메뉴 건너뛰기




Volumn 159, Issue 10, 1997, Pages 4686-4692

IL-4 Prevents Insulitis and Insulin-Dependent Diabetes Mellitus in Nonobese Diabetic Mice by Potentiation of Regulatory T Helper-2 Cell Function

Author keywords

[No Author keywords available]

Indexed keywords

HERMES ANTIGEN; IMMUNOGLOBULIN E; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 4;

EID: 0031573072     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (215)

References (44)
  • 1
    • 0028026652 scopus 로고
    • Insulin-dependent diabetes mellitus as an autoimmune disease
    • Bach, J. F. 1994. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr. Rev. 15:516.
    • (1994) Endocr. Rev. , vol.15 , pp. 516
    • Bach, J.F.1
  • 2
    • 0028779842 scopus 로고
    • Mechanisms of disease: The pathosenesis of insulin-dependent diabetes mellitus
    • Atkinson, M. A., and N. K. Maclaren. 1994. Mechanisms of disease: the pathosenesis of insulin-dependent diabetes mellitus. N. Engl. J. Med. 331:1428.
    • (1994) N. Engl. J. Med. , vol.331 , pp. 1428
    • Atkinson, M.A.1    Maclaren, N.K.2
  • 3
    • 0029954214 scopus 로고    scopus 로고
    • Insulin-dependent diabetes mellitus
    • Tisch, R., and H. O. McDevitt. 1996. Insulin-dependent diabetes mellitus. Cell 85:291.
    • (1996) Cell , vol.85 , pp. 291
    • Tisch, R.1    McDevitt, H.O.2
  • 6
    • 0029026658 scopus 로고
    • Islet-infiltrating lymphocytes from prediabetic NOD mice rapidly transfer diabetes to NOD-scid/scid mice
    • Rohane, P. W., A. Shimada, D. T. Kim, C. T. Edwards, B. Charlton, L. D. Shultz, and C. G. Fathman. 1995. Islet-infiltrating lymphocytes from prediabetic NOD mice rapidly transfer diabetes to NOD-scid/scid mice. Diabetes 44:550.
    • (1995) Diabetes , vol.44 , pp. 550
    • Rohane, P.W.1    Shimada, A.2    Kim, D.T.3    Edwards, C.T.4    Charlton, B.5    Shultz, L.D.6    Fathman, C.G.7
  • 11
    • 0028354067 scopus 로고
    • Immunoregulatory and cytokine imbalances in the pathosenesis of IDDM: Therapeutic intervention by immunostimulation?
    • Rabinovitch, A. 1994. Immunoregulatory and cytokine imbalances in the pathosenesis of IDDM: therapeutic intervention by immunostimulation? Diabetes 43: 613.
    • (1994) Diabetes , vol.43 , pp. 613
    • Rabinovitch, A.1
  • 12
    • 0029030964 scopus 로고
    • T helper cell subsets in insulin- Dependent diabetes
    • Katz, J. D., C. Benoist, and D. Mathis. 1995. T helper cell subsets in insulin-dependent diabetes. Science 268:1185.
    • (1995) Science , vol.268 , pp. 1185
    • Katz, J.D.1    Benoist, C.2    Mathis, D.3
  • 13
    • 0343773445 scopus 로고    scopus 로고
    • IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease
    • Rocken, M. R., M. Racke, and E. M. Schevach. 1996. IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease. Immunol. Today 17:225.
    • (1996) Immunol. Today , vol.17 , pp. 225
    • Rocken, M.R.1    Racke, M.2    Schevach, E.M.3
  • 14
    • 0025735437 scopus 로고
    • Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune nonobese diabetic mice
    • Zipris, D., A. H. Lazarus, A. R. Crow, M. Hadzija, and T. L. Delovitch. 1991. Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune nonobese diabetic mice. J. Immunol. 146:3763.
    • (1991) J. Immunol. , vol.146 , pp. 3763
    • Zipris, D.1    Lazarus, A.H.2    Crow, A.R.3    Hadzija, M.4    Delovitch, T.L.5
  • 17
    • 0029838995 scopus 로고    scopus 로고
    • Pancreatic expression of inter leukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice
    • Mueller, R., T. Krahl, and N. Sarvetnick. 1996. Pancreatic expression of inter leukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice. J. Exp. Med. 184:1093.
    • (1996) J. Exp. Med. , vol.184 , pp. 1093
    • Mueller, R.1    Krahl, T.2    Sarvetnick, N.3
  • 18
    • 0028061186 scopus 로고
    • Insulin-dependent diabetes mellitus in the non-obese diabetic mouse: A disease mediated by T cell anergy?
    • Jaramillo, A., B. M. Gill, and T. L. Delovitch. 1994. Insulin-dependent diabetes mellitus in the non-obese diabetic mouse: a disease mediated by T cell anergy? Life Sci. 55:1163.
    • (1994) Life Sci. , vol.55 , pp. 1163
    • Jaramillo, A.1    Gill, B.M.2    Delovitch, T.L.3
  • 20
    • 0029785167 scopus 로고    scopus 로고
    • Interleukin-4: Potential immunoregulatory agent in therapy of insulin-dependent diabetes mellitus
    • Arreaza, G. A., M. J. Cameron, and T. L. Delovitch. 1996. Interleukin-4: potential immunoregulatory agent in therapy of insulin-dependent diabetes mellitus. Clin. Immunother. 4:251.
    • (1996) Clin. Immunother. , vol.4 , pp. 251
    • Arreaza, G.A.1    Cameron, M.J.2    Delovitch, T.L.3
  • 21
    • 0027173967 scopus 로고
    • The role of macrophage inflammatory protein 1α in Schistosoma mansoni egg-induced granulomatous inflammation
    • Lukacs, N. W., S. L. Kunkel, R. M. Strieter, K. Warmington, and S. W. Chensue. 1993. The role of macrophage inflammatory protein 1α in Schistosoma mansoni egg-induced granulomatous inflammation. J. Exp. Med. 177:1551.
    • (1993) J. Exp. Med. , vol.177 , pp. 1551
    • Lukacs, N.W.1    Kunkel, S.L.2    Strieter, R.M.3    Warmington, K.4    Chensue, S.W.5
  • 22
    • 0030638775 scopus 로고    scopus 로고
    • Interleukin-4 and its receptor: Essential mediators of the allergic response
    • Ryan, J. J. 1997. Interleukin-4 and its receptor: essential mediators of the allergic response. J. Allergy Clin. Immunol. 99:1.
    • (1997) J. Allergy Clin. Immunol. , vol.99 , pp. 1
    • Ryan, J.J.1
  • 23
    • 0024435017 scopus 로고
    • CD44: A molecule involved in leukocyte adherence and T cell activation
    • Haynes, B., M. J. Telen, L. P. Hale, and S. M. Denning. 1989. CD44: a molecule involved in leukocyte adherence and T cell activation. Immunol. Today 10:423.
    • (1989) Immunol. Today , vol.10 , pp. 423
    • Haynes, B.1    Telen, M.J.2    Hale, L.P.3    Denning, S.M.4
  • 24
    • 0030588502 scopus 로고    scopus 로고
    • CD44: One ligand, two functions
    • Aruffo, A. 1996. CD44: one ligand, two functions. J. Clin. Invest. 98:2191.
    • (1996) J. Clin. Invest. , vol.98 , pp. 2191
    • Aruffo, A.1
  • 25
    • 0029808003 scopus 로고    scopus 로고
    • Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages: The role of HA size and CD44
    • McKee, C. M., M. B. Penno, M. Cowman, M. D. Burdick, R. M. Strieter, C. Bao, and P. W. Noble. 1996. Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages: the role of HA size and CD44. J. Clin. Invest. 98:2403.
    • (1996) J. Clin. Invest. , vol.98 , pp. 2403
    • McKee, C.M.1    Penno, M.B.2    Cowman, M.3    Burdick, M.D.4    Strieter, R.M.5    Bao, C.6    Noble, P.W.7
  • 26
    • 0028236480 scopus 로고
    • Expression of homing and adhesion molecules in infiltrated islets of Langerhans and salivary glands of nonobese diabetic mice
    • Faveeuw, C., M. C. Gagnerault, and F. Lepault. 1994. Expression of homing and adhesion molecules in infiltrated islets of Langerhans and salivary glands of nonobese diabetic mice. J. Immunol. 152:5969.
    • (1994) J. Immunol. , vol.152 , pp. 5969
    • Faveeuw, C.1    Gagnerault, M.C.2    Lepault, F.3
  • 27
    • 0029889759 scopus 로고    scopus 로고
    • Expression of a specific subset of CD44 variant transcripts in NOD pancreatic islets
    • Milde, K. F., M. Alonso, S. S. Kong, R. Alejandro, D. H. Mintz, and R. L. Pastori. 1996. Expression of a specific subset of CD44 variant transcripts in NOD pancreatic islets. Diabetes 45:718.
    • (1996) Diabetes , vol.45 , pp. 718
    • Milde, K.F.1    Alonso, M.2    Kong, S.S.3    Alejandro, R.4    Mintz, D.H.5    Pastori, R.L.6
  • 28
    • 0029002861 scopus 로고
    • Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis
    • Mikecz, K., F. R. Brennan, J. H. Kim, and T. T. Glant. 1995. Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis. Nat. Med. 1:558.
    • (1995) Nat. Med. , vol.1 , pp. 558
    • Mikecz, K.1    Brennan, F.R.2    Kim, J.H.3    Glant, T.T.4
  • 29
    • 0031092631 scopus 로고    scopus 로고
    • IL-4 expression at the onset of islet inflammation predicts nondestructive insulitis in nonobese diabetic mice
    • Fox, C. J., and J. S. Danska. 1997. IL-4 expression at the onset of islet inflammation predicts nondestructive insulitis in nonobese diabetic mice. J. Immunol. 158:2414.
    • (1997) J. Immunol. , vol.158 , pp. 2414
    • Fox, C.J.1    Danska, J.S.2
  • 31
    • 0029071483 scopus 로고
    • Developmental commitment to the Th2 lineage by extinction of IL-12 signaling
    • Szabo, S. J., N. G. Jacobson, A. S. Dighe, U. Gubler, and K. M. Murphy. 1995. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 2:665.
    • (1995) Immunity , vol.2 , pp. 665
    • Szabo, S.J.1    Jacobson, N.G.2    Dighe, A.S.3    Gubler, U.4    Murphy, K.M.5
  • 32
    • 8044250881 scopus 로고    scopus 로고
    • Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 Cells
    • Szabo, S. J., A. S. Dighe, U. Gubler, and K. M. Murphy. 1997. Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 Cells. J. Exp. Med. 185:817.
    • (1997) J. Exp. Med. , vol.185 , pp. 817
    • Szabo, S.J.1    Dighe, A.S.2    Gubler, U.3    Murphy, K.M.4
  • 34
    • 0029919962 scopus 로고    scopus 로고
    • Enhanced development of Th2-like primary CD4 effectors in response to sustained exposure to limited rlL-4 in vivo
    • Yoshimoto, K., S. L. Swain, and L. M. Bradley. 1996. Enhanced development of Th2-like primary CD4 effectors in response to sustained exposure to limited rlL-4 in vivo. J. Immunol. 156:3267.
    • (1996) J. Immunol. , vol.156 , pp. 3267
    • Yoshimoto, K.1    Swain, S.L.2    Bradley, L.M.3
  • 35
    • 0028971717 scopus 로고
    • Demonstration of a Th1 cytokine profile in the late phase of NOD insulitis
    • Pilstrom, B., L. Bjork, and J. Bohme. 1995. Demonstration of a Th1 cytokine profile in the late phase of NOD insulitis. Cytokine 7:806.
    • (1995) Cytokine , vol.7 , pp. 806
    • Pilstrom, B.1    Bjork, L.2    Bohme, J.3
  • 36
    • 0029949222 scopus 로고    scopus 로고
    • Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin
    • Herold, K. C., V. Vezys, Q. Sun, D. Viktora, E. Seung, S. Reiner, and D. R. Brown. 1996. Regulation of cytokine production during development of autoimmune diabetes induced with multiple low doses of streptozotocin. J. Immunol. 156:3521.
    • (1996) J. Immunol. , vol.156 , pp. 3521
    • Herold, K.C.1    Vezys, V.2    Sun, Q.3    Viktora, D.4    Seung, E.5    Reiner, S.6    Brown, D.R.7
  • 37
    • 0028989087 scopus 로고
    • IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice
    • Rabinovitch, A., W. Suarez, O. Sorensen, C. Bleackley, and R. F. Power. 1995. IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J. Immunol. 154:4874.
    • (1995) J. Immunol. , vol.154 , pp. 4874
    • Rabinovitch, A.1    Suarez, W.2    Sorensen, O.3    Bleackley, C.4    Power, R.F.5
  • 38
    • 0027291701 scopus 로고
    • Altered cytokine activity in adjuvant inhibition of autoimmune diabetes
    • Shehadeh, N. N., F. LaRosa, and K. J. Lafferty. 1993. Altered cytokine activity in adjuvant inhibition of autoimmune diabetes. J. Autoimmun. 6:291.
    • (1993) J. Autoimmun. , vol.6 , pp. 291
    • Shehadeh, N.N.1    LaRosa, F.2    Lafferty, K.J.3
  • 39
    • 0031051747 scopus 로고    scopus 로고
    • Interferon-γ is essential for destruction of β cells and development of IDDM
    • von Herrath, M. G., and M. B. A. Oldstone. 1997. Interferon-γ is essential for destruction of β cells and development of IDDM. J. Exp. Med. 185:531.
    • (1997) J. Exp. Med. , vol.185 , pp. 531
    • Von Herrath, M.G.1    Oldstone, M.B.A.2
  • 40
    • 0343773445 scopus 로고    scopus 로고
    • IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease
    • Rocken, M. R., M. Racke, and E. M. Shevach. 1996. IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease. Immunol. Today 17:225.
    • (1996) Immunol. Today , vol.17 , pp. 225
    • Rocken, M.R.1    Racke, M.2    Shevach, E.M.3
  • 42
    • 0028786579 scopus 로고
    • + TC1 cells: Loss of IL-2 synthesis and autonomous proliferation but retention of cytotoxicity and synthesis of other cytokines
    • + TC1 cells: loss of IL-2 synthesis and autonomous proliferation but retention of cytotoxicity and synthesis of other cytokines. J. Exp. Med. 182:1505.
    • (1995) J. Exp. Med. , vol.182 , pp. 1505
    • Sad, S.1    Mossmann, T.R.2
  • 43
    • 0027249369 scopus 로고
    • + T cells in recovery from antigen-induced autoimmune disease
    • + T cells in recovery from antigen-induced autoimmune disease. J. Exp. Med. 178:909.
    • (1993) J. Exp. Med. , vol.178 , pp. 909
    • Kumar, V.1    Sercarz, E.E.2
  • 44
    • 0028518985 scopus 로고
    • Generation and in vivo persistence of polarized Th1 and Th2 memory cells
    • Swain, S. L. 1994. Generation and in vivo persistence of polarized Th1 and Th2 memory cells. Immunity 1:543.
    • (1994) Immunity , vol.1 , pp. 543
    • Swain, S.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.