메뉴 건너뛰기




Volumn 55, Issue 1, 2005, Pages 81-86

Lentiviral gene therapy with platelet-derived growth factor B sustains accelerated healing of diabetic wounds over time

Author keywords

Diabetic wound; Lentiviral gene therapy; PDGF

Indexed keywords

LENTIVIRUS VECTOR; PLATELET DERIVED GROWTH FACTOR B;

EID: 21244435687     PISSN: 01487043     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.sap.0000168211.76318.fa     Document Type: Article
Times cited : (24)

References (45)
  • 1
    • 0033016846 scopus 로고    scopus 로고
    • Incidence, outcomes, and cost of foot ulcers in patients with diabetes
    • Ramsey SD, Newton K, Blough D, et al. Incidence, outcomes, and cost of foot ulcers in patients with diabetes. Diabetes Care. 1999;22:382-387.
    • (1999) Diabetes Care , vol.22 , pp. 382-387
    • Ramsey, S.D.1    Newton, K.2    Blough, D.3
  • 2
    • 4444378325 scopus 로고    scopus 로고
    • Costs of lower-extremity ulcers among patients with diabetes
    • Stockl K, Vanderplas A, Tafesse E, et al. Costs of lower-extremity ulcers among patients with diabetes. Diabetes Care. 2004;27:2129-2134.
    • (2004) Diabetes Care , vol.27 , pp. 2129-2134
    • Stockl, K.1    Vanderplas, A.2    Tafesse, E.3
  • 3
    • 11844293372 scopus 로고    scopus 로고
    • Preventing foot ulcers in patients with diabetes
    • Singh N, Armstrong DG, Lipsky BA. Preventing foot ulcers in patients with diabetes. JAMA. 2005;293:217-228.
    • (2005) JAMA , vol.293 , pp. 217-228
    • Singh, N.1    Armstrong, D.G.2    Lipsky, B.A.3
  • 4
    • 0025359279 scopus 로고
    • PDGF and FGF stimulate wound healing in the genetically diabetic mouse
    • Greenhalgh DG, Sprugel KH, Murray MJ, et al. PDGF and FGF stimulate wound healing in the genetically diabetic mouse. Am J Pathol. 1990;136:1235-1246.
    • (1990) Am J Pathol , vol.136 , pp. 1235-1246
    • Greenhalgh, D.G.1    Sprugel, K.H.2    Murray, M.J.3
  • 5
    • 0028334260 scopus 로고
    • PDGF and TGF-alpha act synergistically to improve wound healing in the genetically diabetic mouse
    • Brown RL, Breeden MP, Greenhalgh DG. PDGF and TGF-alpha act synergistically to improve wound healing in the genetically diabetic mouse. J Surg Res. 1994;56:562-570.
    • (1994) J Surg Res , vol.56 , pp. 562-570
    • Brown, R.L.1    Breeden, M.P.2    Greenhalgh, D.G.3
  • 6
    • 0035123387 scopus 로고    scopus 로고
    • Inhibition of lipid peroxidation restores impaired vascular endothelial growth factor expression and stimulates wound healing and angiogenesis in the genetically diabetic mouse
    • Altavilla D, Saitta A, Cucinotta D, et al. Inhibition of lipid peroxidation restores impaired vascular endothelial growth factor expression and stimulates wound healing and angiogenesis in the genetically diabetic mouse. Diabetes. 2001;50:667-674.
    • (2001) Diabetes , vol.50 , pp. 667-674
    • Altavilla, D.1    Saitta, A.2    Cucinotta, D.3
  • 7
    • 0037218315 scopus 로고    scopus 로고
    • Wound healing and diabetes mellitus
    • Greenhalgh DG. Wound healing and diabetes mellitus. Clin Plast Surg. 2003;30:37-45.
    • (2003) Clin Plast Surg , vol.30 , pp. 37-45
    • Greenhalgh, D.G.1
  • 8
    • 0028906062 scopus 로고
    • Pharmacologic enhancement of wound healing
    • Pierce GF, Mustoe TA. Pharmacologic enhancement of wound healing. Annu Rev Med. 1995;46:467-481.
    • (1995) Annu Rev Med , vol.46 , pp. 467-481
    • Pierce, G.F.1    Mustoe, T.A.2
  • 9
    • 0025894052 scopus 로고
    • Role of platelet-derived growth factor in wound healing
    • Pierce GF, Mustoe TA, Altrock BW, et al. Role of platelet-derived growth factor in wound healing. J Cell Biochem. 1991;45:319-326.
    • (1991) J Cell Biochem , vol.45 , pp. 319-326
    • Pierce, G.F.1    Mustoe, T.A.2    Altrock, B.W.3
  • 10
    • 0026718378 scopus 로고
    • Platelet-derived growth factor (BB homodimer), transforming growth factor-beta 1, and basic fibroblast growth factor in dermal wound healing: Neovessel and matrix formation and cessation of repair
    • Pierce GF, Tarpley JE, Yanagihara D. et al. Platelet-derived growth factor (BB homodimer), transforming growth factor-beta 1, and basic fibroblast growth factor in dermal wound healing: neovessel and matrix formation and cessation of repair. Am J Pathol. 1992;140:1375-1388.
    • (1992) Am J Pathol , vol.140 , pp. 1375-1388
    • Pierce, G.F.1    Tarpley, J.E.2    Yanagihara, D.3
  • 11
    • 0022371706 scopus 로고
    • Stimulation of granulation tissue formation by platelet-derived growth factor in normal and diabetic rats
    • Grotendorst GR, Martin GR, Pencev D, et al. Stimulation of granulation tissue formation by platelet-derived growth factor in normal and diabetic rats. J Clin Invest. 1985;76:2323-2329.
    • (1985) J Clin Invest , vol.76 , pp. 2323-2329
    • Grotendorst, G.R.1    Martin, G.R.2    Pencev, D.3
  • 12
    • 0026019087 scopus 로고
    • Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model
    • Mustoe TA, Pierce GF, Morishima C. et al. Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model. J Clin Invest. 1991;87:694-703.
    • (1991) J Clin Invest , vol.87 , pp. 694-703
    • Mustoe, T.A.1    Pierce, G.F.2    Morishima, C.3
  • 13
    • 0027301146 scopus 로고
    • PDGF and FGF reverse the healing impairment in protein-malnourished diabetic mice
    • Albertson S, Hummel RP 3rd, Breeden M, et al. PDGF and FGF reverse the healing impairment in protein-malnourished diabetic mice. Surgery. 1993;114:368-372.
    • (1993) Surgery , vol.114 , pp. 368-372
    • Albertson, S.1    Hummel III, R.P.2    Breeden, M.3
  • 14
    • 0029616562 scopus 로고
    • Platelet-derived growth factor and wound contraction in the rat
    • Karr BP, Bubak PJ, Sprugel KH, et al. Platelet-derived growth factor and wound contraction in the rat. J Surg Res. 1995;59:739-742.
    • (1995) J Surg Res , vol.59 , pp. 739-742
    • Karr, B.P.1    Bubak, P.J.2    Sprugel, K.H.3
  • 15
    • 0024441779 scopus 로고
    • Reversal of impaired wound healing in irradiated rats by platelet-derived growth factor-BB
    • Mustoe TA, Purdy J, Gramates P, et al. Reversal of impaired wound healing in irradiated rats by platelet-derived growth factor-BB. Am J Surg. 1989;158:345-350.
    • (1989) Am J Surg , vol.158 , pp. 345-350
    • Mustoe, T.A.1    Purdy, J.2    Gramates, P.3
  • 16
    • 0036318172 scopus 로고    scopus 로고
    • Topical platelet-derived growth factor enhances wound closure in the absence of wound contraction: An experimental and clinical study
    • Saba AA, Freedman BM, Gaffield JW, et al. Topical platelet-derived growth factor enhances wound closure in the absence of wound contraction: an experimental and clinical study. Ann Plast Surg. 2002;49: 62-66.
    • (2002) Ann Plast Surg , vol.49 , pp. 62-66
    • Saba, A.A.1    Freedman, B.M.2    Gaffield, J.W.3
  • 17
    • 0031681266 scopus 로고    scopus 로고
    • Clinical efficacy of becaplermin (rhPDGF-BB) gel: Becaplermin Gel Studies Group
    • Wieman TJ. Clinical efficacy of becaplermin (rhPDGF-BB) gel: Becaplermin Gel Studies Group. Am J Surg. 1998;176(2A suppl):74S-79S.
    • (1998) Am J Surg , vol.176 , Issue.2 A SUPPL.
    • Wieman, T.J.1
  • 18
    • 0026737331 scopus 로고
    • Recombinant human platelet-derived growth factor-BB for the treatment of chronic pressure ulcers
    • Robson MC, Phillips LG, Thomason A, et al. Recombinant human platelet-derived growth factor-BB for the treatment of chronic pressure ulcers. Ann Plast Surg. 1992;29:193-201.
    • (1992) Ann Plast Surg , vol.29 , pp. 193-201
    • Robson, M.C.1    Phillips, L.G.2    Thomason, A.3
  • 19
    • 0026595966 scopus 로고
    • Platelet-derived growth factor BB for the treatment of chronic pressure ulcers
    • Robson MC, Phillips LG, Thomason A, et al. Platelet-derived growth factor BB for the treatment of chronic pressure ulcers. Lancet. 1992; 339:23-25.
    • (1992) Lancet , vol.339 , pp. 23-25
    • Robson, M.C.1    Phillips, L.G.2    Thomason, A.3
  • 20
    • 0028873980 scopus 로고
    • Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity diabetic ulcers: Diabetic Ulcer Study Group
    • Steed DL. Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity diabetic ulcers: Diabetic Ulcer Study Group. J Vasc Surg. 1995;21:71-78.
    • (1995) J Vasc Surg , vol.21 , pp. 71-78
    • Steed, D.L.1
  • 21
    • 0031734833 scopus 로고    scopus 로고
    • Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers: A phase III randomized placebo-controlled double-blind study
    • Wieman TJ, Smiell JM, Su Y. Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers: a phase III randomized placebo-controlled double-blind study. Diabetes Care. 1998;21:822-827.
    • (1998) Diabetes Care , vol.21 , pp. 822-827
    • Wieman, T.J.1    Smiell, J.M.2    Su, Y.3
  • 22
    • 0035074207 scopus 로고    scopus 로고
    • Treatment options for diabetic neuropathic foot ulcers: A cost-effectiveness analysis
    • Kantor J, Margolis DJ. Treatment options for diabetic neuropathic foot ulcers: a cost-effectiveness analysis. Dermatol Surg. 2001;27:347-351.
    • (2001) Dermatol Surg , vol.27 , pp. 347-351
    • Kantor, J.1    Margolis, D.J.2
  • 23
    • 0036162046 scopus 로고    scopus 로고
    • Gene therapy, electroporation, and the future of wound-healing therapies
    • Cupp CL, Bloom DC. Gene therapy, electroporation, and the future of wound-healing therapies. Facial Plast Surg. 2002;18:53-57.
    • (2002) Facial Plast Surg , vol.18 , pp. 53-57
    • Cupp, C.L.1    Bloom, D.C.2
  • 24
    • 1642567557 scopus 로고    scopus 로고
    • Growth factors and chronic wound healing: Past, present, and future
    • Goldman R. Growth factors and chronic wound healing: past, present, and future. Adv Skin Wound Care. 2004;17:24-35.
    • (2004) Adv Skin Wound Care , vol.17 , pp. 24-35
    • Goldman, R.1
  • 25
    • 0032707850 scopus 로고    scopus 로고
    • Gene-enhanced tissue engineering: Applications for wound healing using cultured dermal fibroblasts transduced retrovirally with the PDGF-B gene
    • Breitbart AS, Mason JM, Urmacher C, et al. Gene-enhanced tissue engineering: applications for wound healing using cultured dermal fibroblasts transduced retrovirally with the PDGF-B gene. Ann Plast Surg. 1999;43:632-639.
    • (1999) Ann Plast Surg , vol.43 , pp. 632-639
    • Breitbart, A.S.1    Mason, J.M.2    Urmacher, C.3
  • 26
    • 0035051114 scopus 로고    scopus 로고
    • Treatment of ischemic wounds using cultured dermal fibroblasts transduced retrovirally with PDGF-B and VEGF121 genes
    • Breitbart AS, Grande DA, Laser J, et al. Treatment of ischemic wounds using cultured dermal fibroblasts transduced retrovirally with PDGF-B and VEGF121 genes. Ann Plant Surg. 2001;46:555-561.
    • (2001) Ann Plant Surg , vol.46 , pp. 555-561
    • Breitbart, A.S.1    Grande, D.A.2    Laser, J.3
  • 27
    • 0141754108 scopus 로고    scopus 로고
    • Accelerated diabetic wound healing using cultured dermal fibroblasts retrovirally transduced with the platelet-derived growth factor B gene
    • Breitbart AS, Laser J. Parrett B, et al. Accelerated diabetic wound healing using cultured dermal fibroblasts retrovirally transduced with the platelet-derived growth factor B gene. Ann Plast Surg. 2003;51:409-414.
    • (2003) Ann Plast Surg , vol.51 , pp. 409-414
    • Breitbart, A.S.1    Laser, J.2    Parrett, B.3
  • 29
    • 0034721690 scopus 로고    scopus 로고
    • Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    • Kordower JH, Emborg ME, Bloch J, et al. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science. 2000;290:767-773.
    • (2000) Science , vol.290 , pp. 767-773
    • Kordower, J.H.1    Emborg, M.E.2    Bloch, J.3
  • 30
    • 21244437020 scopus 로고    scopus 로고
    • Lentiviral transfection with the PDGF-B gene improves diabetic wound healing
    • In press
    • Lee JA, Conejero JA, Mason JM, et al. Lentiviral transfection with the PDGF-B gene improves diabetic wound healing. Plast Recon Surg. In press.
    • Plast Recon Surg
    • Lee, J.A.1    Conejero, J.A.2    Mason, J.M.3
  • 31
    • 0034244658 scopus 로고    scopus 로고
    • A stable system for the high-titer production of multiply attenuated lentiviral vectors
    • Klages N, Zufferey R, Trono D. A stable system for the high-titer production of multiply attenuated lentiviral vectors. Mol Ther. 2000;2: 170-176.
    • (2000) Mol Ther , vol.2 , pp. 170-176
    • Klages, N.1    Zufferey, R.2    Trono, D.3
  • 32
    • 0026361447 scopus 로고
    • The use of the Picrosirius-polarization method for the study of the biopathology of collagen
    • Montes GS, Junqueira LC. The use of the Picrosirius-polarization method for the study of the biopathology of collagen. Mem Inst Oswalde Cruz. 1991;86(suppl 3):1-11.
    • (1991) Mem Inst Oswalde Cruz , vol.86 , Issue.SUPPL. 3 , pp. 1-11
    • Montes, G.S.1    Junqueira, L.C.2
  • 33
    • 0032939574 scopus 로고    scopus 로고
    • Image processing techniques for quantitative analysis of skin structures
    • Sanders JE.,Goldstein BS, Leotta DF, et al. Image processing techniques for quantitative analysis of skin structures. Comput Methods Programs Biomed. 1999;59:167-180.
    • (1999) Comput Methods Programs Biomed , vol.59 , pp. 167-180
    • Sanders, J.E.1    Goldstein, B.S.2    Leotta, D.F.3
  • 34
    • 0020045888 scopus 로고
    • Diabetes-obesity syndromes in mice
    • Coleman DL. Diabetes-obesity syndromes in mice. Diabetes. 1982; 31(suppl 1 pt 2):1-6.
    • (1982) Diabetes , vol.31 , Issue.SUPPL. 1 PART 2 , pp. 1-6
    • Coleman, D.L.1
  • 35
    • 84989052485 scopus 로고
    • Synergistic actions of platelet-derived growth factor and the insulin-like growth factors in vivo
    • Greenhalgh DG, Hummel RP 3rd, Albertson S, et al. Synergistic actions of platelet-derived growth factor and the insulin-like growth factors in vivo. Wound Repair Regen. 1993;1:69-81.
    • (1993) Wound Repair Regen , vol.1 , pp. 69-81
    • Greenhalgh, D.G.1    Hummel III, R.P.2    Albertson, S.3
  • 36
    • 0035085050 scopus 로고    scopus 로고
    • Expressional regulation of angiopoietin-1 and -2 and the tie-1 and -2 receptor tyrosine kinases during cutaneous wound healing: A comparative study of normal and impaired repair
    • Kampfer H, Pfeilschifter J, Frank S. Expressional regulation of angiopoietin-1 and -2 and the tie-1 and -2 receptor tyrosine kinases during cutaneous wound healing: a comparative study of normal and impaired repair. Lab Invest. 2001;81:361-373.
    • (2001) Lab Invest , vol.81 , pp. 361-373
    • Kampfer, H.1    Pfeilschifter, J.2    Frank, S.3
  • 37
    • 0033894983 scopus 로고    scopus 로고
    • Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: Prolonged persistence of neutrophils and macrophages during the late phase of repair
    • Wetzler C, Kampfer H, Stallmeyer B, et al. Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair. J Invest Dermatol. 2000;115: 245-253.
    • (2000) J Invest Dermatol , vol.115 , pp. 245-253
    • Wetzler, C.1    Kampfer, H.2    Stallmeyer, B.3
  • 38
    • 0028999404 scopus 로고
    • Laser Doppler velocimetry and platelet-derived growth factor as prognostic indicators for the healing of ulcers and ischaemic lesions of the lower limb
    • Chleboun JO, Martins R, Rao S. Laser Doppler velocimetry and platelet-derived growth factor as prognostic indicators for the healing of ulcers and ischaemic lesions of the lower limb. Cardiovasc Surg. 1995;3:285-290.
    • (1995) Cardiovasc Surg , vol.3 , pp. 285-290
    • Chleboun, J.O.1    Martins, R.2    Rao, S.3
  • 39
    • 0029149872 scopus 로고
    • Detection of platelet-derived growth factor (PDGF)-AA in actively healing human wounds treated with recombinant PDGF-BB and absence of PDGF in chronic nonhealing wounds
    • Pierce GF, Tarpley JE, Tseng J, et al. Detection of platelet-derived growth factor (PDGF)-AA in actively healing human wounds treated with recombinant PDGF-BB and absence of PDGF in chronic nonhealing wounds. J Clin Invest. 1995;96:1336-1:350.
    • (1995) J Clin Invest , vol.96 , pp. 1336-1350
    • Pierce, G.F.1    Tarpley, J.E.2    Tseng, J.3
  • 41
    • 0024460181 scopus 로고
    • Improved retroviral vectors for gene transfer and expression
    • Miller AD, Rosman GJ. Improved retroviral vectors for gene transfer and expression. Bio techniques 1989;7:980-982; 984-986, 989-990.
    • (1989) Bio Techniques , vol.7 , pp. 980-982
    • Miller, A.D.1    Rosman, G.J.2
  • 42
    • 4744351350 scopus 로고    scopus 로고
    • Adenoviral mediated gene transfer of PDGF-B enhances wound healing in type I and type II diabetic wounds
    • Keswani SG, Katz AB, Lim FY, et al. Adenoviral mediated gene transfer of PDGF-B enhances wound healing in type I and type II diabetic wounds. Wound Repair Regen. 2004;12:497-504.
    • (2004) Wound Repair Regen , vol.12 , pp. 497-504
    • Keswani, S.G.1    Katz, A.B.2    Lim, F.Y.3
  • 43
    • 2442718933 scopus 로고    scopus 로고
    • Adenovirus encoding human platelet-derived growth factor-B delivered in collagen exhibits safety, biodistribution, and immunogenicity profiles favorable for clinical use
    • Gu DL. Nguyen T, Gonzalez AM, et al. Adenovirus encoding human platelet-derived growth factor-B delivered in collagen exhibits safety, biodistribution, and immunogenicity profiles favorable for clinical use. Mol Ther. 2004;9:699-711.
    • (2004) Mol Ther , vol.9 , pp. 699-711
    • Gu, D.L.1    Nguyen, T.2    Gonzalez, A.M.3
  • 44
  • 45
    • 4544296841 scopus 로고    scopus 로고
    • Adenoviral vectors for gene replacement therapy
    • Cao H, Koehler DR, Hu J. Adenoviral vectors for gene replacement therapy. Virol Immunol. 2004;17:327-333.
    • (2004) Virol Immunol , vol.17 , pp. 327-333
    • Cao, H.1    Koehler, D.R.2    Hu, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.