Generation of insulin-producing cells from human bone marrow mesenchymal stem cells by genetic manipulation

Stem Cells

Volumn 25, Issue 11, 2007, Pages 2837-2844

  Karnieli, Ohad ^a   Izhar Prato, Yael ^a   Bulvik, Shlomo ^b   Efrat, Shimon ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b LANIADO HOSPITAL   (Israel)

Author keywords

Cell replacement; Cell transplantation; Insulin secretion; Pancreatic duodenal homeobox 1

Indexed keywords

GLUCOSE; INSULIN; NEUROGENIC DIFFERENTIATION FACTOR; PANCREAS HORMONE; RNA; TRANSCRIPTION FACTOR PDX 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL TRANSPLANTATION; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; GENETIC MANIPULATION; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREATIC DOUDENAL HOMEOBOX 1 GENE; PHENOTYPE; PROTEIN ANALYSIS; RNA ANALYSIS; STREPTOZOCIN DIABETES;

ADULT; AGED; ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; MICE, SCID; MIDDLE AGED; RATS; TRANS-ACTIVATORS;

MUS;

EID: 36248934727     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-0164     Document Type: Article

References (36)

1. Jiang Y, Jahagirdar BN, Reinhardt RL et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002;418:41-49.
2. Krause DS, Theise ND, Collector MI et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001;105:369-377.
3. Okamoto R, Yajima T, Yamazaki M et al. Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract. Nat Med 2002;8:1011-1017.
4. Caplice NM, Bunch TJ, Stalboerger PG et al. Smooth muscle cells in human coronary atherosclerosis can originate from cells administered at marrow transplantation. Proc Natl Acad Sci U S A 2003;100:4754-4759.
5. Ianus A, Holz GG, Theise ND et al. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 2003;111:843-850.
6. Choi JB, Uchino H, Azuma K et al. Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells. Diabetologia 2003;46:1366-1374.
7. Lechner A, Yang YG, Blacken RA et al. No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes 2004;53:616-623.
8. Taneera J, Rosengren A, Renstrom E et al. Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate. Diabetes 2006;55:290-296.
9. Hess D, Li L, Martin M et al. Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol 2003;21:763-770.
10. Lee RH, Seo MJ, Reger RL et al. Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proc Natl Acad Sci U S A 2006;103:17438-17443.
11. Oh SH, Muzzonigro TM, Bae SH et al. Adult bone marrow-derived cells trans-differentiating into insulin-producing cells for the treatment of type I diabetes. Lab Invest 2004;84:607-617.
12. Tang DQ, Cao LZ, Burkhardt BR et al. In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes 2004;53:1721-1732.
13. Chen LB, Jiang XB, Yang L. Differentiation of rat marrow mesenchymal stem cells into pancreatic islet beta-cells. World J Gastroenterol 2004;10:3016-3020.
14. Choi KS, Shin JS, Lee JJ et al. In vitro trans-differentiation of rat mesenchymal cells into insulin-producing cells by rat pancreatic extract. Biochem Biophys Res Commun 2005;330:1299-1305.
15. Zalzman M, Gupta S, Giri R et al. Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells. Proc Natl Acad Sci U S A 2003;100:7253-7258.
16. Zalzman M, Anker-Kitai L, Efrat S. Differentiation of human liver-derived insulin-producing cells towards the beta-cell phenotype. Diabetes 2005;54:2568-2575.
17. Ferber S, Halkin A, Cohen H et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 2000;6:568-572.
18. Kojima H, Nakamura T, Fujita Y et al. Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin. Diabetes 2002;51:1398-1408.
19. Yoshida S, Kajimoto Y, Yasuda T et al. PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells. Diabetes 2002;51:2505-2513.
20. Horb ME, Shen CN, Tosh D et al. Experimental conversion of liver to pancreas. Curr Biol 2003;13:105-115.
21. Miyatsuka T, Kaneto H, Kajimoto Y et al. Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis. Biochem Biophys Res Commun 2003;310:1017-1025.
22. Fodor A, Harel C, Fodor L et al. Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: An ex vivo gene therapy approach. Diabetologia 2007;50:121-130.
23. Moriscot C, de Fraipont F, Richard MJ et al. Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro. STEM CELLS 2005;23:594-603.
24. Sun J, Yang Y, Wang X et al. Expression of Pdx-1 in bone marrow mesenchymal stem cells promotes differentiation of islet-like cells in vitro. Sci China C Life Sci 2006;49:480-489.
25. Colter DC, Class R, DiGirolamo CM et al. Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proc Natl Acad Sci U S A 2000;97:3213-3218.
26. Peister A, Mellad JA, Wang M et al. Stable transfection of MSCs by electroporation. Gene Ther 2004;11:224-228.
27. Gregory CA, Singh H, Perry AS et al. The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow. J Biol Chem 2003;278:28067-28078.
28. Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147.
29. Pittenger MF, Martin BJ. Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res 2004;95:9-20.
30. Aslan H, Zilberman Y, Kandel L et al. Osteogenic differentiation of noncultured immunoisolated bone marrow-derived CD105+ cells. STEM CELLS 2006;24:1728-1737.
31. Ratajczak MZ, Kucia M, Reca R et al. Stem cell plasticity revisited: CXCR4-positive cells expressing mRNA for early muscle, liver and neural cells 'hide out' in the bone marrow. Leukemia 2004;18:29-40.
32. Liu WD, Wang HW, Muguira M et al. INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases. Biochem J 2006;397:169-177.
33. Eizirik DL, Korbutt GS, Hellerstrom C. Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function. J Clin Invest 1992;90:1263-1268.
34. Brandhorst H, Brandhorst D, Brendel MD et al. Assessment of intracellular insulin content during all steps of human islet isolation procedure. Cell Transplant 1998;7:489-495.
35. Lukinius A, Ericsson JL, Grimelius L et al. Ultrastructural studies of the ontogeny of fetal human and porcine endocrine pancreas, with special reference to colocalization of the four major islet hormones. Dev Biol 1992;153:376-385.
36. Burt RK, Oyama Y, Traynor A et al. Hematopoietic stem cell therapy for type 1 diabetes: Induction of tolerance and islet cell neogenesis. Autoimmun Rev 2002;1:133-138.