Long-term correction of diabetes in rats after lentiviral hepatic insulin gene therapy

Diabetologia

Volumn 50, Issue 9, 2007, Pages 1910-1920

  Ren, B ^a   O'Brien, B A ^a   Swan, M A ^b   Koina, M E ^a,d   Nassif, N ^a   Wei, M Q ^c   Simpson, A M ^a  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d CANBERRA HOSPITAL   (Australia)

Author keywords

Beta cell transcription factors; Gene therapy; Hepatocytes; Insulin storage; Lentiviral vector; Type 1 diabetes; Wistar rats

Indexed keywords

FURIN; GLUCOSE; INSULIN; LENTIVIRUS VECTOR; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL DIFFERENTIATION; CELL GRANULE; DIABETES MELLITUS; ELECTRON MICROSCOPY; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; ISOLATED LIVER; LENTIVIRINAE; LIVER CELL; MALE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOZOCIN DIABETES; VIRAL GENE THERAPY;

ANIMALS; BLOOD GLUCOSE; CLONING, MOLECULAR; DIABETES MELLITUS, EXPERIMENTAL; GENE THERAPY; HEPATOCYTES; INSULIN; LENTIVIRUS; MALE; RATS; RATS, WISTAR; REFERENCE VALUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 34547701718     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0722-0     Document Type: Article

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