The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus

New England Journal of Medicine

Volumn 329, Issue 14, 1993, Pages 977-986

[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ADOLESCENT; ADULT; ARTICLE; BLOOD GLUCOSE MONITORING; CLINICAL TRIAL; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DIABETIC NEUROPATHY; DIABETIC RETINOPATHY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN PUMP; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; PRIMARY PREVENTION; PRIORITY JOURNAL; PROTEINURIA; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ADULT; BLOOD GLUCOSE; CONFIDENCE INTERVALS; DIABETES MELLITUS, INSULIN-DEPENDENT; DIABETIC NEPHROPATHIES; DIABETIC NEUROPATHIES; DIABETIC RETINOPATHY; FEMALE; FOLLOW-UP STUDIES; HUMAN; INSULIN; INSULIN INFUSION SYSTEMS; MALE; SUPPORT, U.S. GOV'T, P.H.S.; TREATMENT OUTCOME;

EID: 0027370108     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199309303291401     Document Type: Article

References (43)

1. National Diabetes Data Group. Diabetes in America: diabetes data compiled 1984. Bethesda, Md.: National Institutes of Health, 1985. (NIH publication no. 85-1468.)
2. Deckert T, Poulsen JE, Larsen M Prognosis of diabetics with diabetes onset before the age of thirty-one. Diabetologia 1978; 14: 363-377
3. Engerman R, Bloodworth JM Jr, Nelson S Relationship of microvascular disease in diabetes to metabolic control. Diabetes 1977; 26: 760-769
4. Engerman RL, Kern TS Progression of incipient diabetic retinopathy during good glycemic control. Diabetes 1987; 36: 808-812
5. Cohen AJ, McGill PD, Rossetti RG, Guberski DL, Like AA Glomerulopathy in spontaneously diabetic rat: impact of glycemic control. Diabetes 1987; 36: 944-951
6. Klein R, Klein BE, Moss SE, Davis MD, DeMets DL The Wisconsin epidemiologic study of diabetic retinopathy. II. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years. Arch Ophthalmol 1984; 102: 520-526
7. Klein R, Klein BE, Moss SE, Davis MD, DeMets DL Glycosylated hemoglobin predicts the incidence and progression of diabetic retinopathy. JAMA 1988; 260: 2864-2871
8. Chase HP, Jackson WE, Hoops SL, Cockerham RS, Archer PG, O'Brien D Glucose control and the renal and retinal complications of insulin-dependent diabetes. JAMA 1989; 261: 1155-1160
9. Kroc Collaborative Study Group. Blood glucose control and the evolution of diabetic retinopathy and albuminuria: a preliminary multicenter trial. N Engl J Med 1984; 311: 365-372
10. Lauritzen T, Frost-Larsen K, Larsen H-W, Deckert T Two-year experience with continuous subcutaneous insulin infusion in relation to retinopathy and neuropathy. Diabetes 1985; 34: Suppl: 74-79
11. Brinchmann-Hansen O, Dahl-Jorgensen K, Hanssen KF, Sandvik L The response of diabetic retinopathy to 41 months of multiple insulin injections, insulin pumps, and conventional insulin therapy. Arch Ophthalmol 1988; 106: 1242-1246
12. Reichard P, Nilsson B-Y, Rosenqvist U The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus. N Engl J Med 1993; 329: 304-309
13. DCCT Research Group. The Diabetes Control and Complications Trial (DCCT): design and methodologic considerations for the feasibility phase. Diabetes 1986; 35: 530-545
14. DCCT Research Group. Diabetes Control and Complications Trial (DCCT): results of feasibility study. Diabetes Care 1987; 10: 1-19
15. DCCT Research Group. Diabetes Control and Complications Trial (DCCT): update. Diabetes Care 1990; 13: 427-433
16. Siebert C, Clark DM Jr Operational and policy considerations of data monitoring in clinical trials: the Diabetes Control and Complications Trial experience. Control Clin Trials 1993; 14: 30-44
17. DCCT Research Group. Implementation of a multicomponent process to obtain informed consent in the Diabetes Control and Complications Trial. Control Clin Trials 1989; 10: 83-96
18. DCCT Research Group. Color photography vs fluorescein angiography in the detection of diabetic retinopathy in the Diabetes Control and Complications Trial. Arch Ophthalmol 1987; 105: 1344-1351
19. DCCT Research Group. Factors in development of diabetic neuropathy: baseline analysis of neuropathy in feasibility phase of Diabetes Control and Complications Trial (DCCT). Diabetes 1988; 37: 476-481
20. Schumer M, Burton G, Burton C, Crum D, Pfeifer MA Diabetic autonomic neuropathy -- part I: autonomic nervous system data analysis by a computerized central unit in a multicenter trial. Am J Med 1988; 85: 137-143
21. DCCT Research Group. Feasibility of centralized measurements of glycated hemoglobin in the Diabetes Control and Complications Trial: a multicenter study. Clin Chem 1987; 33: 2267-2271
22. DCCT Research Group. A screening algorithm to identify clinically significant changes in neuropsychological function in the Diabetes Control and Complications Trial. J Clin Exp Neuropsychol (in press).
23. DCCT Research Group. Reliability and validity of a diabetes quality-of-life measure for the Diabetes Control and Complications Trial (DCCT). Diabetes Care 1988; 11: 725-732
24. DCCT Research Group. DCCT protocol. Springfield, Va.: Department of Commerce, National Technical Information Service, 1988. (Publication no. 88-116462-AS.)
25. DCCT Research Group. DCCT manual of operations. Springfield, Va.: Department of Commerce, National Technical Information Service, 1993. (Publication no. 93-183382.)
26. Early Treatment Diabetic Retinopathy Study Research Group. Fundus photographic risk factors for progression of diabetic retinopathy: ETDRS report no. 12. Ophthalmology 1991; 98: 823-833
27. Wei LJ, Lachin JM Properties of the urn randomization in clinical trials. Control Clin Trials 1988; 9: 345-364
28. Early Treatment Diabetic Retinopathy Study Research Group. Grading diabetic retinopathy from stereoscopic color fundus photographs -- an extension of the modified Airlie House classification: ETDRS report no. 10. Ophthalmology 1991; 98: 786-806
29. Early Treatment Diabetic Retinopathy Study Research Group. Early photocoagulation for diabetic retinopathy: ETDRS report number 9. Ophthalmology 1991; 98: Suppl: 766-785
30. Snedecor GW, Cochran WG. Statistical methods. 6th ed. Ames: Iowa State University Press, 1967.
31. Kleinbaum DG, Kupper LL, Morgenstern H. Epidemiologic research: principles and quantitative methods. Belmont, Calif.: Lifetime Learning, 1982:359.
32. Lee ET. Statistical methods for survival data analysis. Belmont, Calif.: Lifetime Learning, 1980:88-92, 127-9, 306-12.
33. Tygstrup N, Lachin JM, Juhl E, eds. The randomized clinical trial and therapeutic decisions. New York: Marcel Dekker, 1982:174.
34. McCullagh P, Nelder JA. Generalized linear models. 2nd ed. New York: Chapman & Hall, 1989:194-200, 429-30.
35. Dorman JS, Laporte RE, Kuller LH, The Pittsburgh insulin-dependent diabetes mellitus (IDDM) morbidity and mortality study: mortality results. Diabetes 1984; 33: 271-276
36. DCCT Research Group. Epidemiology of severe hypoglycemia in the Diabetes Control and Complications Trial. Am J Med 1991; 90: 450-459
37. DCCT Research Group. Weight gain associated with intensive therapy in the Diabetes Control and Complications Trial. Diabetes Care 1988; 11: 567-573
38. Lauritzen T, Frost-Larsen K, Larsen HW, Deckert T Effect of 1 year of near-normal blood glucose levels on retinopathy in insulin-dependent diabetics. Lancet 1983; 1: 200-204
39. Dahl-Jorgensen K, Brinchmann-Hansen O, Hanssen KF, Sandvik L, Aagenaes O Rapid tightening of blood glucose control leads to transient deterioration of retinopathy in insulin dependent diabetes mellitus: the Oslo study. BMJ 1985; 290: 811-815
40. Feldt-Rasmussen B, Mathiesen ER, Deckert T Effect of two years of strict metabolic control on progression of incipient nephropathy in insulin-dependent diabetes. Lancet 1986; 2: 1300-1304
41. Lawson PM, Champion MC, Canny C, Continuous subcutaneous insulin infusion (CSII) does not prevent progression of proliferative and preproliferative retinopathy. Br J Ophthalmol 1982; 66: 762-766
42. Klein R, Klein BE, Moss SE, Davis MD, DeMets DL The Wisconsin epidemiologic study of diabetic retinopathy. III. Prevalence and risk of diabetic retinopathy when age at diagnosis is 30 or more years. Arch Ophthalmol 1984; 102: 527-532
43. Nathan DM, Singer DE, Godine JE, Harrington CH, Perlmuter LC Retinopathy in older type II diabetics: association with glucose control. Diabetes 1986; 35: 797-801