메뉴 건너뛰기




Volumn 19, Issue 3, 2007, Pages 281-286

Differentiation and function of Th17 T cells

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 23; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 34247555353     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2007.04.005     Document Type: Review
Times cited : (603)

References (49)
  • 1
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin-17 family members and inflammation
    • Kolls J.K., and Linden A. Interleukin-17 family members and inflammation. Immunity 21 (2004) 467-476
    • (2004) Immunity , vol.21 , pp. 467-476
    • Kolls, J.K.1    Linden, A.2
  • 5
    • 32244442562 scopus 로고    scopus 로고
    • TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • This article identifies the crucial factors necessary for differentiation of Th17 T cells from naïve CD4 T-cell precursors, and rules out IL-23 as a differentiation factor.
    • Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., and Stockinger B. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006) 179-189. This article identifies the crucial factors necessary for differentiation of Th17 T cells from naïve CD4 T-cell precursors, and rules out IL-23 as a differentiation factor.
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 6
    • 33646577466 scopus 로고    scopus 로고
    • H17 and regulatory T cells
    • This article shows that in vitro Treg formation in the presence of TGF-β is subverted to Th17 generation in the presence of IL-6. Transgenic overexpression of TGF-β increases symptoms of EAE and numbers of Th17 T cells.
    • H17 and regulatory T cells. Nature 441 (2006) 235-238. This article shows that in vitro Treg formation in the presence of TGF-β is subverted to Th17 generation in the presence of IL-6. Transgenic overexpression of TGF-β increases symptoms of EAE and numbers of Th17 T cells.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 7
    • 33646560950 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces development of the T(H)17 lineage
    • This article also shows the divergent effects of TGF-β depending upon the presence of IL-6. It furthermore shows that IL-23 is necessary to maintain Th17 effector function against an intestinal bacterial pathogen.
    • Mangan P.R., Harrington L.E., O'Quinn D.B., Helms W.S., Bullard D.C., Elson C.O., Hatton R.D., Wahl S.M., Schoeb T.R., and Weaver C.T. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441 (2006) 231-234. This article also shows the divergent effects of TGF-β depending upon the presence of IL-6. It furthermore shows that IL-23 is necessary to maintain Th17 effector function against an intestinal bacterial pathogen.
    • (2006) Nature , vol.441 , pp. 231-234
    • Mangan, P.R.1    Harrington, L.E.2    O'Quinn, D.B.3    Helms, W.S.4    Bullard, D.C.5    Elson, C.O.6    Hatton, R.D.7    Wahl, S.M.8    Schoeb, T.R.9    Weaver, C.T.10
  • 8
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • Aggarwal S., Ghilardi N., Xie M.H., de Sauvage F.J., and Gurney A.L. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 278 (2003) 1910-1914
    • (2003) J Biol Chem , vol.278 , pp. 1910-1914
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.H.3    de Sauvage, F.J.4    Gurney, A.L.5
  • 11
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    • Sutton C., Brereton C., Keogh B., Mills K.H., and Lavelle E.C. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 203 (2006) 1685-1691
    • (2006) J Exp Med , vol.203 , pp. 1685-1691
    • Sutton, C.1    Brereton, C.2    Keogh, B.3    Mills, K.H.4    Lavelle, E.C.5
  • 15
    • 33747588291 scopus 로고    scopus 로고
    • Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    • •] highlight an important negative feedback regulation of Th17 T cells by IL-27. IL-27 inhibits in vitro differentiation of Th17 T cells, and its absence in IL-27-deficient mice exacerbates autoimmune pathology in the nervous system.
    • •] highlight an important negative feedback regulation of Th17 T cells by IL-27. IL-27 inhibits in vitro differentiation of Th17 T cells, and its absence in IL-27-deficient mice exacerbates autoimmune pathology in the nervous system.
    • (2006) Nat Immunol , vol.7 , pp. 929-936
    • Batten, M.1    Li, J.2    Yi, S.3    Kljavin, N.M.4    Danilenko, D.M.5    Lucas, S.6    Lee, J.7    de Sauvage, F.J.8    Ghilardi, N.9
  • 19
    • 17044430217 scopus 로고    scopus 로고
    • Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter
    • Wan Y.Y., and Flavell R.A. Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc Natl Acad Sci USA 102 (2005) 5126-5131
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 5126-5131
    • Wan, Y.Y.1    Flavell, R.A.2
  • 21
    • 0037436119 scopus 로고    scopus 로고
    • + T cell-mediated suppression by dendritic cells
    • + T cell-mediated suppression by dendritic cells. Science 299 (2003) 1033-1036
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 24
    • 0038623916 scopus 로고    scopus 로고
    • IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist
    • Nakae S., Saijo S., Horai R., Sudo K., Mori S., and Iwakura Y. IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc Natl Acad Sci USA 100 (2003) 5986-5990
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5986-5990
    • Nakae, S.1    Saijo, S.2    Horai, R.3    Sudo, K.4    Mori, S.5    Iwakura, Y.6
  • 25
    • 33645959483 scopus 로고    scopus 로고
    • STAT3 and NF-κB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice
    • Cho M.L., Kang J.W., Moon Y.M., Nam H.J., Jhun J.Y., Heo S.B., Jin H.T., Min S.Y., Ju J.H., Park K.S., et al. STAT3 and NF-κB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice. J Immunol 176 (2006) 5652-5661
    • (2006) J Immunol , vol.176 , pp. 5652-5661
    • Cho, M.L.1    Kang, J.W.2    Moon, Y.M.3    Nam, H.J.4    Jhun, J.Y.5    Heo, S.B.6    Jin, H.T.7    Min, S.Y.8    Ju, J.H.9    Park, K.S.10
  • 27
    • 33749318470 scopus 로고    scopus 로고
    • Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    • This article identifies IL-22 as a Th17-derived cytokine that is important in the innate response to skin infections. IL-22 production is upregulated by IL-23, establishing yet another function for this cytokine in the control of Th17 effector function.
    • Liang S.C., Tan X.-Y., Luxenberg D.P., Karim R., Danussi-Joannopoulos K., Collins M., and Fouser L.A. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 203 (2006) 2271-2279. This article identifies IL-22 as a Th17-derived cytokine that is important in the innate response to skin infections. IL-22 production is upregulated by IL-23, establishing yet another function for this cytokine in the control of Th17 effector function.
    • (2006) J Exp Med , vol.203 , pp. 2271-2279
    • Liang, S.C.1    Tan, X.-Y.2    Luxenberg, D.P.3    Karim, R.4    Danussi-Joannopoulos, K.5    Collins, M.6    Fouser, L.A.7
  • 29
    • 33750142276 scopus 로고    scopus 로고
    • Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease
    • This article establishes the obligatory role for TGF-β signalling in T cells for development of EAE, but also shows that chronic inflammation is required for autoimmune pathology. Certain pathogen-derived molecules such as zymosan can activate Th17 and initiate EAE but cannot sustain ongoing inflammation. As a consequence, autoimmune pathology is reversed.
    • Veldhoen M., Hocking R.J., Flavell R.A., and Stockinger B. Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat Immunol 7 (2006) 1151-1156. This article establishes the obligatory role for TGF-β signalling in T cells for development of EAE, but also shows that chronic inflammation is required for autoimmune pathology. Certain pathogen-derived molecules such as zymosan can activate Th17 and initiate EAE but cannot sustain ongoing inflammation. As a consequence, autoimmune pathology is reversed.
    • (2006) Nat Immunol , vol.7 , pp. 1151-1156
    • Veldhoen, M.1    Hocking, R.J.2    Flavell, R.A.3    Stockinger, B.4
  • 30
    • 0034131557 scopus 로고    scopus 로고
    • Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
    • Gorelik L., and Flavell R.A. Abrogation of TGFβ signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 12 (2000) 171-181
    • (2000) Immunity , vol.12 , pp. 171-181
    • Gorelik, L.1    Flavell, R.A.2
  • 31
    • 33748465396 scopus 로고    scopus 로고
    • Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-β receptor
    • Marie J.C., Liggitt D., and Rudensky A.Y. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-β receptor. Immunity 25 (2006) 441-454
    • (2006) Immunity , vol.25 , pp. 441-454
    • Marie, J.C.1    Liggitt, D.2    Rudensky, A.Y.3
  • 32
    • 33748448717 scopus 로고    scopus 로고
    • Transforming growth factor-β controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    • Li M.O., Sanjabi S., and Flavell R.A. Transforming growth factor-β controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity 25 (2006) 455-471
    • (2006) Immunity , vol.25 , pp. 455-471
    • Li, M.O.1    Sanjabi, S.2    Flavell, R.A.3
  • 34
    • 0032534730 scopus 로고    scopus 로고
    • IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells
    • Samoilova E.B., Horton J.L., Hilliard B., Liu T.S., and Chen Y. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J Immunol 161 (1998) 6480-6486
    • (1998) J Immunol , vol.161 , pp. 6480-6486
    • Samoilova, E.B.1    Horton, J.L.2    Hilliard, B.3    Liu, T.S.4    Chen, Y.5
  • 35
    • 1042267236 scopus 로고    scopus 로고
    • Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    • Lubberts E., Koenders M.I., Oppers-Walgreen B., van den Bersselaar L., Coenen-de Roo C.J., Joosten L.A., and van den Berg W.B. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum 50 (2004) 650-659
    • (2004) Arthritis Rheum , vol.50 , pp. 650-659
    • Lubberts, E.1    Koenders, M.I.2    Oppers-Walgreen, B.3    van den Bersselaar, L.4    Coenen-de Roo, C.J.5    Joosten, L.A.6    van den Berg, W.B.7
  • 36
    • 33751243318 scopus 로고    scopus 로고
    • Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitis
    • Uyttenhove C., and Van Snick J. Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitis. Eur J Immunol 36 (2006) 2868-2874
    • (2006) Eur J Immunol , vol.36 , pp. 2868-2874
    • Uyttenhove, C.1    Van Snick, J.2
  • 39
    • 33747623280 scopus 로고    scopus 로고
    • Interleukin 18-independent engagement of interleukin 18 receptor-α is required for autoimmune inflammation
    • Gutcher I., Urich E., Wolter K., Prinz M., and Becher B. Interleukin 18-independent engagement of interleukin 18 receptor-α is required for autoimmune inflammation. Nat Immunol 7 (2006) 946-953
    • (2006) Nat Immunol , vol.7 , pp. 946-953
    • Gutcher, I.1    Urich, E.2    Wolter, K.3    Prinz, M.4    Becher, B.5
  • 41
  • 44
    • 3242814586 scopus 로고    scopus 로고
    • Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice
    • Huang W., Na L., Fidel P.L., and Schwarzenberger P. Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis 190 (2004) 624-631
    • (2004) J Infect Dis , vol.190 , pp. 624-631
    • Huang, W.1    Na, L.2    Fidel, P.L.3    Schwarzenberger, P.4
  • 45
    • 0034541221 scopus 로고    scopus 로고
    • Microbial lipopeptides induce the production of IL-17 in Th cells
    • Infante-Duarte C., Horton H.F., Byrne M.C., and Kamradt T. Microbial lipopeptides induce the production of IL-17 in Th cells. J Immunol 165 (2000) 6107-6115
    • (2000) J Immunol , vol.165 , pp. 6107-6115
    • Infante-Duarte, C.1    Horton, H.F.2    Byrne, M.C.3    Kamradt, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.