IL-4 Expression by Grafts from Transgenic Mice Fails to Prevent Allograft Rejection

Journal of Immunology

Volumn 159, Issue 4, 1997, Pages 1599-1603

  Mueller, Regula ^a   Davies, Joanna D ^a   Krahl, Troy ^a   Sarvetnick, Nora ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 4;

ALLOTRANSPLANTATION; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; GRAFT REJECTION; IMMUNOLOGY; MALE; MOUSE; PANCREAS TRANSPLANTATION; PHYSIOLOGY; TH2 CELL; TRANSGENIC MOUSE;

ANIMALS; GRAFT REJECTION; INTERLEUKIN-4; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; PANCREAS TRANSPLANTATION; TH2 CELLS; TRANSPLANTATION, HOMOLOGOUS;

EID: 0031571310     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Dallman, M. J. 1995. Cytokines and transplantation: Th1/Th2 regulation of the immune response to solid organ transplants in the adult. Curr. Opin. Immunol. 7:632.
2. Dallman, M. J. 1993. Cytokines as mediators of organ graft rejection and tolerance. Curr. Opin. Immunol. 5:788.
3. Mosmann, T. R., and R. L. Coffman. 1989. Th1- and Th2-cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
4. Rabinovitch, A. 1994. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Diabetes 43:613.
5. Burdick, J. F., and L. W. Clow. 1990. Rejection of primarily vascularized heart grafts. III Depression of the interleukin 2 mechanism early after grafting. Transplantation 50:476.
6. Dallman, M. J., O. Shiho, T. H. Page, K. J. Wood, and P. J. Morris. 1991. Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway. J. Exp. Med. 173:79.
7. Dallman, M. J., C. P. Larsen, and P. J. Morris. 1991. Cytokine gene transcription in vascularized organ grafts: analysis using semi-quantitative polymerase chain reaction. J. Exp. Med. 174:493.
8. Bugeon, L., M.-C. Cuturi, M.-M. Hallet, J. Paineau, D. Chabannes, and J.-P. Soulillou. 1992. Peripheral tolerance to an allograft in adult rats: characterization by low interleukin-2 and interferon-γ mRNA levels and by strong accumulation of major histocompatibility complex transcripts in the graft. Transplantation 54: 219.
9. + T cells in vivo: differential expression of IL-2 and IL-4 in recipients of cardiac allografts. J. Immunol. 148:1308.
10. Kupiec-Weglinski, J. W., B. Wasowska, I. Papp, O. Schmidbauer, M. H. Sayegh, W. M. Baldwin, K. J. Wieder, and W. W. Hancock. 1993. CD4 mAb therapy modulates alloantibody production and intracardiac graft deposition in association with selective inhibition of Th1 lymphokines. J. Immunol. 151:5053.
11. Siegling, A., M. Lehmann, H. Riedel, C. Platzer, J Brock, F. Emmrich, and H.-D. Volk. 1994. A nondepleting anti-rat CD4 monoclonal antibody that suppresses T helper 1-like but not T helper 2-like intragraft lymphokine secretion induces long-term survival of renal allografts. Transplantation 57:464.
12. Mueller, R., T. Krahl, and N. Sarvetnick. 1996. Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice. J. Exp. Med. 184:1093.
13. Mueller, R., T. Krahl, and N. Sarvetnick. 1997. Tissue-specific expression of interleukin-4 induces extracellular matrix accumulation and extravasation of B cells. Lab. Invest. 76:117.
14. Cobbold, S. P., G. Martin, S. Qin, and H. Waldmann. 1986. Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance. Nature 323: 164.
15. Mandel, T. E., and L. Higginbotham. 1979. Organ culture and transplantation of fetal mouse pancreatic tissue. Transplant. Proc. 11:1505.
16. Duncan, D. D., and S. L. Swain. 1994. Role of antigen-presenting cells in the polarized development of helper T cell subsets: evidence for differential cytokine production by Th0 cells in response to antigen presentation by B cells and macrophages. Eur. J. Immunol. 24:2506.
17. Shizuru, J. A., A. K. Gregory, C. T.-B. Chao, and C. G. Fathman. 1987. Islet allograft survival after a single course of treatment of recipient with antibody to L3T4. Semin. Immunol. 237:278.
18. Hall, B. M. 1991. Cells mediating allograft rejection. Transplantation 51:1141.
19. Fitch, F. W., M. D. McKisic, D. W. Lancki, and T. F. Gajewski. 1993. Differential regulation of murine T lymphocyte subsets. Annu. Rev. Immunol. 11:29.
20. Fischer-Lindahl, K., and D. B. Wilson. 1977. Histocompatibility antigen-activated cytotoxic T lymphocytes. II. Estimates of frequency and specificity of precursors. J. Exp. Med. 145:508.
21. Auchincloss, H. 1995. Antigen presentation. In Transplantation Immunology. F. H. Bach and H. Auchincloss, eds. Wiley-Liss, New York, p. 87.
22. Mandel, T. E., J. Kovarik, and M. Koulmanda. 1995. A comparison of organ cultured fetal pancreas allo-, iso-, and xenografts (pig) in non-immunosuppressed non-obese diabetic mice. Am. J. Pathol. 147:834.
23. Foster, P. F., A. Bhattacharayya, H. N. Sankary, J. Coleman, M. Ashmann, and J. W. Williams. 1991. Eosinophil cationic protein's role in human allograft rejection. Hepatology 13:1117.
24. Martinez, O. M., N. L. Ascher, L. Ferrell, J. Villanueva, J. Lake, J. P. Roberts, and S. M. Krams. 1993. Evidence for a nonclassical pathway of graft rejection involving interleukin 5 and eosinophils. Transplantation 55:909.
25. Vossen, A. C. T. M., G. J. M. Tibbe, R. Benner, and H. F. J. Savelkoul. 1995. T-lymphocyte and cytokine-directed strategies for inhibiting skin allograft rejection in mice. Transplant. Proc. 27:380.
26. Maliszewski, C. R., P. J. Morrissey, W. C. Fanslow, T. A. Sato, C. Willis, and B. Davison. 1992. Delayed allograft rejection in mice transgenic for a soluble form of the IL-4 receptor. Cell. Immunol. 143:434.
27. Fanslow, W. C., K. N. Clifford, L. S. Park, A. S. Rubin, R. F. Voice, M. P. Beckmann, and M. B. Widmer. 1991. Regulation of alloreactivity in vivo by IL-4 and the soluble IL-4 receptor. J. Immunol. 147:535.
28. Picotti, J. R., S. Y. Chan, R. E. Goodman, J. Magram, E. J. Eichwald, and D. K. Bishop. 1996. IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. J. Immunol. 157:1951.