Hepatic insulin gene expression as treatment for type 1 diabetes mellitus in rats

Molecular Endocrinology

Volumn 11, Issue 6, 1997, Pages 833-837

  Muzzin, Patrick ^a,c   Eisensmitht, Randy C ^a,d   Copeland, Kenneth C ^a   Woo, Savio L C ^a,b,d  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Box 1496   (United States)

^c UNIVERSITY OF GENEVA   (Switzerland)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ARTICLE; GENE THERAPY; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; KETOACIDOSIS; PRIORITY JOURNAL;

ANIMALIA; UNIDENTIFIED RETROVIRUS;

EID: 0030946203     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.11.6.0017     Document Type: Article

References (11)

1. Cahill GF 1971 The physiology of insulin in man. Diabetes 20:785-798
2. Vignati L, Asmal AC, Black WL, Brink SJ, Hare JW 1985 Coma and diabetes. In: Marble A, Krall LP, Bradley RF, Christlieb AR, Soeldner JS (eds): Joslin's Diabetes Mellitus. Lea & Febiger, Philadelphia, p 526 and p 867
3. Kolodka TM, Finegold M, Moss L, Woo SLC 1995 Gene therapy for diabetes mellitus in rats by hepatic expression of insulin. Proc Natl Acad Sci USA 92:3293-3297
4. Valera A, Fillat C, Costa C, Sabater J, Visa J, Pujol A, Bosch F 1994 Regulated expression of human insulin in the liver of transgenic mice corrects diabetic alterations. FASEB J 8:440-447
5. Griffen SC, Russel SM, Katz LS, Nicoll CS 1987 Insulin exerts metabolic and growth-promoting effects by a direct action on the liver in vivo: clarification of the functional significance of the portal vascular link between the beta cells of the pancreatic islets and the liver. Proc Natl Acad Sci USA 84:7300-7304
6. Bowles NE, Eisensmith RC, Mohuiddin R, Pyron M, Woo SLC 1996 A simple and efficient method for the concentration and purification of recombinant retrovirus for increased hepatocyte transduction in vivo. Hum Gene Ther 7:1735-1742
7. Hosaka M, Nagahama M, Kim WS, Watanabe T, Hatsuzawa K, Ikemizu J, Murakami K, Nakayama K 1991 Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway. J Biol Chem 266:12127-12130
8. Thompson KS, Towle HC 1991 Localization of the carbohydrate response element of the rat L-type pyruvate kinase gene. J Biol Chem 266:8679-8682
9. Chen R, Doiron B, Kahn A 1995 Glucose responsiveness of a reporter gene transduced into hepatocytic cells using a retroviral vector. FEBS Lett 365:223-226
10. Sarkar G, Sommer SS 1990 The "megaprimer" method of site-directed mutagenesis. BioTechniques 8:404-407
11. Kolodka TM, Finegold M, Woo SLC 1993 Hepatic gene therapy: efficient retroviral-mediated gene transfer into rat hepatocytes in vivo. Somat Cell Mol Genet 19:491-497