Retroviral delivery of GAD-IgG fusion construct induces tolerance and modulates diabetes: A role for CD4+ regulatory T cells and TGF-β?

Gene Therapy

Volumn 11, Issue 20, 2004, Pages 1487-1496

  Song, L ^a   Wang, J ^a   Wang, R ^a   Yu, M ^a   Sun, Y ^a   Han, G ^a   Li, Y ^a   Qian, J ^b   Scott, D W ^c   Kang, Y ^c   Soukhareva, N ^c   Shen, B ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b NATIONAL CANCER INSTITUTE   (United States)

^c HOLLAND LABORATORY   (United States)

Author keywords

CD4+ regulatory T cells; Diabetes; GAD IgG fusion construct; Immune tolerance; TGF

Indexed keywords

CD4 ANTIGEN; EPITOPE; GLUTAMATE DECARBOXYLASE; IMMUNOGLOBULIN G; INTERLEUKIN 2 RECEPTOR; LIPOPOLYSACCHARIDE; PEPTIDE; RETROVIRUS VECTOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CONTROLLED STUDY; EXPERIMENTAL DIABETES MELLITUS; EXPRESSION VECTOR; FEMALE; GENE CONSTRUCT; GENE FUSION; GENETIC TRANSDUCTION; HELPER CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOSTIMULATION; IMMUNOTHERAPY; IN VITRO STUDY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROLYMPHOCYTE; SPLEEN CELL; THYMUS; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; COCULTURE TECHNIQUES; DIABETES MELLITUS, TYPE 1; FEMALE; FLOW CYTOMETRY; GENE THERAPY; GENETIC VECTORS; GLUTAMATE DECARBOXYLASE; IMMUNE TOLERANCE; IMMUNOGLOBULIN G; INTERLEUKIN-10; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED NOD; RECOMBINANT FUSION PROTEINS; RETROVIRIDAE; TRANSFORMING GROWTH FACTOR BETA;

EID: 5444221869     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302327     Document Type: Article

References (25)

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