Purified allogeneic hematopoietic stem cell transplantation blocks diabetes pathogenesis in NOD mice

Diabetes

Volumn 52, Issue 1, 2003, Pages 59-68

  Beilhack, Georg F ^a   Scheffold, Yolanda C ^a   Weissman, Irving L ^a   Taylor, Cariel ^a   Jerabek, Libuse ^a   Burge, Matthew J ^a   Masek, Marilyn A ^a   Shizuru, Judith A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; AUTOANTIGEN; MONOCLONAL ANTIBODY; RABBIT ANTISERUM; SUPERANTIGEN;

ALLOGRAFT; ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BONE MARROW TRANSPLANTATION; CELL SELECTION; CHIMERA; COMPARATIVE STUDY; CONTROLLED STUDY; DIABETES MELLITUS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HYPERGLYCEMIA; IMMUNE RESPONSE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TISSUE GRAFT; TRANSGENIC MOUSE;

ANIMALS; DIABETES MELLITUS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; MICE, INBRED NOD; PANCREATITIS; T-LYMPHOCYTES; TRANSPLANTATION CHIMERA; TRANSPLANTATION, HOMOLOGOUS; TRANSPLANTATION, ISOGENEIC;

EID: 0037219227     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.1.59     Document Type: Article

References (36)

1. Ikehara S, Ohtsuki H, Good RA, Asamoto H, Nakamura T, Sekita K, Muso E, Tochino Y, Ida T, Kuzuya H, et al: Prevention of type I diabetes in nonobese diabetic mice by allogenic bone marrow transplantation. Proc Natl Acad Sci U S A 82:7743-7747, 1985
2. Li H, Kaufman CL, Boggs SS, Johnson PC, Patrene KD, Ildstad ST: Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune diabetes and reverses insulitis in nonobese diabetic (NOD) mice. J Immunol 156:380-388, 1996
3. LaFace DM, Peck AB: Reciprocal allogeneic bone marrow transplantation between NOD mice and diabetes-nonsusceptible mice associated with transfer and prevention of autoimmune diabetes. Diabetes 38:894-901, 1989
4. Wicker LS, Miller BJ, Chai A, Terada M, Mullen Y: Expression of genetically determined diabetes and insulitis in the nonobese diabetic (NOD) mouse at the level of bone marrow-derived cells: transfer of diabetes and insulitis to nondiabetic (NOD X B10) F1 mice with bone marrow cells from NOD mice. J Exp Med 167:1801-1810, 1988
5. Serreze DV, Leiter EH, Worthen SM, Shultz LD: NOD marrow stem cells adoptively transfer diabetes to resistant (NOD x NON)F1 mice. Diabetes 37:252-255, 1988
6. Bendelac A, Carnaud C, Boitard C, Bach JF: Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates: Requirement for both L3T4+ and Lyt-2+ T cells. J Exp Med 166:823-832, 1987
7. Christianson SW, Shultz LD, Leiter EH: Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice: relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors. Diabetes 42:44-55, 1993
8. Miller BJ, Appel MC, O'Neil JJ, Wicker LS: Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. J Immunol 140:52-58, 1988
9. Shizuru JA, Jerabek L, Edwards CT, Weissman IL: Transplantation of purified hematopoietic stem cells: Requirements for overcoming the barriers of allogeneic engraftment. Biol Blood Marrow Transplant 2:3-14, 1996
10. Spangrude GJ, Heimfeld S, Weissman IL: Purification and characterization of mouse hematopoietic stem cells. Science 241:58, 1988
11. Baum CM, Weissman IL, Tsukamoto AS, Buckle AM, Peault B: Isolation of a candidate human hematopoietic stem-cell population. Proc Natl Acad Sci U S A 89:2804-2808, 1992
12. Gandy KL, Domen J, Aguila H, Weissman IL: CD8+ TCR+ and CD8+ TCR-cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers. Immunity 11:579-590, 1999
13. Sullivan K: Graft-versus-host disease. In Hematopoietic Cell Transplantation. 2nd Ed. Thomas E, Blume KG, Forman SJ, Eds. Malden, MA, Blackwell Science, 1999, p. 515-536
14. Randall TD, Lund FE, Howard MC, Weissman IL: Expression of murine CD38 defines a population of long-term reconstituting hematopoietic stem cells. Blood 87:4057-4067, 1996
15. Kemp CB, Knight MJ, Scharp DW, Lacy PE, Ballinger WF: Transplantation of isolated pancreatic islets into the portal vein of diabetic rats. Nature 244:447, 1973
16. Wicker LS, Appel MC, Dotta F, Pressey A, Miller BJ, DeLarato NH, Fischer PA, Boltz RC Jr, Peterson LB: Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice: The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes. J Exp Med 176:67-77, 1992
17. Kanagawa O, Martin SM, Vaupel BA, Carrasco-Marin E, Unanue ER: Autoreactivity of T cells from nonobese diabetic mice: An I-Ag7-dependent reaction. Proc Natl Acad Sci U S A 95:1721-1724, 1998
18. Moller G: Superantigens. Immunol Rev 131:5-200, 1993
19. Fairchild S, Knight AM, Dyson PJ, Tomonari K: Co-segregation of a gene encoding a deletion ligand for Tcrb-V3+ T cells with Mtv-3. Immunogenetics 34:227-230, 1991
20. Wade T, Bill J, Marrack PC, Palmer E, Kappler JW: Molecular basis for the nonexpression of V beta 17 in some strains of mice. J Immunol 141:2165-2167, 1988
21. Shizuru JA, Weissman IL, Kernoff R, Masek M, Scheffold YC: Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection. Proc Natl Acad Sci U S A 97:9555-9560, 2000
22. Martin PJ: Donor CD8 cells prevent allogeneic marrow graft rejection in mice: Potential implications for marrow transplantation in humans. J Exp Med 178:703-712, 1993
23. Kaufman CL, Colson YL, Wren SM, Watkins S, Simmons RL, Ildstad ST: Phenotypic characterization of a novel bone marrow-derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood 84:2436-2446, 1994
24. Krug J, Williams AJ, Beales PE, Doniach I, Gale EA, Pozzilli P: Parathyroiditis in the non-obese diabetic mouse: A new finding. J Endocrinol 131:193-196, 1991
25. Matsuoka N, Bernard N, Concepcion ES, Graves PN, Ben-Nun A, Davies TF: T-cell receptor V region beta-chain gene expression in the autoimmune thyroiditis of non-obese diabetic mice. J Immunol 151:1691-1701, 1993
26. Strober S, Weissman I: Immunosuppressive and tolerogenic effects of whole body, total lymphoid and regional irradiation. In The Current Status of Modern Therapy. Salaman J, Ed. Lancester, England, MTP Press, 1981, p. 19-53
27. Georgiou HM, Slattery RM, Charlton B: Bone marrow transplantation prevents autoimmune diabetes in nonobese diabetic mice. Transplant Proc 25:2896-2897, 1993
28. Kaufman CL, Li H, Ildstad ST: Patterns of hemopoietic reconstitution in nonobese diabetic mice: Dichotomy of allogeneic resistance versus competitive advantage of disease-resistant marrow. J Immunol 158:2435-2442, 1997
29. Knaan-Shanzer S, Houben P, Kinwel-Bohre EP, van Bekkum DW: Remission induction of adjuvant arthritis in rats by total body irradiation and autologous bone marrow transplantation. Bone Marrow Transplant 8:333-338, 1991
30. van Gelder M, van Bekkum DW: Effective treatment of relapsing experimental autoimmune encephalomyelitis with pseudoautologous bone marrow transplantation. Bone Marrow Transplant 18:1029-1034, 1996
31. Karussis DM, Vourka-Karussis U, Lehmann D, Ovadia H, Mizrachi-Koll R, Ben-Nun A, Abramsky O, Slavin S: Prevention and reversal of adoptively transferred, chronic relapsing experimental autoimmune encephalomyelitis with a single high dose cytoreductive treatment followed by syngeneic bone marrow transplantation. J Clin Invest 92:765-772, 1993
32. Burt RK, Burns W, Ruvolo P, Fischer A, Shiao C, Guimaraes A, Barrett J, Hess A: Syngeneic bone marrow transplantation eliminates V beta 8.2 T lymphocytes from the spinal cord of Lewis rats with experimental allergic encephalomyelitis. J Neurosci Res 41:526-531, 1995
33. Kamath AT, Pooley J, O'Keeffe MA, Vremec D, Zhan Y, Lew AM, D'Amico A, Wu L, Tough DF, Shortman K: The development, maturation, and turnover rate of mouse spleen dendritic cell populations. J Immunol 165:6762-6770, 2000
34. Traver D, Akashi K, Manz M, Merad M, Miyamoto T, Engleman EG, Weissman IL: Development of CD8a-positive dendritic cells from a common myeloid progenitor. Science 290:2152-2154, 2000
35. Li H, Kaufman CL, Ildstad ST: Allogeneic chimerism induces donor-specific tolerance to simultaneous islet allografts in nonobese diabetic mice. Surgery 118:192-197; discussion 197-198, 1995
36. Seung E, Iwakoshi N, Woda BA, Markees TG, Mordes JP, Rossini AA, Greiner DL: Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD 154 antibody: Absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice. Blood 95:2175-2182, 2000