Viral IL-10-mediated immune regulation in pancreatic islet transplantation

Molecular Therapy

Volumn 12, Issue 2, 2005, Pages 360-368

  Carter, Jeffrey D ^a   Ellett, Justin D ^a,c   Chen, Meng ^a   Smith, Kellie M ^a   Fialkow, Lawrence B ^a,d   McDuffie, Marcia J ^a   Tung, Kenneth S ^b   Nadler, Jerry L ^a   Yang, Zandong ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Adeno associated viral vector; Autoimmune recurrence; Islet transplantation; NOD mice; T cell activation; Viral IL 10

Indexed keywords

BETA GALACTOSIDASE; GAMMA INTERFERON; INSULIN ZINC SUSPENSION; INTERLEUKIN 10; INTERLEUKIN 2; PARVOVIRUS VECTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CONTROLLED STUDY; DIABETES MELLITUS; DONOR; DRUG EFFICACY; FEMALE; GENE TRANSFER; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; INHIBITION KINETICS; MOUSE; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; RECIPIENT; RECURRENT DISEASE; T LYMPHOCYTE ACTIVATION; TREATMENT OUTCOME; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; AUTOIMMUNITY; DIABETES MELLITUS, TYPE 1; FEMALE; GENE THERAPY; GENETIC VECTORS; GRAFT SURVIVAL; INTERLEUKIN-10; ISLETS OF LANGERHANS TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED NOD; RECURRENCE; T-LYMPHOCYTES; TRANSFECTION; TRANSPLANTATION, ISOGENEIC;

EID: 22644438152     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2005.02.030     Document Type: Article

References (49)

1. A.M. Shapiro et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen N. Engl. J. Med. 343 2000 230-238
2. D.E. Sutherland F.C. Goetz and R.K. Sibley Recurrence of disease in pancreas transplants Diabetes 38 Suppl. 1 1989 85-87
3. S. Slavin et al. New approaches for control of anti-self reactivity in type 1 diabetes mellitus and transplantation of pancreatic islets J. Mol. Med. 77 1999 223-225
4. M.D. Stegall K.J. Lafferty I. Kam and R.G. Gill Evidence of recurrent autoimmunity in human allogeneic islet transplantation Transplantation 61 1996 1272-1274
5. A. Rabinovitch W.L. Suarez-Pinzon O. Sorensen R.C. Bleackley R.F. Power and R.V. Rajotte Combined therapy with interleukin-4 and interleukin-10 inhibits autoimmune diabetes recurrence in syngeneic islet-transplanted nonobese diabetic mice: Analysis of cytokine mRNA expression in the graft Transplantation 60 1995 368-374
6. P. Vieira et al. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: Homology to Epstein-Barr virus open reading frame BCRFI Proc. Natl. Acad. Sci. USA 88 1991 1172-1176
7. K.W. Moore P. Vieira D.F. Fiorentino M.L. Trounstine T.A. Khan and T.R. Mosmann Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI Science 248 1990 1230-1234
8. Z. Yang et al. Suppression of autoimmune diabetes by viral IL-10 gene transfer J. Immunol. 168 2002 6479-6485
9. Z. Yang M. Chen J.D. Ellett L.B. Fialkow J.D. Carter and J.L. Nadler The novel anti-inflammatory agent lisofylline prevents autoimmune diabetic recurrence after islet transplantation Transplantation 77 2004 55-60
10. T. Jung U. Schauer C. Heusser C. Neumann and C. Rieger Detection of intracellular cytokines by flow cytometry J. Immunol. Methods 159 1993 197-207
11. D.V. Serreze S.A. Fleming H.D. Chapman S.D. Richard E.H. Leiter and R.M. Tisch B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice J. Immunol. 161 1998 3912-3918
12. K.W. Moore M.R. de Waal R.L. Coffman and A. O'Garra Interleukin-10 and the interleukin-10 receptor Annu. Rev. Immunol. 19 2001 683-765
13. B. Wittig C. Schwarzler N. Fohr U. Gunthert and M. Zoller Curative treatment of an experimentally induced colitis by a CD44 variant V7-specific antibody J. Immunol. 161 1998 1069-1073
14. B. Wittig S. Seiter D.S. Schmidt M. Zuber M. Neurath and M. Zoller CD44 variant isoforms on blood leukocytes in chronic inflammatory bowel disease and other systemic autoimmune diseases Lab. Invest. 79 1999 747-759
15. D.D. Brand et al. Detection of early changes in autoimmune T cell phenotype and function following intravenous administration of type II collagen in a TCR-transgenic model J. Immunol. 168 2002 490-498
16. K.M. Gilbert J.M. Griffin and N.R. Pumford Trichloroethylene activates CD4+ T cells: Potential role in an autoimmune response Drug Metab. Rev. 31 1999 901-916
17. D.L. Perkins et al. Restriction of the TCR repertoire inhibits the development of memory T cells and prevents autoimmunity in lpr mice J. Immunol. 156 1996 4961-4968
18. H. Ponta L. Sherman and P.A. Herrlich CD44: From adhesion molecules to signalling regulators Nat. Rev. Mol. Cell Biol. 4 2003 33-45
19. H.C. DeGrendele P. Estess and M.H. Siegelman Requirement for CD44 in activated T cell extravasation into an inflammatory site Science 278 1997 672-675
20. L. Santos-Argumedo P.W. Kincade S. Partida-Sanchez and R.M. Parkhouse CD44-stimulated dendrite formation ('spreading') in activated B cells Immunology 90 1997 147-153
21. A. Rafi M. Nagarkatti and P.S. Nagarkatti Hyaluronate-CD44 interactions can induce murine B-cell activation Blood 89 1997 2901-2908
22. R. Galandrini M. Piccoli L. Frati and A. Santoni Tyrosine kinase-dependent activation of human NK cell functions upon triggering through CD44 receptor Eur. J. Immunol. 26 1996 2807-2811
23. M.C. Levesque and B.F. Haynes Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-alpha and is inhibited by IL-4 and IL-13 J. Immunol. 159 1997 6184-6194
24. H.C. DeGrendele P. Estess L.J. Picker and M.H. Siegelman CD44 and its ligand hyaluronate mediate rolling under physiologic flow: A novel lymphocyte-endothelial cell primary adhesion pathway J. Exp. Med. 183 1996 1119-1130
25. N.J. Davidson et al. T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice J. Exp. Med. 184 1996 241-251
26. R.K. Sellon et al. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice Infect. Immun. 66 1998 5224-5231
27. F. Atzeni et al. Induction of CD69 activation molecule on human neutrophils by GM-CSF, IFN-gamma, and IFN-alpha Cell. Immunol. 220 2002 20-29
28. A. Gessl and W. Waldhausl Elevated CD69 expression on naive peripheral blood T-cells in hyperthyroid Graves' disease and autoimmune thyroiditis: Discordant effect of methimazole on HLA-DR and CD69 Clin. Immunol. Immunopathol. 87 1998 168-175
29. J.L. Huang L.S. Ou C.H. Tsao L.C. Chen and M.L. Kuo Reduced expression of CD69 and adhesion molecules of T lymphocytes in asthmatic children receiving immunotherapy Pediatr. Allergy Immunol. 13 2002 426-433
30. P.J. Egan K.E. Lawlor W.S. Alexander and I.P. Wicks Suppressor of cytokine signaling-1 regulates acute inflammatory arthritis and T cell activation J. Clin. Invest. 111 2003 915-924
31. C. Sharp C. Thompson E.T. Samy R. Noelle and K.S. Tung CD40 ligand in pathogenesis of autoimmune ovarian disease of day 3-thymectomized mice: implication for CD40 ligand antibody therapy J. Immunol. 170 2003 1667-1674
32. W. Boonyasrisawat et al. Flow cytometry for the analysis of T cells expressing CD69 after stimulation with glutamic acid decarboxylase Asian Pac.J. Allergy Immunol. 20 2002 37-42
33. S. Fujisaki H. Miyake S. Amano H. Nakayama T. Oida and H. Takizawa Expression of CD44 in rat liver allografts during rejection J. Hepatobiliary Pancreat. Surg. 5 1998 196-199
34. A.M. Posselt F. Vincenti M. Bedolli M. Lantz J.P. Roberts and R. Hirose CD69 expression on peripheral CD8 T cells correlates with acute rejection in renal transplant recipients Transplantation 76 2003 190-195
35. P. Creemers J. Brink H. Wainwright K. Moore E. Shephard and D. Kahn Evaluation of peripheral blood CD4 and CD8 lymphocyte subsets, CD69 expression and histologic rejection grade as diagnostic markers for the presence of cardiac allograft rejection Transplant. Immunol. 10 2002 285-292
36. W. Zhang et al. Blocking of cd44-hyaluronic acid interaction prolongs rat allograft survival Transplantation 69 2000 665-668
37. A. Knoflach et al. Immunomodulatory functions of hyaluronate in the LEW-to-F344 model of chronic cardiac allograft rejection Transplantation 67 1999 909-914
38. M. Prochazka D.V. Serreze W.N. Frankel and E.H. Leiter NOR/Lt mice: MHC-matched diabetes-resistant control strain for NOD mice Diabete. 41 1992 98-106
39. L.D. Shultz et al. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-SCID mice J. Immunol. 154 1995 180-191
40. E.F. Lampeter S.R. McCann and H. Kolb Transfer of diabetes type 1 by bone-marrow transplantation Lancet 351 1998 568-569
41. E.F. Lampeter et al. Transfer of insulin-dependent diabetes between HLA-identical siblings by bone marrow transplantation Lancet 341 1993 1243-1244
42. M.C. Gagnerault J.J. Luan C. Lotton and F. Lepault Pancreatic lymph nodes are required for priming of beta cell reactive T cells in NOD mice J. Exp. Med. 196 2002 369-377
43. S. Turley L. Poirot M. Hattori C. Benoist and D. Mathis Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model J. Exp. Med. 198 2003 1527-1537
44. Y.C. Zhang et al. Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice Diabetes 52 2003 708-716
45. B. Balasa et al. A mechanism for IL-10-mediated diabetes in the nonobese diabetic (NOD) mouse: ICAM-1 deficiency blocks accelerated diabetes J. Immunol. 165 2000 7330-7337
46. F. Uchikoshi et al. Prevention of autoimmune recurrence and rejection by adenovirus-mediated CTLA4Ig gene transfer to the pancreatic graft in BB rat Diabetes 48 1999 652-657
47. S.T. Bartlett T. Chin B. Dirden A. Quereshi and G. Hadley Inclusion of peripancreatic lymph node cells prevents recurrent autoimmune destruction of islet transplants: Evidence of donor chimerism Surgery 118 1995 392-397
48. E. Seung et al. Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: Absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice Blood 95 2000 2175-2182
49. C. Aspord S. Rome and C. Thivolet Early events in islets and pancreatic lymph nodes in autoimmune diabetes J. Autoimmun. 23 2004 27-35