immune cells to the pancreas and delays STZ-induced diabetes
    • Krakowski M, Abdelmalik R, Mocnik L, Krahl T, Sarvetnick N. Granulocyte macrophagecolony stimulating factor (GM-CSF) recruits immune cells to the pancreas and delays STZ-induced diabetes. J Pathol. 2002;196:103-12.
    • (2002) J Pathol , vol.196 , pp. 103-112
    • Krakowski, M.1    Abdelmalik, R.2    Mocnik, L.3    Krahl, T.4    Sarvetnick, N.5
  • 72
    • 35748929090 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of CD4+CD25+ regulatory T cells
    • Gaudreau S, Guindi C, Menard M, Besin G, Dupuis G, Amrani A. Granulocyte-macrophage colony-stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of CD4+CD25+ regulatory T cells. J Immunol. 2007;179:3638-47.
    • (2007) J Immunol , vol.179 , pp. 3638-3647
    • Gaudreau, S.1    Guindi, C.2    Menard, M.3    Besin, G.4    Dupuis, G.5    Amrani, A.6
  • 73
    • 0033011514 scopus 로고    scopus 로고
    • Transfer of dendritic cells (DC) ex vivo stimulated with interferon-gamma (IFN-gamma) down-modulates autoimmune diabetes in non-obese diabetic (NOD) mice
    • Shinomiya M, Fazle Akbar SM, Shinomiya H, Onji M. Transfer of dendritic cells (DC) ex vivo stimulated with interferon-gamma (IFN-gamma) down-modulates autoimmune diabetes in non-obese diabetic (NOD) mice. Clin Exp Immunol. 1999;117:38-43.
    • (1999) Clin Exp Immunol , vol.117 , pp. 38-43
    • Shinomiya, M.1    Fazle Akbar, S.M.2    Shinomiya, H.3    Onji, M.4
  • 74
    • 0031725364 scopus 로고    scopus 로고
    • Epitope dominance: Evidence for reciprocal determinant spreading to glutamic acid decarboxylase in nonobese diabetic mice
    • Zechel MA, Krawetz MD, Singh B. Epitope dominance: evidence for reciprocal determinant spreading to glutamic acid decarboxylase in nonobese diabetic mice. Immunol Rev. 1998;164:111-8.
    • (1998) Immunol Rev , vol.164 , pp. 111-118
    • Zechel, M.A.1    Krawetz, M.D.2    Singh, B.3
  • 75
    • 0031452948 scopus 로고    scopus 로고
    • Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens
    • Tian J, Lehmann PV, Kaufman DL. Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens. J Exp Med. 1997;186:2039-43.
    • (1997) J Exp Med , vol.186 , pp. 2039-2043
    • Tian, J.1    Lehmann, P.V.2    Kaufman, D.L.3
  • 76
    • 0035876930 scopus 로고    scopus 로고
    • The frequency of high avidity T cells determines the hierarchy of determinant spreading
    • Tian J, Gregori S, Adorini L, Kaufman DL. The frequency of high avidity T cells determines the hierarchy of determinant spreading. J Immunol. 2001;166:7144-50.
    • (2001) J Immunol , vol.166 , pp. 7144-7150
    • Tian, J.1    Gregori, S.2    Adorini, L.3    Kaufman, D.L.4
  • 77
    • 16244396427 scopus 로고    scopus 로고
    • The stages of type 1A diabetes: 2005
    • Gianani R, Eisenbarth GS. The stages of type 1A diabetes: 2005. Immunol Rev. 2005;204:232-49.
    • (2005) Immunol Rev , vol.204 , pp. 232-249
    • Gianani, R.1    Eisenbarth, G.S.2
  • 78
    • 33847629171 scopus 로고    scopus 로고
    • Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes
    • Di Lorenzo TP, Peakman M, Roep BO. Translational mini-review series on type 1 diabetes: systematic analysis of T cell epitopes in autoimmune diabetes. Clin Exp Immunol. 2007;148:1-16.
    • (2007) Clin Exp Immunol , vol.148 , pp. 1-16
    • Di Lorenzo, T.P.1    Peakman, M.2    Roep, B.O.3
  • 79
    • 0035867792 scopus 로고    scopus 로고
    • Vaccination with glutamic acid decarboxylase plasmid DNA protects mice from spontaneous autoimmune diabetes and B7/CD28 costimulation circumvents that protection
    • Balasa B, Boehm BO, Fortnagel A, Karges W, Van Gunst K, Jung N, Camacho SA, Webb SR, Sarvetnick N. Vaccination with glutamic acid decarboxylase plasmid DNA protects mice from spontaneous autoimmune diabetes and B7/CD28 costimulation circumvents that protection. Clin Immunol. 2001;99:241-52.
    • (2001) Clin Immunol , vol.99 , pp. 241-252
    • Balasa, B.1    Boehm, B.O.2    Fortnagel, A.3    Karges, W.4    Van Gunst, K.5    Jung, N.6    Camacho, S.A.7    Webb, S.R.8    Sarvetnick, N.9
  • 80
    • 0035573750 scopus 로고    scopus 로고
    • Effects of plasmid DNA injection on cyclophosphamide-accelerated diabetes in NOD mice
    • Filippova M, Liu J, Escher A. Effects of plasmid DNA injection on cyclophosphamide-accelerated diabetes in NOD mice. DNA Cell Biol. 2001;20:175-81.
    • (2001) DNA Cell Biol , vol.20 , pp. 175-181
    • Filippova, M.1    Liu, J.2    Escher, A.3
  • 81
    • 0035985085 scopus 로고    scopus 로고
    • Prevention of autoimmune diabetes by immunogene therapy using recombinant vaccinia virus expressing glutamic acid decarboxylase
    • Jun HS, Chung YH, Han J, Kim A, Yoo SS, Sherwin RS, Yoon JW. Prevention of autoimmune diabetes by immunogene therapy using recombinant vaccinia virus expressing glutamic acid decarboxylase. Diabetologia. 2002;45:668-76.
    • (2002) Diabetologia , vol.45 , pp. 668-676
    • Jun, H.S.1    Chung, Y.H.2    Han, J.3    Kim, A.4    Yoo, S.S.5    Sherwin, R.S.6    Yoon, J.W.7
  • 82
    • 0035253510 scopus 로고    scopus 로고
    • Antigen-specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination
    • Tisch R, Wang B, Weaver DJ, Liu B, Bui T, Arthos J, Serreze DV. Antigen-specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination. J Immunol. 2001;166:2122-32.
    • (2001) J Immunol , vol.166 , pp. 2122-2132
    • Tisch, R.1    Wang, B.2    Weaver, D.J.3    Liu, B.4    Bui, T.5    Arthos, J.6    Serreze, D.V.7
  • 83
    • 0035451681 scopus 로고    scopus 로고
    • Plasmid vaccination with insulin B chain prevents autoimmune diabetes in nonobese diabetic mice
    • Bot A, Smith D, Bot S, Hughes A, Wolfe T, Wang L, Woods C, von Herrath M. Plasmid vaccination with insulin B chain prevents autoimmune diabetes in nonobese diabetic mice. J Immunol. 2001;167:2950-5.
    • (2001) J Immunol , vol.167 , pp. 2950-2955
    • Bot, A.1    Smith, D.2    Bot, S.3    Hughes, A.4    Wolfe, T.5    Wang, L.6    Woods, C.7    von Herrath, M.8
  • 84
    • 0035399816 scopus 로고    scopus 로고
    • Plasmid DNAs encoding insulin and glutamic acid decarboxylase 65 have distinct effects on the progression of autoimmune diabetes in nonobese diabetic mice
    • Weaver DJ Jr, Liu B, Tisch R. Plasmid DNAs encoding insulin and glutamic acid decarboxylase 65 have distinct effects on the progression of autoimmune diabetes in nonobese diabetic mice. J Immunol. 2001;167:586-92.
    • (2001) J Immunol , vol.167 , pp. 586-592
    • Weaver Jr, D.J.1    Liu, B.2    Tisch, R.3
  • 85
    • 20144388199 scopus 로고    scopus 로고
    • Active tolerance induction and prevention of autoimmune diabetes by immunogene therapy using recombinant adenoassociated virus expressing glutamic acid decarboxylase 65 peptide GAD (500-585)
    • Han G, Li Y, Wang J, Wang R, Chen G, Song L, Xu R, Yu M, Wu X, Qian J, Shen B. Active tolerance induction and prevention of autoimmune diabetes by immunogene therapy using recombinant adenoassociated virus expressing glutamic acid decarboxylase 65 peptide GAD (500-585). J Immunol. 2005;174:4516-24.
    • (2005) J Immunol , vol.174 , pp. 4516-4524
    • Han, G.1    Li, Y.2    Wang, J.3    Wang, R.4    Chen, G.5    Song, L.6    Xu, R.7    Yu, M.8    Wu, X.9    Qian, J.10    Shen, B.11
  • 86
    • 37749038350 scopus 로고    scopus 로고
    • Gene delivery GAD 500 autoantigen by AAV serotype 1 prevented diabetes in NOD mice: Transduction efficiency do not play important roles
    • Han G, Wang R, Chen G, Wang J, Xu R, Feng J, Yu M, Wu X, Qian J, Shen B, Li Y. Gene delivery GAD 500 autoantigen by AAV serotype 1 prevented diabetes in NOD mice: transduction efficiency do not play important roles. Immunol Lett. 2008;115:110-6.
    • (2008) Immunol Lett , vol.115 , pp. 110-116
    • Han, G.1    Wang, R.2    Chen, G.3    Wang, J.4    Xu, R.5    Feng, J.6    Yu, M.7    Wu, X.8    Qian, J.9    Shen, B.10    Li, Y.11
  • 87
    • 33747842285 scopus 로고    scopus 로고
    • Treatment of diabetes in NOD mice by gene transfer of Ig-fusion proteins into B cells: Role of T regulatory cells
    • Soukhareva N, Jiang Y, Scott DW. Treatment of diabetes in NOD mice by gene transfer of Ig-fusion proteins into B cells: role of T regulatory cells. Cell Immunol. 2006;240:41-6.
    • (2006) Cell Immunol , vol.240 , pp. 41-46
    • Soukhareva, N.1    Jiang, Y.2    Scott, D.W.3
  • 88
    • 34248210131 scopus 로고    scopus 로고
    • The type and frequency of immunoregulatory CD4+ T-cells govern the efficacy of antigen-specific immunotherapy in nonobese diabetic mice
    • Pop SM, Wong CP, He Q, Wang Y, Wallet MA, Goudy KS, Tisch R. The type and frequency of immunoregulatory CD4+ T-cells govern the efficacy of antigen-specific immunotherapy in nonobese diabetic mice. Diabetes. 2007;56:1395-402.
    • (2007) Diabetes , vol.56 , pp. 1395-1402
    • Pop, S.M.1    Wong, C.P.2    He, Q.3    Wang, Y.4    Wallet, M.A.5    Goudy, K.S.6    Tisch, R.7
  • 89
    • 0037530413 scopus 로고    scopus 로고
    • More stringent conditions of plasmid DNA vaccination are required to protect grafted versus endogenous islets in nonobese diabetic mice
    • Seifarth C, Pop S, Liu B, Wong CP, Tisch R. More stringent conditions of plasmid DNA vaccination are required to protect grafted versus endogenous islets in nonobese diabetic mice. J Immunol. 2003;171:469-76.
    • (2003) J Immunol , vol.171 , pp. 469-476
    • Seifarth, C.1    Pop, S.2    Liu, B.3    Wong, C.P.4    Tisch, R.5
  • 90
    • 0038204841 scopus 로고    scopus 로고
    • Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase
    • Jaeckel E, Klein L, Martin-Orozco N, von Boehmer H. Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase. J Exp Med. 2003;197:1635-44.
    • (2003) J Exp Med , vol.197 , pp. 1635-1644
    • Jaeckel, E.1    Klein, L.2    Martin-Orozco, N.3    von Boehmer, H.4
  • 91
    • 26944475538 scopus 로고    scopus 로고
    • Tolerance induction via a B-cell delivered gene therapy-based protocol: Optimization and role of the Ig scaffold
    • Lei TC, Su Y, Scott DW. Tolerance induction via a B-cell delivered gene therapy-based protocol: optimization and role of the Ig scaffold. Cell Immunol. 2005;235:12-20.
    • (2005) Cell Immunol , vol.235 , pp. 12-20
    • Lei, T.C.1    Su, Y.2    Scott, D.W.3
  • 92
    • 0031093505 scopus 로고    scopus 로고
    • Both resting and activated B lymphocytes expressing engineered peptide-Ig molecules serve as highly efficient tolerogenic vehicles in immunocompetent adult recipients
    • Zambidis ET, Barth RK, Scott DW. Both resting and activated B lymphocytes expressing engineered peptide-Ig molecules serve as highly efficient tolerogenic vehicles in immunocompetent adult recipients. J Immunol. 1997;158:2174-82.
    • (1997) J Immunol , vol.158 , pp. 2174-2182
    • Zambidis, E.T.1    Barth, R.K.2    Scott, D.W.3
  • 93
    • 0034011748 scopus 로고    scopus 로고
    • B cell tolerance and autoimmunity
    • Tsubata T, Honjo T. B cell tolerance and autoimmunity. Rev Immunogenet. 2000;2:18-25.
    • (2000) Rev Immunogenet , vol.2 , pp. 18-25
    • Tsubata, T.1    Honjo, T.2
  • 95
    • 5444221869 scopus 로고    scopus 로고
    • Retroviral delivery of GAD-IgG fusion construct induces tolerance and modulates diabetes: A role for CD4+ regulatory T cells and TGF-beta?
    • Song L, Wang J, Wang R, Yu M, Sun Y, Han G, Li Y, Qian J, Scott DW, Kang Y, Soukhareva N, Shen B. Retroviral delivery of GAD-IgG fusion construct induces tolerance and modulates diabetes: a role for CD4+ regulatory T cells and TGF-beta? Gene Ther. 2004;11:1487-96.
    • (2004) Gene Ther , vol.11 , pp. 1487-1496
    • Song, L.1    Wang, J.2    Wang, R.3    Yu, M.4    Sun, Y.5    Han, G.6    Li, Y.7    Qian, J.8    Scott, D.W.9    Kang, Y.10    Soukhareva, N.11    Shen, B.12
  • 96
    • 0036933006 scopus 로고    scopus 로고
    • Decreased insulitis and blood glucose levels after injection of GAD-transduced lymphocytes into NOD mice
    • Li F, Filippova M, Fagoaga O, Nehlsen-Cannarella S, Escher A. Decreased insulitis and blood glucose levels after injection of GAD-transduced lymphocytes into NOD mice. Mol Ther. 2002;6:701-9.
    • (2002) Mol Ther , vol.6 , pp. 701-709
    • Li, F.1    Filippova, M.2    Fagoaga, O.3    Nehlsen-Cannarella, S.4    Escher, A.5
  • 97
    • 33751247344 scopus 로고    scopus 로고
    • Transplantation of bone marrow genetically engineered to express proinsulin II protects against autoimmune insulitis in NOD mice
    • Chan J, Clements W, Field J, Nasa Z, Lock P, Yap F, Toh BH, Alderuccio F. Transplantation of bone marrow genetically engineered to express proinsulin II protects against autoimmune insulitis in NOD mice. J Gene Med. 2006;8:1281-90.
    • (2006) J Gene Med , vol.8 , pp. 1281-1290
    • Chan, J.1    Clements, W.2    Field, J.3    Nasa, Z.4    Lock, P.5    Yap, F.6    Toh, B.H.7    Alderuccio, F.8
  • 98
    • 0038326717 scopus 로고    scopus 로고
    • Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes
    • Steptoe RJ, Ritchie JM, Harrison LC. Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes. J Clin Invest. 2003;111:1357-63.
    • (2003) J Clin Invest , vol.111 , pp. 1357-1363
    • Steptoe, R.J.1    Ritchie, J.M.2    Harrison, L.C.3
  • 99
    • 0024500755 scopus 로고
    • T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice
    • Boitard C, Yasunami R, Dardenne M, Bach JF. T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice. J Exp Med. 1989;169:1669-80.
    • (1989) J Exp Med , vol.169 , pp. 1669-1680
    • Boitard, C.1    Yasunami, R.2    Dardenne, M.3    Bach, J.F.4
  • 100
    • 16844365788 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
    • Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol. 2005;6:345-52.
    • (2005) Nat Immunol , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 101
    • 0033682056 scopus 로고    scopus 로고
    • B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    • Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JA. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 2000;12:431-40.
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1    Lenschow, D.J.2    Rhee, L.3    Ashourian, N.4    Singh, B.5    Sharpe, A.6    Bluestone, J.A.7
  • 102
    • 2942692039 scopus 로고    scopus 로고
    • CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
    • Tarbell KV, Yamazaki S, Olson K, Toy P, Steinman RM. CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med. 2004;199:1467-77.
    • (2004) J Exp Med , vol.199 , pp. 1467-1477
    • Tarbell, K.V.1    Yamazaki, S.2    Olson, K.3    Toy, P.4    Steinman, R.M.5
  • 103
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299:1057-61.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 104
    • 12744262844 scopus 로고    scopus 로고
    • Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes
    • Jaeckel E, von Boehmer H, Manns MP. Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes. Diabetes. 2005;54:306-10.
    • (2005) Diabetes , vol.54 , pp. 306-310
    • Jaeckel, E.1    von Boehmer, H.2    Manns, M.P.3
  • 105
    • 34248593473 scopus 로고    scopus 로고
    • Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction
    • Peng J, Dicker B, Du W, Tang F, Nguyen P, Geiger T, Wong FS, Wen L. Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction. J Autoimmun. 2007;28:188-200.
    • (2007) J Autoimmun , vol.28 , pp. 188-200
    • Peng, J.1    Dicker, B.2    Du, W.3    Tang, F.4    Nguyen, P.5    Geiger, T.6    Wong, F.S.7    Wen, L.8
  • 106
    • 34547103003 scopus 로고    scopus 로고
    • Foxp3-expressing CD4(+)T cells under the control of INF-gamma promoter prevent diabetes in NOD mice
    • Wang R, Han G, Wang J, Song L, Chen G, Xu R, Yu M, Qian J, Shen B, Li Y. Foxp3-expressing CD4(+)T cells under the control of INF-gamma promoter prevent diabetes in NOD mice. Mol Ther. 2007;15:1551-7.
    • (2007) Mol Ther , vol.15 , pp. 1551-1557
    • Wang, R.1    Han, G.2    Wang, J.3    Song, L.4    Chen, G.5    Xu, R.6    Yu, M.7    Qian, J.8    Shen, B.9    Li, Y.10
  • 107
    • 34548534750 scopus 로고    scopus 로고
    • Transplant tolerance: Is it really free of concerns?
    • Zhao Y, Li XC. Transplant tolerance: is it really free of concerns? Trends Immunol. 2007;28:376-7.
    • (2007) Trends Immunol , vol.28 , pp. 376-377
    • Zhao, Y.1    Li, X.C.2
  • 108
    • 0028922437 scopus 로고
    • Genetic control of autoimmune diabetes in the NOD mouse
    • Wicker LS, Todd JA, Peterson LB. Genetic control of autoimmune diabetes in the NOD mouse. Annu Rev Immunol. 1995;13:179-200.
    • (1995) Annu Rev Immunol , vol.13 , pp. 179-200
    • Wicker, L.S.1    Todd, J.A.2    Peterson, L.B.3
  • 109
    • 0031847984 scopus 로고    scopus 로고
    • Molecular basis for HLA-DQ associations with IDDM
    • Nepom GT, Kwok WW. Molecular basis for HLA-DQ associations with IDDM. Diabetes. 1998;47:1177-84.
    • (1998) Diabetes , vol.47 , pp. 1177-1184
    • Nepom, G.T.1    Kwok, W.W.2
  • 110
    • 0032403094 scopus 로고    scopus 로고
    • The role of MHC class II molecules in susceptibility and resistance to autoimmunity
    • McDevitt H. The role of MHC class II molecules in susceptibility and resistance to autoimmunity. Curr Opin Immunol. 1998;10:677-81.
    • (1998) Curr Opin Immunol , vol.10 , pp. 677-681
    • McDevitt, H.1
  • 111
    • 0001657878 scopus 로고
    • Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: A family study
    • Morel PA, Dorman JS, Todd JA, McDevitt HO, Trucco M. Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study. Proc Natl Acad Sci U S A. 1988;85:8111-5.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 8111-8115
    • Morel, P.A.1    Dorman, J.S.2    Todd, J.A.3    McDevitt, H.O.4    Trucco, M.5
  • 115
    • 0003403213 scopus 로고
    • The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique
    • Acha-Orbea H, McDevitt HO. The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique. Proc Natl Acad Sci U S A. 1987;84:2435-9.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 2435-2439
    • Acha-Orbea, H.1    McDevitt, H.O.2
  • 116
    • 0034079792 scopus 로고    scopus 로고
    • Co-expression of HLA DR3 and DQ8 results in the development of spontaneous insulitis and loss of tolerance to GAD65 in transgenic mice
    • Abraham RS, Kudva YC, Wilson SB, Strominger JL, David CS. Co-expression of HLA DR3 and DQ8 results in the development of spontaneous insulitis and loss of tolerance to GAD65 in transgenic mice. Diabetes. 2000;49:548-54.
    • (2000) Diabetes , vol.49 , pp. 548-554
    • Abraham, R.S.1    Kudva, Y.C.2    Wilson, S.B.3    Strominger, J.L.4    David, C.S.5
  • 118
    • 0032400950 scopus 로고    scopus 로고
    • Exceptional stability of the HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC molecule associated with protection from insulin-dependent diabetes mellitus
    • Ettinger RA, Liu AW, Nepom GT, Kwok WW. Exceptional stability of the HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC molecule associated with protection from insulin-dependent diabetes mellitus. J Immunol. 1998;161:6439-45.
    • (1998) J Immunol , vol.161 , pp. 6439-6445
    • Ettinger, R.A.1    Liu, A.W.2    Nepom, G.T.3    Kwok, W.W.4
  • 120
    • 2642654250 scopus 로고    scopus 로고
    • Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities
    • Luhder F, Katz J, Benoist C, Mathis D. Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities. J Exp Med. 1998;187:379-87.
    • (1998) J Exp Med , vol.187 , pp. 379-387
    • Luhder, F.1    Katz, J.2    Benoist, C.3    Mathis, D.4
  • 121
    • 0027340693 scopus 로고
    • An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells
    • Singer SM, Tisch R, Yang X, McDevitt HO. An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells. Proc Natl Acad Sci U S A. 1993;90:9566-70.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 9566-9570
    • Singer, S.M.1    Tisch, R.2    Yang, X.3    McDevitt, H.O.4
  • 122
    • 0024947844 scopus 로고
    • An explanation for the protective effect of the MHC class II I-E molecule in murine diabetes
    • Reich EP, Sherwin RS, Kanagawa O, Janeway CA Jr. An explanation for the protective effect of the MHC class II I-E molecule in murine diabetes. Nature. 1989;341:326-8.
    • (1989) Nature , vol.341 , pp. 326-328
    • Reich, E.P.1    Sherwin, R.S.2    Kanagawa, O.3    Janeway Jr., C.A.4
  • 126
    • 0030779118 scopus 로고    scopus 로고
    • A mechanism for the major histocompatibility complex-linked resistance to autoimmunity
    • Schmidt D, Verdaguer J, Averill N, Santamaria P. A mechanism for the major histocompatibility complex-linked resistance to autoimmunity. J Exp Med. 1997;186:1059-75.
    • (1997) J Exp Med , vol.186 , pp. 1059-1075
    • Schmidt, D.1    Verdaguer, J.2    Averill, N.3    Santamaria, P.4
  • 129
    • 0033561541 scopus 로고    scopus 로고
    • Autoantigen-independent deletion of diabetogenic CD4+ thymocytes by protective MHC class II molecules
    • Schmidt D, Amrani A, Verdaguer J, Bou S, Santamaria P. Autoantigen-independent deletion of diabetogenic CD4+ thymocytes by protective MHC class II molecules. J Immunol. 1999;162:4627-36.
    • (1999) J Immunol , vol.162 , pp. 4627-4636
    • Schmidt, D.1    Amrani, A.2    Verdaguer, J.3    Bou, S.4    Santamaria, P.5
  • 130
    • 0029671326 scopus 로고    scopus 로고
    • Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune diabetes and reverses insulitis in nonobese diabetic (NOD) mice
    • Li H, Kaufman CL, Boggs SS, Johnson PC, Patrene KD, Ildstad ST. Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune diabetes and reverses insulitis in nonobese diabetic (NOD) mice. J Immunol. 1996;156:380-8.
    • (1996) J Immunol , vol.156 , pp. 380-388
    • Li, H.1    Kaufman, C.L.2    Boggs, S.S.3    Johnson, P.C.4    Patrene, K.D.5    Ildstad, S.T.6
  • 131
    • 0029092748 scopus 로고    scopus 로고
    • Li H, Colson YL, Ildstad ST. Mixed allogeneic chimerism achieved by lethal and nonlethal conditioning approaches induces donor-specific tolerance to simultaneous islet allografts. Transplantation. 1995;60:523-9.
    • Li H, Colson YL, Ildstad ST. Mixed allogeneic chimerism achieved by lethal and nonlethal conditioning approaches induces donor-specific tolerance to simultaneous islet allografts. Transplantation. 1995;60:523-9.
  • 132
    • 0034998737 scopus 로고    scopus 로고
    • Impact of bone marrow transplantation on type I diabetes
    • Domenick MA, Ildstad ST. Impact of bone marrow transplantation on type I diabetes. World J Surg. 2001;25:474-80.
    • (2001) World J Surg , vol.25 , pp. 474-480
    • Domenick, M.A.1    Ildstad, S.T.2
  • 135
    • 0034654374 scopus 로고    scopus 로고
    • Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: Absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in isletallografted NOD/Lt mice
    • Seung E, Iwakoshi N, Woda BA, Markees TG, Mordes JP, Rossini AA, Greiner DL. Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in isletallografted NOD/Lt mice. Blood. 2000;95:2175-82.
    • (2000) Blood , vol.95 , pp. 2175-2182
    • Seung, E.1    Iwakoshi, N.2    Woda, B.A.3    Markees, T.G.4    Mordes, J.P.5    Rossini, A.A.6    Greiner, D.L.7
  • 136
    • 0141693112 scopus 로고    scopus 로고
    • Induction of T cell tolerance to a protein expressed in the cytoplasm through retroviral-mediated gene transfer
    • Tian C, Bagley J, Kaye J, Iacomini J. Induction of T cell tolerance to a protein expressed in the cytoplasm through retroviral-mediated gene transfer. J Gene Med. 2003;5:359-65.
    • (2003) J Gene Med , vol.5 , pp. 359-365
    • Tian, C.1    Bagley, J.2    Kaye, J.3    Iacomini, J.4
  • 137
    • 0037103238 scopus 로고    scopus 로고
    • Induction of central deletional T cell tolerance by gene therapy
    • Kang ES, Iacomini J. Induction of central deletional T cell tolerance by gene therapy. J Immunol. 2002;169:1930-5.
    • (2002) J Immunol , vol.169 , pp. 1930-1935
    • Kang, E.S.1    Iacomini, J.2
  • 138
    • 0012365354 scopus 로고    scopus 로고
    • Inducing tolerance by molecular chimerism
    • Iacomini J, Bracy JL. Inducing tolerance by molecular chimerism. Graft. 2001;4:102-4.
    • (2001) Graft , vol.4 , pp. 102-104
    • Iacomini, J.1    Bracy, J.L.2
  • 139
    • 0034330694 scopus 로고    scopus 로고
    • Induction of B-cell tolerance by retroviral gene therapy
    • Bracy JL, Iacomini J. Induction of B-cell tolerance by retroviral gene therapy. Blood. 2000;96:3008-15.
    • (2000) Blood , vol.96 , pp. 3008-3015
    • Bracy, J.L.1    Iacomini, J.2
  • 140
    • 0032544673 scopus 로고    scopus 로고
    • Inhibition of xenoreactive natural antibody production by retroviral gene therapy
    • Bracy JL, Sachs DH, Iacomini J. Inhibition of xenoreactive natural antibody production by retroviral gene therapy. Science. 1998;281:1845-7.
    • (1998) Science , vol.281 , pp. 1845-1847
    • Bracy, J.L.1    Sachs, D.H.2    Iacomini, J.3
  • 141
    • 0035666554 scopus 로고    scopus 로고
    • Induction of molecular chimerism by gene therapy prevents antibody-mediated heart transplant rejection
    • Bracy JL, Chase CM, Russell PS, Mauiyyedi S, Colvin RB, Iacomini J. Induction of molecular chimerism by gene therapy prevents antibody-mediated heart transplant rejection. Gene Ther. 2001;8:1738-44.
    • (2001) Gene Ther , vol.8 , pp. 1738-1744
    • Bracy, J.L.1    Chase, C.M.2    Russell, P.S.3    Mauiyyedi, S.4    Colvin, R.B.5    Iacomini, J.6
  • 142
    • 17544386950 scopus 로고    scopus 로고
    • Establishing immunological tolerance through the induction of molecular chimerism
    • Bagley J, Bracy JL, Tian C, Kang ES, Iacomini J. Establishing immunological tolerance through the induction of molecular chimerism. Front Biosci. 2002;7:d1331-7.
    • (2002) Front Biosci , vol.7
    • Bagley, J.1    Bracy, J.L.2    Tian, C.3    Kang, E.S.4    Iacomini, J.5
  • 145
    • 38449092694 scopus 로고    scopus 로고
    • Induction of robust diabetes resistance and prevention of recurrent type 1 diabetes following islet transplantation by gene therapy
    • Tian C, Ansari MJ, Paez-Cortez J, Bagley J, Godwin J, Donnarumma M, Sayegh MH, Iacomini J. Induction of robust diabetes resistance and prevention of recurrent type 1 diabetes following islet transplantation by gene therapy. J Immunol. 2007;179:6762-9.
    • (2007) J Immunol , vol.179 , pp. 6762-6769
    • Tian, C.1    Ansari, M.J.2    Paez-Cortez, J.3    Bagley, J.4    Godwin, J.5    Donnarumma, M.6    Sayegh, M.H.7    Iacomini, J.8
  • 147
    • 33846219561 scopus 로고    scopus 로고
    • Borjesson A, Andersson AK, Sandler S. Survival of an islet allograft deficient in iNOS after implantation into diabetic NOD mice. Cell Transplant. 2006;15:769-75.
    • Borjesson A, Andersson AK, Sandler S. Survival of an islet allograft deficient in iNOS after implantation into diabetic NOD mice. Cell Transplant. 2006;15:769-75.
  • 148
    • 0027054055 scopus 로고
    • Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide
    • Corbett JA, Wang JL, Sweetland MA, Lancaster JR Jr, McDaniel ML. Interleukin 1 beta induces the formation of nitric oxide by beta-cells purified from rodent islets of Langerhans. Evidence for the beta-cell as a source and site of action of nitric oxide. J Clin Invest. 1992;90:2384-91.
    • (1992) J Clin Invest , vol.90 , pp. 2384-2391
    • Corbett, J.A.1    Wang, J.L.2    Sweetland, M.A.3    Lancaster Jr, J.R.4    McDaniel, M.L.5
  • 149
    • 0032830997 scopus 로고    scopus 로고
    • Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro
    • Giannoukakis N, Rudert WA, Ghivizzani SC, Gambotto A, Ricordi C, Trucco M, Robbins PD. Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro. Diabetes. 1999;48:1730-6.
    • (1999) Diabetes , vol.48 , pp. 1730-1736
    • Giannoukakis, N.1    Rudert, W.A.2    Ghivizzani, S.C.3    Gambotto, A.4    Ricordi, C.5    Trucco, M.6    Robbins, P.D.7
  • 150
    • 21344471092 scopus 로고    scopus 로고
    • Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat
    • Jorns A, Gunther A, Hedrich HJ, Wedekind D, Tiedge M, Lenzen S. Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat. Diabetes. 2005;54:2041-52.
    • (2005) Diabetes , vol.54 , pp. 2041-2052
    • Jorns, A.1    Gunther, A.2    Hedrich, H.J.3    Wedekind, D.4    Tiedge, M.5    Lenzen, S.6
  • 151
    • 3142659582 scopus 로고    scopus 로고
    • Immunoregulatory role of nitric oxide in Kilham rat virus-induced autoimmune diabetes in DRBB rats
    • Mendez, II, Chung YH, Jun HS, Yoon JW. Immunoregulatory role of nitric oxide in Kilham rat virus-induced autoimmune diabetes in DRBB rats. J Immunol. 2004;173:1327-35.
    • (2004) J Immunol , vol.173 , pp. 1327-1335
    • Mendez, I.1    Chung, Y.H.2    Jun, H.S.3    Yoon, J.W.4
  • 153
    • 13244278034 scopus 로고    scopus 로고
    • Adenoviral overexpression of interleukin-1 receptor antagonist protein increases beta-cell replication in rat pancreatic islets
    • Tellez N, Montolio M, Biarnes M, Castano E, Soler J, Montanya E. Adenoviral overexpression of interleukin-1 receptor antagonist protein increases beta-cell replication in rat pancreatic islets. Gene Ther. 2005;12:120-8.
    • (2005) Gene Ther , vol.12 , pp. 120-128
    • Tellez, N.1    Montolio, M.2    Biarnes, M.3    Castano, E.4    Soler, J.5    Montanya, E.6
  • 154
    • 33846826610 scopus 로고    scopus 로고
    • Adenoviral overproduction of interleukin-1 receptor antagonist increases beta cell replication and mass in syngeneically transplanted islets, and improves metabolic outcome
    • Tellez N, Montolio M, Estil-les E, Escoriza J, Soler J, Montanya E. Adenoviral overproduction of interleukin-1 receptor antagonist increases beta cell replication and mass in syngeneically transplanted islets, and improves metabolic outcome. Diabetologia. 2007;50:602-11.
    • (2007) Diabetologia , vol.50 , pp. 602-611
    • Tellez, N.1    Montolio, M.2    Estil-les, E.3    Escoriza, J.4    Soler, J.5    Montanya, E.6
  • 156
    • 5444226677 scopus 로고    scopus 로고
    • Machen J, Bertera S, Chang Y, Bottino R, Balamurugan AN, Robbins PD, Trucco M, Giannoukakis N. Prolongation of islet allograft survival following ex vivo transduction with adenovirus encoding a soluble type 1 TNF receptor-Ig fusion decoy. Gene Ther. 2004;11:1506-14.
    • Machen J, Bertera S, Chang Y, Bottino R, Balamurugan AN, Robbins PD, Trucco M, Giannoukakis N. Prolongation of islet allograft survival following ex vivo transduction with adenovirus encoding a soluble type 1 TNF receptor-Ig fusion decoy. Gene Ther. 2004;11:1506-14.
  • 159
    • 1842584372 scopus 로고    scopus 로고
    • Codelivery of pro-apoptotic BAX with a DNA vaccine recruits dendritic cells and promotes efficacy of autoimmune diabetes prevention in mice
    • Li AF, Hough J, Henderson D, Escher A. Codelivery of pro-apoptotic BAX with a DNA vaccine recruits dendritic cells and promotes efficacy of autoimmune diabetes prevention in mice. Vaccine. 2004;22:1751-63.
    • (2004) Vaccine , vol.22 , pp. 1751-1763
    • Li, A.F.1    Hough, J.2    Henderson, D.3    Escher, A.4
  • 160
    • 34548438601 scopus 로고    scopus 로고
    • Angiopoietin-1 production in islets improves islet engraftment and protects islets from cytokine-induced apoptosis
    • Su D, Zhang N, He J, Qu S, Slusher S, Bottino R, Bertera S, Bromberg J, Dong HH. Angiopoietin-1 production in islets improves islet engraftment and protects islets from cytokine-induced apoptosis. Diabetes. 2007;56:2274-83.
    • (2007) Diabetes , vol.56 , pp. 2274-2283
    • Su, D.1    Zhang, N.2    He, J.3    Qu, S.4    Slusher, S.5    Bottino, R.6    Bertera, S.7    Bromberg, J.8    Dong, H.H.9
  • 162
    • 4243066440 scopus 로고    scopus 로고
    • Adenovirus-based vascular endothelial growth factor gene delivery to human pancreatic islets
    • Cheng K, Fraga D, Zhang C, Kotb M, Gaber AO, Guntaka RV, Mahato RI. Adenovirus-based vascular endothelial growth factor gene delivery to human pancreatic islets. Gene Ther. 2004;11:1105-16.
    • (2004) Gene Ther , vol.11 , pp. 1105-1116
    • Cheng, K.1    Fraga, D.2    Zhang, C.3    Kotb, M.4    Gaber, A.O.5    Guntaka, R.V.6    Mahato, R.I.7
  • 163
    • 34247354627 scopus 로고    scopus 로고
    • Coexpression of vascular endothelial growth factor and interleukin-1 receptor antagonist for improved human islet survival and function
    • Jia X, Cheng K, Mahato RI. Coexpression of vascular endothelial growth factor and interleukin-1 receptor antagonist for improved human islet survival and function. Mol Pharm. 2007;4:199-207.
    • (2007) Mol Pharm , vol.4 , pp. 199-207
    • Jia, X.1    Cheng, K.2    Mahato, R.I.3
  • 166
    • 33750591089 scopus 로고    scopus 로고
    • Co-expression of vascular endothelial growth factor and interleukin-1 receptor antagonist improves human islet survival and function
    • Narang AS, Sabek O, Gaber AO, Mahato RI. Co-expression of vascular endothelial growth factor and interleukin-1 receptor antagonist improves human islet survival and function. Pharm Res. 2006;23:1970-82.
    • (2006) Pharm Res , vol.23 , pp. 1970-1982
    • Narang, A.S.1    Sabek, O.2    Gaber, A.O.3    Mahato, R.I.4
  • 168
    • 0034509569 scopus 로고    scopus 로고
    • Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I
    • Giannoukakis N, Mi Z, Rudert WA, Gambotto A, Trucco M, Robbins P. Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I. Gene Ther. 2000;7:2015-22.
    • (2000) Gene Ther , vol.7 , pp. 2015-2022
    • Giannoukakis, N.1    Mi, Z.2    Rudert, W.A.3    Gambotto, A.4    Trucco, M.5    Robbins, P.6
  • 169
    • 33846239410 scopus 로고    scopus 로고
    • Adenovirus-mediated expression of the anticoagulant hirudin in human islets: A tool to make the islets biocompatible to blood
    • Cabric S, Elgue G, Nilsson B, Korsgren O, Schmidt P. Adenovirus-mediated expression of the anticoagulant hirudin in human islets: a tool to make the islets biocompatible to blood. Cell Transplant. 2006;15:759-67.
    • (2006) Cell Transplant , vol.15 , pp. 759-767
    • Cabric, S.1    Elgue, G.2    Nilsson, B.3    Korsgren, O.4    Schmidt, P.5
  • 171
    • 12844263380 scopus 로고    scopus 로고
    • Residual beta-cell function and male/female ratio are higher in incident young adults than in children: The registry of type 1 diabetes of the province of Turin, Italy, 1984-2000
    • Bruno G, Cerutti F, Merletti F, Cavallo-Perin P, Gandolfo E, Rivetti M, Runzo C, Pinach S, Pagano G. Residual beta-cell function and male/female ratio are higher in incident young adults than in children: the registry of type 1 diabetes of the province of Turin, Italy, 1984-2000. Diabetes Care. 2005;28:312-7.
    • (2005) Diabetes Care , vol.28 , pp. 312-317
    • Bruno, G.1    Cerutti, F.2    Merletti, F.3    Cavallo-Perin, P.4    Gandolfo, E.5    Rivetti, M.6    Runzo, C.7    Pinach, S.8    Pagano, G.9
  • 172
    • 0038027366 scopus 로고    scopus 로고
    • GLP-1 gene delivery for the treatment of type 2 diabetes
    • Oh S, Lee M, Ko KS, Choi S, Kim SW. GLP-1 gene delivery for the treatment of type 2 diabetes. Mol Ther. 2003;7:478-83.
    • (2003) Mol Ther , vol.7 , pp. 478-483
    • Oh, S.1    Lee, M.2    Ko, K.S.3    Choi, S.4    Kim, S.W.5
  • 174
    • 33846010782 scopus 로고    scopus 로고
    • Prolonged remission of diabetes by regeneration of beta cells in diabetic mice treated with recombinant adenoviral vector expressing glucagon-like peptide-1
    • Liu MJ, Shin S, Li N, Shigihara T, Lee YS, Yoon JW, Jun HS. Prolonged remission of diabetes by regeneration of beta cells in diabetic mice treated with recombinant adenoviral vector expressing glucagon-like peptide-1. Mol Ther. 2007;15:86-93.
    • (2007) Mol Ther , vol.15 , pp. 86-93
    • Liu, M.J.1    Shin, S.2    Li, N.3    Shigihara, T.4    Lee, Y.S.5    Yoon, J.W.6    Jun, H.S.7
  • 175
    • 34249884271 scopus 로고    scopus 로고
    • In vivo expression of GLP-1/IgG-Fc fusion protein enhances beta-cell mass and protects against streptozotocin-induced diabetes
    • Soltani N, Kumar M, Glinka Y, Prud'homme GJ, Wang Q. In vivo expression of GLP-1/IgG-Fc fusion protein enhances beta-cell mass and protects against streptozotocin-induced diabetes. Gene Ther. 2007;14:981-8.
    • (2007) Gene Ther , vol.14 , pp. 981-988
    • Soltani, N.1    Kumar, M.2    Glinka, Y.3    Prud'homme, G.J.4    Wang, Q.5
  • 176
    • 0034707028 scopus 로고    scopus 로고
    • Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue
    • Lee HC, Kim SJ, Kim KS, Shin HC, Yoon JW. Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue. Nature. 2000;408:483-8.
    • (2000) Nature , vol.408 , pp. 483-488
    • Lee, H.C.1    Kim, S.J.2    Kim, K.S.3    Shin, H.C.4    Yoon, J.W.5
  • 177
    • 0031730473 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of a modified human proinsulin gene reverses hyperglycemia in diabetic mice
    • Short DK, Okada S, Yamauchi K, Pessin JE. Adenovirus-mediated transfer of a modified human proinsulin gene reverses hyperglycemia in diabetic mice. Am J Physiol. 1998;275:E748-56.
    • (1998) Am J Physiol , vol.275
    • Short, D.K.1    Okada, S.2    Yamauchi, K.3    Pessin, J.E.4
  • 178
    • 0030946203 scopus 로고    scopus 로고
    • Hepatic insulin gene expression as treatment for type 1 diabetes mellitus in rats
    • Muzzin P, Eisensmith RC, Copeland KC, Woo SL. Hepatic insulin gene expression as treatment for type 1 diabetes mellitus in rats. Mol Endocrinol. 1997;11:833-7.
    • (1997) Mol Endocrinol , vol.11 , pp. 833-837
    • Muzzin, P.1    Eisensmith, R.C.2    Copeland, K.C.3    Woo, S.L.4
  • 181
    • 17644425265 scopus 로고    scopus 로고
    • Plasmid-electroporated primary hepatocytes acquire quasi-physiological secretion of human insulin and restore euglycemia in diabetic mice
    • Chen NK, Sivalingam J, Tan SY, Kon OL. Plasmid-electroporated primary hepatocytes acquire quasi-physiological secretion of human insulin and restore euglycemia in diabetic mice. Gene Ther. 2005;12:655-67.
    • (2005) Gene Ther , vol.12 , pp. 655-667
    • Chen, N.K.1    Sivalingam, J.2    Tan, S.Y.3    Kon, O.L.4
  • 182
    • 0037184731 scopus 로고    scopus 로고
    • Glucose-regulated insulin production in hepatocytes
    • Alam T, Sollinger HW. Glucose-regulated insulin production in hepatocytes. Transplantation. 2002;74:1781-7.
    • (2002) Transplantation , vol.74 , pp. 1781-1787
    • Alam, T.1    Sollinger, H.W.2
  • 183
    • 0033122314 scopus 로고    scopus 로고
    • Naked plasmid-mediated gene transfer to skeletal muscle ameliorates diabetes mellitus
    • Kon OL, Sivakumar S, Teoh KL, Lok SH, Long YC. Naked plasmid-mediated gene transfer to skeletal muscle ameliorates diabetes mellitus. J Gene Med. 1999;1:186-94.
    • (1999) J Gene Med , vol.1 , pp. 186-194
    • Kon, O.L.1    Sivakumar, S.2    Teoh, K.L.3    Lok, S.H.4    Long, Y.C.5
  • 184
    • 0034778099 scopus 로고    scopus 로고
    • Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia
    • Shifrin AL, Auricchio A, Yu QC, Wilson J, Raper SE. Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia. Gene Ther. 2001;8:1480-9.
    • (2001) Gene Ther , vol.8 , pp. 1480-1489
    • Shifrin, A.L.1    Auricchio, A.2    Yu, Q.C.3    Wilson, J.4    Raper, S.E.5
  • 187
    • 33845957180 scopus 로고    scopus 로고
    • Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: An ex vivo gene therapy approach
    • Fodor A, Harel C, Fodor L, Armoni M, Salmon P, Trono D, Karnieli E. Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach. Diabetologia. 2007;50:121-30.
    • (2007) Diabetologia , vol.50 , pp. 121-130
    • Fodor, A.1    Harel, C.2    Fodor, L.3    Armoni, M.4    Salmon, P.5    Trono, D.6    Karnieli, E.7
  • 190
    • 44949159838 scopus 로고    scopus 로고
    • Adeno-associated virus-mediated pancreatic and duodenal homeobox gene-1 expression enhanced differentiation of hepatic oval stem cells to insulin-producing cells in diabetic rats
    • Li H, Li X, Lam KS, Tam S, Xiao W, Xu R. Adeno-associated virus-mediated pancreatic and duodenal homeobox gene-1 expression enhanced differentiation of hepatic oval stem cells to insulin-producing cells in diabetic rats. J Biomed Sci. 2008;15:487-97.
    • (2008) J Biomed Sci , vol.15 , pp. 487-497
    • Li, H.1    Li, X.2    Lam, K.S.3    Tam, S.4    Xiao, W.5    Xu, R.6
  • 191
    • 15944417831 scopus 로고    scopus 로고
    • PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance
    • Kaneto H, Nakatani Y, Miyatsuka T, Matsuoka TA, Matsuhisa M, Hori M, Yamasaki Y. PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance. Diabetes. 2005;54:1009-22.
    • (2005) Diabetes , vol.54 , pp. 1009-1022
    • Kaneto, H.1    Nakatani, Y.2    Miyatsuka, T.3    Matsuoka, T.A.4    Matsuhisa, M.5    Hori, M.6    Yamasaki, Y.7
  • 193
    • 0038413922 scopus 로고    scopus 로고
    • NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice
    • Kojima H, Fujimiya M, Matsumura K, Younan P, Imaeda H, Maeda M, Chan L. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med. 2003;9:596-603.
    • (2003) Nat Med , vol.9 , pp. 596-603
    • Kojima, H.1    Fujimiya, M.2    Matsumura, K.3    Younan, P.4    Imaeda, H.5    Maeda, M.6    Chan, L.7
  • 194
    • 34447100368 scopus 로고    scopus 로고
    • Reversal of streptozotocin-induced diabetes in rats by gene therapy with betacellulin and pancreatic duodenal homeobox-1
    • Chen S, Ding J, Yu C, Yang B, Wood DR, Grayburn PA. Reversal of streptozotocin-induced diabetes in rats by gene therapy with betacellulin and pancreatic duodenal homeobox-1. Gene Ther. 2007;14:1102-10.
    • (2007) Gene Ther , vol.14 , pp. 1102-1110
    • Chen, S.1    Ding, J.2    Yu, C.3    Yang, B.4    Wood, D.R.5    Grayburn, P.A.6
  • 195
    • 36248934727 scopus 로고    scopus 로고
    • Generation of insulin-producing cells from human bone marrow mesenchymal stem cells by genetic manipulation
    • Karnieli O, Izhar-Prato Y, Bulvik S, Efrat S. Generation of insulin-producing cells from human bone marrow mesenchymal stem cells by genetic manipulation. Stem Cells. 2007;25:2837-44.
    • (2007) Stem Cells , vol.25 , pp. 2837-2844
    • Karnieli, O.1    Izhar-Prato, Y.2    Bulvik, S.3    Efrat, S.4
  • 196
    • 0031793875 scopus 로고    scopus 로고
    • The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XVII. The 14-year incidence and progression of diabetic retinopathy and associated risk factors in type 1 diabetes
    • Klein R, Klein BE, Moss SE, Cruickshanks KJ. The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XVII. The 14-year incidence and progression of diabetic retinopathy and associated risk factors in type 1 diabetes. Ophthalmology. 1998;105:1801-15.
    • (1998) Ophthalmology , vol.105 , pp. 1801-1815
    • Klein, R.1    Klein, B.E.2    Moss, S.E.3    Cruickshanks, K.J.4
  • 197
    • 34548087845 scopus 로고    scopus 로고
    • Management of diabetic retinopathy: A systematic review
    • Mohamed Q, Gillies MC, Wong TY. Management of diabetic retinopathy: a systematic review. JAMA. 2007;298:902-16.
    • (2007) JAMA , vol.298 , pp. 902-916
    • Mohamed, Q.1    Gillies, M.C.2    Wong, T.Y.3
  • 198
    • 33646246183 scopus 로고    scopus 로고
    • Basic and clinical aspects of gene therapy for retinopathy induced by diabetes
    • Ting JH, Martin DK. Basic and clinical aspects of gene therapy for retinopathy induced by diabetes. Curr Gene Ther. 2006;6:193-214.
    • (2006) Curr Gene Ther , vol.6 , pp. 193-214
    • Ting, J.H.1    Martin, D.K.2
  • 199
    • 33847305368 scopus 로고    scopus 로고
    • Gene therapy for ocular neovascularization
    • Campochiaro PA. Gene therapy for ocular neovascularization. Curr Gene Ther. 2007;7:25-33.
    • (2007) Curr Gene Ther , vol.7 , pp. 25-33
    • Campochiaro, P.A.1
  • 203
    • 0037173042 scopus 로고    scopus 로고
    • Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization
    • Raisler BJ, Berns KI, Grant MB, Beliaev D, Hauswirth WW. Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization. Proc Natl Acad Sci U S A. 2002;99:8909-14.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 8909-8914
    • Raisler, B.J.1    Berns, K.I.2    Grant, M.B.3    Beliaev, D.4    Hauswirth, W.W.5
  • 205
    • 35148861116 scopus 로고    scopus 로고
    • Helper-dependent adenovirus for the gene therapy of proliferative retinopathies: Stable gene transfer, regulated gene expression and therapeutic efficacy
    • Lamartina S, Cimino M, Roscilli G, Dammassa E, Lazzaro D, Rota R, Ciliberto G, Toniatti C. Helper-dependent adenovirus for the gene therapy of proliferative retinopathies: stable gene transfer, regulated gene expression and therapeutic efficacy. J Gene Med. 2007;9:862-74.
    • (2007) J Gene Med , vol.9 , pp. 862-874
    • Lamartina, S.1    Cimino, M.2    Roscilli, G.3    Dammassa, E.4    Lazzaro, D.5    Rota, R.6    Ciliberto, G.7    Toniatti, C.8
  • 207
    • 0038748037 scopus 로고    scopus 로고
    • Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model
    • Reich SJ, Fosnot J, Kuroki A, Tang W, Yang X, Maguire AM, Bennett J, Tolentino MJ. Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. Mol Vis. 2003;9:210-6.
    • (2003) Mol Vis , vol.9 , pp. 210-216
    • Reich, S.J.1    Fosnot, J.2    Kuroki, A.3    Tang, W.4    Yang, X.5    Maguire, A.M.6    Bennett, J.7    Tolentino, M.J.8
  • 208
    • 33645139836 scopus 로고    scopus 로고
    • Potential applications for RNAi to probe pathogenesis and develop new treatments for ocular disorders
    • Campochiaro PA. Potential applications for RNAi to probe pathogenesis and develop new treatments for ocular disorders. Gene Ther. 2006;13:559-62.
    • (2006) Gene Ther , vol.13 , pp. 559-562
    • Campochiaro, P.A.1
  • 211
    • 33748117817 scopus 로고    scopus 로고
    • Inhibition of choroidal neovascularization by adenovirus-mediated delivery of short hairpin RNAs targeting VEGF as a potential therapy for AMD
    • Cashman SM, Bowman L, Christofferson J, Kumar-Singh R. Inhibition of choroidal neovascularization by adenovirus-mediated delivery of short hairpin RNAs targeting VEGF as a potential therapy for AMD. Invest Ophthalmol Vis Sci. 2006;47:3496-504.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 3496-3504
    • Cashman, S.M.1    Bowman, L.2    Christofferson, J.3    Kumar-Singh, R.4
  • 212
    • 27744448125 scopus 로고    scopus 로고
    • Wound healing and its impairment in the diabetic foot
    • Falanga V. Wound healing and its impairment in the diabetic foot. Lancet. 2005;366:1736-43.
    • (2005) Lancet , vol.366 , pp. 1736-1743
    • Falanga, V.1
  • 216
    • 33645508703 scopus 로고    scopus 로고
    • COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model
    • Cho CH, Sung HK, Kim KT, Cheon HG, Oh GT, Hong HJ, Yoo OJ, Koh GY. COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model. Proc Natl Acad Sci U S A. 2006;103:4946-51.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 4946-4951
    • Cho, C.H.1    Sung, H.K.2    Kim, K.T.3    Cheon, H.G.4    Oh, G.T.5    Hong, H.J.6    Yoo, O.J.7    Koh, G.Y.8
  • 218
    • 4644250654 scopus 로고    scopus 로고
    • Electroporatic delivery of TGF-beta1 gene works synergistically with electric therapy to enhance diabetic wound healing in db/db mice
    • Lee PY, Chesnoy S, Huang L. Electroporatic delivery of TGF-beta1 gene works synergistically with electric therapy to enhance diabetic wound healing in db/db mice. J Invest Dermatol. 2004;123:791-8.
    • (2004) J Invest Dermatol , vol.123 , pp. 791-798
    • Lee, P.Y.1    Chesnoy, S.2    Huang, L.3
  • 219
    • 0037336442 scopus 로고    scopus 로고
    • Intradermal injection of transforming growth factor-beta1 gene enhances wound healing in genetically diabetic mice
    • Chesnoy S, Lee PY, Huang L. Intradermal injection of transforming growth factor-beta1 gene enhances wound healing in genetically diabetic mice. Pharm Res. 2003;20:345-50.
    • (2003) Pharm Res , vol.20 , pp. 345-350
    • Chesnoy, S.1    Lee, P.Y.2    Huang, L.3
  • 220
    • 0034476928 scopus 로고    scopus 로고
    • Adenoviral-mediated gene transfer in wound healing
    • Crombleholme TM. Adenoviral-mediated gene transfer in wound healing. Wound Repair Regen. 2000;8:460-72.
    • (2000) Wound Repair Regen , vol.8 , pp. 460-472
    • Crombleholme, T.M.1
  • 223
    • 35248846610 scopus 로고    scopus 로고
    • Lentiviral gene transfer of SDF-1 alpha to wounds improves diabetic wound healing
    • Badillo AT, Chung S, Zhang L, Zoltick P, Liechty KW. Lentiviral gene transfer of SDF-1 alpha to wounds improves diabetic wound healing. J Surg Res. 2007;143:35-42.
    • (2007) J Surg Res , vol.143 , pp. 35-42
    • Badillo, A.T.1    Chung, S.2    Zhang, L.3    Zoltick, P.4    Liechty, K.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.