Lentiviral Gene Transfer of SDF-1α to Wounds Improves Diabetic Wound Healing

Journal of Surgical Research

Volumn 143, Issue 1, 2007, Pages 35-42

  Badillo, Andrea T ^a   Chung, Sophie ^a   Zhang, Liping ^a   Zoltick, Philip ^a   Liechty, Kenneth W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

diabetes; gene therapy; SDF 1 ; wound healing

Indexed keywords

GROWTH FACTOR; STROMAL CELL DERIVED FACTOR 1ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; EPITHELIZATION; FEMALE; GENE THERAPY; GRANULATION TISSUE; LENTIVIRINAE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TREATMENT RESPONSE; VIRAL GENE DELIVERY SYSTEM; WOUND; WOUND HEALING;

ANIMALS; CHEMOKINE CXCL12; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION; GENE THERAPY; LENTIVIRUS; MICE; MICE, KNOCKOUT; RNA, MESSENGER; TRANSFECTION; WOUND HEALING; WOUNDS AND INJURIES;

EID: 35248846610     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2007.03.051     Document Type: Article

References (19)

1. Centers for Disease Control and Prevention (CDC), National Center for Health Statistics. Division of Diabetes Translation, data from the National Health Interview Survey (2004)
2. Wieman T.J., Smiell J.M., and Su Y. Efficacy and safety of a topical gel formulation of recombinant human platelet-derived growth factor-BB (becaplermin) in patients with chronic neuropathic diabetic ulcers. A phase III randomized placebo-controlled double-blind study. Diabetes Care 21 (1998) 822
3. Falanga V. Wound healing and its impairment in the diabetic foot. Lancet 366 (2005) 1736
4. Abbott J.D., Huang Y., Liu D., et al. Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation 110 (2004) 3300
5. Ceradini D.J., Kulkarni A.R., Callaghan M.J., et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 10 (2004) 858
6. Tang Y.L., Qian K., Zhang Y.C., et al. Mobilizing of haematopoietic stem cells to ischemic myocardium by plasmid mediated stromal-cell-derived factor-1alpha (SDF-1alpha) treatment. Regul Pept 125 (2005) 1
7. Blakytny R., and Jude E. The molecular biology of chronic wounds and delayed healing in diabetes. Diabet Med 23 (2006) 594
8. Miyoshi H., Blomer U., Takahashi M., et al. Development of a self-inactivating lentivirus vector. J Virol 72 (1998) 8150
9. Naldini L., Blomer U., Gallay P., et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272 (1996) 263
10. Donello J.E., Loeb J.E., and Hope T.J. Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element. J Virol 72 (1998) 5085
11. Zennou V., Serguera C., Sarkis C., et al. The HIV-1 DNA flap stimulates HIV vector-mediated cell transduction in the brain. Nat Biotechnol 19 (2001) 446
12. Sena-Esteves M., Tebbets J.C., Steffens S., et al. Optimized large-scale production of high titer lentivirus vector pseudotypes. J Virol Methods 122 (2004) 131
13. Lapidot T., Dar A., and Kollet O. How do stem cells find their way home?. Blood 106 (2005) 1901
14. Yamani M.H., Ratliff N.B., Cook D.J., et al. Peritransplant ischemic injury is associated with up-regulation of stromal cell-derived factor-1. J Am Coll Cardiol 46 (2005) 1029
15. Schober A., Karshovska E., Zernecke A., et al. SDF-1alpha-mediated tissue repair by stem cells: a promising tool in cardiovascular medicine?. Trends Cardiovasc Med 16 (2006) 103
16. Salcedo R., Wasserman K., Young H.A., et al. Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1alpha. Am J Pathol 154 (1999) 1125
17. Singer A.J., and Clark R.A. Cutaneous wound healing. N Engl J Med 341 (1999) 738
18. Ruiz de Almodovar C., Luttun A., and Carmeliet P. An SDF-1 trap for myeloid cells stimulates angiogenesis. Cell 124 (2006) 18
19. Keating A. Mesenchymal stromal cells. Curr Opin Hematol 13 (2006) 419