Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: An ex vivo gene therapy approach

Diabetologia

Volumn 50, Issue 1, 2007, Pages 121-130

  Fodor, A ^a,b   Harel, C ^a,b   Fodor, L ^a   Armoni, M ^a,b   Salmon, P ^c   Trono, D ^d,e   Karnieli, E ^a,b  

^a RAMBAM MEDICAL CENTER   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c UNIVERSITY OF GENEVA   (Switzerland)

^d Frontiers in Genetics National Center for Competence in Research   (Switzerland)

^e EPFL   (Switzerland)

Author keywords

Gene therapy; Hepatocytes; Lentivirus; PDX 1; Transplantation; Type 1 diabetes

Indexed keywords

ABC TRANSPORTER; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER 2; GREEN FLUORESCENT PROTEIN; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL; LENTIVIRUS VECTOR; NEUROGENIC DIFFERENTIATION FACTOR; NK6 TRANSCRIPTION FACTOR RELATED LOCUS 1 PROTEIN; PANCREATIC DUODENAL HOMEOBOX 1 PROTEIN; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 1; PROTEIN; SULFONYLUREA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MAF; TRANSCRIPTION FACTOR PAX6; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CELL TRANSPLANTATION; CONTROLLED STUDY; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INSULIN RELEASE; KIDNEY CAPSULE; LIVER CELL; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RAT; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOZOCIN DIABETES; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ANIMALS; CELL DIFFERENTIATION; CELL TRANSPLANTATION; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; GENE THERAPY; GENETIC VECTORS; GLUCOSE; HEPATOCYTES; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; LENTIVIRUS; MALE; MICE; MICE, SCID; RATS; RATS, INBRED LEW; STREPTOZOCIN; TRANS-ACTIVATORS; TRANSFECTION;

EID: 33845957180     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-006-0509-8     Document Type: Article

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