NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice

Nature Medicine

Volumn 9, Issue 5, 2003, Pages 596-603

  Kojima, Hideto ^a   Fujimiya, Mineko ^b   Matsumura, Kazuhiro ^a   Younan, Patrick ^a   Imaeda, Hirotsugu ^b   Maeda, Makiko ^a,b   Chan, Lawrence ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BETACELLULIN; GENE PRODUCT; GLUCAGON; GLUCOKINASE; GLUCOSE; INSULIN; NEUROGENIC DIFFERENTIATION FACTOR; PANCREAS POLYPEPTIDE; PROINSULIN; SOMATOSTATIN; STREPTOZOCIN; SULFONYLUREA RECEPTOR; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL GRANULE; CONTROLLED STUDY; EXOCRINE CELL; GENE THERAPY; GLUCOSE BLOOD LEVEL; HEPATITIS; HOMEOBOX; IMMUNOCYTOCHEMISTRY; IMMUNOELECTRON MICROSCOPY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN SYNTHESIS; LIVER; MALE; MOUSE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADENOVIRIDAE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DNA-BINDING PROTEINS; GENE THERAPY; HEPATITIS; HOMEODOMAIN PROTEINS; INSULIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; ISLETS OF LANGERHANS; LIVER; MALE; MICE; MICE, INBRED C57BL; STREPTOZOCIN; TRANS-ACTIVATORS;

ADENOVIRIDAE; ANIMALIA;

EID: 0038413922     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm867     Document Type: Article

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